Heart rhythm最新文献

{"title":"Right Atrial Reverse Remodeling After Pulmonary Vein Isolation: Analyzing Changes in Volume and Function Using Cardiac Magnetic Resonance Imaging.","authors":"Nikki van Pouderoijen, Luuk H G A Hopman, Leontine E Wentrup, Joris R de Groot, Michiel J B Kemme, Cornelis P Allaart, Marco J W Götte","doi":"10.1016/j.hrthm.2025.03.1976","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.03.1976","url":null,"abstract":"<p><strong>Background: </strong>Successful pulmonary vein isolation (PVI) promotes left atrial (LA) reverse remodeling, but its effect on right atrial (RA) remodeling remains unclear.</p><p><strong>Objective: </strong>To study the impact of radiofrequency (RF) PVI on RA volumes and function in atrial fibrillation (AF) patients, assessed by cardiac MRI (CMR).</p><p><strong>Methods: </strong>Forty-three AF patients (74.4% male, 61±7 years) undergoing first RF PVI, without atrial flutter ablation, underwent three CMR scans: pre-PVI, early (<72 hours), and 3 months post-PVI. Indexed atrial volumes (RAVImin/max, LAVImin/max) and function were derived from two- and four chamber cine images, with longitudinal atrial strain analyzed using feature tracking.</p><p><strong>Results: </strong>Early post-PVI, RAVImin significantly decreased (28.7±10.3mL/m² to 26.0±9.9mL/m²,p=0.03), while RA EF significantly increased (37.3±11.5% to 41.7±10.1%,p=0.03). At 3 months, both RAVImin and RAVImax showed significant further reductions compared to baseline (28.7±10.3mL/m² to 24.8±8.8mL/m²,p=0.002; 45.2±11.8mL/m² to 40.3±11.9mL/m²,p<0.001, respectively). During this period, RA functional improvement persisted, as evidenced by RA reservoir and contractile strain (16.2±4.1% to 18.9±3.6%,p=0.003; 6.6±2.6% to 8.3±2.8%,p=0.005, respectively). LA volumes remained unchanged early post-PVI, but at 3 months, LAVImax significantly decreased compared to baseline (46.1±13.0mL/m² to 39.1±11.3mL/m²,p<0.001). LA function, demonstrated by reservoir and contractile strain, was significantly diminished early post-PVI, which persisted at 3 months compared with baseline (18.6±4.0% to 17.0±3.4%,p=0.04; 8.5±3.0% to 6.9±2.4%,p<0.01, respectively).</p><p><strong>Conclusion: </strong>This study demonstrates that RF PVI results in reverse bi-atrial remodeling, with significant reductions observed in RA and LA volumes. RA function showed a significant improvement post-PVI, while LA function demonstrated a persistent impaired function at 3 months, possibly due to LA ablation scarring.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex difference of genetic risk in the prevalence of atrial fibrillation.","authors":"Sayuri Tokioka, Masato Takase, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba, Kotaro Nochioka, Hirohito Metoki, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Gen Tamiya, Nobuo Fuse, Shinichi Kuriyama, Satoshi Yasuda, Atsushi Hozawa","doi":"10.1016/j.hrthm.2025.03.1974","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.03.1974","url":null,"abstract":"<p><strong>Background: </strong>Early detection and management of atrial fibrillation (AF) are crucial. Combined models incorporating genetic risks and clinical risks have been developed to improve predictive ability. Although sex differences have been reported in many aspects of AF, sex differences in genetic risk have not been studied.</p><p><strong>Objective: </strong>To assess the sex difference in the effect of AF-PRS on AF prevalence using cross-sectional data from the Tohoku Medical Megabank Project Community-Based Cohort Study in Japan.</p><p><strong>Methods: </strong>Polygenic risk score for AF (AF-PRS) and Cohorts for Heart and Aging Research in Genomic Epidemiology AF (CHARGE-AF) score were used for genetic AF risks and clinical AF risks, respectively. Sex differences in the association of AF-PRS with the prevalence of AF were evaluated.</p><p><strong>Results: </strong>Among 16,853 participants (mean age, 63.4 years and 30.7% men), the prevalence of AF was 4.9% in men and 1.1% in women. In the group with high AF-PRS and high CHARGE-AF score, the odds ratio for AF was highest in men and women (8.2 in men and 9.4 in women), compared to that in the group with low AF-PRS and low CHARGE-AF score. Integrating AF-PRS into the CHARGE-AF score significantly enhanced the area under the curve of receiver operating characteristic for AF in men (from 0.639 to 0.749) but not in women (from 0.710 to 0.733).</p><p><strong>Conclusion: </strong>Our study is the first to show a sex difference in the association of AF-PRS and AF prevalence. AF-PRS is more closely associated with the prevalence of AF in men than in women.