Hellenic journal of nuclear medicine最新文献

{"title":"Effect tracking of ¹³¹I treatment in Graves' hyperthyroidism patients within 1 year and analysis of the factors that may influence the cure.","authors":"Yue Zhao,&nbsp;Xin Tian,&nbsp;Zhaowei Meng","doi":"10.1967/s002449912554","DOIUrl":"https://doi.org/10.1967/s002449912554","url":null,"abstract":"<p><strong>Objective: </strong>To observe the disease development and outcome of Graves' disease (GD) patients within 1 year after iodine-131 (¹³¹I) treatment, and analyze the factors affecting the treatment effect.</p><p><strong>Subjects and methods: </strong>Clinical data of 221 patients who received the first treatment with ¹³¹I in our department from June 2016 to October 2018 were retrospectively analyzed and they were followed up at 3 months, 6 months and 1 year after the treatment. According to the three follow-up records, the cure rate was calculated and the follow-up chart was drawn. The factors that may affect the clinical cure were analyzed according to the follow-up results after 1 year: Independent risk factors affecting the prognosis were screened out by Logistic regression analysis, and the effects of the above factors on the prognosis were further analyzed by Chi-square test, and the cure multiple relationship caused by the influencing factors was analyzed by Logistic regression analysis.</p><p><strong>Results: </strong>The cure rate was 58.82% and the effective rate was 71.95%. At the 3-month follow-up, 11 patients (4.98%) presented complete response, 99 patients (44.80%) presented hypothyroidism, 93 patients (42.08%) presented partial response, and 18 patients (8.14%) presented no effect or recurrence. At 6 months, 18 cases (8.14%) had complete response, 90 cases (40.72%) had hypothyroidism, 59 cases (26.70%) had partial response, and 54 cases (24.43%) had no effect or recurrence. At 12 months, 36 cases (16.29%) had complete response, 94 cases (42.53%) had hypothyroidism, 29 cases (13.12%) had partial response, and 62 cases (28.05%) had no effect or recurrence. Thyroid weight and thyroid peroxidase antibody (TPOAb) were the influencing factors. Among all patients, patients with thyroid weight ≤28.70g were 4.25 times more likely to achieve clinical cure than patients with >28.70g [OR (95%CI):4.252 (2.383-7.588), P<0.01)], female patients with the thyroid weight ≤28.70g was 5.78 times than those with >28.70g [OR (95%CI): 5.776 (2.951-11.308), P<0.01]. In male, patients with TPOAb≤449.00IU/mL were 0.27 times more likely to achieve clinical cure than those with >449.00IU/mL [OR (95%CI): 0.274 (0.081-0.919), P<0.05].</p><p><strong>Conclusion: </strong>Iodine-131 was an effective treatment to GD. Thyroid weight before treatment was the influencing factor for all patients and female patients, while TPOAb was the influencing factor for male patients.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"26 1","pages":"35-40"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9367650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of RAH VQ SPECT/CT lobar quantification program using a modified version of GE Q lung.","authors":"Chong Ghee Chew,&nbsp;Benjamin Crouch,&nbsp;Stirling Ha,&nbsp;Alice Burke,&nbsp;Jennie Louise","doi":"10.1967/s002449912551","DOIUrl":"https://doi.org/10.1967/s002449912551","url":null,"abstract":"<p><strong>Objective: </strong>The value of ventilation-perfusion (VQ) single photon emission tomography/computed tomography (SPECT/CT) lobar quantification for pre-operative assessment of lobectomy and lung volume reduction is known. Our in-house developed software, RAH ventilation perfusion SPECT/CT quantification (RAHVQSQ) has been shown to be able to identify the target lobe for collapse in bronchoscopic lung volume reduction (BLVR) for advanced emphysema. We have proven inter and intra observer reproducibility but are yet to validate the accuracy of our program. This study aims to validate the accuracy of our quantitative program through comparison with a modified version of GE Q lung which is a commercial program certified for clinical use.