Heart rhythm最新文献

{"title":"Long-term prognosis of patients with an SCN5A loss-of-function variant and progressive cardiac conduction disorder or Brugada syndrome.","authors":"Fenna Tuijnenburg, Virginnio M Proost, Aurélie Thollet, Julien Barc, Alexander J A Groffen, Christiaan C Veerman, Saskia N van der Crabben, Vincent R van der Pas, Florence Kyndt, Sean J Jurgens, Michael W T Tanck, Pieter G Postema, J Peter van Tintelen, Connie R Bezzina, Vincent Probst, Arthur A M Wilde, Jean-Baptiste Gourraud, Ahmad S Amin","doi":"10.1016/j.hrthm.2024.10.057","DOIUrl":"https://doi.org/10.1016/j.hrthm.2024.10.057","url":null,"abstract":"<p><strong>Background: </strong>The long-term prognosis of patients with a loss-of-function variant in the cardiac sodium channel gene SCN5A is unknown.</p><p><strong>Objective: </strong>This study aimed to evaluate the long-term arrhythmic risk in patients with an SCN5A loss-of-function variant to identify predictors of arrhythmic events.</p><p><strong>Methods: </strong>Probands and family members with (likely-)pathogenic SCN5A loss-of-function variants were retrospectively included. Clinical and ECG data at baseline and last follow-up were collected. Patients with a history of cardiac arrest, sustained ventricular tachycardia, symptomatic or documented atrial tachy- or bradyarrhythmia, or arrhythmogenic syncope, were categorized as symptomatic. Arrhythmic events at follow-up were defined as sudden death, aborted cardiac arrest, documented ventricular fibrillation and/or sustained ventricular tachycardia.</p><p><strong>Results: </strong>We included 615 patients (349 males, 242 probands, 157 spontaneous type-1 Brugada-ECG and 111 symptomatic at baseline). During 9.5 (5.0-14.3) years follow-up, arrhythmic events occurred in 41 patients (6.7%), equating an overall event rate of 0.7%/year; 2.0%/year in symptomatic and 0.3%/year in asymptomatic patients. In the overall study population, symptoms at baseline, male sex, and QRS prolongation were identified as independent predictors of arrhythmic events. In asymptomatic patients, also male sex and QRS prolongation were identified as predictors. Asymptomatic women with QRS <100ms did not experience arrhythmic events at follow-up.</p><p><strong>Conclusion: </strong>Key predictors of arrhythmic risk in patients with an SCN5A loss-of-function variant, regardless of a Brugada syndrome diagnosis, are symptoms at baseline, male sex, and prolonged QRS. Our findings may enable more tailored management strategies in patients with an SCN5A loss-of-function variant based on their individual risk profiles.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and Safety of Pulsed Field Ablation at the Ventricular Outflow Tract Using Focal Point Catheter.","authors":"Lihui Zheng, Pakezhati Maimaitijiang, Aiyue Chen, Zihao Lai, Yan Yao","doi":"10.1016/j.hrthm.2024.10.059","DOIUrl":"https://doi.org/10.1016/j.hrthm.2024.10.059","url":null,"abstract":"<p><strong>Background: </strong>Ventricular arrhythmias commonly originate from the ventricular outflow tract (VOT). It remains unexplored whether pulsed-field ablation (PFA) can create durable lesions safely at the VOT.</p><p><strong>Objective: </strong>This study aimed at evaluating the feasibility and safety of a novel PFA catheter to deliver focal ablation to the VOT, especially pulmonary and aortic sinus cusps (PSCs and ASCs).</p><p><strong>Methods: </strong>Twelve swine were divided into three groups: 24-hour, 2-week, and 4-week post-ablation. PFA was delivered to pre-defined sites of PSCs and ASCs with a focal point catheter, positioned via mapping system, fluoroscopy, and intracardiac echocardiography (ICE). Electrophysiologic assessment, coronary angiography, transesophageal echocardiogram (TEE), gross and histologic examination were performed to evaluate the impact of PFA delivery on cardiac structure and function.</p><p><strong>Results: </strong>All subjects survived, and no adverse events were observed. There was a significant decrease in voltage amplitude and increase in pacing thresholds at PSCs and ASCs. There were no significant differences in A-H or H-V intervals between pre- and post-ablation (A-H, P = .70; H-V, P = .90). After PFA delivery to ASCs, coronary arteries were fully perfused in each heart, without ST-segment elevation observed. No severe valvular dysfunction was observed based on ICE and TEE. Gross and histologic examination confirmed the creation of well-demarcated lesions at the targeted sites without damage to adjacent structures.</p><p><strong>Conclusion: </strong>PFA delivered via the focal point catheter could create durable lesions at PSCs and ASCs without damage to coronary arteries, atrioventricular block, or valvular dysfunction, indicative of the feasibility and safety of this novel PFA catheter at the VOT.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long and winding road to electrocardiographic imaging (ECGI)","authors":"Yoram Rudy PhD, FHRS,","doi":"10.1016/j.hrthm.2024.08.060","DOIUrl":"10.1016/j.hrthm.2024.08.060","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Top Stories: Syncope","authors":"Benjamin M. Moore MBBS, PhD,&nbsp;Andrew D. Krahn MD, FHRS","doi":"10.1016/j.hrthm.2024.08.057","DOIUrl":"10.1016/j.hrthm.2024.08.057","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ivabradine use in children","authors":"Christopher M. Janson MD","doi":"10.1016/j.hrthm.2024.09.025","DOIUrl":"10.1016/j.hrthm.2024.09.025","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sinus Node Dysfunction: An Under-Recognized Marker of Biatrial Myopathy?","authors":"Sohaib A Virk, Jonathan Kalman","doi":"10.1016/j.hrthm.2024.10.056","DOIUrl":"https://doi.org/10.1016/j.hrthm.2024.10.056","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Table Of Content","authors":"","doi":"10.1016/S1547-5271(24)03424-6","DOIUrl":"10.1016/S1547-5271(24)03424-6","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Top stories on using computational modeling and artificial intelligence to uncover arrhythmogenic mechanisms and advance arrhythmia management","authors":"Natalia A. Trayanova PhD, FHRS, FAHA ,&nbsp;Minglang Yin PhD ,&nbsp;Adityo Prakosa PhD","doi":"10.1016/j.hrthm.2024.07.034","DOIUrl":"10.1016/j.hrthm.2024.07.034","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is it Possible to Identify Patients at Risk of Idiopathic Ventricular Fibrillation?","authors":"Bernard Belhassen","doi":"10.1016/j.hrthm.2024.10.054","DOIUrl":"https://doi.org/10.1016/j.hrthm.2024.10.054","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing Leakage from Post-Release Device Shift During Left Atrial Appendage Closure Using a Disc Occluder.","authors":"Yi-Hao Wu, Yuan-Nan Lin, Jing Xu, Yue-Chun Li","doi":"10.1016/j.hrthm.2024.10.055","DOIUrl":"https://doi.org/10.1016/j.hrthm.2024.10.055","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}