Hellenic journal of nuclear medicine最新文献

{"title":"Organizing and operating a one day clinic / theragnostic center.","authors":"Emmanouil Papanastasiou","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The increasing success of recent nuclear medicine therapies, which followed the NETTER-1 and VISION trials, has boosted the interest for setting up and operating theragnostic centers. EANM, SNMMI and IAEA have recently published a joint guideline in order to assist nuclear medicine centers towards that path. The present paper will focus on the main points of these guidelines, with reference to the Greek radiation protection legislation.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"26 Suppl ","pages":"16-18"},"PeriodicalIF":1.5,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10141291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in the concept and practice of radioembolization (SIRT).","authors":"Trifon Spyridonidis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The experience gained through the practice of radioembolization (SIRT) results in improvement of clinical outcomes. Improved outcomes are a prerequisite for the clinicians to reffer patients for SIRT. In recent years there are some critical changes in the concept and practice of SIRT that also contribute to the improvement of clinical outcomes, beyond the experience of the center performing SIRT. Two of them are dosimetry and a trend toward more focused therapies in the form of radiation lobectomy or segmentectomy.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"26 Suppl ","pages":"57-59"},"PeriodicalIF":1.5,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10135773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of CT-based attenuation correction on quantitative SPECT/CT of jawbone.","authors":"Tatsuya Tsuchitani,&nbsp;Kazuhiro Kitajima,&nbsp;Yoshiyuki Takahashi,&nbsp;Rika Yoshida,&nbsp;Hayato Kiada,&nbsp;Masakatsu Tsurusaki,&nbsp;Tetsuya Minami,&nbsp;Noriko Kotura","doi":"10.1967/s002449912573","DOIUrl":"10.1967/s002449912573","url":null,"abstract":"<p><strong>Objective: </strong>With single photon emission computed tomography (SPECT)/computed tomography (CT) quantitative examinations, CT-based attenuation correction (CTAC) is considered necessary, though its effect on the quantitative values of an examined area close to the body surface, such as the jawbone, has not been elucidated. We performed an investigation to determine whether quantitative evaluation using a bone SPECT standalone device without CT is possible.</p><p><strong>Subjects and methods: </strong>The calculated indices were maximum standardized uptake value (SUVmax) and SUVpeak. Grouping was performed based on the presence or absence of CTAC. The CTAC group underwent CTAC, while the noAC group did not.Validation was performed using clinical data of patients who underwent a jawbone SPECT/CT examination. Becquerel calibration factor (BCF) is required for calculation of SUV, and was determined with values obtained with both phantom and syringe methods. The index for the uptake areas in each group was assessed using a paired t-test.</p><p><strong>Results: </strong>Using BCF obtained with the phantom method, both SUVmax and SUVpeak were higher in the noAC group. In contrast, BCF obtained with the syringe method showed no significant difference between the CTAC and noAC groups in regard to SUVmax and SUVpeak. This tendency was found regardless of the device used. Also, a high correlation was observed between the groups for both devices (r=0.95 and 0.93).</p><p><strong>Conclusion: </strong>Our findings show that BCF obtained with a syringe method should be used when performing quantitative evaluation without CTAC. They also indicate that quantitative evaluation using a SPECT standalone device may be possible for jawbone SPECT/CT examinations.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"26 2","pages":"108-113"},"PeriodicalIF":1.5,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10045776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of ¹³¹I-RGDyC-PEG-PAMAM-DTX targeted drug delivery system and study of its physicochemical properties and biological activity.","authors":"Qianqian Chen,&nbsp;Jinhe Zhang,&nbsp;Mutu Huang,&nbsp;Peiqi Wang,&nbsp;Xiao Zhang,&nbsp;Mingjun Ma","doi":"10.1967/s002449912574","DOIUrl":"10.1967/s002449912574","url":null,"abstract":"<p><strong>Objective: </strong>To construct a novel targeted drug delivery nanoprobe: iodine-131-arginine-glycine-aspartate-tyrosine-cysteine peptide-polyethylene glycol-fifth generation polyamide-amine-docetaxel (¹³¹I-RGDyC-PEG-PAMAM-DTX) and to investigate its physicochemical properties and biological activity.