Gynecological Endocrinology最新文献_第3页

The associations of sleep parameters with sexual quality of life among postmenopausal women. 绝经后妇女睡眠参数与性生活质量的关系。

IF 3 4区医学

Gynecological Endocrinology Pub Date : 2026-12-31 Epub Date: 2026-05-26 DOI: 10.1080/09513590.2026.2679796

Gizem Koc Kulaksiz, Tevfik Yoldemir

{"title":"The associations of sleep parameters with sexual quality of life among postmenopausal women.","authors":"Gizem Koc Kulaksiz, Tevfik Yoldemir","doi":"10.1080/09513590.2026.2679796","DOIUrl":"10.1080/09513590.2026.2679796","url":null,"abstract":"Objective: Aging and menopause negatively affect women's sexual quality of life, and midlife women often report sleep difficulties. The aim of the present study was to investigate the relationship between sleep quality and sexual quality of life in postmenopausal women.Methods: A total of 303 postmenopausal women attending the Gynecology and Menopause Clinics of a university-affiliated training hospital completed the sexual quality of life questionnaire-female (SQoL-F) and the Pittsburgh sleep quality index (PSQI). SQOL-F and PSQI scores were compared by time since menopause, educational level, and age in decades. Correlations between SQoL-F and PSQI domain scores were analyzed.Results: One hundred thirteen women (37.3%) had good sexual quality of life (SQoL-F > 84). SQoL-F and PSQI domain scores did not differ by time since menopause. Sexual and relationship satisfaction were higher among women aged 40-49 years, while other SQoL-F domains showed similar scores across age groups. PSQI domains were also comparable between age categories. Demographic characteristics did not differ between women with good versus poor sleep quality. Correlations between SQoL-F and PSQI domains were negligible to low, including total scores. The correlations reported are unadjusted. The Spearman rho values between the four domains of SQoL-F and seven domains of PSQI ranged between -0.181 and 0.033 (95% CI: -0.281 to 0.129), -0.144 and 0.026 (95% CI: -0.256 to 0.173), -0.159 and 0.043 (95% CI: -0.270 to 0.170), -0.087 and 0.009 (95% CI: -0.207 to 0.140), respectively.Conclusion: Younger and better-educated postmenopausal women showed a better overall sexual quality of life. No meaningful association was found between sleep parameters and sexual outcomes.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"42 1","pages":"2679796"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148029530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DT56a (Femarelle) effectively manages vulvovaginal atrophy in postmenopausal women. DT56a （Femarelle）有效治疗绝经后妇女外阴阴道萎缩。

IF 3 4区医学

Gynecological Endocrinology Pub Date : 2026-12-31 Epub Date: 2026-09-06 DOI: 10.1080/09513590.2026.2722484

Margaret Nachtigall, Lila E Nachtigall

{"title":"DT56a (Femarelle) effectively manages vulvovaginal atrophy in postmenopausal women.","authors":"Margaret Nachtigall, Lila E Nachtigall","doi":"10.1080/09513590.2026.2722484","DOIUrl":"https://doi.org/10.1080/09513590.2026.2722484","url":null,"abstract":"Objective: To examine the effect of DT56a (Femarelle®), a non-hormonal oral treatment for the management of menopause, on symptoms of vulvovaginal atrophy (VVA)/genitourinary syndrome of menopause (GSM) in postmenopausal women.Methods: Twelve (n = 12) postmenopausal women with severe VVA (100% parabasal cells on cervical cytology) and at least one severe VVA symptom were recruited for a 12-week open-label pilot study. At baseline and week 12, participants underwent physical examination, Pap smear, vaginal ultrasound, vaginal cultures, vaginal pH assessment, and vaginal maturation index evaluation. Subjects also completed questionnaires assessing atrophy symptoms and quality of life using the Utian Quality of Life (UQoL) scale. Follow-up at 24 months was available for several participants.Results: After 12 weeks of treatment, all patients showed a significant reduction in vaginal pH. In addition, 11 of the 12 women demonstrated significant improvement in the vaginal maturation index and UQoL questionnaire scores.Conclusions: DT56a significantly improved subjective and objective parameters of VVA/GSM, including vaginal pH, vaginal maturation index, and quality of life. These findings support its potential role as a non-hormonal systemic treatment option for women with VVA/GSM.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"42 1","pages":"2722484"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction statement: Nitric oxide donors increase the pregnancy rate in patients with unexplained infertility undergoing clomiphene citrate stimulation and intrauterine insemination: A randomized controlled pilot study. 撤回声明：一氧化氮供体增加不明原因不孕症患者接受枸橼酸克罗米芬刺激和宫内人工授精的妊娠率：一项随机对照试点研究。

