Gut最新文献 - Book学术

Giving proton-pump inhibitors after variceal ligation: is it time to change practice? 静脉曲张结扎后给予质子泵抑制剂：是时候改变做法了吗？

IF 24.6 1区医学

Gut Pub Date : 2026-10-16 DOI: 10.1136/gutjnl-2026-339334

Dhiraj Tripathi, Sanchit Sharma

引用次数: 0

Can commercial artificial intelligence replace onsite cytopathologists for rapid onsite evaluation during EUS-guided tissue acquisition? 商业人工智能能否取代现场细胞病理学家，在eus引导的组织采集过程中进行快速的现场评估？

IF 24.6 1区医学

Gut Pub Date : 2026-10-16 DOI: 10.1136/gutjnl-2026-339837

Inge de Vries, Shyam Varadarajulu, Konrad Krall, Jayapal Ramesh, Ji Young Bang

引用次数: 0

Burden of liver fibrosis and steatosis coexisting with hepatitis B or C infection in China: a population-based study from the 2020 National Serological Survey. 中国乙型或丙型肝炎感染并发肝纤维化和脂肪变性负担：一项来自2020年全国血清学调查的基于人群的研究

IF 24.6 1区医学

Gut Pub Date : 2026-10-16 DOI: 10.1136/gutjnl-2026-338285

Tongtong Meng, Yu Wang, Hui Zheng, Jian Li, Dongyang Sun, Yifan Wang, Yan Wang, Xiaoning Wu, Fuzhen Wang, Liping Shen, Feng Wang, Ning Miao, Guomin Zhang, Min Wang, Guanhua Zhang, Hao Wang, Shuyan Chen, Yameng Sun, Min Li, Yu Wang, Hong You, Hui Zhuang, Zundong Yin, Jidong Jia, Yuanyuan Kong

引用次数: 0

Boosting the nuclear Wnt/β-catenin feedback loop for the specific elimination of colorectal cancer. 促进核Wnt/β-catenin反馈回路特异性消除结直肠癌。

IF 24.6 1区医学

Gut Pub Date : 2026-10-12 DOI: 10.1136/gutjnl-2026-338973

Shixin Liao, Rongrong Du, Xiaoyu Zeng, Jincheng Zhai, Yaqi Zhang, Kai Li, Xi Li, Jiayi Wu, Runjie Song, Zhenzhen Chen, Qiankun He, Pingping Zhu

引用次数: 0

Tumour-like ileal lesion in an adolescent with massive gastrointestinal bleeding. 青少年大量胃肠道出血的肿瘤样回肠病变。

IF 24.6 1区医学

Gut Pub Date : 2026-10-09 DOI: 10.1136/gutjnl-2026-340670

Zhigang Ke, Peng Zhong, Zhongyi Qin, Bin Huang

引用次数: 0

Prospective study of phosphatidylethanol (PEth) as a diagnostic biomarker for identifying alcohol use disorder (AUD) among participants at risk for steatotic liver disease. 磷脂酰乙醇（PEth）作为识别酒精使用障碍（AUD）在有脂肪变性肝病风险的参与者中的诊断性生物标志物的前瞻性研究

IF 24.6 1区医学

Gut Pub Date : 2026-10-08 DOI: 10.1136/gutjnl-2026-339702

Rohan R Loomba, Luis Antonio Díaz, Kaleb Tesfai, Richele Bettencourt, Egbert Madamba, Veeral Ajmera, Rohit Loomba

引用次数: 0

Consensus guidance of immune checkpoint inhibitors in locally advanced rectal cancer. 局部晚期直肠癌免疫检查点抑制剂的共识指导。

IF 24.6 1区医学

Gut Pub Date : 2026-10-07 DOI: 10.1136/gutjnl-2025-336979

Zhengyang Yang, Fan Xia, Jian Li, Jing Jin, Guiying Wang, GuoLe Lin, Xinxiang Li, Aiwen Wu, Tao Zhang, Wei Zhang, JianMin Xu, Kaixiong Tao, Peirong Ding, Yong Li, Ye Xu, Zhangfa Song, Leping Li, Yanhong Deng, Xiangbo Wan, Rui-Hua Xu, Zhen Zhang, Hongwei Yao, Zhongtao Zhang

{"title":"Consensus guidance of immune checkpoint inhibitors in locally advanced rectal cancer.","authors":"Zhengyang Yang, Fan Xia, Jian Li, Jing Jin, Guiying Wang, GuoLe Lin, Xinxiang Li, Aiwen Wu, Tao Zhang, Wei Zhang, JianMin Xu, Kaixiong Tao, Peirong Ding, Yong Li, Ye Xu, Zhangfa Song, Leping Li, Yanhong Deng, Xiangbo Wan, Rui-Hua Xu, Zhen Zhang, Hongwei Yao, Zhongtao Zhang","doi":"10.1136/gutjnl-2025-336979","DOIUrl":"10.1136/gutjnl-2025-336979","url":null,"abstract":"In the past 5 years, clinical trials on immune checkpoint inhibitors (ICIs) for the treatment of locally advanced rectal cancer (LARC) have flourished globally, and China has become one of the leading regions in this field. In response to the breakthrough progress and accumulation of evidence from key clinical trials, the Chinese Society of Colorectal Surgery has recognised the need for updated consensus guidance on the development of perioperative and organ-preserving treatment strategies for LARC. This expert consensus guidance provided unified standards for the indications, medication regimens, efficacy evaluations and follow-up of ICIs in this population, with a focus mainly on perioperative management and organ-sparing strategies. The diagnostic part of this consensus guidance is based on the internationally recognised definition of mismatch repair/microsatellite instability detection and emphasises the importance of multidisciplinary teams in treatment decision-making. In terms of treatment, based on the results of key trials that have changed clinical practice in the past 5 years, this expert consensus provides graded recommendations for the duration of preoperative immunotherapy and the necessity of postoperative adjuvant therapy, local resection and organ preservation strategies. Moreover, we refined the management process for the safety of perioperative immunotherapy. This document aims to provide a reference for surgeons; internal medicine, radiation therapy, pathology and imaging physicians; patients and nursing staff involved in the treatment of LARC, as well as health policy makers.","PeriodicalId":12825,"journal":{"name":"Gut","volume":" ","pages":"2102-2117"},"PeriodicalIF":24.6,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147305063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of genetic analysis in adult cholestatic liver disease: lessons from progressive paediatric syndromes and cohort studies. 遗传分析在成人胆汁淤积性肝病中的应用：来自进行性儿科综合征和队列研究的经验教训

