Graefe’s Archive for Clinical and Experimental Ophthalmology最新文献

{"title":"Changes in relative peripheral refraction after implantable collamer lenses implantation.","authors":"I-Chun Lin, Mingwei Li, Yinjie Jiang, Guanghan Xu, Mingrui Cheng, Boliang Li, Yadi Lei, Zhiwei Mao, Rui Ning, Xun Chen, Xiaoying Wang","doi":"10.1007/s00417-024-06730-4","DOIUrl":"10.1007/s00417-024-06730-4","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to measure the changes in refraction difference value (RDV) in different parts of the retina before and after implantable collamer lenses (ICL) surgery.</p><p><strong>Design: </strong>Prospective study.</p><p><strong>Methods: </strong>This study included 40 eyes of 40 patients who underwent ICL implantation for myopia. RDV measurements were taken across several ranges: 0°-15°, 15°-30°, 30°-45°, and 45°-53°, and categorized into four sectors: superior (RDV-S), inferior (RDV-I), temporal (RDV-T), and nasal (RDV-N), along with total RDV (TRDV). Measurements were taken preoperatively, and at one week and one month postoperatively.</p><p><strong>Results: </strong>TRDV, RDV beyond 15° eccentricity, and RDV-S, RDV-I, RDV-T, and RDV-N were significantly increased postoperatively. The one-week and one-month follow-up of RDVs had no significant differences. Significant differences in the increments were observed among RDV-15, RDV-15-30, RDV-30-45, and RDV-45-53 both at one-week and one-month follow-up. Similarly, there were significant differences in the increments among RDV-S, RDV-I, RDV-T, and RDV-N both at one-week and one-month follow-up. TRDV, RDV-30-45, RDV-45-53, RDV-S, RDV-T, and RDV-N showed significant differences in the variation preoperatively and postoperatively between the high (SE > -9.00 D) and ultra-high (SE ≤ -9.00 D) myopia groups.</p><p><strong>Conclusions: </strong>Peripheral refraction showed a hyperopic defocused state that can stabilize in the early postoperative period after ICL implantation. The variation in the hyperopic defocused shift in peripheral refraction increased more in the regions farther from the central retina. The temporal regions exhibited the most changes.</p><p><strong>Key messages: </strong>WHAT IS KNOWN : Myopia is generally believed to stabilize after adulthood, but some individuals continue to experience myopia progression, accompanied by axial length elongation. Traditional spectacle lenses correct myopia by focusing light on the fovea but may introduce peripheral hyperopic defocus, which is thought to contribute to myopia progression. ICL surgery effectively corrects high degrees of myopia and astigmatism. Previous studies have demonstrated the safety and efficacy of ICL in addressing central refractive errors, but peripheral refraction changes post-surgery have not been well-explored.</p><p><strong>What is new: </strong>ICL surgery increased peripheral hyperopic defocus while correcting central refractive error, with significant changes in peripheral refraction observed from the preoperative to postoperative one-week and one-month.. After ICL implantation, a hyperopic shift was observed in peripheral areas, with RDV values within 15° of the central retina appearing emmetropic and increasing hyperopic defocus noted moving away from the posterior pole. Peripheral refraction stabilized approximately one week after ICL surgery, with no significant differences observ","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"1479-1487"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term cultivation of retinal pigment epithelium cells on nanofiber scaffolds.","authors":"Julian A Zimmermann, Lucy Irlenbusch, Uwe Hansen, Marcus Himmler, Chun Zeng, Nicole Eter, Thomas Fuchsluger, Peter Heiduschka","doi":"10.1007/s00417-024-06707-3","DOIUrl":"10.1007/s00417-024-06707-3","url":null,"abstract":"<p><strong>Purpose: </strong>The retinal pigment epithelium (RPE) plays an important role in the pathogenesis of age-related macular degeneration (AMD) and other retinal degenerative diseases. The introduction of healthy RPE cell cultures into the subretinal space offers a potential treatment strategy. The aim of this study was the long-term culture and characterisation of RPE cells on nanofiber scaffolds.