Gut最新文献

筛选
英文 中文
Hepatocyte senescence in alcohol-associated hepatitis: epiphenomenon or disease-driving mechanism? 酒精相关性肝炎的肝细胞衰老:附带现象还是疾病驱动机制?
IF 24.5 1区 医学
Gut Pub Date : 2025-07-17 DOI: 10.1136/gutjnl-2025-335271
Adrien Guillot, Elisa Pose
{"title":"Hepatocyte senescence in alcohol-associated hepatitis: epiphenomenon or disease-driving mechanism?","authors":"Adrien Guillot, Elisa Pose","doi":"10.1136/gutjnl-2025-335271","DOIUrl":"https://doi.org/10.1136/gutjnl-2025-335271","url":null,"abstract":"Alcohol-associated hepatitis (AH) is a severe clinical syndrome within the spectrum of alcohol-related liver disease (ALD), characterised by acute-onset jaundice, systemic inflammation and liver dysfunction in individuals with chronic excessive alcohol use and underlying chronic liver disease in most of the cases. The prognosis of AH is poor, and effective therapeutic options besides corticosteroid therapy are scarce.1 There are few studies evaluating the histological changes that occur in the liver following an episode of AH. While it is known that some patients experience improvement with abstinence and medical management, the specific histopathological and molecular evolution remains poorly explored.2 The assessment of post-AH liver biopsies could provide valuable insights into mechanisms of fibrosis regression, resolution of inflammation and persistence of liver injury, and provide the needed information to identify potential therapeutic strategies to promote liver recovery. In Gut , Rodrigo-Torres et al performed bulk RNA sequencing on a cohort …","PeriodicalId":12825,"journal":{"name":"Gut","volume":"42 8 Pt 1 1","pages":""},"PeriodicalIF":24.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To be or not to be (a biliary cancer): RAS (signalling) is the question 生存还是毁灭(胆道癌):RAS(信号)是一个问题
IF 24.5 1区 医学
Gut Pub Date : 2025-07-15 DOI: 10.1136/gutjnl-2025-335690
Konstantina Morali, Silvestre Vicent
{"title":"To be or not to be (a biliary cancer): RAS (signalling) is the question","authors":"Konstantina Morali, Silvestre Vicent","doi":"10.1136/gutjnl-2025-335690","DOIUrl":"https://doi.org/10.1136/gutjnl-2025-335690","url":null,"abstract":"Intrahepatic cholangiocarcinoma (iCCA) is the second most prevalent type of primary liver cancer, presents with a highly dismal prognosis, and its incidence is on the rise compared with most cancers.1 iCCA features histological traits of the biliary tract including expression of biliary epithelial cell markers such as SRY-box transcription factor 9 and cytokeratin 19. Based on the histological appearance, iCCA has been considered to arise from mature cholangiocytes. Indeed, epidemiological studies associate iCCA with pathological conditions involving the biliary compartment such as primary sclerosing cholangitis and liver fluke infection.1 Nonetheless, the presence of mixed hepatocellular carcinoma (HCC)/iCCA tumours, along with the association of iCCA with conditions affecting the hepatocellular compartment such as hepatitis B and C, and cirrhosis, points to the potential involvement of additional cell types, such as hepatocytes, in the origin of iCCA.1 Pioneering lineage tracing studies reported the development of murine iCCA derived from hepatocytes on treatment with the carcinogenic agent thioacetamide or by hydrodynamic tail vein injection (HTVI) delivery of iCCA-related oncogene Notch (ie, Notch intracellular domain), into hepatocytes of adult mice using the Sleeping Beauty transposon-transposase system.2 3 Hepatocyte to biliary cell (H-BC) transdifferentiation was further supported by subsequent studies using HTVI to overexpress oncogenes and/or deplete tumour suppressor genes (TSGs) and, more recently, by the use of adeno-associated virus with preferential tropism to hepatocytes.4–8 While these studies started to highlight that different liver injuries and pro-oncogenic insults foster H-BC transdifferentiation, the molecular understanding of how this process is regulated is far from being complete. This issue of Gut features a study …","PeriodicalId":12825,"journal":{"name":"Gut","volume":"52 1","pages":""},"PeriodicalIF":24.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144639774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut microbiota and atherosclerosis 肠道微生物群和动脉粥样硬化
IF 24.5 1区 医学
Gut Pub Date : 2025-07-11 DOI: 10.1136/gutjnl-2025-335610
William Fusco, Timon Adolph, Giovanni Cammarota, Antonio Gasbarrini, Gianluca Ianiro, Herbert Tilg