</p><p><strong>Materials and methods: </strong>Docetaxel was wrapped by solvent volatilization method, and the regression curve of DTX was constructed by high-performance liquid chromatography to determine its drug loading. The particle size of RGDyC-PEG-PAMAM-DTX was detected by dynamic light scattering. The ¹³¹I labeling was performed by a chloramine-T method and purified by Sephadex-G50 column chromatography, and it is in vitro stability and lipid-water partition coefficient was investigated. The cytotoxicity of RGDyC-PEG-PAMAM-DTX and ¹³¹I-RGDyC-PEG-PAMAM-DTX on A549 cells in vitro was detected by Cell Counting Kit-8 assay.</p><p><strong>Results: </strong>Arginine-glycine-aspartate-tyrosine-cysteine peptide-PEG-PAMAM-DTX was successfully prepared by solvent volatilization with a loading capacity of about 44μg/mg. The average particle size of RGDyC-PEG-PAMAM-DTX was 57.8nm; the labeling rate of ¹³¹I-RGDyC-PEG-PAMAM-DTX by the chloramine-T method was 74.09%-76.09%, and the radiochemical purity was 88.9%-92.6% after purification. The in vitro stability showed that the radiochemical purity was above 80% after 72h in fetal bovine serum and PBS buffer (25^oC and 37^oC).CCK-8 assay showed that RGDyC-PEG-PAMAM-DTX and ¹³¹I-RGDyC-PEG-PAMAM-DTX had more pronounced cytotoxic effects than free DTX and ¹³¹I.</p><p><strong>Conclusion: </strong>Iodine-131-RGDyC-PEG-PAMAM-DTX has good physicochemical properties and apparent cytotoxic effectsandis expected to be used in treating tumors.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"26 2","pages":"114-122"},"PeriodicalIF":1.5,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10047750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality assurance in clinical dosimetry.","authors":"Manuel Bardiès","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Clinical dosimetry in nuclear medicine is developing fast, with an increasing number of procedures performed for a variety of therapeutic applications. In that context, the advent of CE-marked commercial clinical dosimetry software is a positive signal, as they should, in principle, optimize the workflow and increase robustness. However, they pose the problem of the evaluation of their performances, in terms of accuracy but also ease of use (user-friendliness).</p><p><strong>Aim: </strong>The aim of this presentation is to discuss the various steps required for the evaluation of clinical dosimetry procedures in general, and dosimetry software in particular.</p><p><strong>Materials and methods: </strong>The clinical dosimetry workflow (CDW) is the suite of steps that lead from calibration procedures to the final reporting of the clinical dosimetry procedure. The study of the CDW implemented in various software shows a age variability in the implementation of the steps that constitute the CDW, and the order of their implementation. This can be accepted, however it raises the issue of comparing software that, basically, do not do the same thing, or do things in a different order.</p><p><strong>Results and discussion: </strong>The various steps that compose the CDW have to be studied (benchmarked) using specific tools: If assessing calibrations/reconstructions can be made using phantoms filled with radioactive sources, rigid objects are not adapted to the evaluation of registration procedures. Computing anthropomorphic models can be used to verify absorbed dose calculation algorithms (for example using Monte Carlo radiation transport modelling as the gold standard). As can be seen, a range of tools of different type (test objects, models, patient data) must be used - and sometimes developed - to evaluate each step of the CDW. Finally, the end-to-end process must be benchmarked on \"real\" clinical data, but the price to pay is that the ground truth is not known, thereby limiting these approaches to precision rather than accuracy.