Graefe’s Archive for Clinical and Experimental Ophthalmology最新文献_第6页

Diagnostic performance of corneal epithelium- and Bowman's layer thickness mapping in patients with unilateral Keratoconus.

IF 2.4 3区医学

Graefe’s Archive for Clinical and Experimental Ophthalmology Pub Date : 2025-01-30 DOI: 10.1007/s00417-025-06750-8

Niklas Pircher, Raphael Kilian, Florian Beer, Ruth Donner, Philipp Roberts, Michael Pircher, Christoph K Hitzenberger, Julia Aschauer, Gerald Schmidinger, Jan Lammer

{"title":"Diagnostic performance of corneal epithelium- and Bowman's layer thickness mapping in patients with unilateral Keratoconus.","authors":"Niklas Pircher, Raphael Kilian, Florian Beer, Ruth Donner, Philipp Roberts, Michael Pircher, Christoph K Hitzenberger, Julia Aschauer, Gerald Schmidinger, Jan Lammer","doi":"10.1007/s00417-025-06750-8","DOIUrl":"https://doi.org/10.1007/s00417-025-06750-8","url":null,"abstract":"Purpose: To investigate the role of corneal epithelium- and Bowman's layer-thickness (ET and BLT) changes as possible early biomarkers of keratoconus (KC) development.Methods: In this cross-sectional study patients with unilateral KC (UKC) and a group of healthy controls underwent polarization sensitive optical coherence tomography (PS-OCT) for the evaluation of corneal ET and BLT. These values were compared among three subgroups of eyes, i.e., eyes with KC, topographically and tomographically normal fellow eyes (FE) of patients with UKC, and healthy eyes (HE).Results: Twelve patients with UKC (12 eyes with KC and 12 FE) and 21 healthy age-matched controls (HE) were included. While KC eyes showed the typical epithelial \"doughnut pattern\" on epithelial maps, there were no differences in ET between FE and HE. BLT was significantly higher in FE compared to HE (average BLT p = 0.049, minimum BLT p = 0.02, nasal-inferior quadrant p = 0.04) as weIl as KC eyes (average BLT p = 0.048, minBLT p = 0.04, nasal-inferior quadrant p = 0.03).Conclusions: Increase in BLT seems to occur before epithelial thinning in FE of patients with UKC. Since many of KC patients develop the disease bilaterally, Bowman's layer thickening might represent an early biomarker of KC-development.","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FoxO1 promotes high glucose-induced inflammation and cataract formation via JAK1/STAT1.

IF 2.4 3区医学

Graefe’s Archive for Clinical and Experimental Ophthalmology Pub Date : 2025-01-29 DOI: 10.1007/s00417-025-06744-6

Yike Li, An-Peng Pan, Yishan Ye, Xu Shao, Ruixue Tu, Yang Liu, A-Yong Yu

{"title":"FoxO1 promotes high glucose-induced inflammation and cataract formation via JAK1/STAT1.","authors":"Yike Li, An-Peng Pan, Yishan Ye, Xu Shao, Ruixue Tu, Yang Liu, A-Yong Yu","doi":"10.1007/s00417-025-06744-6","DOIUrl":"https://doi.org/10.1007/s00417-025-06744-6","url":null,"abstract":"Purpose: To investigate whether in diabetic cataract (DC), FoxO1 regulates high glucose (HG)-induced activation of NLRC4/IL-6 inflammatory mediators in human lens epithelial cells (SRA01/04) via the JAK1/STAT1 pathway, leading to cataract formation.Methods: Expression levels of FoxO1, inflammatory factor IL-6 and inflammatory vesicle NLRC4 were examined in SRA01/04 under high glucose (HG) stress at 25-150 mM. Rat lenses were also cultured using HG medium with or without the addition of the FoxO1 inhibitor AS1842856 and the JAK1 agonist RO8191. 5.5 mM glucose concentration group (NG) was used as a control. Real-time PCR, Western blots, and immunofluorescent staining evaluated the mRNA and protein levels of FoxO1, NLRC4, and IL-6. Apoptosis, cell viability, and EDU Staining were also assessed.Results: HG stimulation induced elevated FoxO1 expression and caused NLRC4/IL-6 activation in a concentration-dependent manner. Whereas knockdown of FoxO1 inhibited the high expression of NLRC4/IL-6 inflammatory mediators in response to HG stimulation. The growth of SRA01/04 was inhibited under HG condition, and the cell proliferation ability was restored and even promoted by knocking out FoxO1. HG incubation of rat lens resulted in lens clouding and cataract formation, which was prevented by AS1842856 treatment and reversed by RO8191.Conclusion: FoxO1 positively regulates HG-induced SRA01/04 inflammatory activation through the JAK1/STAT1 pathway and promotes DC. This provides a feasible strategy for the treatment of diabetic cataract.","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crystalline lens power and astigmatism calculation in myopia by swept-source optical coherence tomography: A pilot study.

