Graefe’s Archive for Clinical and Experimental Ophthalmology最新文献

{"title":"Optimizing instilled drug delivery: a scoping review of microdrops in ophthalmology.","authors":"Aikaterini K Seliniotaki, Tatiana Tziola, Maria Lithoxopoulou, Argyrios Tzamalis, Nikolaos Ziakas, Asimina Mataftsi","doi":"10.1007/s00417-025-06773-1","DOIUrl":"10.1007/s00417-025-06773-1","url":null,"abstract":"<p><p>Eyedrop instillation constitutes the most commonly used ocular drug delivery method that serves for both diagnostic and therapeutic purposes. Ocular disposition and bioavailability of instilled drugs depend on the anatomy and physiology of the ocular surface as well as the physicochemical properties of the active agent. Intraocular bioavailability is positively associated with the amount of drug available onto the ocular surface and the precorneal residence time. Concerns are raised regarding systemic absorption of the instilled drugs intraocularly, percutaneously, via the conjunctiva, through the nasolacrimal system, or through the nasal, oral, and gastrointestinal mucosa. Special considerations exist regarding the anatomical features and the limited pharmacokinetic data on the pediatric population that complicate further the efficacy and systemic toxicity of the instilled medications. Both preclinical and clinical studies propose the reduction of the instilled drop volume, in the form of microdrops, as a means to enhance intraocular bioavailability of topically applied drugs, while minimizing patient discomfort and systemic adverse events. We summarize existing data on the clinical application of microdrops in a wide age range, from preterm infants to elderly adults. Studies regarding microdrops of mydriatics and ocular hypotensives show promising results in optimizing the provided everyday care.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"1765-1787"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12373704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement in vision-related quality-of-life using the NEI-VFQ-9 over 1-year in the Manhattan Vision Screening and Follow-up Study (NYC-SIGHT).","authors":"Lisa A Hark, Prakash Gorroochurn, Haotian Tang, Desiree R Torres, Brendan Blackburn, Stefania C Maruri, Daniel F Diamond, Noga Harizman, Qing Wang, Yujia Wang, Jeffrey M Liebmann, George A Cioffi, Jason D Horowitz, Lisa Park","doi":"10.1007/s00417-024-06727-z","DOIUrl":"10.1007/s00417-024-06727-z","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the nine-item National Eye Institute Vision Function Questionnaire (NEI-VFQ-9) scores at baseline and 12 months in participants enrolled in the Manhattan Vision Screening and Follow-up Study (NYC-SIGHT) and determine factors associated with improvements in vision-related quality-of-life (VRQOL).</p><p><strong>Methods: </strong>Retrospective review of NEI-VFQ-9 scores at baseline and 12-month follow-up in a community-based eye health screening study conducted in Upper Manhattan, New York. Participants were age ≥ 40 years and older, living independently in public/affordable housing developments and able to provide informed consent. Paired t-tests compared baseline and 12-month NEI-VFQ-9 composite and sub-scores and a multivariable linear regression model identified significant predictors of improvement in quality-of-life at the 95% confidence interval (CI).</p><p><strong>Results: </strong>A total of 515 participants completed both the NEI-VFQ-9 at baseline and 12-months. Significant increases in the composite NEI-VFQ-9 score were seen with general vision, near vision tasks, and role limitation (P < 0.001). Multivariable linear regression showed that being unemployed was associated with a statistically significant increase in NEI-VFQ-9 composite score (β = 5.6, 95% CI: 0.5,10.7, P = 0.033), and the absence of ocular conditions was negatively associated with improvement in the composite score over 12 months (β = -5.4, 95% CI: -10.3, -0.5, P = 0.031).</p><p><strong>Conclusions: </strong>These results can help researchers, clinicians, and eye health professionals better understand the factors associated with VRQOL outcomes in underserved populations utilizing the NEI-VFQ-9. Community-based vision research clinical trials can easily incorporate the NEI-VFQ-9 into baseline and follow-up instruments to assess VRQOL for future comparisons.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"2069-2079"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premacular membranes and glaucoma: a review of clinical and therapeutic considerations.","authors":"Nikolaos Dervenis, Teresa Sandinha, Ivan Sychev, David H Steel","doi":"10.1007/s00417-025-06796-8","DOIUrl":"10.1007/s00417-025-06796-8","url":null,"abstract":"<p><strong>Purpose: </strong>Primary epiretinal, or more precisely termed pre macular membranes (PMM) and glaucomatous optic neuropathy are both common conditions affecting a predominantly elderly population. There are several relevant clinical and pathological considerations when they are both diagnosed in the same eye.