</p><p><strong>Subjects and methods: </strong>Ventilation-perfusion SPECT/CT data of 19 subjects from our previous study using RAHVQSQ for BLVR assessment were re-analysed using Q lung by 2 technologists independently and in a blinded fashion to determine lobar differential ventilation, perfusion and volume percentages. The data were from GE Hawkeye 4 and external CT, thus a modified version of Q lung was used. To determine interobserver variation in the 3 parameters between the 3 assessors, intraclass correlation coefficient (ICC) and Bland-Altman limits of agreement (LoA) were generated.</p><p><strong>Results: </strong>Paired comparisons between the 3 assessors had high ICC (range for ventilation: 0.69-0.97; perfusion: 0.69-0.97; volume: 0.63-0.97) and means of LoA differences close to zero (range for ventilation: -0.04 - 0.10; perfusion: 0.00-0.02; volume: -0.12 - 0.09) were noted indicative of good concordance for all parameters.</p><p><strong>Conclusion: </strong>Using VQ SPECT/CT data of participants with advanced airway disease, our study has found a close concordance of estimated differential lobar ventilation, perfusion and volume percentages using RAHVQSQ when compared with a duplicated blinded assessment using Q lung. The good concordance supports the validity of our quantitative methodology.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"26 1","pages":"9-19"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9361279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differentiated thyroid cancer: Case report of false positive ¹³¹I uptake on whole body scintigraphy in a patient with bilateral femur osteonecrosis.","authors":"Evanthia Giannoula,&nbsp;Georgia Koutsouki,&nbsp;Paraskevi Exadaktylou,&nbsp;Nikitas Papadopoulos,&nbsp;Emmanouil Papanastasiou,&nbsp;Argirios Doumas,&nbsp;Ioannis Iakovou","doi":"10.1967/s002449912556","DOIUrl":"https://doi.org/10.1967/s002449912556","url":null,"abstract":"<p><strong>Objective: </strong>Differentiated thyroid cancer (DTC) is one of the fastest growing cancers worldwide. Despite the generally good prognosis of thyroid carcinoma, about 5% of patients will develop metastatic disease, exhibiting a more aggressive behavior. Radioiodine whole-body scintigraphy (WBS) has been used in the detection of DTC. Radioiodine is a sensitive marker for detection of thyroid cancer; however, radioiodine uptake is not specific for thyroid tissue. It can also be seen in healthy tissue as well as in inflammation, or in a variety of benign and malignant non-thyroidal entities.</p><p><strong>Subject and methods: </strong>The subject of the present case report is a 52 years old man with brain metastatic DTC who received radioiodine therapy and corticosteroids as palliative therapy. Whole-body scintigraphy revealed bilateral iodine uptake of the femur. Corticosteroid therapy is among the most widely recognized risk factor for osteonecrosis, which at the present case had to be recognized as a false positive (iodine-131) ¹³¹I uptake in order to avoid diagnostic error.</p><p><strong>Results: </strong>Post therapeutic whole body scintigraphy revealed no uptake in the thyroid bed as well as pathologic uptake of radioiodine in both femurs. The magnetic resonance imaging (MRI) of the femurs combined with the history of long term exposition on high doses of corticosteroids evidenced diagnosis of steroid-induced osteonecrosis of the femurs.</p><p><strong>Conclusion: </strong>Radioiodine WBS plays an important role in clinical decision making for the evaluation and the management of patients with DTC. Despite its high range of sensitivity and specificity, a variety of reports of false positive whole body scans has demonstrated a diversity of causes. Comprehension of the physiology of iodine uptake and of the pathophysiology of clinical entities which end up giving false positives scans, provides clinicians a useful tool in order to avoid diagnostic and therapeutic errors as far as DTC is concerned.