Graefe’s Archive for Clinical and Experimental Ophthalmology最新文献

{"title":"Management practices and surgical techniques for ab externo less invasive glaucoma surgery: a literature review and expert recommendations.","authors":"Kin Sheng Lim, Julián García-Feijóo, Karsten Klabe","doi":"10.1007/s00417-025-06843-4","DOIUrl":"10.1007/s00417-025-06843-4","url":null,"abstract":"<p><strong>Purpose: </strong>Subconjunctival bleb-forming devices (SBD) can provide greater intraocular pressure reductions than minimally invasive glaucoma surgery (MIGS) whilst remaining less invasive than traditional surgical techniques. However, variations in management practices and surgical techniques indicate the need for concise and clear guidance on these procedures in diverse patient populations. Here we describe current recommendations on the use of PRESERFLO MicroShunt, an ab externo SBD, according to a review of current literature and the opinions of 20 international glaucoma experts.</p><p><strong>Methods: </strong>A literature search was performed to return all publications relating to the PRESERFLO MicroShunt, which were then reviewed to extract information or guidance on patient selection, pre-operative patient preparation, peri-operative practices and techniques, and post-operative management. Alongside the literature search findings, participants in an expert panel meeting discussed their current practices relating to these same four aspects of PRESERFLO MicroShunt use.</p><p><strong>Results: </strong>PRESERFLO MicroShunt can be considered for the majority of patients with medically uncontrolled open-angle glaucoma, as well as in patients with uveitic glaucoma, advanced glaucoma and high myopia, adults with congenital glaucoma, and in some cases normal tension glaucoma patients. Prior to surgery, steroid drops may be given for 2-4 weeks if feasible, and acetazolamide may also be useful in patients with advanced glaucoma and high IOP. During surgery, a deep (8 mm) and wide sub-Tenon pocket is essential to surgical success. Mitomycin C is generally used at a concentration of 0.4 mg/mL for a minimum of 2-3 min. Intracameral bevacizumab and/or dexamethasone may be considered to increase the chance of surgical success. Post-operatively, antibiotics should be given for 7 days and steroid drops for 3-6 months. Monitoring visits may be less frequent than in patients undergoing trabeculectomy.</p><p><strong>Conclusion: </strong>Management practices and surgical techniques for ab externo SBD vary, and surgeons must use their best clinical judgement based on the requirements of the individual patient. However, here we provide some recommendations for patient selection and pre-, peri- and post-surgical management based on the opinions of experts in the use of PRESERFLO MicroShunt, which we hope will prove useful in optimizing surgical outcomes.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"2149-2161"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12414032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter to the editor regarding \"Prolene suture stenting: a novel approach to mitigate postoperative hypotony in PRESERFLO MicroShunt surgery\".","authors":"Lorenzo Governatori, Leandro Oliverio, Alessandra Scampoli, Tomaso Caporossi","doi":"10.1007/s00417-025-06754-4","DOIUrl":"10.1007/s00417-025-06754-4","url":null,"abstract":"","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"2409-2410"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolene suture stenting: a novel approach to mitigate postoperative hypotony in PRESERFLO MicroShunt surgery.","authors":"Eamon Sharkawi, Maria L Dari, Adriano Guarnieri","doi":"10.1007/s00417-025-06753-5","DOIUrl":"10.1007/s00417-025-06753-5","url":null,"abstract":"","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"2407-2408"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing pain management and pupil dilation in cataract surgery: a systematic review and meta-analysis of phenylephrine/ketorolac (OMIDRIA®).","authors":"Mohamed Abo Zeid, Amr Elrosasy, Kareem Khalefa, Mohamed Elhadary, Shrouk F Mohamed, Amr Elkelany, Hashem Abu Serhan","doi":"10.1007/s00417-025-06811-y","DOIUrl":"10.1007/s00417-025-06811-y","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review and meta-analysis aims to evaluate the efficacy and safety of the combination of phenylephrine 1% and ketorolac 0.3% (OMIDRIA®) for optimizing pain management and maintaining pupil dilation during cataract surgery. Comparisons were made against placebo/vehicle, phenylephrine alone, and epinephrine.