</p><p><strong>Methods: </strong>Nanofiber scaffolds consisting of polycaprolactone (PCL) and collagen were prepared by electrospinning. Porcine RPE cell cultures were maintained on PCL scaffolds, PCL-collagen scaffolds, and controls at the bottom of 24-well plates. Cell culture analysis was performed by immunohistochemistry, while the release of inflammatory cytokines IL-6, IL-8, TNF-α, and PDGF-β was measured by ELISA and multiplex assays. Ultrastructural features were examined by transmission electron microscopy.</p><p><strong>Results: </strong>The observation period averaged 42.7 weeks for controls, 38.7 weeks for PCL scaffold cultures, and 36.1 weeks for PCL-collagen scaffold cultures, with cell number and morphology remaining stable. TNF-α levels in the supernatants were minimal, IL-6 levels were consistently low, and IL-8 levels decreased from initially high to lower levels over time.</p><p><strong>Conclusion: </strong>RPE cells were stably cultured on nanofiber scaffolds for extended periods of time. The long-term physiological properties of RPE cells, including phagocytic ability and visual cycle enzyme activity, need to be further investigated before clinical application. In addition, controlling the expression of inflammatory mediators is a major challenge. Despite these hurdles, overcoming them is critical given the increasing prevalence of retinal degenerative diseases.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"1327-1336"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual reality-based Harms tangent screen test for strabismus measurement.","authors":"Yaroslava Wenner, Johann Schneider, Timo Drisser, Yu Yi Yang, Thilo Demeter, Maria Fronius, Birgit Lorenz, Thomas Kohnen, Michael Müller, Jochen Triesch","doi":"10.1007/s00417-024-06724-2","DOIUrl":"10.1007/s00417-024-06724-2","url":null,"abstract":"<p><strong>Purpose: </strong>Our study presents a virtual reality-based tangent screen test (VTS) to measure subjective ocular deviations including torsion in nine directions of gaze. The test was compared to the analogous Harms tangent screen test (HTS).</p><p><strong>Methods: </strong>We used an Oculus Go^® controller and head-mounted-display with rotation sensors to measure patient's head orientation for the VTS. The software was developed with Unity^®. We assessed subjective squint angles of adult patients with eye motility disorders of different origin in nine positions of gaze by means of HTS and VTS. We calculated mean difference, 95% limits of agreement and intraclass correlations (ICC) for horizontal, vertical and torsional deviations.</p><p><strong>Results: </strong>We included 85 patients. Measured horizontal and vertical deviations showed very good agreement between the two methods in all gaze directions (horizontal and vertical ICC: 0.93-0.98). Agreement was lower for torsional deviations (ICC: 0.79-0.93). The mean difference in primary position was 1.5° (95% limits of agreement -3.5° to 6.5°) for horizontal, 0° (-2,7° to 2,7°) for vertical, and 0.3° (-4.0° to 3.0°) for torsional deviations. The average examination time was 6 min with the VTS compared to 15 min with the HTS.</p><p><strong>Conclusions: </strong>Vertical and horizontal deviations showed good agreement between both tests measuring a slightly higher esodeviation with VTS probably due to an increased vergence demand. Measurement of torsional misalignment would benefit from a controller with more holding stability, such as a PC-mouse with central wheel, facilitating fine adjustments. VTS allowed automatic documentation, required less time and was easier to use than HTS.</p><p><strong>Key messages: </strong>What is known The incidence of neurogenic diplopia increases in the ageing population. The Harms tangent screen test (HTS) reliably measures subjective ocular deviations in patients with diplopia. The HTS requires staff well-trained in orthoptics limiting its use. What is new A novel virtual reality-based tangent screen test (VTS) enables measurement of horizontal, vertical and torsional ocular misalignment and shows a good comparability to the HTS. VTS uses commercially available head-mounted-display and controller, and specifically developed software, requires less time than HTS and allows automatic documentation. VTS administration does not require orthoptic training and can eventually be implemented in a clinical setting to provide a wider availability of subjective squint angle measurements.