</p><p><strong>Methods: </strong>We systematically searched the literature to review the challenges clinicians must address when dealing with patients with co-existing PMM and glaucoma.</p><p><strong>Results: </strong>Although the current literature is limited there appears to be a link between the occurrence of glaucomatous optic neuropathy and idiopathic PMM. The presence of PMM can confound glaucomatous progression detection on optical coherence tomography (OCT). Vitrectomy and membrane peeling may improve vision in some patients with co-existing disease but there may be an increased risk of glaucoma progression particularly in eyes with advanced glaucoma and more extensive neuronal loss. Peeling of the retinal inner limiting membrane in addition to PMM peeling may result in an increased risk of visual loss. Inner nuclear layer hypo-reflective spaces on OCT are particularly prevalent in eyes with glaucoma and PMM and may be a negative prognostic sign for outcome.</p><p><strong>Conclusion: </strong>Patients should be counseled regarding the guarded prognosis, and careful consideration given to the benefits of PMM surgery. Further research is needed to guide clinical practice.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"1801-1812"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravitreal Dexamethasone Implant in Vitreoretinal Surgery: An Overview of the Literature.","authors":"Giacomo Boscia, Alessandro Feo, Alfonso Savastano, Pasquale Viggiano, Luca Landini, Arcangelo Clemente, Giacomo Scotti, Maria Oliva Grassi, Guglielmo Parisi, Ermete Giancipoli, Giovanni Alessio, Francesco Boscia, Rodolfo Mastropasqua, Michele Reibaldi, Mario R Romano, Enrico Borrelli","doi":"10.1007/s00417-025-06797-7","DOIUrl":"10.1007/s00417-025-06797-7","url":null,"abstract":"<p><strong>Background: </strong>The sustained-release intravitreal 0.7 mg dexamethasone implant (DEX implant) (Ozurdex®, Allergan®, an AbbVie Company, North Chicago, Illinois, USA) is widely used to treat various inflammatory retinal disorders. Notably, its application is expanding in the field of vitreoretinal surgery.</p><p><strong>Methods: </strong>We conducted a comprehensive literature search across the Web of Science, PubMed, EMBASE, and ScienceDirect databases for articles related to Ozurdex and its applications in vitreoretinal disorders. Additionally, relevant studies were identified from the reference lists of retrieved articles. Our search was limited to studies written in English or those in other languages that provided an English abstract with sufficient information.</p><p><strong>Results: </strong>Multiple studies have demonstrated the efficacy and safety of the DEX implant across a broad spectrum of vitreoretinal and post-surgical conditions. Notably, the implant's unique pharmacokinetics remain largely unaffected by the vitrectomized status of the eye, ensuring consistent effectiveness in vitreoretinal surgery. Our research highlights the primary off-label applications of the DEX implant, which include epiretinal membrane (ERM), rhegmatogenous retinal detachment (RRD), post-surgical cystoid macular edema (PSCME), and refractory diabetic macular edema (DME).</p><p><strong>Conclusion: </strong>This review highlights the increasing role of the DEX implant in vitreoretinal surgery, emphasizing its effectiveness and safety in various surgical and post-surgical settings, while also addressing associated complications.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"1813-1823"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term visual function and refractive changes after vitrectomy for stage 4 retinopathy of prematurity.","authors":"Kuniko Tachibana, Chiharu Iwahashi, Kazuki Kuniyoshi, Shunji Kusaka","doi":"10.1007/s00417-025-06801-0","DOIUrl":"10.1007/s00417-025-06801-0","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate longitudinal changes in best-corrected visual acuity (BCVA) and refraction in patients following vitrectomy for stage 4 retinopathy of prematurity (ROP).</p><p><strong>Methods: </strong>We conducted a retrospective review of 42 eyes from 25 patients (35 eyes with stage 4A, 7 eyes with stage 4B) who had successful vitrectomy for stage 4 ROP and were followed for at least 8 years. Postoperative BCVAs and refractive errors between ages 5 and 8 years were compared. Factors related to BCVA at ages 5 and 8, as well as their differences, were analyzed.