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New-onset atrial fibrillation in acute coronary syndrome: To anticoagulate or not?","authors":"Hani Essa, Joel P Giblett, Gregory Y H Lip","doi":"10.1016/j.hrthm.2025.02.047","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.02.047","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrophysiological conduction characteristics and clinical implications of prolonged Stim-R wave peak time during left bundle branch pacing.","authors":"Gengwei Hu, Dan Xu, Fengqian Chen, Siyuan Xue, Shun Xu, Zhiyong Qian, Yao Wang, Jiangang Zou, Xiaofeng Hou","doi":"10.1016/j.hrthm.2025.03.1972","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.03.1972","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Pulsed Field Ablation and Left Atrial Appendage Occlusion - A Multicenter Comparative Study.","authors":"Mark Tk Tam, Pipin Kojodjojo, Yat-Yin Lam, Jeremy Chow, Cliff Wong, Kevin Ka-Ho Kam, Geri Ling-Na Wong, Chin-Pang Chan, Joseph Ys Chan, Kent Chak-Yu So","doi":"10.1016/j.hrthm.2025.03.1968","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.03.1968","url":null,"abstract":"<p><strong>Background: </strong>Combining pulsed field ablation (PFA) and left atrial appendage occlusion (LAAO) to one procedure is appealing for atrial fibrillation treatment.</p><p><strong>Objective: </strong>To compare the outcome of combined and standalone procedures METHODS: This is a retrospective cohort study of consecutive patients undergoing combined PFA and LAAO procedures in 3 centers in 2023. They underwent PFA pulmonary vein isolation (PVI) with Farapulse, followed by LAAO with Watchman FLX guided by transesophageal echocardiogram (TEE). Pulmonary ridge thickness was measured at 45 degrees, 5mm from tip of the ridge, before and after PFA. At 3-month, TEE or computed tomography was performed for LAAO patients to assess occlusion result. Peri-device leak (PDL) of more than 3mm was defined as significant. Consecutive PFA or LAAO standalone procedures served as control.</p><p><strong>Results: </strong>This cohort included 36 combined, 48 standalone LAAO and 52 standalone PFA cases. Acute PVI was achieved in all combined and PFA standalone procedures. Successful LAAO implantation with Watchman FLX was achieved in 97.2% combined procedures, and all standalone LAAO procedures. In the combined cohort, pulmonary ridge thickness increased after ablation by 2.72±1.19mm (p<0.001) or 69.4%±51.4%. At 3-month, the rate of PDL did not differ between combined and standalone LAAO cohorts (26.7 vs 15.2%, p=0.22). However, significant PDL (>3mm) occurred more commonly in the combined cohort compared to standalone LAAO cohort (20% vs 2.2%, P=0.013).</p><p><strong>Conclusion: </strong>Combined PFA and LAAO was feasible. However, we observed a mean 69.4% increase in pulmonary ridge thickness immediately following PFA. Significant PDL was more prevalent in combined procedure.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance imaging analysis of left atrial scar formation following atrial fibrillation ablation using a novel variable loop catheter for pulsed field ablation.","authors":"Thomas Fink, Vanessa Sciacca, Kevin Bannmann, Maximilian Moersdorf, Denise Guckel, Sebastian Beyer, Mustapha El Hamriti, Moneeb Khalaph, Martin Braun, Maxim Didenko, Guram Imnadze, Philipp Sommer, Christian Sohns","doi":"10.1016/j.hrthm.2025.03.1969","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.03.1969","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sudden cardiac death in patients with kidney failure on renal replacement therapy: an unsolved problem.","authors":"Simonetta Genovesi, Giulia Lieti, A John Camm","doi":"10.1016/j.hrthm.2025.03.1970","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.03.1970","url":null,"abstract":"<p><p>Sudden cardiac death is an important cause of mortality in patients with kidney failure undergoing renal replacement therapy, either hemodialysis or peritoneal dialysis. The risk factors associated with sudden cardiac death in these patients only partly overlap with those in the general population. Kidney failure per se and hemodialysis therapy expose these patients to an increased risk of sudden cardiac death compared with individuals with preserved renal function. Studies of the implantable cardioverter defibrillator for primary prevention of sudden cardiac death in patients with kidney failure have failed to demonstrate its usefulness. Moreover, the incidence of complications associated with cardiac electronic device implantation in this population is extremely high. This review aims to provide an update on the available studies on the pathophysiology and prevention of sudden cardiac death in patients with kidney failure undergoing dialysis, and to propose the adoption of clinical practices to reduce its incidence.