</p><p><strong>Conclusion: </strong>Nuclear medicine dosimetry quality assurance (QA) is in its infancy. However, procedures already applied in external beam radiotherapy may be easily transposed to nuclear medicine, and it will not take decades until nuclear medicine benefits from sound, reproducible procedures that will increase the robustness of clinical dosimetry procedures.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"26 Suppl ","pages":"14"},"PeriodicalIF":1.5,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10141292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Al ¹⁸F-NOTA-FAPI-04 and ¹⁸F-FDG in recurrent esophageal cancer after surgery.","authors":"Wei Zhang,&nbsp;Wei Diao,&nbsp;Zhuzhong Cheng","doi":"10.1967/s002449912559","DOIUrl":"https://doi.org/10.1967/s002449912559","url":null,"abstract":"<p><p>Recently, radionuclide labelling fibroblast activating protein inhibitors (FAPI) is regarded as the most promising imaging tracer forvarious tumours. Here we present the imaging finding of aluminium-[¹⁸F] fluoride (Al¹⁸F)-labelled 1,4,7-triazacyclononane-N,N',N\"-triacetic acid (Al¹⁸F-NOTA-FAPI-04) and fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) in postoperative recurrence esophageal cancer. The results presented that imaging with Al¹⁸F-NOTA-FAPI-04 showed significant improvement in detection of local recurrence and distant metastasis with higher maximum standardized uptake value (SUVmax) in the lesions compared with ¹⁸F-FDG.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"26 1","pages":"75-77"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9361281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-FDG PET/CT in Waldenström associated amyloidosis.","authors":"Lynn De Mey,&nbsp;Sim Vermeulen,&nbsp;Sophie Bourgeois,&nbsp;Lode Goethals,&nbsp;Frank De Geeter","doi":"10.1967/s002449912557","DOIUrl":"https://doi.org/10.1967/s002449912557","url":null,"abstract":"<p><p>Amyloidoisis in patients with Waldenström macroglobulinemia (WM) mostly involves the heart, peripheral nerves and kidneys. Retroperitoneal amyloidosis is a rare finding. We describe a 62-year-old man with an incidental finding of a monoclonal gammopathy and elevated inflammatory parameters. Bilateral moderately active retroperitoneal infiltration with punctiform calcifications was found on fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) imaging. Taken together, these findings are suggestive of Waldenström associated amyloidosis. Computed tomography-guided retroperitoneal biopsy confirmed the diagnosis.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"26 1","pages":"70-72"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9367651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in Nuclear Medicine Physics and Imaging.","authors":"Konstantinos Papachristou,&nbsp;Emmanouil Panagiotidis,&nbsp;Anna Makridou,&nbsp;Theodoros Kalathas,&nbsp;Vasilis Masganis,&nbsp;Anna Paschali,&nbsp;Maria Aliberti,&nbsp;Vassiliki Chatzipavlidou","doi":"10.1967/s002449912561","DOIUrl":"https://doi.org/10.1967/s002449912561","url":null,"abstract":"<p><p>No one can deny the significant impact of artificial intelligence (AI) on everyday life, especially in the health sector where it has emerged as a crucial and beneficial tool in Nuclear Medicine (NM) and molecular imaging. The objective of this review is to provide a summary of the various applications of AI in single-photon emission computed tomography (SPECT) and positron emission tomography (PET), with or without anatomical information (CT or magnetic resonance imaging (MRI)). This review analyzes subsets of AI, such as machine learning (ML) and Deep Learning (DL), and elaborates on their applications in NM imaging (NMI) physics, including the generation of attenuation maps, estimation of scattered events, depth of interaction (DOI), time of flight (TOF), NM image reconstruction (optimization of the reconstruction algorithm), and low dose imaging.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"26 1","pages":"57-65"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9373451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of diffuse lymphadenopathy via various quantitative PET/CT parameters.","authors":"Güler Silov,&nbsp;Emel Çankaya,&nbsp;Seyhan Karaçavuş","doi":"10.1967/s002449912555","DOIUrl":"https://doi.org/10.1967/s002449912555","url":null,"abstract":"<p><strong>Objective: </strong>Discovery of diffuse lymphadenopathy (DLAP) in fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) imaging alerts for the existence of many pathologic conditions with severity ranging from benign to malignancy. This study examines the role of various metabolic parameters reflecting ¹⁸F-FDG characteristics of organs/tissues to reach an accurate differential diagnosis for further clinical assessment.