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"1435-1442"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ambient atmospheric pressure on intraocular pressure measured using a Goldman applanation tonometer in normal eyes under ordinary conditions.","authors":"Toru Ikushima, Aiko Iwase, Makoto Araie, Hiroshi Murata, Morio Ueno, Kazuhiko Mori, Yoko Ikeda, Hiroki Mieno, Chie Sotozono, Shigeru Kinoshita, Tetsuya Yamamoto","doi":"10.1007/s00417-024-06711-7","DOIUrl":"10.1007/s00417-024-06711-7","url":null,"abstract":"<p><strong>Purpose: </strong>Little is known about the effects of ambient atmospheric pressure (AP) on intraocular pressure (IOP) under ordinary conditions. This study aimed to investigate the effects of AP on Goldmann applanation tonometer-measured IOP (GAT-IOP) in normal eyes under everyday atmospheric conditions adjusting for effects of possible confounding factors including other climatic factors.</p><p><strong>Methods: </strong>Data obtained from 2,431 normal healthy eyes of 2,431 subjects (mean age: 56.9 years) who participated in this population-based glaucoma survey in Japan were analyzed via multivariable linear regression analysis, where the GAT-IOP was the response variable; explanatory variables were the ocular and systemic factors and calendar factors reportedly correlated with GAT-IOP as well as AP, relative humidity, temperature, wind speed, and weather. The Bonferroni correction was adopted to obtain P values.</p><p><strong>Results: </strong>Only AP of the outside air when each subject was examined was positively correlated with GAT-IOP (regression coefficient (RC) = 0.0460; P = 0.0051). Central corneal thickness, body mass index, and systolic blood pressure were positively correlated (RC = 0.0133, 0.0754, 0.0131; P < 0.0001, P < 0.0001, P = 0.0016, respectively), and corneal curvature radius and age were negatively correlated (RC=-0.7017, -0.0225; P = 0.0144, P = 0.0111, respectively) with GAT-IOP. The seasonal effect on GAT-IOP was also significant (P < 0.0001), and in reference to winter, summer was correlated with lower GAT-IOP and spring was correlated with higher GAT-IOP (RC=-0.5133, 0.4590; P = 0.0087, P = 0.0001, respectively).</p><p><strong>Conclusions: </strong>AP was found to have a significantly positive correlation with GAT-IOP in normal healthy eyes under ordinary conditions, though the actual impact of AP on IOP in normal individuals under ordinary conditions would be minimal.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"1391-1398"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating anterior segment stability and corneal endothelium after prolene gonioscopy assisted transluminal trabeculotomy (GATT) in open-angle glaucoma.","authors":"Yavuz Kemal Aribas, Zeynep Aktas, Mestan Ertop","doi":"10.1007/s00417-024-06713-5","DOIUrl":"10.1007/s00417-024-06713-5","url":null,"abstract":"<p><strong>Introduction: </strong>This study investigates the short-term effects of prolene gonioscopy-assisted transluminal trabeculotomy (GATT) on anterior segment parameters and corneal endothelium in patients with open-angle glaucoma.</p><p><strong>Methods: </strong>This retrospective study included 30 eyes from 30 patients who underwent GATT surgery. Demographic data, ophthalmological examination findings, and intraocular pressure (IOP) measurements using a Goldman applanation tonometer were recorded. Scheimpflug images were acquired at the pre-operative stage, as well as on the 1st day, 1st week, and 1st month postoperatively. Corneal endothelial cell counts were obtained via specular microscopy.