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"26 1","pages":"66-69"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9367652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of ⁶⁸Ga-FAPI-04 and ¹⁸F-FDG PET/CT for diagnosis of metastatic lesions in patients with recurrent papillary thyroid carcinoma.","authors":"Zeynel Abidin Sayiner,&nbsp;Umut Elboğa,&nbsp;Ertan Sahin,&nbsp;Sadettin Ozturk,&nbsp;Yusuf Burak Cayirli,&nbsp;Yusuf Zeki Celen,&nbsp;Ersin Akarsu,&nbsp;Ilkay Dogan,&nbsp;Benan Kilbas,&nbsp;Kurtulus Eryilmaz,&nbsp;Davut Cakici","doi":"10.1967/s002449912560","DOIUrl":"https://doi.org/10.1967/s002449912560","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to evaluate the gallium-68-labeled fibroblast-activation protein inhibitor (⁶⁸Ga-FAPI) positron emission tomography/computed tomography (PET/CT) in localizing papillary thyroid carcinoma (PTC) foci in patients with biochemical relapse. Papillary thyroid carcinoma has achieved biochemical recovery after appropriate treatment and had biochemical relapse in the last follow-up were included in this retrospective study. Gallium-68-FAPI and fluorine-18-fluorodeoxyglucose (⁶⁸F-FDG) PET/CT were performed to detect recurrence foci.</p><p><strong>Subjects and methods: </strong>Biochemically relapsed patients who underwent total thyroidectomy and were diagnosed with pathologically differentiated thyroid cancer were included in our study. Gallium-68-FAPI and ¹⁸F-FDG PET/CT imaging methods were used to determine the focus of metastasis or recurrence in all patients.</p><p><strong>Results: </strong>Among 29 patients enrolled to the study, pathological subgroups were papillary (n=26) and poorly differentiated (n=3) PTC. Anti-thyroglobulin (TG) antibody positivity were noted in 5 of the patients, while all 29 of them were TG positive and had been consist of three groups as follows: 2-10ng/mL (n=4), 11-300ng/mL (n=14), 301ng/mL and above (n=11). Recurrence was detected in 72.4% (n=21) and 86% (n=25) of the patients via ¹⁸F-FDG and ⁶⁸Ga-FAPI, respectively. Accuracy of detection noted as 100% (5/5), 75% (3/4), and 92.9% (13/14) in groups with the anti-TG antibody positivity, TG levels of 2-10ng/mL and 11-300ng/mL, respectively, when the two imaging modalities were utilized together. Furthermore, accuracy of ⁶⁸Ga-FAPI was 100% (11/11) in the group with TG levels of 301ng/mL and above, whereas accuracy of ¹⁸F-FDG was 81.8% (9/11). Lastly, median maximum standardized uptake value (SUVmax) of recurrent lesions detected by the ⁶⁸Ga-FAPI (median SUVmax: 6.0) were statistically higher than the ones detected by the ¹⁸F-FDG (median SUVmax: 3.7) (P=0.002).</p><p><strong>Conclusion: </strong>In recurrent PTC especially in case of higher TG levels, ⁶⁸Ga-FAPI can be used in patients with inconclusive ¹⁸F-FDG findings.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"26 1","pages":"41-46"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9378845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-FDG PET/CT image of tenosynovial giant cell tumor in the thoracic vertebra.","authors":"Qin He,&nbsp;Liu Xiao,&nbsp;Yuhao Li","doi":"10.1967/s002449912558","DOIUrl":"https://doi.org/10.1967/s002449912558","url":null,"abstract":"<p><p>Diffuse-type tenosynovial giant cell tumor (D-TSGCT) is a destructive benign tumor-like proliferative disease. Diffuse-type tenosynovial giant cell tumorrarely arises from the axial skeleton. We report a case of image findings of D-TSGCT in the thoracic vertebra. On fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) image, it presented a lytic bone destruction of 6^th thoracic vertebra, vertebral processes as well as adjacent sixth rib with intense ¹⁸F-FDG uptake. Our case hints another unusual D-TSGCT image characteristic, which should be considered as a differential diagnosis when we interpret similar sign on ¹⁸F-FDG PET/CT.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"26 1","pages":"73-74"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9361278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indeterminate thyroid cytology in an iodine-deficient population: Prevalence, operation rate, risk of malignancy anddiagnostic value of thyroid scintigraphy and ¹⁸F-FDG PET imaging parameters.","authors":"Charlotte Elberling Almasi,&nbsp;Anna Poulsgaard Frandsen,&nbsp;Daiva Erentaite,&nbsp;Kirsten Duch,&nbsp;Helle D Zacho","doi":"10.1967/s002449912550","DOIUrl":"https://doi.org/10.1967/s002449912550","url":null,"abstract":"<p><strong>Objective: </strong>Patients with indeterminate thyroid cytology often have a diagnostic hemithyroidectomy. The role of molecular imaging, particularly fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET), is controversial, and demographic variations in tumor prevalence and histology influence test performance and clinical utility. We retrospectively assessed the prevalence of indeterminate thyroid cytology and the malignancy rate in patients from an iodine deficient area, and evaluated the diagnostic value of preoperative thyroid scintigraphy and ¹⁸F-FDG PET/CT among operated patients.