IF 2.4 3区医学

Graefe’s Archive for Clinical and Experimental Ophthalmology Pub Date : 2025-01-29 DOI: 10.1007/s00417-025-06746-4

Shulin Wang, Dan Cheng, Xueying Zhu, Fangjun Bao, Jun Zhu, Chenjiu Pang, Yufeng Ye

{"title":"Crystalline lens power and astigmatism calculation in myopia by swept-source optical coherence tomography: A pilot study.","authors":"Shulin Wang, Dan Cheng, Xueying Zhu, Fangjun Bao, Jun Zhu, Chenjiu Pang, Yufeng Ye","doi":"10.1007/s00417-025-06746-4","DOIUrl":"https://doi.org/10.1007/s00417-025-06746-4","url":null,"abstract":"Purpose: To calculate the crystalline lens power and astigmatism, as well as their changes following cycloplegia, in individuals with myopia using swept-source optical coherence tomography (SS-OCT).Methods: Participants were divided into two groups according to axial length (AL). Crystalline lens parameters, including power, lens thickness (LT), anterior chamber depth (ACD), and astigmatism, were measured with SS-OCT and analysed before and after cycloplegia. The lensmaker's equation was used to calculate lens power, and differences between three consecutive measurements < 22.5 degrees was set as the screening criterion for meridian direction measurement repeatability.Results: Sixty-three eyes met the screening criterion on the anterior surface both before and after cycloplegia was included. The majority of eyes exhibited lens astigmatism ranging from + 0.76 D to + 1.50 D on both anterior and posterior surfaces. Before cycloplegia, 61 eyes (96.8%) had with-the-rule (WTR) astigmatism on the anterior surface. Meanwhile, 25 eyes met the criterion on posterior surface, of which 21 eyes (84.0%) had against-the-rule (ATR) astigmatism. After cycloplegia, 60 eyes (95.2%) had WTR astigmatism on the anterior surface. Meanwhile, 23 eyes met the criterion on posterior surface, of which 19 eyes (82.6%) had ATR astigmatism. After cycloplegia, there were significant changes in the lens power, astigmatism, thickness, and ACD.Conclusions: Astigmatism of crystalline lens on the anterior and posterior surfaces was mainly WTR and ATR, respectively, with similar refractive power. After cycloplegia, changes in parameters and refractive power of the lens mainly occur on the anterior surface.","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishing an objective quantitative method for assessing the severity of plus disease in retinopathy of prematurity.

IF 2.4 3区医学

Graefe’s Archive for Clinical and Experimental Ophthalmology Pub Date : 2025-01-27 DOI: 10.1007/s00417-025-06743-7

Puja Maitra, Eugene Yu-Chuan Kang, Wei-Chi Wu

{"title":"Establishing an objective quantitative method for assessing the severity of plus disease in retinopathy of prematurity.","authors":"Puja Maitra, Eugene Yu-Chuan Kang, Wei-Chi Wu","doi":"10.1007/s00417-025-06743-7","DOIUrl":"https://doi.org/10.1007/s00417-025-06743-7","url":null,"abstract":"Background: To establish an objective method for assessing plus disease severity in retinopathy of prematurity.Methods: Six images of plus diseases that were color-coded according to severity and published in the International Classification of Retinopathy of Prematurity, Third Edition (ICROP3) were analyzed. These images were individually processed, and the best-fit curve and vessel course in zone I were obtained using ImageJ software. Tortuosity indices (TIs) of the major vessels in the temporal quadrants were calculated. Data from real-world patients with no plus, pre-plus, and plus diseases were analyzed and compared with those of the ICROP.Results: The TIs of the arteries and veins, the sum of these TIs, and the artery/vein (A/V) TI ratios increased incrementally from grades 1 to 6. The trend revealed that the arterial tortuosity increased more than the venous tortuosity. The degree of venous tortuosity was similar from grades 3-5 but higher in grade 6. The A/V TI ratio increased in grades 1-3, stabilized in grades 3-5, and peaked in grade 6. Analysis of data from real-world patients showed increased TI of both arteries and veins, similar to the ICROP3. However, the A/V TI ratio did not show an increasing trend.Conclusion: Objective methods for assessing disease severity can provide insights into the potential pathophysiological mechanisms of plus disease progression. Arterial tortuosity is more prominent than venous tortuosity. Venous features become more prominent as plus disease progresses, which may obscure the progression of arterial tortuosity.","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biofeedback rehabilitation in patients with binocular inhibition due to macular disease.