</p><p><strong>Results: </strong>The mean age of patients was 60.3 ± 15.5 years. Anterior chamber depth and central corneal thickness increased on the 1st postoperative day (p:0.002, p < 0.001, respectively). Changes in anterior chamber depth values at the postoperative 1st week and 1st month compared to baseline were not statistically significant. Central corneal thickness decreased significantly at the 1st postoperative month compared to baseline (p:0.007). Corneal endothelial cell counts at the 1st month were comparable to baseline values (p:0.936).</p><p><strong>Conclusion: </strong>Our findings reveal that prolene gonioscopy-assisted transluminal trabeculotomy induces temporary changes in anterior segment parameters but preserves corneal endothelial cell count within the first month, suggesting a promising profile for GATT in glaucoma management.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"1399-1404"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum and demographic profile of pediatric intraocular tumors from a single center in India: an analysis of 445 eyes.","authors":"Abhishek Das, Devu K Thulaseedharan, Parag K Shah, Prema Subramaniam, Narendran Venkatapathy","doi":"10.1007/s00417-024-06728-y","DOIUrl":"10.1007/s00417-024-06728-y","url":null,"abstract":"<p><strong>Background: </strong>To describe the spectrum, demographic profile and distribution of intraocular oncology cases; both benign and malignant, in pediatric population in India.</p><p><strong>Methods: </strong>It was a retrospective study done at a tertiary care hospital over a period of seven years (January 2015- December 2022) which included all the children aged 0-16 years, clinically diagnosed as intraocular tumors (benign or malignant) referred to our Ocular Oncology clinic. The data was retrieved from medical records department as well as electronic medical system (EMR) system. Age-wise distribution and demographic details were analyzed amongst these children.</p><p><strong>Results: </strong>A total of 310 (n = 445) patients were included. Mean age at presentation was 28.80 ± 28.58 months (median, 22 months; range, 0-176). Males were 168 (54.2%) and females were 142 (45.9%). 43.9% of the patients were in the age group between 2 and 3 years. 69.1% of the patients travelled around 100-500 km for treatment. Mean duration of symptoms was 4.7 ± 8.9 months, mean time interval between symptom and visit to our hospital was 4.8 ± 8.9 months and mean total follow-up period was 34 ± 30.7 months (median, 25 months; range, 0-105). Leukocoria (65.5%) was the most common presenting symptom amongst all the patients. Most common intraocular tumor amongst all the age group was retinoblastoma (88.4%). This was followed by combined hamartoma of retina and retinal pigment epithelium (CHRRPE) (3%, n = 11), astrocytic hamartoma (2.6%, n = 15), retinocytoma (1.6%, n = 5), choroidal hemangioma (1%, n = 3), simple hamartoma of retinal pigment epithelium (RPE) (1%, n = 3), Medulloepithelioma (1%, n = 3) and others (2%).</p><p><strong>Conclusion: </strong>The most common malignant tumor was retinoblastoma and benign tumor was CHRRPE. Appropriate referral and early detection of these oncological diseases will play a crucial role in their prognosis and outcome.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"1461-1468"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crystalline lens power and astigmatism calculation in myopia by swept-source optical coherence tomography: A pilot study.","authors":"Shulin Wang, Dan Cheng, Xueying Zhu, Fangjun Bao, Jun Zhu, Chenjiu Pang, Yufeng Ye","doi":"10.1007/s00417-025-06746-4","DOIUrl":"10.1007/s00417-025-06746-4","url":null,"abstract":"<p><strong>Purpose: </strong>To calculate the crystalline lens power and astigmatism, as well as their changes following cycloplegia, in individuals with myopia using swept-source optical coherence tomography (SS-OCT).</p><p><strong>Methods: </strong>Participants were divided into two groups according to axial length (AL). Crystalline lens parameters, including power, lens thickness (LT), anterior chamber depth (ACD), and astigmatism, were measured with SS-OCT and analysed before and after cycloplegia. The lensmaker's equation was used to calculate lens power, and differences between three consecutive measurements < 22.5 degrees was set as the screening criterion for meridian direction measurement repeatability.