Gynecological Endocrinology最新文献

{"title":"Reproductive transitions and autoimmunity: implications for women's health in rheumatology and gastroenterology.","authors":"Lorenzo Cavagna, Marco Vincenzo Lenti, Laura Cucinella, Francesca Bottazzi, Antonio Di Sabatino, Rossella E Nappi","doi":"10.1080/09513590.2026.2645835","DOIUrl":"10.1080/09513590.2026.2645835","url":null,"abstract":"<p><p>Women's reproductive life encompasses dynamic phases, including menarche, menstrual cycles, pregnancy, lactation, and menopause, as well as transitional periods of variable duration. These stages drive physiological changes that influence both physical and mental well-being and may modulate susceptibility to autoimmunity. The interplay between autoimmunity and reproductive milestones is bidirectional: reproductive stages can affect disease onset and progression, while autoimmune disorders influence fertility, pregnancy outcomes, and the timing of menopause. Persistent challenges in detecting autoimmune diseases, particularly within rheumatology and gastroenterology, underscore the need for targeted screening, multidisciplinary collaboration, and patient-centered strategies. Fertility preservation, preconception counseling, and individualized pregnancy management are essential to safeguard reproductive rights and optimize maternal and neonatal outcomes. Post-reproductive life, especially the menopause transition, represents a vulnerable period in which immune, hormonal, and metabolic changes converge. This manuscript highlights the importance of a comprehensive, lifespan-oriented approach to reproductive well-being in women with autoimmune diseases, integrating preventive, diagnostic, and therapeutic strategies across all stages of reproduction.</p>","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"42 1","pages":"2645835"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidimensional health evaluation in mid-aged women: cross-sectional study protocol for a future-implementable program.","authors":"Peter Chedraui, Melissa Sánchez-Briones, Marcela Mendoza-Burgos, María C Monteverde-Álvarez, Camilo R Nevárez-Gilbert, Ricardo Echeverría-Castro, Tiziana Fidecicchi, Tommaso Simoncini","doi":"10.1080/09513590.2026.2645743","DOIUrl":"https://doi.org/10.1080/09513590.2026.2645743","url":null,"abstract":"<p><strong>Objective: </strong>To conduct a comprehensive assessment of physical, functional, emotional, cognitive, nutritional, metabolic, and sexual health in mid-aged women.</p><p><strong>Methods: </strong>This cross-sectional study was conducted at the Universidad Espíritu Santo Clinic (UEES Clinic), Ecuador, as part of a multidisciplinary integrated health initiative. Women aged 40-60 years were recruited through social media outreach by the UEES Research Center and Clinic between 1 October 2024 and 1 October 2025. Interested participants scheduled a clinical evaluation by telephone. Assessments included laboratory tests (complete blood count, FSH, estradiol, HDL-C, triglycerides, glucose, and thyroid hormones [T3, T4]); validated surveys: Menopause Rating Scale (MRS) for climacteric symptoms and quality of life; Center for Epidemiologic Studies Depression Scale, 10-item version (CESD-10) for depressive mood; short Everyday Memory Questionnaire-Revised (EMQ-R) for cognition; and FSFI-6 for sexual function. Participants also underwent anthropometric measurements, body composition analysis, muscle strength testing, and dietary assessment.</p><p><strong>Discussion: </strong>This methods paper describes a multidisciplinary approach for the comprehensive health evaluation of mid-aged women. It enables early identification of factors affecting quality of life and provides a replicable framework relevant to both local and broader Latin American contexts, serving as a model for similar initiatives across the region.</p>","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"42 1","pages":"2645743"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147473214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction statement: effects of the position of fibroids on fertility.","authors":"","doi":"10.1080/09513590.2026.2661492","DOIUrl":"https://doi.org/10.1080/09513590.2026.2661492","url":null,"abstract":"","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"42 1","pages":"2661492"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiota and adenomyosis: exploring mechanisms and therapeutic potential.","authors":"Qi Zhang, Lili Zou, Hongbo Yu, Junjie Wang","doi":"10.1080/09513590.2026.2660983","DOIUrl":"https://doi.org/10.1080/09513590.2026.2660983","url":null,"abstract":"<p><strong>Objective: </strong>This review comprehensively explores the potential relationship between the microbiota and adenomyosis, aiming to identify specific microbial biomarkers, elucidate the molecular mechanisms underlying the involvement of the microbiota in the disease, and provide insights into more precise and personalized therapeutic strategies for patients with adenomyosis.</p><p><strong>Methods: </strong>This article adopts the narrative review method to comprehensively analyze the literature on the relationship between the microbiota and adenomyosis. A comprehensive literature search was conducted in PubMed, Embase and Web of Science databases. A total of 8 articles were included, among which one was an animal experiment. This review focuses on analyzing the differences in the composition of the microbiota between patients with adenomyosis and healthy control groups, as well as the potential molecular mechanisms by which the microbiota participates in the development of adenomyosis.