</p><p><strong>Results: </strong>In stage 4A ROP eyes, the mean logMAR BCVA improved significantly from 0.83 (20/135) to 0.63 (20/85) (p < 0.001) and a myopic shift of 1 D or more occurred in 21 eyes (61.8%) between ages 5 and 8. In the poor BCVA group at age 5 in the stage 4A eyes, dominant eyes showed a trend of BCVA improvement by ages 5-8 (p = 0.06). Multiple regression analysis of the patients with stage 4A ROP showed that phakic and dominant eyes at age 5 were independently associated with better BCVA at ages 5 and 8 (p = 0.006 and 0.016 for age 5; p = 0.009 and 0.002 for age 8). No significant BCVA improvement was noted in stage 4B ROP eyes during the same period.</p><p><strong>Conclusion: </strong>This study indicated the possibility of continued visual improvement beyond age 5 in patients who underwent vitrectomy for stage 4A ROP, although a myopic shift occurred concurrently.</p><p><strong>Key messages: </strong>What is known Previous studies have reported long-term visual prognosis and refractive errors at specific time points after vitrectomy for ROP in small case series, but there has been limited research on serial changes. What is new This study demonstrates the potential for ongoing visual improvement beyond age 5 and highlights longitudinal myopic changes between ages 5 and 8 in patients who underwent vitrectomy for stage 4A ROP. In patients with poor visual acuity at age 5, being the dominant eye was significantly associated with improved visual acuity by age 8. The findings indicate that postoperative visual acuity in ROP patients gradually improves, even as myopia progresses, underscoring the need for long-term follow-up.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"2041-2048"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12373698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study of deep learning for automatic contouring of sulcus-to-sulcus diameter in ultrasound biomicroscopy.","authors":"Xiaohong Zheng, Xiaokang Li, Ke Hu, Jingji Long, Xingtao Zhou, Yuanyuan Wang, Yi Guo, Ke Zheng","doi":"10.1007/s00417-025-06764-2","DOIUrl":"10.1007/s00417-025-06764-2","url":null,"abstract":"<p><strong>Purpose: </strong>To construct a deep learning (DL) algorithm for automatic prediction of sulcus-to-sulcus diameter (STS) and distance between STS plane and anterior crystalline lens surface (STSL) from ultrasound biomicroscopy (UBM) images based on YOLOv8 and verify its accuracy and reliability.</p><p><strong>Methods: </strong>This study used data from 100 eyes of 100 myopic patients treated with ICL from March 2023 to August 2024. UBM was used for the measurements of the STS and STSL (4 images for each eye). The data set (400 images) was randomly split at the patient level into a train, validation and test sets at the ratio of 8:1:1. The ciliary sulci on both sides and the anterior capsule of the lens in the UBM images were located with the YOLOv8 algorithm, and then the distances were calculated and compared with the manual labeled values and compared against an external expert with ANOVA, the YOLOv8 algorithm was tested in 26 eyes (104 images ) independent UBM data sets. Bland-Altman tests and intergroup correlation coefficients (ICCs) were used to assess the agreement between the labeled and YOLOv8 predicted values.</p><p><strong>Results: </strong>The deep learning-predicted STS and STSL demonstrated a high level of accuracy and reduced contouring time (by savings of 98.80% of work time) when compared with manual labeling contours in the testing set and showed a good accuracy when compared with external ophthalmologist manual labeling contours and in the external evaluation. The prediction error of the STS being 3.27 ± 2.01% and STSL being 67.95 ± 140.09% for the YOLOv8 algorithm at testing set, 4.10 ± 3.00 (%), and 49.66 ± 42.73 (%) in the external test set. The ICC was 0.312 between the predicted and labeled STS (P = 0.01) and 0.086 between the predicted and labeled STSL (P > 0.05).</p><p><strong>Conclusions: </strong>The deep learning-predicted STS and STSL demonstrated high accuracy and reduced measurement time, which could have a positive impact on the clinical setting.</p><p><strong>Key messages: </strong>What is known: ICL implantation remains challenging because of difficulties in determining the appropriate lens size. There is a wide variation in the values of ciliary sulcus-to-sulcus (STS) diameter measurements.</p><p><strong>What is new: </strong>This is the first study to automatically measure the STS-related distance based on YOLOv8 and assess the accuracy compared to the conventional manual labeling. The YOLOv8 algorithm proposed advantages in high accuracy, automatic prediction of posterior chamber STS-related parameters from ultrasound biomicroscope images.