</p><p><strong>Results: </strong>Sixty-three eyes met the screening criterion on the anterior surface both before and after cycloplegia was included. The majority of eyes exhibited lens astigmatism ranging from + 0.76 D to + 1.50 D on both anterior and posterior surfaces. Before cycloplegia, 61 eyes (96.8%) had with-the-rule (WTR) astigmatism on the anterior surface. Meanwhile, 25 eyes met the criterion on posterior surface, of which 21 eyes (84.0%) had against-the-rule (ATR) astigmatism. After cycloplegia, 60 eyes (95.2%) had WTR astigmatism on the anterior surface. Meanwhile, 23 eyes met the criterion on posterior surface, of which 19 eyes (82.6%) had ATR astigmatism. After cycloplegia, there were significant changes in the lens power, astigmatism, thickness, and ACD.</p><p><strong>Conclusions: </strong>Astigmatism of crystalline lens on the anterior and posterior surfaces was mainly WTR and ATR, respectively, with similar refractive power. After cycloplegia, changes in parameters and refractive power of the lens mainly occur on the anterior surface.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"1355-1363"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous GA and CNV/MNV: incidence, characteristics, and treatments.","authors":"Keiko Kataoka, Richard Gale, Xiaoxin Li, Figen Şermet, Cynthia X Qian, Chui Ming Gemmy Cheung, Miltiadis K Tsilimbaris, Igor Kozak","doi":"10.1007/s00417-024-06721-5","DOIUrl":"10.1007/s00417-024-06721-5","url":null,"abstract":"<p><strong>Purpose: </strong>Understanding the clinical characteristics and underlying mechanisms of simultaneous geographic atrophy (GA) and choroidal neovascularization (CNV)/macular neovascularization (MNV) is necessary for the long-term management of late age-related macular degeneration (AMD) in clinical practice.</p><p><strong>Methods: </strong>The authors reviewed the literature on the incidence, risk factors, and clinical characteristics of simultaneous GA and CNV/MNV and developed consensus recommendations for the diagnosis, assessment, and management of simultaneous GA and CNV/MNV in clinical practice.</p><p><strong>Results: </strong>The incidence rate of CNV/MNV in eyes with GA is reported as 7.4% per patient-year or 13.8% in 4.1 years, while that of macular atrophy (MA) subsequent to CNV/MNV is reported as 24.4% to 37% in 24 months. Recent studies using optical coherence tomography angiography (OCT-A) revealed the presence of subclinical CNV/MNV in 11% to 16% of eyes with GA. Fundus autofluorescence is used to detect MA; optical coherence tomography (OCT) and OCT-A are useful for detecting MA, especially around the fovea, with OCT-A offering high sensitivity and specificity in the detection of both MA and CNV/MNV. GA and CNV/MNV share the genetic risk factors of HTRA1, complement factor H, complement factors 3 and 2, and ARMS2, and clinical risk factors of large drusen, cuticular drusen, intraretinal hyperreflective foci, and subretinal drusenoid deposits, suggesting that simultaneous GA and CNV/MNV represents a continuum of AMD. Anti-vascular endothelial growth factor therapy for CNV/MNV is reported to have no impact on the speed or magnitude of MA development or enlargement. An association has been observed between CNV subtype and MA progression, with the latter being slower in the presence of type 1 CNV/MNV.</p><p><strong>Conclusions: </strong>These findings suggest there is a high probability of coexistence of GA and CNV/MNV and that they should not be considered separately. Future clinical studies should assess the two conditions simultaneously using OCT and OCT-A.</p><p><strong>Key messages: </strong>What is known Owing to differences in their clinical characteristics, geographic atrophy (GA) and choroidal neovascularization (CNV)/macular neovascularization (MNV) have historically been regarded as two separate entities; however, several cases of coexistent GA and CNV/MNV have been reported recently in the published literature. What is new The findings of this review confirm that GA and CNV/MNV share common genetic risk factors and clinical characteristics, and suggest that these two entities are part of a continuum of late-stage age-related macular degeneration (AMD). The potential for GA and CNV/MNV to coexist should be considered in any discussion of the long-term management of late AMD; moreover, clinicians should assess for CNV/MNV in patients with GA, and for GA in those with CNV/MNV, using multimodal imaging.