IF 3 4区医学

Gynecological Endocrinology Pub Date : 2026-12-31 Epub Date: 2026-10-07 DOI: 10.1080/09513590.2026.2731759

引用次数: 0

Ovulation induction versus artificial cycles in women with polycystic ovary syndrome: a retrospective cohort study. 多囊卵巢综合征女性诱导排卵与人工周期：一项回顾性队列研究。

IF 3 4区医学

Gynecological Endocrinology Pub Date : 2026-12-31 Epub Date: 2026-09-06 DOI: 10.1080/09513590.2026.2716513

Yanan Liu, Xitong Liu, Yu Wang, Xiaoming Teng

{"title":"Ovulation induction versus artificial cycles in women with polycystic ovary syndrome: a retrospective cohort study.","authors":"Yanan Liu, Xitong Liu, Yu Wang, Xiaoming Teng","doi":"10.1080/09513590.2026.2716513","DOIUrl":"https://doi.org/10.1080/09513590.2026.2716513","url":null,"abstract":"Objective: We aim to clarify the comparative clinical efficacy of ovulation induction and artificial cycle (AC) protocols for frozen-thawed embryo transfer (FET) in reproductive-aged women with polycystic ovary syndrome (PCOS), given the conflicting findings and ongoing controversy surrounding this issue in existing studies.Methods: This was a retrospective cohort study conducted at a public fertility center in China, which included a total of 1331 women with PCOS who underwent FET between January 2021 and December 2024; the study compared the efficacy of two endometrial preparation interventions during FET, ovulation induction cycles (n = 543) and AC (n = 788). The primary outcome measure was live birth rate, while the secondary outcome measures were categorized into three types: clinical outcomes, maternal outcomes and perinatal outcomes.Results: Endometrial thickness on the day of progesterone administration was significantly greater in the ovulation induction group (10.3 (9.0-12.2) vs. 9.2 (8.0-10.8), p < 0.001) than in the AC group. Following adjustment for potential confounding factors, the ovulation induction cycle group exhibited a significantly higher clinical pregnancy rate (59.5% vs. 51.5%, aOR = 1.3, 95%CI: 1.1-1.7) and live birth rate (48.8% vs. 39.7%, aOR = 1.4, 95%CI: 1.1-1.7) relative to the artificial cycle group. Perinatal outcomes were comparable between AC and ovulation induction.Conclusions: In conclusion, ovulation induction significantly improves live birth rates over artificial cycles in PCOS women undergoing FET, with comparable perinatal safety. Despite the limitations of retrospective, single-center data, this study provides real-world evidence to guide endometrial preparation. Prospective randomized trials are warranted to confirm these findings.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"42 1","pages":"2716513"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of Concern: Metabolic changes in overweight and obese women above 35 years using Ethinylestradiol/drosperinone combined contraceptive pills: a 3-year case-control study. 关注表达：35岁以上超重和肥胖妇女使用炔雌醇/drosperinone联合避孕药的代谢变化：一项为期3年的病例对照研究。

IF 3 4区医学

Gynecological Endocrinology Pub Date : 2026-12-31 Epub Date: 2026-09-22 DOI: 10.1080/09513590.2026.2733778

引用次数: 0

Bushen Huatan formula improves reproductive and endocrine metabolic disorders in non-obese polycystic ovary syndrome rats via adipose tissue-derived exosomal miR-27a-3p/PPARG signaling pathway. 补肾化脓方通过脂肪组织源性外泌体miR-27a-3p/PPARG信号通路改善非肥胖型多囊卵巢综合征大鼠生殖和内分泌代谢紊乱。

IF 3 4区医学

Gynecological Endocrinology Pub Date : 2026-12-31 Epub Date: 2026-04-09 DOI: 10.1080/09513590.2026.2655498