IF 24.6 1区医学

Gut Pub Date : 2026-10-07 DOI: 10.1136/gutjnl-2025-337027

Roman Liebe, Frank Lammert, Hartmut H Schmidt, Marcin Krawczyk

{"title":"Use of genetic analysis in adult cholestatic liver disease: lessons from progressive paediatric syndromes and cohort studies.","authors":"Roman Liebe, Frank Lammert, Hartmut H Schmidt, Marcin Krawczyk","doi":"10.1136/gutjnl-2025-337027","DOIUrl":"10.1136/gutjnl-2025-337027","url":null,"abstract":"The increasing availability and decreasing costs of DNA sequencing have resulted in the re-grouping of rare, severe paediatric cases of progressive familial intrahepatic cholestasis (PFIC) with more frequent, later-onset cases of cholestasis (eg, intrahepatic cholestasis of pregnancy, benign recurrent intrahepatic cholestasis, low phospholipid-associated cholelithiasis) under the umbrella of genetic cholestasis. The common denominator is the presence of functional variants in the PFIC-associated genes, predominantly in ABCB4, ABCB11 and ATP8B1, which cause PFIC types 1-3. Several other congenital diseases such as Alagille syndrome and alpha1-antitrypsin deficiency comprise cholestatic pruritus as frequent symptoms.With the availability of intestinal bile acid transporter inhibitors (IBATi) as new and efficacious therapeutics for pruritus, the most debilitating symptom of PFIC, it is essential to envision their usefulness for patients with later-onset cholestatic liver disease suffering from pruritus.In this review, we summarise published studies on the genetic makeup of patients with paediatric, juvenile and adult-onset cholestasis, and discuss their findings with respect to genotype-specific treatment with IBATi, ursodeoxycholic acid, or alternative drugs. The aim is to provide an overview of the genetic variants likely to be encountered in future sequencing investigations of patients with cholestatic liver diseases, and how to translate this genetic information into personalised treatment recommendations.","PeriodicalId":12825,"journal":{"name":"Gut","volume":" ","pages":"2267-2277"},"PeriodicalIF":24.6,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unravelling the heterogeneous HCC risk in indeterminate chronic hepatitis B. 揭示不确定的慢性乙型肝炎的异质性HCC风险。

IF 24.6 1区医学

Gut Pub Date : 2026-10-07 DOI: 10.1136/gutjnl-2025-335915

Chien-Wei Su, Yuh-Jin Liang, Jaw-Ching Wu

引用次数: 0

Modulating the gut-reproductive tract axis: microbial influence on gynaecological cancer pathogenesis and treatment. 调节肠道-生殖道轴：微生物对妇科癌症发病和治疗的影响。

IF 24.6 1区医学

Gut Pub Date : 2026-10-07 DOI: 10.1136/gutjnl-2025-337778

Xinyi Chen, Zhenqiang Zuo, Bingbing Xiao, Fangqing Zhao

{"title":"Modulating the gut-reproductive tract axis: microbial influence on gynaecological cancer pathogenesis and treatment.","authors":"Xinyi Chen, Zhenqiang Zuo, Bingbing Xiao, Fangqing Zhao","doi":"10.1136/gutjnl-2025-337778","DOIUrl":"10.1136/gutjnl-2025-337778","url":null,"abstract":"The gut microbiota plays a crucial role in regulating host immunity, metabolism and inflammation, with accumulating evidence linking its composition and function to the development and progression of cancers in the reproductive tract. Patients with ovarian, endometrial and cervical cancers exhibit distinct alterations in their gut microbiota, characterised by reduced microbial diversity and shifts towards taxa associated with dysbiosis and chronic inflammation. Mechanistically, gut-derived metabolites and microbial translocation appear to influence systemic immune responses and oestrogen metabolism, thereby fostering a tumour microenvironment conducive to cancer growth. Beyond its role in tumourigenesis, the gut microbiota also affects treatment outcomes. Dysbiosis can reduce sensitivity to chemotherapy and alter immunotherapy responses, while antibiotic use during cancer treatment has been linked to poorer prognosis. Clinically, these insights highlight emerging applications of microbiome modulation as biomarkers for patient stratification and as adjuvant approaches to enhance therapeutic efficacy in gynaecological oncology, underscoring the therapeutic potential of targeting the microbiota-through dietary interventions, probiotics or faecal microbiota transplantation-to improve cancer treatment outcomes. However, most of these applications remain investigational, and current evidence is limited by heterogeneity across study designs, patient cohorts and cancer subtypes. This review summarises current understanding of gut microbiota profiles in reproductive tract cancers, examines potential mechanisms by which the microbiota influences malignancy, discusses its impact on therapy response and explores its emerging role in precision oncology.","PeriodicalId":12825,"journal":{"name":"Gut","volume":" ","pages":"2278-2291"},"PeriodicalIF":24.6,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146156929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0