</p><p><strong>Methods: </strong>A comprehensive search of PubMed, Cochrane CENTRAL, Embase, Scopus, and Web of Science was conducted. Eligible studies were randomized clinical trials and observational studies assessing intracameral phenylephrine/ketorolac against control groups. Key outcomes included pain management, pupil diameter, and adverse events. Data were synthesized using meta-analysis with fixed and random-effects models, and heterogeneity was assessed using the I² statistic.</p><p><strong>Results: </strong>Ten studies, including 220,061 patients, were analyzed. The combination of phenylephrine/ketorolac significantly reduced postoperative pain (RR = 0.72, 95% CI: 0.60-0.86) and opioid use (RR = 0.45, 95% CI: 0.23-0.89) compared to vehicle and epinephrine. PE/K also maintained a larger pupil diameter (MD = 0.54 mm, 95% CI: 0.32-0.75) with minimal heterogeneity (I² = 0%) and reduced the incidence of severe pain (RR = 0.41, 95% CI: 0.27-0.63). No significant differences in adverse events such as elevated intraocular pressure, inflammation, or headaches were observed.</p><p><strong>Conclusion: </strong>Phenylephrine/ketorolac (OMIDRIA®) demonstrates superior efficacy in maintaining intraoperative mydriasis, reducing postoperative pain, and minimizing opioid use without increasing adverse events. This combination offers a preferable alternative to traditional agents, potentially setting a new standard for pain management and pupil dilation in cataract surgery.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"2265-2275"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12414053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of iris-ciliary angle with haptic position and vault after implantation of implantable collamer lens.","authors":"Wenxin Xue, Xiaohang Jiao, Weiqun Wang, Yanhui Bai","doi":"10.1007/s00417-025-06806-9","DOIUrl":"10.1007/s00417-025-06806-9","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the impact of the iris-ciliary angle (ICA) on the position of the implantable collamer lens (ICL) haptic and vault following ICL implantation.</p><p><strong>Methods: </strong>A prospective, observational study was conducted using data from 135 patients who underwent horizontal ICL implantation. Patients were categorized into three groups by ICA: ICA1 (0-32°), ICA2 (32-64°), and ICA3 (64-96°) to compare parameters. The parameters correlated with the distance from the iris root to the end of the ICL haptic (IRH) and vault was analysed respectively. A multiple linear stepwise regression model was constructed to estimate IRH.</p><p><strong>Results: </strong>The vault decreased sequentially across the three groups (P < 0.001) and was negatively correlated with ICA (P < 0.001). The proportion of ICL haptic insertion under the ciliary body was significantly higher in the ICA3 group compared with the ICA1 and ICA2 groups (P = 0.039). Stepwise regression analysis showed that IRH = -1.174 + 0.005 × ICA + 0.118 × horizontal sulcus-to-sulcus (STS) distance (adjusted R² = 0.334, Durbin-Watson value = 1.908, P < 0.001), with ICA as the primary influencing factor (β = 0.536, P < 0.001), followed by horizontal STS distance (β = 0.348, P < 0.001).</p><p><strong>Conclusions: </strong>When the ICA is excessively large, the ICL haptic is more likely to be inserted under the ciliary body. An increase in ICA is associated with a greater IRH and a lower vault.</p><p><strong>Key messages: </strong>What is known: • More posterior chamber anatomical parameters of eyes are needed to improve the accuracy of predicting the vault. • A negative correlation exists between the iris-ciliary angle (ICA) and vault.</p><p><strong>What is new: </strong>• When the ICA is excessively large, the ICL haptic is more likely to be inserted under the ciliary body. • The ICA is the primary influencing factor when predicting the distance from the iris root to the end of the ICL haptic (IRH).</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"2379-2387"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying potential tear biomarkers in premature infants with retinopathy of prematurity based on proteome and transcriptome analysis.","authors":"Dongting Wu, Zixin Fan, Yarou Hu, Yi Chen, Ruyin Tian, Cui Wang, Honghui He, Yuhang Yang, Guoming Zhang","doi":"10.1007/s00417-025-06838-1","DOIUrl":"10.1007/s00417-025-06838-1","url":null,"abstract":"<p><strong>Aim: </strong>To identify the potential tear fluid biomarkers in premature infants with and without retinopathy of prematurity (ROP) based on proteomic and transcriptomic analysis.