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"2049-2058"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of localized corneal collagen crosslinking with a conventional device in progressive keratoconus.","authors":"Ofri Vorobichik Berar, Rachel Shemesh, Nir Gomel, Yoav Berger, Irina S Barequet","doi":"10.1007/s00417-025-06803-y","DOIUrl":"10.1007/s00417-025-06803-y","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the outcomes of localized crosslinking (L-CXL) for progressive keratoconus utilizing a standard CXL device.</p><p><strong>Design: </strong>This retrospective cohort study.</p><p><strong>Methods: </strong>included patients diagnosed with progressive keratoconus and treated with a localized cone-centered CXL (based on corneal topography) using the accelerated CXL protocol with a standard CXL device.</p><p><strong>Results: </strong>We Identified 24consecutive eyes. The average BDVA before CXL was 0.282 ± 0.35 LogMar, remained overall stable at 12-month post-surgery at 0.204 ± 0.173 LogMar (P = 0.395). Ten eyes (of eight patients) (42%) demonstrated an improvement in BDVA at 12 months of 1-4 lines and none of the other eyes lost BDVA. These eyes had significantly lower pre-operative BDVA than the stable eyes (P = 0.034). Ten eyes (of eight patients) (42%) demonstrated an improvement in K-max at 12 months post-operatively, of at least 1D; six of these eyes had improvement in both BDVA and Kmax. None of the eyes developed an increase in Kmax throughout the follow-up.</p><p><strong>Conclusion: </strong>In this series, cone-centered L-CXL, using a conventional CXL device resulted in significant stabilization and even improvements in BDVA and Kmax in almost half of the eyes, without significant adverse events. Addressing the CXL application onto the affected area results in beneficial results.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"1949-1956"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12373528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term visual outcomes of patients with neovascular age-related macular degeneration treated with anti-VEGF therapy lost to follow-up.","authors":"Ki Tae Nam, Cheolmin Yun","doi":"10.1007/s00417-025-06798-6","DOIUrl":"10.1007/s00417-025-06798-6","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the long-term visual outcomes of patients with neovascular age-related macular degeneration (AMD) who were lost to follow-up (LTFU) during treatment compared with those with continuous follow-up (CFU).</p><p><strong>Methods: </strong>A retrospective study was conducted on patients diagnosed with neovascular AMD who received anti-VEGF therapy from 2010 to 2022. The patients were classified into the long-term LTFU group (LTFU for more than 6 months), the short-term LTFU group (LTFU for 2 months to less than 6 months), and the CFU group. We conducted a comparative analysis of baseline characteristics, factors related to visual prognosis, and differences in the occurrence of severe vision loss.</p><p><strong>Results: </strong>A total of 169 patients were classified into 43 in the long-term LTFU group, 57 in the short-term LTFU group, and 69 in the CFU group. The mean follow-up duration was 57.12 ± 31.68 months. There was no significant difference in baseline visual acuity (logMAR) among the long-term LTFU, short-term LTFU, and CFU groups (0.76 ± 0.54, 0.68 ± 0.51, and 0.72 ± 0.54, respectively; P = 0.734). The final visual acuity was significantly lower in the long-term LTFU group (1.12 ± 0.79) compared with the short-term LTFU group (0.65 ± 0.62) and the CFU group (0.65 ± 0.56) (P < 0.001), and the change in visual acuity was significantly greater in the long-term LTFU group (0.36 ± 0.69) compared with the short-term LTFU group (-0.03 ± 0.64) and the CFU group (-0.07 ± 0.58) (P = 0.001). Long-term LTFU was significantly associated with changes in visual acuity from the baseline to the final visit (P = 0.002) and severe vision loss (P = 0.002).</p><p><strong>Conclusion: </strong>In patients with neovascular AMD, those LTFU for more than six months during treatment had worse long-term visual outcomes compared to those with regular follow-up or shorter LTFU durations.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"1837-1845"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of angle opening after lens extraction in patients with shallow peripheral anterior chamber.","authors":"Yue Fu, Yufeng Chen, Xiuqin Li, Lingzi Huang, Lufan Li, Nan Zhang, Yixin Hu, Wen Zeng, Min Ke","doi":"10.1007/s00417-025-06784-y","DOIUrl":"10.1007/s00417-025-06784-y","url":null,"abstract":"<p><strong>Purpose: </strong>To predict the degree of angle opening after lens extraction (LE) in patients with shallow peripheral anterior chamber.