Gastroenterologia y hepatologia最新文献

{"title":"Less is more: Simplifying therapy in post-ablative antral hyperplasia","authors":"Rut Fernandez Bezanilla,&nbsp;Irene Arteagoitia Casero,&nbsp;Mario Salvador Argueta Valdez,&nbsp;Ainara Torralba Gallego,&nbsp;Pilar Pazo Meijide,&nbsp;Iñigo Roa Esparza","doi":"10.1016/j.gastrohep.2026.502758","DOIUrl":"10.1016/j.gastrohep.2026.502758","url":null,"abstract":"<div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (183KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"49 7","pages":"Article 502758"},"PeriodicalIF":2.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rectal spirochetosis: An unusual endoscopic finding","authors":"Daniel Álvarez de Castro,&nbsp;María Pérez Pérez,&nbsp;Ángela Benavides Zamara,&nbsp;Álvaro Yagüe Parada","doi":"10.1016/j.gastrohep.2026.502655","DOIUrl":"10.1016/j.gastrohep.2026.502655","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"49 7","pages":"Article 502655"},"PeriodicalIF":2.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neumatosis de colon ascendente secundaria a estenosis de sigma","authors":"Natalia Ansó-Molina,&nbsp;María Martínez-Galilea,&nbsp;María Díaz-Tobarra,&nbsp;Serafín Andrés Pérez","doi":"10.1016/j.gastrohep.2026.502709","DOIUrl":"10.1016/j.gastrohep.2026.502709","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"49 7","pages":"Article 502709"},"PeriodicalIF":2.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147304953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subclinical atherosclerosis in inflammatory bowel disease: Prevalence, vascular distribution and implications for cardiovascular risk stratification","authors":"Gonzalo Fernández Villar,&nbsp;Fernando Garagoli,&nbsp;Solange Martinez Elhelou,&nbsp;Walter Masson,&nbsp;Maria Josefina Etchevers,&nbsp;Maria Josefina Sobrero,&nbsp;Maria Belen Sanchez,&nbsp;Rodolfo Pizarro","doi":"10.1016/j.gastrohep.2026.502755","DOIUrl":"10.1016/j.gastrohep.2026.502755","url":null,"abstract":"<div><h3>Objective</h3><div>Cardiovascular (CV) risk assessment in patients with inflammatory bowel disease (IBD) remains insufficiently explored. This study aimed to assess the role of vascular Doppler ultrasound in refining CV risk stratification in patients with IBD.</div></div><div><h3>Patients and methods</h3><div>We conducted a cross-sectional study including patients with Crohn's disease (CD) and ulcerative colitis (UC) under active follow-up in a tertiary referral center. Consecutive patients referred for cardiology assessment according to predefined clinical criteria between May 2024 and December 2025 underwent carotid and femoral Doppler ultrasound to estimate the prevalence of atherosclerosis. Ultrasound operators were blinded to the CV risk score results and clinical risk stratification at time to image acquisition and interpretation. In the primary prevention cohort, the ability of the PREVENT 10-year risk score for detecting subclinical atherosclerosis was assessed using receiver operating characteristic (ROC) analysis. The optimal cutoff point was determined using the Youden index.</div></div><div><h3>Results</h3><div>A total of 106 patients were included, of whom 100 without established atherosclerotic cardiovascular disease (ASCVD) constituted the main analytical population. The median age was 54.4 years, and 59% were men. Before Doppler assessment, 55% of patients were classified as low risk, 10% as borderline risk, 28% as intermediate risk, and 7% as high risk. Subclinical atherosclerosis was detected in 46%, prompting risk reclassification. Overall upward reclassification occurred in 41% and downward reclassification in 5%, yielding a net reclassification of 36%. The PREVENT 10-year risk score showed good discriminatory performance for the detection of subclinical atherosclerosis (AUC<!--> <!-->=<!--> <!-->0.85; 95% CI, 0.77–0.93), with an optimal cutoff value of 2.8%.</div></div><div><h3>Conclusions</h3><div>Vascular Doppler imaging revealed a high prevalence of subclinical atherosclerosis and was associated with substantial CV risk reclassification beyond traditional scores.</div></div>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"49 7","pages":"Article 502755"},"PeriodicalIF":2.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uso de bevacizumab en angiodisplasias gastrointestinales refractarias a tratamiento endoscópico y médico convencional","authors":"María Escuin Sanmartin,&nbsp;Guillén Bernal Bandres,&nbsp;Sergio García Mateo,&nbsp;Enrique Ceamanos Ibarra,&nbsp;Marta Latre Santos,&nbsp;Adela Navarro Pueyo,&nbsp;Marta Fernández Arquillué,&nbsp;María Galochino Ballano,&nbsp;Julia López de la Cruz,&nbsp;María Concepción Aso Gonzalvo,&nbsp;Maria Ortiz de Solorzano Reig,&nbsp;Antonio Aguilar Muñiz,&nbsp;Mónica Llorente Barrio","doi":"10.1016/j.gastrohep.2026.502701","DOIUrl":"10.1016/j.gastrohep.2026.502701","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"49 7","pages":"Article 502701"},"PeriodicalIF":2.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curación funcional de la hepatitis crónica B: la cara amable del trasplante alogénico de progenitores hematopoyéticos","authors":"Blanca Mesonero,&nbsp;Joud Zanabili,&nbsp;Elena Granda,&nbsp;Mercedes Rodríguez,&nbsp;Manuel Rodríguez","doi":"10.1016/j.gastrohep.2026.502721","DOIUrl":"10.1016/j.gastrohep.2026.502721","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"49 7","pages":"Article 502721"},"PeriodicalIF":2.