</p><p><strong>Subjects and methods: </strong>From 2006-2018, all patients with indeterminate thyroid cytology from the North Denmark region were included in the study (population 600,000).Clinical data, including operation rate, preoperative molecular imaging, and histopathological diagnosis, were retrieved. The results from preoperative thyroid scintigraphy and ¹⁸F-FDG PET/CT-scanning were compared to the final histopathological diagnosis.</p><p><strong>Results: </strong>Four hundred and thirty-three patients were found with indeterminate thyroid cytology.The main registered reasons for conducting a fine needle aspiration biopsy (FNAB) were \"cold nodule\", goiter or a palpable nodule (n=312). In 40 patients (9%), FNAB was registered as conducted due to a PET incidentaloma. Four hundred and two patients (93%) underwent diagnostic lobectomy, and this population formed the study population for the following explorative study: One-hundred and two patients (25%) had a malignant diagnosis. In 226 (56%) and 51 (25%) patients, respectively, preoperative thyroid scintigraphy and ¹⁸F-FDG PET/computed tomography (CT) was performed. Among patients with a final malignant disease who had a thyroid scintigraphy (40 patients), a cold nodule was seen in 90% of cases; one (atypical) patient presented a warm nodule. Among patients with a final malignant disease 16 patients (16%) had a ¹⁸F-FDG PET (incl. 3 missing PET scans). Among the 51 patients with preoperative ¹⁸F-FDG PET/CT, no difference in the PET-derived parameters was found between benign (n=33) and malignant tumors (n=13).</p><p><strong>Conclusion: </strong>The prevalence of malignancy (25%) was comparable with that in other studies. In patients with a preoperative thyroid scintigraphy, 90% of malignant cases had a cold nodule on scintigraphy. In patients with a preoperative PET/CT-scanning presenting focal ¹⁸F-FDG-uptake, PET-derived parameters had no diagnostic value. However, the diagnostic value of ¹⁸F-FDG-avidity vs. non-avidity needs to be addressed prospectively.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"26 1","pages":"2-8"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9373541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of ⁶⁸GA-FAPI-04 PET/CT and ¹⁸F-FDG PET/CT findings in peritonitis carcinomatosa cases.","authors":"Yunus Güzel,&nbsp;İhsan Kaplan","doi":"10.1967/s002449912553","DOIUrl":"https://doi.org/10.1967/s002449912553","url":null,"abstract":"<p><strong>Objective: </strong>This study was conducted to compare the diagnostic accuracy of gallium-68-radiolabeled fibroblast activation protein inhibitor (⁶⁸Ga-FAPI-04), positron emission tomography/computed tomography (PET/CT), and fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) PET/CT based on the peritoneal carcinomatosis (PC) index for detecting peritoneal metastases of various cancer types, and to evaluate the potential benefits of FAPI PET/CT in patients with peritoneal metastases.</p><p><strong>Subjects and methods: </strong>This retrospective study included 57 patients with peritoneal metastases between November 2020 and December 2021. All patients underwent ⁶⁸Ga-FAPI-04 PET/CT and ¹⁸F-FDG PET/CT scans within 7 days.</p><p><strong>Results: </strong>Among the 57 patients included, 32 (56.1%) were male and the median age was 54 years (22-86 years). In the visual evaluation made from a total of 13 quadrants on the abdominopelvic peritoneal surfaces, positive findings were observed in 111 quadrants in 39 patients by ¹⁸F-FDG PET/CT and in 280 quadrants in 57 patients by ⁶⁸Ga-FAPI-04 PET/CT (P<0.001). The maximum standardized uptake value (SUVmax) and target-to-background ratio (TBR) values of ⁶⁸Ga-FAPI-04 PET/CT for the PC lesions were significantly higher than the SUVmax and TBR values of ¹⁸F-FDG PET/CT in all patients and in all quadrants (SUVmax 6.45 vs 4.1; P<0.001; TBR 14.9 vs 6.8; P<0.001).