IF 2.4 3区医学

Graefe’s Archive for Clinical and Experimental Ophthalmology Pub Date : 2025-01-25 DOI: 10.1007/s00417-025-06749-1

Valeria Silvestri, Paola Piscopo, Simona Turco, Filippo Amore, Stanislao Rizzo, Mark S Mandelcorn, Luminita Tarita-Nistor

{"title":"Biofeedback rehabilitation in patients with binocular inhibition due to macular disease.","authors":"Valeria Silvestri, Paola Piscopo, Simona Turco, Filippo Amore, Stanislao Rizzo, Mark S Mandelcorn, Luminita Tarita-Nistor","doi":"10.1007/s00417-025-06749-1","DOIUrl":"https://doi.org/10.1007/s00417-025-06749-1","url":null,"abstract":"Background: To investigate whether patients with binocular reading inhibition due to central vision loss benefit from a new biofeedback (BF) rehabilitation method that aimed at improving fixation stability and at establishing a correspondence between the monocular preferred retinal loci (PRLs) on functioning retina in both eyes.Methods: Thirty-three patients with bilateral macular disease and with binocular reading inhibition participated in 10 training sessions consisting of 10-min visual stimulation for each eye to stabilize fixation and relocate the PRL (if needed) using the BF module of the MP-1 microperimeter (Nidek Technologies Srl., Vigonza, PD, Italy). Binocular and monocular reading performance, contrast sensitivity, and visual acuity were evaluated pre and post training. Binocular summation/inhibition was evaluated with binocular ratio (BR).Results: Fixation stability improved significantly post training in both eyes. Maximum reading speed during binocular viewing increased from 57 ± 24wpm pre training to 67 ± 24wpm post training. BR increased for all parameters of reading, visual acuity, and contrast sensitivity. Training resulted in a complete reversal of binocular reading inhibition in 30% of patients.Conclusions: For patients with binocular inhibition due to central vision loss, BF training to stabilize fixation and to bring the monocular PRLs into correspondence on functioning retina in both eyes is an efficient rehabilitation method to improve binocular performance.","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intracellular dark endothelial spots detected using specular microscopy are associated with graft failure after Descemet's membrane endothelial keratoplasty.

IF 2.4 3区医学

Graefe’s Archive for Clinical and Experimental Ophthalmology Pub Date : 2025-01-25 DOI: 10.1007/s00417-025-06745-5

Ami Igarashi, Masato Takeda, Naoko Mashiko, Toshiki Shimizu, Kentaro Yuda, Yoshinori Oie, Naoki Okumura, Takefumi Yamaguchi, Satoru Yamagami, Takahiko Hayashi

{"title":"Intracellular dark endothelial spots detected using specular microscopy are associated with graft failure after Descemet's membrane endothelial keratoplasty.","authors":"Ami Igarashi, Masato Takeda, Naoko Mashiko, Toshiki Shimizu, Kentaro Yuda, Yoshinori Oie, Naoki Okumura, Takefumi Yamaguchi, Satoru Yamagami, Takahiko Hayashi","doi":"10.1007/s00417-025-06745-5","DOIUrl":"https://doi.org/10.1007/s00417-025-06745-5","url":null,"abstract":"Purpose: To investigate the correlation between intracellular dark endothelial spots (IDESs) detected by specular microscopy and the incidence of graft failure after Descemet's membrane endothelial keratoplasty (DMEK).Methods: We reviewed 100 consecutive DMEK patients performed by a single surgeon at two centres between January 2015 and July 2022. Central corneal thickness was evaluated using anterior segment optical coherence tomography (SS-1000; Tomey, Aichi, Japan), and endothelial cell density was measured using specular microscopy. Kaplan-Meier estimates and Cox regression models were used to evaluate graft failure and associated risk factors.Results: Of the 97 eyes included, 9 experienced graft failure within the follow-up period (52.9 ± 23.9 months). IDES presence significantly correlated with decreased endothelial cell density and higher graft failure rates (hazard ratio = 4.68, 95% confidence interval = [0.96, 22.7], P = 0.034).Conclusion: IDESs represent a significant risk factor for graft failure post-DMEK. Careful postoperative management is imperative to minimise this risk.","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of choroidal markers of activity in pachychoroid disease spectrum.