</p><p><strong>Methods: </strong>We collected the ultrasound biomicroscopy (UBM) parameters before and one month after LE retrospectively. The binary logistic regression and artificial neural network (ANN) models of angle opening after LE were established using preoperative UBM parameters, and the predictive factors were screened. The performances of models were evaluated using the area under the receiver operator characteristic curve (AUROC).</p><p><strong>Results: </strong>Patients from the Zhongnan Hospital of Wuhan University were randomized into a training set (n = 91) or a test set (n = 39) for internal validation. External validation employed the entire Zhongnan Hospital cohort as the training set (n = 130) and Dawu County People's Hospital cohort as the test set (n = 30). Both internal and external validation using both models showed that iris curvature (IC), iris-ciliary process angle (ICPA), trabecular-iris angle (TIA), and gender were significantly predictive of the degree of angle opening after LE (p < 0.05). Both models achieved an AUROC of 0.993 (0.997-1.0) in the internal validation training set, and an AUROC of 0.929 (0.774-1.0) in the internal validation test set. In the external validation training set, both models achieved an AUROC of 0.995 (0.984-1.0), while in the external validation test, both models had an AUROC of 0.938 (0.800-1.0).</p><p><strong>Conclusion: </strong>In patients with shallow peripheral anterior chamber, a smaller preoperative TIA, ICPA and IC predicts unsatisfactory angle opening after LE. Female can also be a risk factor for the narrow angle after LE.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"1957-1965"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo assessment of regional scleral stiffness by shear wave elastography and its association with choroid and retinal nerve fiber layer characteristics in high myopia.","authors":"Ying Yuan, Fang Li, Weijung Ten, Chengcheng Jin, Yue Wu, Yuying Liu, Bilian Ke","doi":"10.1007/s00417-024-06679-4","DOIUrl":"10.1007/s00417-024-06679-4","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the posterior scleral stiffness of different regions in high myopic eyes and to explore its associations with macular choroidal and peripapillary retinal nerve fiber layer (pRNFL) thickness and vasculature.</p><p><strong>Methods: </strong>Thirty subjects with high myopic eyes and 30 subjects with low myopic eyes were included in this study. The elastic modulus of the macular and peripapillary sclera at the temporal, nasal, superior and inferior regions were determined via shear wave elastography (SWE). Optical coherence tomography and angiography (OCT/OCTA) centered on the fovea and optic disc was obtained by using a commercially available swept-source OCT/OCTA device. Built-in automated software was used to quantify macular subfovea choroidal vessel volume (SFCVV), macular subfovea choroidal thickness (SFCT) and pRNFL thickness.</p><p><strong>Results: </strong>The SWE results demonstrated that high myopic eyes had significantly lower macular and peripapillary scleral elastic modulus than low myopic eyes (P < 0.001). The reduction in the elastic modulus was slightly greater in the temporal peripapillary region, followed by the superior peripapillary, inferior and nasal peripapillary regions (P > 0.05). The linear regression analysis demonstrated a significant association between the posterior scleral elastic modulus and SFCT and inferior pRNFL thickness (P < 0.001).</p><p><strong>Conclusion: </strong>High myopic eyes had weakened posterior scleral stiffness. The regional change in the elastic modulus was associated with the SFCT and inferior quadrant pRNFL thickness. This novel in vivo quantitative assessment of scleral stiffness via SWE may help to characterize the underlying pathologic mechanism of scleral biomechanics on choroid and pRNFL changes in high myopia.</p><p><strong>Key messages: </strong>WHAT IS KNOWN : Previous studies reported significant choroid thickness and peripapillary nerve fiber layer thickness decrease in high myopia The scleral stiffness is weakened in myopic eyes WHAT IS NEW : Shear wave elastography (SWE) is a novel tool to detect posterior scleral biomechanics in myopic eyes in vivo Stiffness of the posterior sclera at macular and peripapillary regions is lower in high myopic than in low myopic eyes The posterior scleral stiffness is correlated with subfovea choroidal thickness and inferior quadrant peripapillary nerve fiber layer thickness.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"2059-2067"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}