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right Atrium and Superior Vena Cava Macro-Reentrant Tachycardia Masquerading as Focal Tachycardia Originating from the Left Atrial Roof.","authors":"Tabito Kino, Hiro Yamasaki, Yuki Komatsu, Miyako Igarashi, Tomoko Ishizu","doi":"10.1016/j.hrthm.2025.03.1971","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.03.1971","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of the Electrocardiogram in TMEM43 p.S358L Arrhythmogenic Cardiomyopathy.","authors":"Stephen A Duffett, Chris Compton, Kieran Vasanthan, Ian Short, Harinder Pal Gill, Terry-Lynn Young, Sean P Connors, Kathleen A Hodgkinson","doi":"10.1016/j.hrthm.2025.03.1965","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.03.1965","url":null,"abstract":"<p><strong>Background: </strong>The electrocardiogram (ECG) is important in the diagnostic evaluation of arrhythmogenic cardiomyopathy (ACM).</p><p><strong>Objective: </strong>The purpose of this study was to identify ECG features associated with TMEM43 p.S358L ACM over long-term assessment.</p><p><strong>Methods: </strong>A total of 634 ECGs were collected from a retrospective cohort of 68 patients with TMEM43 p.S358L ACM. Abnormalities in repolarization, depolarization, conduction intervals, QRS voltage, and rhythm were analyzed.</p><p><strong>Results: </strong>68 patients (32 males, 36 females) with ≥ 5 ECGs (median 9, range 5-17) over 20.5 ± 8.0 years were included. Over follow-up, 56/68 (82.4%) had an abnormality. Task Force Criteria (TFC) repolarization abnormalities were rare. Terminal activation duration ≥ 55 ms was common (20/32 males - 62.5%, 13/36 females - 36.1%). An epsilon wave was demonstrated in 2 female patients. Significant prolongation in the QRS duration occurred for males (97.3±11.6 ms to 137.6±24.8 ms, p <0.001) and females (90.4 ± 12.1 ms to 117.4 ±24.0ms, p <0.001). The most common finding was R wave < 3 mm in V3 (PRWP). Loss of the R wave in V3 < 3mm followed by development of an intraventricular conduction delay or complete left bundle branch block was seen in the majority of patients (42/68, 61.8%), occurring earlier in males than females (p <0.02).</p><p><strong>Conclusion: </strong>Repolarization TFC criteria and epsilon waves are rare in TMEM43 p.S358L ACM. The ECG in TMEM43 p.S358L ACM is characterized by loss of the R wave in V3 to < 3mm and QRS prolongation with development of an IVCD or LBBB.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piezo2 expressed in GP: Potential therapeutic target of atrial fibrillation.","authors":"Xujun Li, Tianyou Xu, Yuhong Wang, Zhipeng Hu, Shoupeng Duan, Chen Peng, Saiting Xu, Chengzhe Liu, Rui Li, Qiang Deng, Yueyi Wang, Liping Zhou, Hong Jiang, Lilei Yu","doi":"10.1016/j.hrthm.2025.03.1964","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.03.1964","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) is closely linked to autonomic nervous system activity, with activation of the cardiac ganglionated plexus (GP) often presents in AF. Piezo, a mechanosensitive ion channel, plays a pivotal role in neuronal modulation. However, its involvement in the GP and AF remains poorly understood.</p><p><strong>Objective: </strong>This study investigates the expression of Piezo2 in GP and its potential role in AF.</p><p><strong>Methods: </strong>GP tissues were collected from patients undergoing cardiac transplantation, and Piezos expression levels were assessed. Rapid atrial pacing (RAP) was performed in a large animal model to induce AF, and Piezos expression in GP tissues was also evaluated. Piezo2 knockdown in GP was achieved via adeno-associated virus in animals subjected to RAP. Atrial electrophysiological parameters, AF inducibility, neural activity and GP function, were subsequently analyzed. RNA sequencing was employed to elucidate underlying mechanisms.</p><p><strong>Results: </strong>In the AF group and in people with higher left atrial pressure, Piezo2 expression was increased in the GP. Knockdown of Piezo2 in GP impaired GP function and neural activity, thereby decreasing AF susceptibility. RNA-seq analysis revealed significant down-regulation of the Notch signaling pathway.</p><p><strong>Conclusions: </strong>These findings suggest that Piezo2 expressed in GP may serve as a novel therapeutic target for the treatment of AF.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}