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"1197-1212"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracellular dark endothelial spots detected using specular microscopy are associated with graft failure after Descemet's membrane endothelial keratoplasty.","authors":"Ami Igarashi, Masato Takeda, Naoko Mashiko, Toshiki Shimizu, Kentaro Yuda, Yoshinori Oie, Naoki Okumura, Takefumi Yamaguchi, Satoru Yamagami, Takahiko Hayashi","doi":"10.1007/s00417-025-06745-5","DOIUrl":"10.1007/s00417-025-06745-5","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the correlation between intracellular dark endothelial spots (IDESs) detected by specular microscopy and the incidence of graft failure after Descemet's membrane endothelial keratoplasty (DMEK).</p><p><strong>Methods: </strong>We reviewed 100 consecutive DMEK patients performed by a single surgeon at two centres between January 2015 and July 2022. Central corneal thickness was evaluated using anterior segment optical coherence tomography (SS-1000; Tomey, Aichi, Japan), and endothelial cell density was measured using specular microscopy. Kaplan-Meier estimates and Cox regression models were used to evaluate graft failure and associated risk factors.</p><p><strong>Results: </strong>Of the 97 eyes included, 9 experienced graft failure within the follow-up period (52.9 ± 23.9 months). IDES presence significantly correlated with decreased endothelial cell density and higher graft failure rates (hazard ratio = 4.68, 95% confidence interval = [0.96, 22.7], P = 0.034).</p><p><strong>Conclusion: </strong>IDESs represent a significant risk factor for graft failure post-DMEK. Careful postoperative management is imperative to minimise this risk.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"1373-1382"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystoid macular edema following repeat DMEK: incidence and risk factors.","authors":"Nicole Mechleb, Costanza Baressi, Georges Caputo, Alain Saad, Youssef Abdelmassih","doi":"10.1007/s00417-024-06700-w","DOIUrl":"10.1007/s00417-024-06700-w","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the incidence of CME in re-DMEK procedures and identify the associated risk factors.</p><p><strong>Methods: </strong>Retrospective case series of 88 patients who underwent re-DMEK surgeries from January 2013 to October 2023. Surgical results were analyzed based on the cause of corneal decompensation, associated ophthalmologic factors, occurrence of CME after primary DMEK surgery, incidence of CME after re-DMEK, time interval between surgery and onset of CME, and management and outcomes of CME.</p><p><strong>Results: </strong>Primary DMEK indications were Fuchs endothelial corneal dystrophy (FECD) in 40 eyes (44.9%), PBK in 30 eyes (33.7%) and herpes simplex virus (HSV) in 10 eyes (11.2%). After the first DMEK surgery, CME occurred in 16 eyes (18%) with a mean interval of 23.4 ± 16.7 weeks. After re-DMEK surgery, CME occurred in 22.5% with a mean interval of 14.2 ± 21.9 weeks. It was a new onset in 13 eyes (65%), recurrent in 6 eyes (30%), and persistent in 1 eye (5%). On multivariate analysis, no significant association was found between the presence of ERM and CME following re-DMEK. Eyes with a history of PPV and prior CME were significantly associated with CME occurrence with odd ratios of 4.9 (95% CI: 1.04-23.1, p = 0.04) and 4.1 (95%CI: 1.2-13.5, p = 0.02) respectively.</p><p><strong>Conclusion: </strong>CME following re-DMEK occurs in 22.5% of cases, primarily within the first three months post-operatively. The main risk factors include a previous occurrence of CME after the initial DMEK and a history of PPV. However, CME does not seem to negatively impact the final visual outcomes of re-DMEK.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"1365-1371"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}