{"title":"Gut microbiota and atherosclerosis","authors":"William Fusco, Timon Adolph, Giovanni Cammarota, Antonio Gasbarrini, Gianluca Ianiro, Herbert Tilg","doi":"10.1136/gutjnl-2025-335610","DOIUrl":"https://doi.org/10.1136/gutjnl-2025-335610","url":null,"abstract":"Atherosclerosis reflects a chronic inflammatory process of arteries. The origin of chronic vascular inflammation has been associated over a long time primarily with lipid disorders, but evidence from the past years has suggested that lipid-independent pathways are also involved. Recent research has demonstrated that the gastrointestinal microbiota has an impact on the development of atherosclerosis. Many clinical studies have revealed that there exist altered gut microbiota and increased intestinal abundance of bacteria from the oral cavity in atherosclerosis-related disorders such as cardiovascular disease or stroke, while several studies have demonstrated insights into underlying mechanisms. Various microbial-derived metabolites, such as the pathogen-associated molecular pattern endotoxin, trimethylamine N-oxide or imidazole propionate, contribute to atherosclerosis, while other bacterial metabolites, such as some tryptophan derivatives, might be protective. Furthermore, gut microbiota and lipid pathways are highly interactive, and the gut microbiota affects lipid absorption and storage, and the gut microbiota also contributes to vascular ageing. Interference with the gut microbiota by prebiotics, probiotics and antibiotics has demonstrated beneficial effects on atherosclerosis mainly in preclinical models. Overall, the gut microbiota has appeared as an important rheostat for vascular inflammation in atherosclerosis, which is controlled by host-microbe interactions that may be therapeutically exploited in the future.","PeriodicalId":12825,"journal":{"name":"Gut","volume":"44 1","pages":""},"PeriodicalIF":24.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic inhibition of HBsAg and HBV cccDNA through a novel phased combination treatment: glycine and interferon-α 通过一种新的阶段性联合治疗:甘氨酸和干扰素-α对HBsAg和HBV cccDNA的治疗性抑制
IF 24.5 1区 医学
Gut Pub Date : 2025-07-11 DOI: 10.1136/gutjnl-2025-334813
Caorui Lin, Ying Huang, Ning Ran, Jie Liu, Linjie Luo, Xin Zhang, Xiaosang Zheng, Zhen Xun, Siyi Xu, Can Liu, Xiaohong Kong, Shiqing Feng, Haiting Mao, Qishui Ou
{"title":"Therapeutic inhibition of HBsAg and HBV cccDNA through a novel phased combination treatment: glycine and interferon-α","authors":"Caorui Lin, Ying Huang, Ning Ran, Jie Liu, Linjie Luo, Xin Zhang, Xiaosang Zheng, Zhen Xun, Siyi Xu, Can Liu, Xiaohong Kong, Shiqing Feng, Haiting Mao, Qishui Ou","doi":"10.1136/gutjnl-2025-334813","DOIUrl":"https://doi.org/10.1136/gutjnl-2025-334813","url":null,"abstract":"Background The elimination of HBV covalently closed circular DNA (cccDNA) remains a critical hurdle for chronic hepatitis B (CHB) management. Objective In this investigation, we examined the efficacy of glycine administration and its potential enhancement in interferon-α (IFN-α) antiviral efficacy to stimulate hepatocyte proliferation to mitigate cccDNA levels. Design The study cohort comprised 89 healthy individuals and 496 HBV-infected patients, with subgroups of 30 and 42 participants receiving randomised nucleos(t)ide analogue (NA) and PegIFN-α treatments, respectively. Glycine concentrations were quantified via liquid chromatography‒tandem mass spectrometry, and its diagnostic potential was assessed via receiver operating characteristic curve analysis. The therapeutic impact of glycine was evaluated in various HBV-infected cell lines and murine models via various methodologies including transcriptomic sequencing, metabolomics sequencing, flow cytometry, immunofluorescence and in situ hybridisation. Results Elevated serum glycine levels with a robust positive correlation with serum alanine aminotransferase levels (R=0.7650) were observed in HBV-infected patients relative to healthy controls. The area under the curve for differentiating patients with HBeAg-expressing CHB from healthy controls was 0.9701. Glycine supplementation diminished HBV cccDNA levels by approximately 50% by promoting hepatocyte proliferation. Glycine is metabolised into a one-carbon unit, activating mTORC1 signalling via glycine transporter-1. Furthermore, glycine ameliorates hepatic inflammation by inhibiting the nuclear factor-kappa B signalling pathway through glycine receptors. Combination therapy with IFN-α effectively suppressed HBV replication, achieving a 60% reduction in HBsAg levels and sustained viral suppression in mice. Conclusion Glycine has the potential to reduce HBV cccDNA levels by stimulating hepatocyte proliferation. The phased administration of glycine and IFN-α significantly enhances its therapeutic efficacy. These findings suggest a novel and promising strategy for the treatment of CHB. Data are available upon reasonable request.","PeriodicalId":12825,"journal":{"name":"Gut","volume":"695 1","pages":""},"PeriodicalIF":24.