IF 2.4 3区医学

Graefe’s Archive for Clinical and Experimental Ophthalmology Pub Date : 2025-01-24 DOI: 10.1007/s00417-025-06740-w

Raphaela M Fuganti, Fernando Campiolo, Ahmad Mansour, Luiz H Lima, Mauricio Maia, Antonio Marcelo Casella

{"title":"Analysis of choroidal markers of activity in pachychoroid disease spectrum.","authors":"Raphaela M Fuganti, Fernando Campiolo, Ahmad Mansour, Luiz H Lima, Mauricio Maia, Antonio Marcelo Casella","doi":"10.1007/s00417-025-06740-w","DOIUrl":"https://doi.org/10.1007/s00417-025-06740-w","url":null,"abstract":"Purpose: To detect choroidal markers of disease activity in eyes with chronic active unilateral pachychoroid disease spectrum (PDS) compared to the non-active contralateral eyes, based on multimodal imaging and particularly indocyanine green angiography (ICGA).Methods: An observational retrospective case-control study. The study evaluated individuals diagnosed with chronic active unilateral PDS (group 1) by comparing the eyes with the non-active fellow eyes (group 2). Imaging was performed using fundus photographs, ICGA, and spectral-domain optical coherence tomography (SD-OCT). Choroidal thickness, choroidal vascular density, choroidal vasodilation, choroidal vascular leakage, and choroidal meridian breakdown were evaluated.Results: Of the 90 patients with chronic PDS with ICGA at our database, 27 Caucasians (mean age: 55.9 years) were identified with active unilateral PDS. Group 1 showed a higher prevalence of the following parameters compared to Group 2: choroidal meridian breakdown (81.5% vs. 25.9%; p < 0.001), choroidal vasodilation (88.9% vs. 48.1%; p < 0.001), greater subfoveal choroidal thickness (420 ± 79.8 μm vs. 346 ± 78.5 μm; p = 0.002), ICGA choroidal vascular leakage (96.3% vs. 29.6%; p < 0.001), and choroidal hyperpermeability (100% vs. 29.6%; p < 0.001), with a nonsignificant increase in choroidal vascular density (55.4%±13.4 vs. 49.3%±13.5 in the contralateral eye; p = 0.167).Conclusion: Choroidal meridian breakdown, thicker choroid, choroidal vasodilation, and ICGA choroidal vascular leakage are potential posterior choroidal markers of disease activity in PDS.","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cushing's syndrome related to higher rates and earlier onset of cataract: A nationwide retrospective cohort study.

IF 2.4 3区医学

Graefe’s Archive for Clinical and Experimental Ophthalmology Pub Date : 2025-01-23 DOI: 10.1007/s00417-025-06752-6

Yael Sharon, Tzipora Shochat, Yaron Rudman, Shiri Kushnir, Alon Zahavi, Ilan Shimon, Maria Fleseriu, Amit Akirov

{"title":"Cushing's syndrome related to higher rates and earlier onset of cataract: A nationwide retrospective cohort study.","authors":"Yael Sharon, Tzipora Shochat, Yaron Rudman, Shiri Kushnir, Alon Zahavi, Ilan Shimon, Maria Fleseriu, Amit Akirov","doi":"10.1007/s00417-025-06752-6","DOIUrl":"https://doi.org/10.1007/s00417-025-06752-6","url":null,"abstract":"Purpose: To investigate the risk of cataract in patients with Cushing's syndrome (CS) and evaluate whether disease onset occurs at an earlier age compared to general population.Methods: A nationwide retrospective matched-cohort study including individuals diagnosed with endogenous CS from 2000 to 2023. Patients with CS were matched in a 1:5 ratio with a control group individually matched for age, sex, socioeconomic status, and body mass index. The primary outcome was the incidence of cataract and cataract surgery. The Cox proportional hazards model, accounting for death without cataract as a competing risk, was employed to estimate hazard ratio.Results: The study cohort included 609 patients with CS, 65% women and 35% men, and 3018 controls. The average age at CS diagnosis was 48.1 ± 17 years. Follow-up duration was 14.6 years (IQR 9.8-20.2). The source of hypercortisolism was Cushing's disease (CD) in 259 (42.6%) and adrenal CS (aCS) in 206 patients (33.8%). After CS diagnosis, cataract was observed in 171 patients (28.1%), and 771 controls (25.5%). Patients with CS had a 34% higher risk of developing cataract compared to their matched controls (HR = 1.34, 95% CI 1.03-1.75, p = 0.03). Cataract developed earlier in patients with CS compared to controls, with a mean age of onset at 64.7 ± 9.7 versus 67.6 ± 8.4 years, respectively (p = 0.01). A total of 49 (8.05%) patients had undergone cataract surgery after a diagnosis of CS compared to 177 (5.86%) in the control group (p = 0.07).Conclusion: Patients with endogenous CS have an increased likelihood of developing cataracts and they experienced onset at a younger age. Guidelines should include annual cataract monitoring for CS patients, beginning 3-5 years earlier than the current general recommendations.","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measuring the visual environment of children and young people at risk of myopia: a scoping review. 测量有近视风险的儿童和青少年的视觉环境：范围审查。