</p><p><strong>Conclusion: </strong>Gallium-68-FAPI-04 PET/CT showed superior sensitivity compared to ¹⁸F-FDG PET/CT in both quantitative and visual evaluations of PC. Considering the low background activity and higher specific activity uptake values, ⁶⁸Ga-FAPI-04 PET/CT helped improve diagnostic accuracy.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"26 1","pages":"26-34"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9373540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A quantitative analysis of thyroid fine needle aspiration (FNA) using needles with different gauges.","authors":"Li Li,&nbsp;Xiaoli Ma,&nbsp;Xuming Li,&nbsp;Yue Rong,&nbsp;Jiesi Zhang,&nbsp;Yuquan Ye","doi":"10.1967/s002449912515","DOIUrl":"https://doi.org/10.1967/s002449912515","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to compare the results of three gauge (G) needles (22G, 23G and 25G) in terms of cell amount in thyroid fine needle aspiration (FNA).</p><p><strong>Subjects and methods: </strong>In the retrospective study, a total of 443 patients undergoing FNA for the first time between 2017 and 2018 were included in the study, and assigned to 3 groups with 22-gauge, 23-gauge and 25-gauge needles, respectively.</p><p><strong>Results: </strong>The cell amount of a suspicion for the four diagnosis groups, including malignancy and malignant, benign nodules, follicular of undetermined significance (FLUS), and follicular neoplasia was mainly in the range of 0-10000, 0-300, 0-150, and 500-2500, respectively. The cut-off values of 22G needle 20000, 300, 1000, and 2500, while the cut-off values of 23G and 25G were 10000, 400, 1000, and 2500; 5000, 400, 1500, and 2000, respectively for the four diagnosis groups.</p><p><strong>Conclusion: </strong>Large-gauge needles resulted in more cellular specimens than small-gauge needles only in the cases of malignant tumors. Small-gauge needles resulted in a higher comfort level of the patients, and had no difference in cell number in nodules with abundant blood supply, compared with large-gauge needles.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"25 3","pages":"269-273"},"PeriodicalIF":1.5,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10799114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of ^99mTc-Trodat-1 SPECT to evaluate the efficacy of deep brain stimulation in Parkinson's disease.","authors":"Chen Dongfang,&nbsp;Mao Xianzhi,&nbsp;Lou Cen,&nbsp;Huang Zhongke","doi":"10.1967/s002449912512","DOIUrl":"https://doi.org/10.1967/s002449912512","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore the availability of striatal dopamine transporter (DAT) after deep brain stimulation (DBS) by single photon emission computed tomography (SPECT) using technetium-99m-labeled tropane derivative (^99mTc-Trodat-1).</p><p><strong>Subjects and methods: </strong>In this cohort, 28 patients with PD were enrolled (including 18 males and 10 females). Among these patients, the age range was 55-75 years. All patients referred for optimized DBS programming were recruited for ^99mTc-Trodat-1 imaging and symptom assessment. Dopamine transporter SPECT was performed under medication-off state before DBS and at the 6^th month after DBS, respectively. The clinical scales including Unified Parkinson Disease Rating Scale (UPDRS), Modified Hoehn & Yahr Scale (MHYS) and Ability of Daily Life Scale (ADLS) were carried out before DBS and at 6 months after DBS under medication-on and medication-off, respectively. Dopamine transporter availability was assessed based on DAT SPECT. In addition, the correlation between DAT availability and clinical scales was investigated. The data were analyzed using SPSS 23.0.