</p><p><strong>Results: </strong>Studies have demonstrated that the composition of the microbiota in women with adenomyosis differs significantly from that in healthy controls.The potential mechanisms by which microbiota may be involved in adenomyosis are closely associated with immune-inflammatory responses and estrogen regulation, which further affect the progression of adenomyosis.</p><p><strong>Conclusions: </strong>Microbiota may play an important role in the pathogenesis of adenomyosis. Elucidating the specific microbial biomarkers and the underlying molecular mechanisms of microbiota in adenomyosis is crucial for developing novel, precise, and personalized therapeutic strategies, which may provide new options for the treatment of adenomyosis.</p>","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"42 1","pages":"2660983"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drawbacks in dopaminergic neurotransmission: compromising sexual performance.","authors":"Anastasia Armeni, Rossella E Nappi, Peter Chedraui","doi":"10.1080/09513590.2026.2662695","DOIUrl":"https://doi.org/10.1080/09513590.2026.2662695","url":null,"abstract":"","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"42 1","pages":"2662695"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147769854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin modulates granulosa cell angiogenesis differently in female- and male-factor infertility.","authors":"Giovanna Santos Cavalcanti, Kátia Cândido Carvalho, Pedro Augusto Araujo Monteleone, Peter Chedraui, José Cipolla-Neto, Joji Ueno, Ricardo Hsieh, Eduardo Carvalho de Arruda Veiga, Edmund Chada Baracat, José Maria Soares","doi":"10.1080/09513590.2025.2606440","DOIUrl":"https://doi.org/10.1080/09513590.2025.2606440","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the effects of melatonin on angiogenesis in cultured granulosa cells from women undergoing in vitro fertilization, comparing those with female-factor versus male-factor infertility.</p><p><strong>Methods: </strong>Granulosa cells were obtained from 47 women undergoing in vitro fertilization treatment, including 31 women with female-factor (FFG) and 16 women with male-factor infertility (MFG). Cells from both groups were cultured and divided into four treatment conditions for 96 h: a) control (culture medium without melatonin); b) vehicle (melatonin diluent-ethanol); c) 0.1 µM melatonin; and d) 10 µM melatonin. Expression of 84 genes involved in angiogenesis signaling pathway was analyzed by real-time PCR.</p><p><strong>Results: </strong>Cultured granulosa cells from both groups expressed aromatase and melatonin receptors. In both groups, cell proliferation peaked at 72 h when exposed to 10 µM melatonin. Of the 84 analyzed genes, three showed significant differential mRNA expression. In the MFG, melatonin at 10 µM upregulated VEGF-B mRNA expression in granulosa cells but downregulated PDGFA and HGF mRNA expression, in contrast to the higher expression of these genes in the FFG under identical conditions.</p><p><strong>Conclusion: </strong>Melatonin differentially modulates angiogenesis-related gene expression in granulosa cells, indicating that its effects may depend on infertility type and melatonin dose in women undergoing in vitro fertilization.</p>","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"42 1","pages":"2606440"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145809796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol flexibility in PCOS: a combination of controlled ovarian stimulation and endometrial preparation strategies shows no impact on live birth outcomes after frozen embryo transfer-a retrospective cohort study.","authors":"Dongdong Chen, Ming-Hui Chen, Zeng-Yan Wang, Lu Luo, Yanwen Xu, Dan Zhang","doi":"10.1080/09513590.2026.2650027","DOIUrl":"https://doi.org/10.1080/09513590.2026.2650027","url":null,"abstract":"<p><strong>Objectives: </strong>This retrospective study compares pregnancy outcomes in polycystic ovary syndrome (PCOS) patients across different controlled ovarian stimulation (COS) protocols-specifically GnRH antagonist and GnRH agonist cycles-combined with various frozen embryo transfer(FET) preparation methods, such as hormone replacement therapy (HRT) and ovulatory cycles. Despite the known variations in COS and FET protocols, the optimal combination for improving pregnancy outcomes in this population remains unclear.</p><p><strong>Methods: </strong>We analyzed the first FET cycles of 2510 patients with PCOS at our center between January 2017 and September 2024. Baseline characteristics and pregnancy outcomes were compared using the Kruskal‒Wallis test, the chi-square (χ²) statistic, the Bonferroni correction for multiple comparisons, and inverse probability of treatment weighting (IPTW) adjustment.</p><p><strong>Results: </strong>After IPTW adjustment, no significant differences were observed in live birth rates or other key reproductive outcomes among the four protocol combinations (all <i>P</i> > 0.05). Exploratory analyses revealed nonsignificant trends, suggesting two patterns: 1) GnRH agonist (vs. antagonist) COS protocols were associated with lower point estimates for the risks of preterm PROM and HDP; 2) ovulation (vs. HRT) cycles for FET preparation were similarly associated with lower point estimates for these risks.