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammatory bowel disease linked to accelerated cognitive decline in individuals with dementia: a nationwide cohort study 炎症性肠病与痴呆症患者认知能力加速下降有关:一项全国性队列研究
IF 24.5 1区 医学
Gut Pub Date : 2025-07-11 DOI: 10.1136/gutjnl-2025-335370
Minjia Mo, Jiangwei Sun, Iris Mikulic, Jonas F Ludvigsson, Sara Garcia-Ptacek, Maria Eriksdotter, Hong Xu
{"title":"Inflammatory bowel disease linked to accelerated cognitive decline in individuals with dementia: a nationwide cohort study","authors":"Minjia Mo, Jiangwei Sun, Iris Mikulic, Jonas F Ludvigsson, Sara Garcia-Ptacek, Maria Eriksdotter, Hong Xu","doi":"10.1136/gutjnl-2025-335370","DOIUrl":"https://doi.org/10.1136/gutjnl-2025-335370","url":null,"abstract":"A recent study by Erkert et al identified a new role for Alzheimer’s disease (AD)-associated presenilins as key molecules involved in maintaining intestinal epithelial function, barrier integrity and immune homeostasis, linking AD and inflammatory bowel disease (IBD) at the molecular level.1 2 Meanwhile, Zhang et al , from an epidemiological perspective, reported that individuals with IBD have a higher risk of developing dementia, particularly AD.3 The ‘gut-brain axis’, which links the intestine and the central nervous system (CNS), has received significant attention in recent years. IBD may impact brain function by triggering systemic inflammation, disrupting neuronal regulation and altering interactions between the gut microbiota and the CNS, potentially leading to dementia.4 5 However, whether IBD accelerates cognitive decline in dementia remains unclear. Dementia is an irreversible disease that worsens over time.6 Since dementia is currently incurable, slowing cognitive decline and understanding its mechanisms are crucial for improving the lives and healthcare support for affected individuals.7 We conducted a propensity score-matched cohort study to investigate the association between IBD and the progression of dementia, as measured by Mini-Mental State Examination (MMSE) scores. Using the Swedish Registry for Cognitive/Dementia Disorders (SveDem) and the Swedish National Patient Register, we identified individuals with dementia and incident IBD from 2007 to 2018. For each individual with dementia with later IBD, we matched 10 individuals with dementia without IBD using the nearest matching method and a calliper of 0.1 to balance confounders between the two groups. We defined …","PeriodicalId":12825,"journal":{"name":"Gut","volume":"23 1","pages":""},"PeriodicalIF":24.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Helicobacter pylori antibiotic resistance: a global challenge in search of solutions 幽门螺杆菌抗生素耐药性:寻求解决方案的全球挑战
IF 24.5 1区 医学
Gut Pub Date : 2025-07-11 DOI: 10.1136/gutjnl-2025-335523
Christian Schulz, Jyh-Ming Liou, Mohamed Alboraie, Jan Bornschein, Christian Campos Nunez, Luiz Gonzaga Coelho, Duc Trong Quach, Carlo A Fallone, Yi-Chu Chen, Markus Gerhard, Javier P Gisbert, Hwoon-Yong Jung, Peter H Katelaris, Jae Gyu Kim, Hong Lu, Lukas Macke, Varocha Mahachai, Steven F Moss, Jose Maria Remes Troche, Arnoldo Riquelme, Marco Romano, Mashiko Setshedi, Stella Smith, Sebastian Suerbaum, Evariste Tshibangu-Kabamba, Ratha-Korn Vilaichone, Abbas Yadegar, Yoshio Yamaoka, Francis Mégraud, Emad M El-Omar, Kentaro Sugano, Peter Malfertheiner