</p><p><strong>Results: </strong>The mean UPDRS total, MHYS and ADLS scores were 62.36, 2.23 and 42.07 under medication-on, respectively. The medication improvement rate of UPDRS total, MHYS and ADLS scores were 27.55%, 21.88% and 54.19%, respectively. Interestingly, we found PD patients with MHYS grade I usually presented unilateral symptoms, but DAT imaging showed that DAT uptake of the bilateral striatum was lower than that of the normal and the S-value of the contralateral side was significantly lower than that of the ipsilateral side. Furthermore, we found that DBS can improve the laterality of symptoms. The DBS improvement rate of UPDRS total scores, ADLS scores and DAT S-value were 37.65%, 72.51% and 18.21%, respectively. The symptom laterality was significantly correlated with the DAT S-value at baseline and at 6 months after DBS (r=0.63, 0.69 and 0.66, 0.75). The dosage of levodopa was 696.43±146.52 and was 455.36±107.44 before DBS surgery and at DBS-on, respectively.</p><p><strong>Conclusion: </strong>Deep brain stimulation can significantly improve the symptom of PD. Dopamine transporter S-value was well correlated with the change of symptoms laterality. Therefore, DAT imaging can be used to diagnose PD in the early stage and to evaluate the curative effect of DBS. However, the validation of this result requires further study.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"25 3","pages":"247-252"},"PeriodicalIF":1.5,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10799572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative assessment of intra- and inter- observer repeatability of three widely used software packages for the quantification of defect size in stress myocardial perfusion scintigraphy.","authors":"Christos Sachpekidis,&nbsp;Annette Kopp-Schneider,&nbsp;Vasileios Sachpekidis,&nbsp;Efstratios Moralidis","doi":"10.1967/s002449912516","DOIUrl":"https://doi.org/10.1967/s002449912516","url":null,"abstract":"<p><strong>Objective: </strong>To assess the intra- and inter-observer repeatability of popular software packages for the quantitative determination of abnormality size in stress myocardial perfusion scintigraphy.</p><p><strong>Subjects and methods: </strong>A total of 182 tomographic stress myocardial perfusion scans were processed in duplicate by an experienced and trainee observer to assess SSSext (summed stress score multiplied by 100/68) and total defect extent (TDE), as % of the left ventricle, with 4 dimension-myocardial (4DM), emory cardiac toolbox (ECTb) and quantitative perfusion SPECT (QPS) packages. The Bland-Altman (B-A) analysis and Lin's concordance correlation coefficient (CCC) were used to assess agreement.</p><p><strong>Results: </strong>In SSSext's intra-observer repeatability, CCC showed substantial agreement for 4DM and QPS, and moderate agreement for ECTb for both observers. In inter-observer repeatability, CCC revealed substantial agreement for 4DM and QPS, and poor agreement for ECTb. Regarding TDE, CCC showed substantial intra-observer repeatability for both operators using all packages, while the inter-observer repeatability was substantial for 4DM and QPS, and moderate for ECTb.In SSSext's intra-observer repeatability for 4DM, ECTb and QPS, the B-A analysis provided (mean±1.96SD of paired measurements) 0.0±4.3, 0.2±7.8, -0.6±7.6 for the experienced physician and 0.2±5.9, 0.0±7.5, -0.5±5.4 for the trainee, respectively; in inter-observer repeatability it provided 0.2±5.4, 0.1±9.6, 0.2±8.1, respectively. Regarding TDE, the B-A values for intra-observer repeatability were 0.1±5.2, 0.1±7.9, 0.1±2.8 for the experienced reader and 0.3±6.6, -0.1±6.4, -0.1±2.4 for the trainee, respectively; in inter-observer agreement the B-A provided 0.6±6.4, -0.2±10.3, -0.1±4.3, respectively.</p><p><strong>Conclusion: </strong>Considerable differences in intra- and inter- observer agreement were noted for the quantitative determination of defect size using widely employed software packages, suggesting limitations in the clinical use of these measurements. Quantitative perfusion SPECT appears preferable, but with no significant advantage over 4DM. There were no significant differences between the observers.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"25 3","pages":"274-284"},"PeriodicalIF":1.5,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10799116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}