Antonietta Gerarda Gravina , Raffaele Pellegrino , Giovanna Palladino, Giuseppe Imperio, Andrea Ventura, Marina Cipullo, Annachiara Coppola, Alessandro Federico
{"title":"Profiling the patient with inflammatory bowel disease in the relationship between physical activity and partner/social network status: A post hoc patient-tailored analysis of the “BE-FIT-IBD” study","authors":"Antonietta Gerarda Gravina , Raffaele Pellegrino , Giovanna Palladino, Giuseppe Imperio, Andrea Ventura, Marina Cipullo, Annachiara Coppola, Alessandro Federico","doi":"10.1016/j.gastrohep.2024.502203","DOIUrl":"10.1016/j.gastrohep.2024.502203","url":null,"abstract":"<div><h3>Introduction</h3><div>Normal quality of life is an ultimate target in the therapeutic approach to inflammatory bowel diseases (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC) in the context of which regular physical activity (PA) is often a chimeric parameter that is not standardized in terms of quality/quantity. The study aimed to profile a sample of IBD patients about the relationship between PA-partner status and social network support.</div></div><div><h3>Patients and methods</h3><div>A <em>post hoc</em> analysis of the “BE-FIT-IBD” study was set up by stratifying the data of PA with that of partner status and the support that the patient's social network (i.e., relatives, friends) provided in inciting the patient to practice regular PA.</div></div><div><h3>Results</h3><div><span>In the 219 patients included, there was a greater tendency for patients with stable partners to view the risk of reactivation/worsening of IBD as a barrier to conducting regular PA (</span><em>p</em> <!--><<!--> <!-->0.0001). Single patients considered PA more as a protective factor (<em>p</em> <!-->=<!--> <!-->0.045). Patients without a PA-supporting social network retained IBD-related treatment as a PA barrier (<em>p</em> <!-->=<!--> <span>0.016) and PA as a risk for IBD complications (</span><em>p</em> <!-->=<!--> <span>0.01), with less confidence that PA could improve the course of IBD (</span><em>p</em> <!--><<!--> <!-->0.001). Rectal syndrome was an IBD-related barrier more represented in patients with PA-deterring social network (<em>p</em> <!--><<!--> <!-->0.0001).</div></div><div><h3>Conclusions</h3><div>These factors are potential targets for recovering the IBD patient's adherence to regular PA.</div></div>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"48 2","pages":"Article 502203"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140897841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sergio Rodríguez-Tajes , Adriana Palom , Álvaro Giráldez-Gallego , Antonio Moreno , Juan José Urquijo , Manuel Rodríguez , Marta Alvarez-Argüelles , Moisés Diago , María García-Eliz , Javier Fuentes , Ana María Martínez-Sapiña , Pilar Castillo , Marta Casado , Elena Pérez-Campos , Raquel Muñoz , Marta Hernández-Conde , Rosa María Morillas , Rafael Granados , Mireia Miquel , María Julia Morillas , Sabela Lens
{"title":"Characterizing Hepatitis Delta in Spain and the gaps in its management","authors":"Sergio Rodríguez-Tajes , Adriana Palom , Álvaro Giráldez-Gallego , Antonio Moreno , Juan José Urquijo , Manuel Rodríguez , Marta Alvarez-Argüelles , Moisés Diago , María García-Eliz , Javier Fuentes , Ana María Martínez-Sapiña , Pilar Castillo , Marta Casado , Elena Pérez-Campos , Raquel Muñoz , Marta Hernández-Conde , Rosa María Morillas , Rafael Granados , Mireia Miquel , María Julia Morillas , Sabela Lens","doi":"10.1016/j.gastrohep.2024.502222","DOIUrl":"10.1016/j.gastrohep.2024.502222","url":null,"abstract":"<div><h3>Background and aims</h3><div>Chronic hepatitis D (CHD) is a severe form of chronic viral hepatitis. The estimated hepatitis delta prevalence in Spain is around 5% of patients with hepatitis B. Reimbursement of new antiviral therapies (Bulevirtide, BLV) was delayed in our country until February 2024. We aimed to characterize the clinical profile of patients with HDV/HBV infection in Spain and current barriers in their management at the time of BLV approval.</div></div><div><h3>Method</h3><div>Multicenter registry including patients with positive anti-HDV serology actively monitored in 30 Spanish centers. Epidemiological, clinical and virological variables were recorded at the start of follow-up and at the last visit.</div></div><div><h3>Results</h3><div>We identified 329 anti-HDV patients, 41% were female with median age 51 years. The most common geographical origin was Spain (53%) and East Europe (24%). Patients from Spain were older and had HCV and HIV coinfection probably associated to past drug injection (<em>p</em> <!--><<!--> <!-->0.01). HDV-RNA was positive in 138 of 221 assessed (62%). Liver cirrhosis was present at diagnosis in 33% and it was more frequent among viremic patients (58% vs 25%, <em>p</em> <!--><<!--> <!-->0.01). After a median follow-up of 6 (3–12) years, 44 (16%) resolved infection (18 spontaneously and 26 after Peg-INF). An additional 10% of patients developed cirrhosis (<em>n</em> <!-->=<!--> <span>137) during follow-up (45% had portal hypertension and 14% liver decompensation). Liver disease progression was associated to persisting viremia.</span></div></div><div><h3>Conclusion</h3><div>One-third of the patients with CHD already have cirrhosis at diagnosis. Persistence of positive viremia is associated to rapid liver disease progression. Importantly, barriers to locally determine/quantify HDV-RNA were present.</div></div>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"48 2","pages":"Article 502222"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francisco Vara-Luiz , Helena Pires , Ivo Mendes , Carolina Palma , Eduardo Fernandes , Ana Elisa Teles , Francisco Martins do Vale , Marta Patita , Jorge Fonseca , Pedro Pinto-Marques
{"title":"Leishmania colitis: An uncommon cause of gastrointestinal bleeding in an immunosuppressed patient","authors":"Francisco Vara-Luiz , Helena Pires , Ivo Mendes , Carolina Palma , Eduardo Fernandes , Ana Elisa Teles , Francisco Martins do Vale , Marta Patita , Jorge Fonseca , Pedro Pinto-Marques","doi":"10.1016/j.gastrohep.2024.502254","DOIUrl":"10.1016/j.gastrohep.2024.502254","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"48 2","pages":"Article 502254"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142284424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comunicaciones orales. Sesión General 2","authors":"","doi":"10.1016/S0210-5705(25)00108-6","DOIUrl":"10.1016/S0210-5705(25)00108-6","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"48 ","pages":"Pages S6-S11"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos Alventosa Mateu , Robert Giner Alventosa , María Lorena Tobar Peñaherrera
{"title":"Aspectos legales relativos al uso de inteligencia artificial en ciencias de la salud","authors":"Carlos Alventosa Mateu , Robert Giner Alventosa , María Lorena Tobar Peñaherrera","doi":"10.1016/j.gastrohep.2024.502227","DOIUrl":"10.1016/j.gastrohep.2024.502227","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"48 2","pages":"Article 502227"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comunicaciones orales. Sesión General 6","authors":"","doi":"10.1016/S0210-5705(25)00112-8","DOIUrl":"10.1016/S0210-5705(25)00112-8","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"48 ","pages":"Pages S29-S33"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}