IF 2.4 3区医学

Graefe’s Archive for Clinical and Experimental Ophthalmology Pub Date : 2025-01-22 DOI: 10.1007/s00417-024-06719-z

Annegret H Dahlmann-Noor, Desta Bokre, Marina Khazova, Luke L A Price

{"title":"Measuring the visual environment of children and young people at risk of myopia: a scoping review.","authors":"Annegret H Dahlmann-Noor, Desta Bokre, Marina Khazova, Luke L A Price","doi":"10.1007/s00417-024-06719-z","DOIUrl":"https://doi.org/10.1007/s00417-024-06719-z","url":null,"abstract":"Purpose: Myopia (short-sightedness) is an emerging WHO priority eye disease. Rise in prevalence and severity are driven by changes in lifestyle and environment of children and young people (CYP), including less time spent in bright daylight and more time spent on near-vision activities. We aimed to systematically map the literature describing direct, objective measurements of the visual environment of CYP.Methods: We conducted searches in Ovid Medline 1946, Ovid Embase and The Cochrane Central Register of Controlled Trials in November 2024. We included primary research written in English on environmental/behavioural factors and myopia onset/progression in CYP 3-18 years. Two reviewers independently screened titles/abstracts/full texts.Results: We included 34 articles: 21 explored the association of indoor and/or outdoor light exposure and myopia and included light measurements, two near-vision activities, four both light and near-work, four time outdoors without illuminance measurements, and three light exposure based on meteorological data. Most measurements were carried out at the level of individual children, rather than the surrounding environment alone.Conclusion: Despite limitations in measurement techniques, there is evidence that reduced illuminance, less time spent in bright light and increased daily duration/sustained episodes of near-vision activities and reduced working distance are associated with increased myopia prevalence/progression.","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent trends and outcomes in immediate and delayed sequential bilateral cataract surgeries: a nationwide cohort study in South Korea. 即刻和延迟顺序双侧白内障手术的近期趋势和结果：韩国的一项全国性队列研究。

IF 2.4 3区医学

Graefe’s Archive for Clinical and Experimental Ophthalmology Pub Date : 2025-01-20 DOI: 10.1007/s00417-025-06737-5

Woojin Kim, Chan Mi Park, Yun Jin Choi, Dong Hyun Kim, Youngsub Eom, Jong Suk Song

{"title":"Recent trends and outcomes in immediate and delayed sequential bilateral cataract surgeries: a nationwide cohort study in South Korea.","authors":"Woojin Kim, Chan Mi Park, Yun Jin Choi, Dong Hyun Kim, Youngsub Eom, Jong Suk Song","doi":"10.1007/s00417-025-06737-5","DOIUrl":"https://doi.org/10.1007/s00417-025-06737-5","url":null,"abstract":"Purpose: To analyze the latest annual trends in immediate sequential bilateral cataract surgery (ISBCS) and delayed sequential bilateral cataract surgery (DSBCS) among patients with bilateral cataracts in Korea, and to identify the factors influencing the choice of surgery and the outcomes associated with ISBCS and DSBCS.Methods: This retrospective, nationwide cohort study included all patients aged 65 and older who were covered by the Korean National Health Insurance and underwent ISBCS or DSBCS from 2016 to 2021. The study recorded yearly numbers of ISBCS and DSBCS procedures, the interval between surgeries in DSBCS cases, patient demographics, types of implanted intraocular lenses (IOLs), and the incidence of cystoid macular edema and endophthalmitis following ISBCS or DSBCS.Results: A total of 50 878 (7.2%) patients underwent ISBCS, and 658 609 (92.8%) patients underwent DSBCS. ISBCS cases more than doubled in 2020 (7902) from 2019 (3703) before increasing even more significantly in number in 2021 (33 645). Age, hospital size, ocular and systemic comorbidities, type of IOL, and calendar year were associated with receiving ISBCS. In 2020 alone, the incidence of postoperative endophthalmitis among ISBCS patients was significantly higher (1.39 per 1000 procedures) than among DSBCS patients (0.40 per 1000 procedures; P = 0.001).Conclusion: The number of patients undergoing ISBCS for bilateral cataracts increased annually, particularly after the onset of the COVID-19 pandemic in Korea in 2020. However, this significant rise in ISBCS also led to a surge in the incidence of postoperative endophthalmitis in 2020.","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0