Effect of light fasting diet therapy on lipid metabolism and sex hormone levels in patients with polycystic ovary syndrome combined with infertility.

IF 2 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Gynecological Endocrinology Pub Date : 2025-12-01 Epub Date: 2025-01-29 DOI:10.1080/09513590.2025.2458084
Xiaomei Jiang, Yongfeng Wang, Hong Tang, Jin Ma, Heyue Li
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引用次数: 0

Abstract

Objective: To investigate the effects of light fasting diet therapy, including flaxseed powder supplementation, on lipid metabolism and sex hormone levels in patients with polycystic ovary syndrome (PCOS) combined with infertility.

Methods: A total of 104 PCOS patients with combined infertility were divided into the control group (n = 52) and intervention group (n = 52) using a random number table method. Over a two-month study period, the control group received light fasting diet therapy with rice flour as a placebo, while the intervention group received light fasting diet therapy supplemented with flaxseed powder. Differences in general clinical data, anthropometric indicators, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P), fasting plasma glucose (FPG), fasting insulin (FINS), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C)) were compared between the two groups.

Results: After treatment, both groups showed significant reductions in FSH, LH, E2, and P levels compared to baseline (p < .05). In the intervention group, the mean FINS and HOMA-IR levels were significantly lower than those in the control group following 2 months of treatment (p < .05). Furthermore, TC, TG, and LDL-C levels were significantly reduced in the intervention group compared to the control group (p < .05).

Conclusion: Light fasting diet therapy, especially with flaxseed powder, improves obesity, lipid, and glucose metabolism disorders in PCOS patients with infertility. However, longitudinal studies are needed to better understand these associations and assess long-term effects before considering this intervention as a standard clinical recommendation for PCOS.

目的:探讨添加亚麻籽粉等轻禁食疗法对多囊卵巢综合征(PCOS)合并不孕症患者脂质代谢及性激素水平的影响。方法:采用随机数字表法将104例PCOS合并不孕症患者分为对照组(n = 52)和干预组(n = 52)。在两个月的研究期间,对照组接受以米粉作为安慰剂的轻度禁食饮食疗法,而干预组则接受辅以亚麻籽粉的轻度禁食饮食疗法。比较两组一般临床资料、人体测量指标、促卵泡激素(FSH)、促黄体生成素(LH)、雌二醇(E2)、黄体酮(P)、空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗稳态模型评估(HOMA-IR)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)的差异。结果:治疗后,两组患者FSH、LH、E2和P水平均较基线水平显著降低(P P P)。结论:轻禁食饮食治疗,特别是亚麻籽粉治疗,可改善PCOS合并不孕症患者的肥胖、脂质和糖代谢紊乱。然而,在考虑将这种干预作为PCOS的标准临床推荐之前,需要进行纵向研究以更好地了解这些关联并评估长期效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Gynecological Endocrinology
Gynecological Endocrinology 医学-妇产科学
CiteScore
4.40
自引率
5.00%
发文量
137
审稿时长
3-6 weeks
期刊介绍: Gynecological Endocrinology , the official journal of the International Society of Gynecological Endocrinology, covers all the experimental, clinical and therapeutic aspects of this ever more important discipline. It includes, amongst others, papers relating to the control and function of the different endocrine glands in females, the effects of reproductive events on the endocrine system, and the consequences of endocrine disorders on reproduction
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