Meng Chen, Ruiyuan Zhang, Ying Huang, Yuxin Pan, Jinrong Yang, Yinghong Huang

{"title":"Bushen Huatan formula improves reproductive and endocrine metabolic disorders in non-obese polycystic ovary syndrome rats via adipose tissue-derived exosomal miR-27a-3p/PPARG signaling pathway.","authors":"Meng Chen, Ruiyuan Zhang, Ying Huang, Yuxin Pan, Jinrong Yang, Yinghong Huang","doi":"10.1080/09513590.2026.2655498","DOIUrl":"10.1080/09513590.2026.2655498","url":null,"abstract":"Objectives: This study aims to investigate the therapeutic effects of the Bushen Huatan (BSHT) Formula on non-obese polycystic ovary syndrome (PCOS) rats, and to explore its potential mechanisms of action.Methods: A PCOS model was induced in rats via letrozole, a high-fat/high-sucrose diet, and a PEPD inhibitor for 35 days; estrous cyclicity, fasting glucose, and glycated hemoglobin were monitored. After modeling, the animals underwent 28 days of assigned treatment, followed by an oral glucose tolerance test (OGTT) and assays for sex steroids and lipids. Ovarian and hepatic histology and hepatic steatosis were evaluated. Adipose-derived exosomes were characterized for size, concentration, and surface markers (TSG101, HSP70, CD63). Detect the expression levels of adipose tissue-derived exosomal microRNA-27a-3p (AT-EXO-miR-27a-3p) and ovarian Pparg mRNA. Ovarian PPARG, P-AKT, GLUT4, INSR and IRS-1 proteins were quantified.Results: Compared with the model control group, BSHT lowered serum testosterone, elevated E₂ and FSH, ameliorated glucose intolerance, and improved lipid profiles by decreasing TC and TG and increasing HDL-C. Polycystic ovarian morphology and hepatic lipid accumulation were also attenuated. BSHT down-regulated AT-EXO-miR-27a-3p expression (mean ± SD: 5.13 ± 0.27 vs 17.91 ± 1.19; p < 0.001) and up-regulated both Pparg mRNA (0.38 ± 0.03 vs 0.08 ± 0.002; p < 0.001) and protein (0.37 ± 0.10 vs 0.12 ± 0.02; p = 0.001), while markedly increasing INSR protein abundance (1.50 ± 0.11 vs 0.37 ± 0.04; p < 0.001).Conclusions: This study demonstrates that the BSHT prescription may alleviate reproductive endocrine disorders in PCOS rats by mitigating the inhibitory effects of fat-derived exosomal miR-27a-3p on PPARG.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"42 1","pages":"2655498"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Involvement of USP33 in ferritinophagy and ferroptosis in endometriosis through the Hippo-YAP pathway. 通过Hippo-YAP途径，USP33参与子宫内膜异位症的铁蛋白吞噬和铁下垂。

IF 1.7 4区医学

Gynecological Endocrinology Pub Date : 2026-12-31 Epub Date: 2025-12-26 DOI: 10.1080/09513590.2025.2589605

Li Li, Wu You, Mingzhe Zhang

{"title":"Involvement of USP33 in ferritinophagy and ferroptosis in endometriosis through the Hippo-YAP pathway.","authors":"Li Li, Wu You, Mingzhe Zhang","doi":"10.1080/09513590.2025.2589605","DOIUrl":"https://doi.org/10.1080/09513590.2025.2589605","url":null,"abstract":"Objective: This study aimed to investigate the mechanism of the involvement of USP33 in autophagic ferroptosis in endometriosis (EMs).Methods: Endometrial stromal cells (ESCs) were isolated from 15 healthy controls and 30 patients with EMs, which were designated NESCs and EESCs, respectively. Real-time PCR and Western blotting were utilized to determine USP33 expression as well as GPX4, LC3II/LC3I, NCOA4, FTH1, LAST1, p-LAST1, YAP, and p-YAP levels. Immunofluorescence was used to detect the colocalization of ferritin and LAMP2, as well as that of LC3 and ferritin. The levels of ROS, Fe2+, MDA, and GSH were measured to assess ferroptosis. An LDH assay was performed to evaluate cell death. A co-IP assay was implemented to identify the interaction between USP33 and LAST1 and detect the level of LAST1 ubiquitination. The stability of the protein was also detected via a cycloheximide (CHX) assay.Results: USP33 was underexpressed in EMs patients. Loss of USP33 conferred resistance to ferroptosis in EESCs, as evidenced by increased proliferation; decreased levels of ROS, Fe2+, and MDA; elevated levels of GPX4 and GSH; and reduced cell death. In addition, USP33, which is localized in autophagosomes, was suggested to promote the degradation of ferritin in autophagosomes. Furthermore, USP33 repressed the Hippo-YAP pathway by suppressing LATS1 ubiquitination, thereby contributing to the reduced resistance of EESCs to ferroptosis.Conclusion: USP33 impedes the ubiquitination of LAST1 and represses the Hippo/YAP pathway, thus facilitating ferritinophagy and ferroptosis in EMs.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"42 1","pages":"2589605"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145833785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-analysis of handgrip strength in subjects with high-normal or mildly increased uric acid compared to low-normal levels reported as quartiles. 以四分位数报告尿酸高正常或轻度升高受试者与低正常水平受试者握力的meta分析。