</p><p><strong>Methods: </strong>Tears were collected from the 46 eyes of the 23 enrolled premature infants, with and without ROP. Data-independent acquisition (DIA) mass spectrometry was utilized for the quantitative proteomic analysis of the two groups. Two published transcriptome datasets involving mouse oxygen-induced retinopathy (OIR) model data were selected from the Gene Expression Omnibus (GEO) database. iDEP (integrated Differential Expression and Pathway analysis) were used for differential expression analysis. Gene Ontology (GO)-based functional and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed.</p><p><strong>Results: </strong>In this study, a total of 1742 proteins were quantified from the two groups. 55 differentially expressed proteins closely related to immune and angiogenesis processes were identified, including 33 highly expressed as well as 22 lowly expressed in the ROP group. Combined with RNA-seq data from OIR model, we screened two particularly critical proteins, LYN and filamin A (FLNA), which were both expressed at significantly elevated levels.</p><p><strong>Conclusions: </strong>According to the findings of the tear proteomics data, we hypothesized two particularly critical proteins, LYN and FLNA, may serve as pivotal regulators of immune and angiogenesis processes in ROP. These results will assist in the provision of new potential targets for the diagnosis of ROP.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"2191-2202"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene therapy in neovascular age related macular degeneration: an update.","authors":"Erika Quesada, Sofía Rojas, Xiomara Campos, Lihteh Wu","doi":"10.1007/s00417-025-06837-2","DOIUrl":"10.1007/s00417-025-06837-2","url":null,"abstract":"<p><p>Neovascular age-related macular degeneration (NV-AMD) is a leading cause of preventable blindness in the elderly. Intravitreal injections of anti-VEGF agents are currently the treatment of choice for NV-AMD. However this treatment is burdensome and fosters non-compliance which leads to inferior visual outcomes. Gene therapy has emerged as a promising therapeutic option for NV-AMD that may improve these outcomes. Potential risks of gene therapy include a potential immune response that may be elicited by the vector, accidental activation of oncogenes or inactivation of tumor suppresor genes leading to malignant transformation via insertational mutagenesis and integration of the viral DNA inserts into the host's DNA. The main strategy of current gene therapy for NV-AMD has focused on delivering transgenes that express anti-angiogenic proteins that directly or indirectly inhibit the VEGF pathway. Ixoberogene soroparvovec, RGX-314 and 4D-150 are the leading NV-AMD genetic treatment programs. Pre-clinical models suggest that genome surgery with clustered regularly interspaced short palindromic repeats (CRISPR) may be another option in the future.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"2135-2148"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of asymmetry in macular structure and function associated with ocular dominance.","authors":"Li Bao, Yutong Song, Xiaoyue Wang, Xi Huang","doi":"10.1007/s00417-025-06782-0","DOIUrl":"10.1007/s00417-025-06782-0","url":null,"abstract":"<p><strong>Purpose: </strong>Research on the correlation between ocular dominance and macular structure and function is inconsistent. This clinical observational study explored the effect of ocular dominance on retinal structure and the correlation between binocular structural asymmetry and ocular dominance.</p><p><strong>Methods: </strong>Forty healthy young adults (aged 20-29 years) were enrolled. Ocular dominance, refractive error, pattern visual evoked potential (PVEP), multifocal electroretinography (mfERG), swept-source optical coherence tomography (SS-OCT), and optical coherence tomography angiography (OCTA)tests were performed.</p><p><strong>Results: </strong>Among the 40 subjects, 24 (60%) were right-eye dominant. The dominant eye had a larger amplitude density of Ring 1 in the mfERG (198.52 ± 51.43 vs. 175.92 ± 50.17, p = 0.003), larger density of the superficial capillary plexus of the macula within the 4-12 mm diameter range (dominant eyes vs. nondominant eyes: 4-6 mm: 80.89 (78.24,83.58) vs. 78.93 (74.85,81.77), p < 0.001; 7-9 mm: 73.01 (69.22,75.90) vs. 71.75 (69.43,74.37), p = 0.009; 10-12 mm: 55.79 ± 5.40 vs. 54.46 ± 7.03, p = 0.033), and a thicker choroidal layer (dominant eyes vs. nondominant eyes: 7-9 mm: 289.70 ± 58.85 vs. 279.86 ± 59.16, p = 0.045; 10-12 m: 270.05 ± 44.87 vs. 259.64 ± 43.50, p = 0.014). The right eye had a higher choroidal vascular density (right eyes vs. left eyes: 0-1 mm: 95.45 (84.56,98.67) vs. 91.04 (79.79,97.04), p = 0.018) and lower superficial retinal vascular density (right eyes vs. left eyes: 10-12 mm: 54.29 ± 5.98 vs. 55.82 ± 6.34, p = 0.027) and choroidal vascular density (right eyes vs. left eyes: 7-9 mm: 90.98 ± 2.89 vs. 92.18 ± 2.61, p = 0.041).