{"title":"Helicobacter pylori antibiotic resistance: a global challenge in search of solutions","authors":"Christian Schulz, Jyh-Ming Liou, Mohamed Alboraie, Jan Bornschein, Christian Campos Nunez, Luiz Gonzaga Coelho, Duc Trong Quach, Carlo A Fallone, Yi-Chu Chen, Markus Gerhard, Javier P Gisbert, Hwoon-Yong Jung, Peter H Katelaris, Jae Gyu Kim, Hong Lu, Lukas Macke, Varocha Mahachai, Steven F Moss, Jose Maria Remes Troche, Arnoldo Riquelme, Marco Romano, Mashiko Setshedi, Stella Smith, Sebastian Suerbaum, Evariste Tshibangu-Kabamba, Ratha-Korn Vilaichone, Abbas Yadegar, Yoshio Yamaoka, Francis Mégraud, Emad M El-Omar, Kentaro Sugano, Peter Malfertheiner","doi":"10.1136/gutjnl-2025-335523","DOIUrl":"https://doi.org/10.1136/gutjnl-2025-335523","url":null,"abstract":"Background Helicobacter pylori resistance to antibiotics commonly used in eradication regimens is increasing dramatically in many locations; new strategies are needed to manage this infectious disease. Objective This study’s aim was to collect and update information on antibiotic resistance (AR) rates in H. pylori as well as current strategies for H. pylori management, including public health issues, from a global perspective. Design An international survey was conducted in 31 countries on 6 continents to address key issues concerning the management of H. pylori -related AR. Individual aspects included the prevalence of AR for specific antibiotics, antibiotic susceptibility testing (AST) in different healthcare systems, availability of drugs, reimbursement issues and strategies for H. pylori AR surveillance. Results Resistance to the most effective antibiotics used in H. pylori eradication regimens is increasing globally, with clarithromycin and levofloxacin resistance exceeding 15% in 24/31 and 18/31 countries, respectively. Amoxicillin remains an exception, with resistance rates under 2% in 14/31 countries; though African countries have reported amoxicillin resistance rates of over 90%. Bismuth-based treatment regimens are the most effective and are recommended as first-line treatment in several countries. However, more than 1 billion inhabitants worldwide have no access to bismuth-based regimens. PCR-based tests for AR are used in 16/26 countries but are reimbursed in only 4, while next generation sequencing-based tests are available, but not reimbursed, in 3 countries. In 22/26 countries only culture-based methods are available (reimbursed in 9/26 countries). AR surveillance programmes have only been established in 4/26 countries. Therefore, in most countries, empirical therapy with the most effective local regimen available locally is practiced. Conclusion The dramatic global rise in H. pylori antibiotic resistance requires an urgent revision of current management strategies. Possible solutions include AST-based selection of effective treatment regimens, identification of novel combinations of existing drugs and exploration of novel drugs. Data are available in a public, open access repository.","PeriodicalId":12825,"journal":{"name":"Gut","volume":"22 1","pages":""},"PeriodicalIF":24.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New player in inflammation-driver liver carcinogenesis: pirin on fire! 炎症驱动肝癌发生的新参与者:匹林着火了!
IF 24.5 1区 医学
Gut Pub Date : 2025-07-09 DOI: 10.1136/gutjnl-2025-335913
Claudia Campani, Jean-Charles Nault
{"title":"New player in inflammation-driver liver carcinogenesis: pirin on fire!","authors":"Claudia Campani, Jean-Charles Nault","doi":"10.1136/gutjnl-2025-335913","DOIUrl":"https://doi.org/10.1136/gutjnl-2025-335913","url":null,"abstract":"Pirin (PIR) is a 32 kDa iron-binding protein belonging to the cupin superfamily, with well-recognised roles that include functioning as a transcriptional co-regulator.1 A single ferrous ion (Fe²+) is housed within the N-terminal domain, where it serves as a redox-sensitive allosteric site.2 This iron-binding region is critical for modulating PIR’s conformational dynamics and subcellular localisation in response to fluctuations in the intracellular redox state.3 Under oxidative conditions, PIR undergoes a redox-dependent transition from its reduced Fe²+ (inactive) to oxidized Fe³+ (active) form.3 This conformational change enhances its binding affinity for multiple transcription factors, including nuclear factor I (NF-I), B-cell lymphoma 3-encoded protein and the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunits p50 and p65/v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) amplifying the expression of downstream genes.4 Through these molecular interactions, PIR acts as a key modulator within signaling pathways that regulate inflammation, apoptosis and innate immune responses. The role of PIR has been previously described in several solid tumors, including breast,5 lung,6 colorectal cancers7 and melanoma,8 where PIR has been implicated in promoting cell proliferation and inflammatory signaling. However, until recently, few data were available about the role of PIR in the pathogenesis of hepatocellular carcinoma (HCC). In Gut , Ma et al 9 provide convincing evidence that PIR plays a pivotal role in linking oxidative stress, chronic inflammation and HCC progression (figure 1). The authors demonstrated that PIR expression is progressively upregulated from metabolic dysfunction-associated steatotic liver disease (MASLD), viral hepatitis and cirrhosis to HCC, a pattern confirmed across independent datasets both at the transcriptome and protein levels. Functionally, PIR …","PeriodicalId":12825,"journal":{"name":"Gut","volume":"10 1","pages":""},"PeriodicalIF":24.