</p><p><strong>Conclusions: </strong>For PCOS patients, live birth success is equivalent regardless of COS/FET protocol combination, supporting flexible treatment personalization. Clinical decision-making involves a critical trade-off: GnRH agonist protocols and ovulation FET cycles may be associated with a trend toward lower obstetric morbidity, potentially linked to the promotion of a more physiological ovulatory milieu. This balance between immediate iatrogenic risk and long-term pregnancy health warrants further study.</p>","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"42 1","pages":"2650027"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iatrogenic menopause and long-term health: a call for better evidence.","authors":"Ipek Betul Ozcivit Erkan, Punith Kempegowda","doi":"10.1080/09513590.2026.2656080","DOIUrl":"https://doi.org/10.1080/09513590.2026.2656080","url":null,"abstract":"","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"42 1","pages":"2656080"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploratory serum metabolomics study for screening and staging of breast cancer.","authors":"Ying Zou, Dili Song, Yongguang Cai, Kun Liang, Jiujiu Fu, Haibo Zhang","doi":"10.1080/09513590.2026.2637977","DOIUrl":"10.1080/09513590.2026.2637977","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates serum metabolic profiles in breast cancer to identify diagnostic biomarkers and stage-specific metabolites, offering insights for clinical practice.</p><p><strong>Methods: </strong>Gas chromatography‒mass spectrometry (GC‒MS)-based metabolomics analyzed serum from healthy controls, patients with benign breast lesions, and malignant breast cancer cohorts. Orthogonal partial least squares discriminant analysis (OPLS-DA) modeling differentiated metabolic signatures between groups, while Spearman's correlation assessed metabolite-stage relationships. Diagnostic performance was assessed through receiver operating characteristic (ROC) analysis.</p><p><strong>Results: </strong>Amino acid metabolism alterations, particularly in alanine, aspartate, and glutamate metabolism, characterized breast cancer. Malignant cases showed elevated glutamic acid and lactic acid but reduced fructose compared to benign lesions, achieving significant diagnostic discrimination (AUC = 0.9757 for glutamic acid, AUC = 0.9583 for lactic acid, AUC = 1.000 for fructose). Glutamic acid demonstrated progressive elevation across health-to-disease continuum (healthy-benign-early-stage-advanced), strongly correlating with the malignancy stage (<i>ρ</i> = 0.934, <i>p</i> < 0.001) and effectively distinguishing early/late-stage cancers (AUC = 0.9500).</p><p><strong>Conclusions: </strong>Serum metabolomics identified glutamic acid as a dynamic biomarker for breast cancer detection and staging, warranting further mechanistic studies.</p>","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"42 1","pages":"2637977"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil/albumin ratio positively associates with type 2 diabetes mellitus risk in women with prior gestational diabetes mellitus: moderation by body mass index.","authors":"Yuan-Fen Chen, Ling-Hua Wang","doi":"10.1080/09513590.2025.2607806","DOIUrl":"https://doi.org/10.1080/09513590.2025.2607806","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the associations of the neutrophil/albumin ratio (NAR) with type 2 diabetes mellitus (T2DM) in women with a history of gestational diabetes mellitus (GDM).</p><p><strong>Methods: </strong>We conducted a cross-sectional study involving 782 participants from the National Health and Nutrition Examination Survey. Logistic regression analyses were performed to explore the relationship between NAR and T2DM, adjusting for various confounding factors across different models. Interaction analyses examined the modifying effects of socio-demographic characteristics on the relationship between NAR and T2DM. Mediation analyses were utilized to investigate whether key laboratory indicators and insulin resistance indices mediated the association between NAR and T2DM.</p><p><strong>Results: </strong>Higher NAR levels were positively associated with T2DM risk. (OR[95%CI]:1.649[1.181,2.309], <i>p</i> = 0.003). Mediation analyses revealed that the effect of NAR on T2DM was entirely mediated through the regulation of red cell distribution width (RDW Coefficient[95%CI]: 0.009[0.001,0.024], <i>p</i> = 0.020) and high-density lipoprotein cholesterol (HDL-C Coefficient[95%CI]: 0.038[0.017,0.067], <i>p</i> < 0.001). Besides, significant interactions and differences were observed in the relationship between NAR and T2DM risk based on body mass index (BMI) (NAR*BMI: interaction coefficient: -0.651, interaction <i>p</i> = 0.027). In individuals with 25 kg/m² ≤ BMI < 30 kg/m², NAR increased the risk of T2DM by regulating the insulin resistance index (HOMA-R) (<i>β</i>[95%CI]: 2.220[0.653,3.787], <i>p</i> = 0.007).</p><p><strong>Conclusion: </strong>This study revealed that among women with GDM history, NAR may influence the risk of T2DM through the modulation of RDW and HDL-C. Furthermore, NAR and BMI had a significant interaction affecting T2DM risk, particularly prominent in women with 25 kg/m² ≤ BMI < 30 kg/m². Within this subgroup, NAR elevated the risk of T2DM via HOMA-R.</p>","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"42 1","pages":"2607806"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}