</p><p><strong>Conclusion: </strong>Ocular dominance influenced macular foveal function, parafoveal vessel density and choroidal thickness. The functional and morphological differences in ocular dominance and laterality are inconsistent.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"2005-2015"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-based progress prediction in accelerated cross-linking for Keratoconus.","authors":"Qi Wan, Qiong Wang, Ran Wei, Jing Tang, Hongbo Yin, Ying-Ping Deng, Ke Ma","doi":"10.1007/s00417-025-06792-y","DOIUrl":"10.1007/s00417-025-06792-y","url":null,"abstract":"<p><strong>Background: </strong>To analyze corneal topographic and biomechanical parameters in keratoconus patients before undergoing accelerated corneal collagen cross-linking (A-CXL) surgery and use machine learning models to identify prognostic factors for disease progression after treatment.</p><p><strong>Methods: </strong>This was a retrospective, single-center study on 95 eyes from 69 keratoconus patients (mean age 21.46 ± 7.07 years) undergoing A-CXL, with 3-22 months follow-up. Corneal tomography (Pentacam) and biomechanical measurements (Corvis ST) were performed at baseline and follow-up visits. Changes in the E-stage were used to define progression. LASSO, XGBoost, and random forest machine learning models were applied to identify prognostic factors. A nomogram was developed to predict progression probabilities.</p><p><strong>Results: </strong>42.1% of eyes showed progression based on E-stage change. Maximal keratometry (Kmax) and index of surface variance (ISV) were significantly higher in the progression group. The nomogram incorporating Kmax and ISV predicted progression better than individual parameters. The progression rate was 51.4% in high-risk eyes versus 16% in low-risk eyes stratified by the nomogram.</p><p><strong>Conclusions: </strong>Kmax and ISV are important prognostic factors for keratoconus progression after A-CXL. The nomogram can improve prediction accuracy compared to single parameters. It enables personalized risk assessment to guide treatment decisions.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"1933-1947"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asymmetric stress distribution on lamina cribrosa in glaucoma patients with high myopia.","authors":"Edward Kang, Ji-Hye Park, Chungkwon Yoo, Yong Yeon Kim","doi":"10.1007/s00417-025-06809-6","DOIUrl":"10.1007/s00417-025-06809-6","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the impact of biomechanical changes in the optic nerve head on glaucoma progression during ocular rotation in highly myopic eyes with primary open-angle glaucoma.</p><p><strong>Methods: </strong>This study retrospectively enrolled 147 patients with primary open-angle glaucoma, including 57 with high myopia and 90 with non-high myopia. Personalized optic nerve head models were designed, and simulations were performed using finite element analysis to evaluate the effect of ocular rotation on the optic nerve head. Biomechanical changes in the optic nerve head were analyzed and compared between the groups.</p><p><strong>Results: </strong>The mean strain on the lamina cribrosa was significantly higher in the high myopia group compared to the non-high myopia group during ocular rotation. The stress ratio, indicating asymmetric stress distribution, was higher in the high myopia group than in the non-high myopia group. The stress ratio increased significantly as axial length increased. Both stress ratio and mean lamina cribrosa strain were correlated with rate of retinal nerve fiber layer thickness reduction (stress ratio: partial coefficient = -0.171, P = 0.040; mean lamina cribrosa strain: partial coefficient = -0.196, P = 0.018).</p><p><strong>Conclusion: </strong>High myopia leads to increased lamina cribrosa strain and asymmetric stress distribution during ocular rotation. These findings underscore the importance of considering optic nerve head biomechanics in patients with high myopia. Additionally, the stress ratio may serve as a novel indicator for predicting glaucoma progression.</p><p><strong>Key messages: </strong>What is known Biomechanical changes in the optic nerve head differ between patients with high myopia and those with non-high myopia. What is new Asymmetric stress distribution on the lamina cribrosa during ocular movement was higher in the high myopia group and was associated with structural progression of glaucoma. A longer axial length increased the asymmetric stress on the lamina cribrosa during ocular movement.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"1985-1995"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}