</p><p><strong>Materials and methods: </strong>Positron emission tomography/CT images of 78 patients with DLAP were reviewed retrospectively. The diameter of the largest lymph node (DLlyn), maximum standardized uptake value (SUVmax) of the liver (L), the largest lymph node (Llyn), spleen (S), and bone marrow (BM) were measured. Ratios to liver SUVmax were calculated for all, resulting LLRmax, SLRmax, and BMLRmax respectively.</p><p><strong>Results: </strong>The diameter of the largest lymph node, Llyn.SUVmax, LLRmax, and SLRmax produced cut-off values as 25.5, 8.86, 2.80, and 0.82 with corresponding sensitivity:specificity values as 65%:83%, 74%:77%, 74%:71%, and 79%:63% respectively for risk stratification of malignant causes. To differentiate lymphoma from sarcoidosis, DLlyn, SLRmax, and BMLRmax were found valuable with cut-off values obtained as 28.5, 0.84, and 1.19 with corresponding sensitivity:specificity values as 79%:91%, 79%:82%, and 54%:91%, respectively.Interdependency between parameters was also evaluated.</p><p><strong>Conclusion: </strong>High values of Llyn.Maximum SUV and LLRmax are the main characteristics of lymphoma, metastasis, and sarcoidosis. The diameter of the largest lymph node, SLRmax, and BMLRmax are determined as distinct parameters for distinguishing lymphoma from sarcoidosis. Besides, observed correlation structures amongst some PET/CT parameters were identified as nodal, extranodal, and diffuse patterns for three disease groups except sarcoidosis. These findings extend the knowledge about diagnostic factors based on ¹⁸F-FDG PET/CT patterns for DLAP.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"26 1","pages":"47-56"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9361280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous insulin preparation administration for myocardial viability ¹⁸F-FDG imaging has the potential to reduce radiation exposure dose.","authors":"Yangchun Chen,&nbsp;Qingqing Wang,&nbsp;Peihao Huang,&nbsp;Yuehui Wang,&nbsp;Yuxuan Chen,&nbsp;Huilin Zhuo,&nbsp;Ruozhu Dai,&nbsp;Huoqiang Wang","doi":"10.1967/s002449912552","DOIUrl":"https://doi.org/10.1967/s002449912552","url":null,"abstract":"<p><strong>Objective: </strong>Fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) injection activity is positively associated with radiation dose and positron emission tomography (PET) image count. Measurement error is greater with smaller counts; therefore, precise analysis is needed to avoid high doses of radiation exposure caused by high ¹⁸F-FDG injection. We aimed to identify and validate the optimal ¹⁸F-FDG injection activity and acquisition time for cardiac viability imaging with intravenous insulin preparation administration based on fixed ¹⁸F-FDG activity.</p><p><strong>Materials and methods: </strong>Cardiac PET images from 30 patients with coronary artery disease (CAD) were retrospectively reconstructed into different durations. An optimal product of the maximum standardized uptake value (SUV) of the myocardium, and segmental uptake (SU), and acquisition time (MSAT) was determined through a receiver operating characteristic curve.</p><p><strong>Results: </strong>The optimal acquisition time (OAT) was equal to MSAT divided by mean SUV of the myocardium (MyoSUV) and was validated in another 26 patients with CAD. The optimal MSAT was 848.2s. In the validation group, the OAT was 129±76s (95% confidence interval, 99-160s), approximately one-third of the usual acquisition time. The MyoSUV and SU were equivalent between PET image duration of OAT and 600s (7.71±3.01 vs. 7.56±2.94; 67.1±15.4% vs. 67.7±15.6%).</p><p><strong>Conclusion: </strong>Intravenous insulin preparation administration has the potential to decrease the radiation exposure or acquisition time in cardiac viability ¹⁸F-FDG imaging to one-third, without losing the accurate measurement of MyoSUV or SU when reaching an OAT.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"26 1","pages":"20-25"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9361277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}