IF 3 4区医学

Gynecological Endocrinology Pub Date : 2026-12-31 Epub Date: 2026-01-04 DOI: 10.1080/09513590.2025.2610083

Faustino R Pérez-López, Ana M Fernández-Alonso, Susana Aidé

{"title":"Meta-analysis of handgrip strength in subjects with high-normal or mildly increased uric acid compared to low-normal levels reported as quartiles.","authors":"Faustino R Pérez-López, Ana M Fernández-Alonso, Susana Aidé","doi":"10.1080/09513590.2025.2610083","DOIUrl":"10.1080/09513590.2025.2610083","url":null,"abstract":"Objective: The purpose of this systematic review and meta-analysis is to assess the association of handgrip strength (HGS) in subjects with high-normal or mildly elevated and low-normal serum uric acid (SUA) reported by quartiles.Methods: The research protocol was registered at PROSPERO (CRD420251050351). We searched four databases to obtain relevant articles reporting HGS by SUA quartiles in subjects without gout. Outcomes were compared by combining the third and fourth SUA (higher) quartiles versus the first and second (low) quartiles. The risk of bias was assessed using the Newcastle‒Ottawa Scale, and heterogeneity with the I2 test. The results are reported as the mean difference (MD), standardized MD (SMD), or odds ratio (OR).Results: Seven cross-sectional studies, including 18,765 adult subjects with higher SUA quartiles showed significant higher HGS (SMD: 0.21, 95% confidence interval [CI]: 0.03, 0.39), body mass index (MD: 1.02 kg/m2, 95% CI: 0.48, 1.55), total cholesterol (SMD: 0.14, 95% CI: 0.05, 0.24), LDL-cholesterol SMD: 0.13, 95% CI: 0.09, 0.17), and triglycerides (SMD: 0.26, 95% CI: 0.11, 0.41) than those with lower SUA quartiles. HDL-cholesterol was significantly reduced in subjects with higher SUA (SMD: -0.13, 95% CI: -0.20, -0.07). High SUA levels were associated with a drinking history (OR: 1.21, 95% CI: 1.10, 1.34) and hypertension (OR: 1.51, 95% CI: 1.15, 1.99).Conclusions: Subjects with higher normal SUA levels showed higher HGS compared to those with lower normal levels.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"42 1","pages":"2610083"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction statement: The role of prophylactic use of low dose aspirin and calheparin in patients with unexplained recurrent abortion. 撤回声明：预防使用低剂量阿司匹林和钙肝素在不明原因复发性流产患者中的作用。

IF 3 4区医学

Gynecological Endocrinology Pub Date : 2026-12-31 Epub Date: 2026-10-04 DOI: 10.1080/09513590.2026.2739037

引用次数: 0

The forgotten organ in midlife women - why gynaecologists should screen for metabolic-associated fatty liver disease. 中年妇女被遗忘的器官——为什么妇科医生应该筛查与代谢相关的脂肪肝疾病。

IF 1.7 4区医学

Gynecological Endocrinology Pub Date : 2026-12-31 Epub Date: 2026-02-10 DOI: 10.1080/09513590.2026.2624205

Santiago Palacios, Mariella Lilue

引用次数: 0