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histology of subepithelial lesions (SELs) in the gastrointestinal tract-resected endoscopic: a database study of 4901 patients. 内镜下胃肠道切除术中上皮下病变(SELs)的组织学:4901例患者的数据库研究。
IF 23 1区 医学
Gut Pub Date : 2025-07-07 DOI: 10.1136/gutjnl-2024-333150
Zhipeng Qi, Enpan Xu, Shuchang Xu, Leiming Xu, XiaoBo Li, Liang Zhong, Dongli He, Pinghong Zhou, Zhendong Jin, Yunshi Zhong
{"title":"Histology of subepithelial lesions (SELs) in the gastrointestinal tract-resected endoscopic: a database study of 4901 patients.","authors":"Zhipeng Qi, Enpan Xu, Shuchang Xu, Leiming Xu, XiaoBo Li, Liang Zhong, Dongli He, Pinghong Zhou, Zhendong Jin, Yunshi Zhong","doi":"10.1136/gutjnl-2024-333150","DOIUrl":"10.1136/gutjnl-2024-333150","url":null,"abstract":"","PeriodicalId":12825,"journal":{"name":"Gut","volume":" ","pages":"1205-1208"},"PeriodicalIF":23.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-cell omics in inflammatory bowel disease: recent insights and future clinical applications. 单细胞组学在炎症性肠病中的应用:最近的见解和未来的临床应用。
IF 23 1区 医学
Gut Pub Date : 2025-07-07 DOI: 10.1136/gutjnl-2024-334165
Victoria Gudiño, Raquel Bartolomé-Casado, Azucena Salas
{"title":"Single-cell omics in inflammatory bowel disease: recent insights and future clinical applications.","authors":"Victoria Gudiño, Raquel Bartolomé-Casado, Azucena Salas","doi":"10.1136/gutjnl-2024-334165","DOIUrl":"10.1136/gutjnl-2024-334165","url":null,"abstract":"<p><p>Inflammatory bowel diseases (IBDs), which include ulcerative colitis (UC) and Crohn's disease (CD), are chronic conditions characterised by inflammation of the intestinal tract. Alterations in virtually all intestinal cell types, including immune, epithelial and stromal cells, have been described in these diseases. The study of IBD has historically relied on bulk transcriptomics, but this method averages signals across diverse cell types, limiting insights. Single-cell omic technologies overcome the intrinsic limitations of bulk analysis and reveal the complexity of multicellular tissues at a cell-by-cell resolution. Within healthy and inflamed intestinal tissues, single-cell omics, particularly single-cell RNA sequencing, have contributed to uncovering novel cell types and cell functions linked to disease activity or the development of complications. Collectively, these results help identify therapeutic targets in difficult-to-treat complications such as fibrostenosis, creeping fat accumulation, perianal fistulae or inflammation of the pouch. More recently, single-cell omics have gradually been adopted in studies to understand therapeutic responses, identify mechanisms of drug failure and potentially develop predictors with clinical utility. Although these are early days, such studies lay the groundwork for the implementation in clinical practice of new technologies in diagnostics, monitoring and prediction of disease prognosis. With this review, we aim to provide a comprehensive survey of the studies that have applied single-cell omics to the study of UC or CD, and offer our perspective on the main findings these studies contribute. Finally, we discuss the limitations and potential benefits that the integration of single-cell omics into clinical practice and drug development could offer.</p>","PeriodicalId":12825,"journal":{"name":"Gut","volume":" ","pages":"1335-1345"},"PeriodicalIF":23.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Putting the best foot forward: rethinking the paradigms in ASUC. 迈出最好的一步:重新思考ASUC的范式。
IF 23 1区 医学
Gut Pub Date : 2025-07-07 DOI: 10.1136/gutjnl-2024-334267
Shaji Sebastian, Vineet Ahuja, Ajit Sood
{"title":"Putting the best foot forward: rethinking the paradigms in ASUC.","authors":"Shaji Sebastian, Vineet Ahuja, Ajit Sood","doi":"10.1136/gutjnl-2024-334267","DOIUrl":"10.1136/gutjnl-2024-334267","url":null,"abstract":"","PeriodicalId":12825,"journal":{"name":"Gut","volume":" ","pages":"1201-1202"},"PeriodicalIF":23.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信