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel biomarkers and multi-omics approaches for diagnosis and management of ulcerative colitis","authors":"Arup Dey,&nbsp;Manish Kumar Gautam,&nbsp;Sandip Mondal,&nbsp;Saikat Sen","doi":"10.1016/j.gastrohep.2026.502764","DOIUrl":"10.1016/j.gastrohep.2026.502764","url":null,"abstract":"<div><h3>Background</h3><div>Ulcerative colitis (UC) remains challenging to diagnose, monitor, and treat due to heterogeneous disease presentation and lack of reliable non-invasive markers. Current diagnostic tools, including endoscopy and routine laboratory tests, are limited by invasiveness, cost, and low sensitivity.</div></div><div><h3>Aim</h3><div>This review evaluates emerging biomarkers and multi-omics strategies in UC, highlighting their potential role in disease diagnosis, prognosis, and therapeutic response prediction.</div></div><div><h3>Methods</h3><div>A comprehensive literature analysis was conducted, focusing on faecal, serological, genetic, epigenetic, microbial, and metabolite-based biomarkers, as well as recent advances in transcriptomics, proteomics, and metabolomics. Integration with machine learning approaches was also assessed for their clinical applicability.</div></div><div><h3>Results</h3><div>Faecal calprotectin and lactoferrin remain reliable non-invasive markers for mucosal inflammation, while serological markers such as CRP and ESR show limited specificity. Genetic variants (IL23R, NOD2) and epigenetic regulators, particularly microRNAs, demonstrate potential for disease stratification. Dysbiosis and altered microbial metabolites further correlate with disease severity and treatment response. Multi-omics integration offers a systems-level view of UC, enabling biomarker panels that improve diagnostic precision and predict therapeutic outcomes. Machine learning tools enhance biomarker-based models, but clinical translation is constrained by variability, validation gaps, and regulatory hurdles.</div></div><div><h3>Conclusion</h3><div>Emerging biomarkers, especially when integrated across omics platforms and supported by artificial intelligence, provide promising avenues for precision medicine in UC. However, standardisation, external validation, and regulatory qualification remain essential for their successful clinical implementation.</div></div>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"49 7","pages":"Article 502764"},"PeriodicalIF":2.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of psychiatric comorbidities on outcomes in cirrhosis: A propensity-matched cohort analysis","authors":"Muhammad Ali Ibrahim Kazi,&nbsp;Mahnoor Sarfraz,&nbsp;Siraj Ahmad,&nbsp;Qetevan Gvazava,&nbsp;Imran Qureshi,&nbsp;Zurabi Lominadze,&nbsp;Maia Tavadze","doi":"10.1016/j.gastrohep.2026.502712","DOIUrl":"10.1016/j.gastrohep.2026.502712","url":null,"abstract":"<div><h3>Background</h3><div>Cirrhosis is a progressive liver disease associated with high morbidity and reduced quality of life. Mood disorders are common in chronic liver disease and may worsen outcomes through inflammation, poor adherence and reduced care engagement. Their specific impact on cirrhosis outcomes, however, remains unclear.</div></div><div><h3>Methods</h3><div>Using the TriNetX global research network, we conducted a retrospective cohort study of adults with cirrhosis, comparing those with comorbid mood disorders to those without. Propensity score matching (1:1) was performed using demographic variables. Outcomes included variceal bleeding, ascites, spontaneous bacterial peritonitis (SBP), hepatic encephalopathy, hepatorenal syndrome, liver transplantation, and all-cause mortality.</div></div><div><h3>Results</h3><div>After matching, cirrhotic patients with mood disorders had significantly higher complication rates than controls, including varices (RR 1.19), ascites (RR 1.13), SBP (RR 1.40), hepatic encephalopathy (RR 1.52), and hepatorenal syndrome (RR 1.34) (all <em>p</em> <!-->&lt;<!--> <!-->0.001). They were also more likely to undergo liver transplantation (RR 1.76) and had a modest increase in all-cause mortality (RR 1.06).</div></div><div><h3>Conclusion</h3><div>Mood disorders in cirrhosis are associated with increased decompensation, transplant utilization, and mortality, highlighting the need for integrated psychiatric care and further prospective evaluation.</div></div>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"49 7","pages":"Article 502712"},"PeriodicalIF":2.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastropatía isquémica: una manifestación infrecuente de aterosclerosis sistémica","authors":"Marta Sánchez Tripiana,&nbsp;Marta Fernández Carrasco,&nbsp;Sara Sánchez Moreno,&nbsp;Carmelo Diéguez Castillo","doi":"10.1016/j.gastrohep.2026.502756","DOIUrl":"10.1016/j.gastrohep.2026.502756","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"49 7","pages":"Article 502756"},"PeriodicalIF":2.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147591758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intususcepción de bulbo duodenal idiopática en el adulto","authors":"Marta Torrero Luna,&nbsp;Laura Zamora Sanclemente,&nbsp;Ana Rodríguez Pérez,&nbsp;Iván Fernández Marzo","doi":"10.1016/j.gastrohep.2026.502760","DOIUrl":"10.1016/j.gastrohep.2026.502760","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"49 7","pages":"Article 502760"},"PeriodicalIF":2.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}