Frontiers in Veterinary Science最新文献

{"title":"Editorial: Mycotoxins in pig feed: health risks, reproductive impacts, and diagnostic innovations.","authors":"Panagiotis Tassis, Alix Pierron, Johannes Kauffold","doi":"10.3389/fvets.2025.1675111","DOIUrl":"10.3389/fvets.2025.1675111","url":null,"abstract":"","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1675111"},"PeriodicalIF":2.9,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Clinical evaluation of a novel fixed-dose combination tablet (Sentorpil^® ForteGold) versus compounded powdered medications in dogs with myxomatous mitral valve disease: a randomized, double-blind study.","authors":"Jiyoung Park, Jiyoon Lee, Sang-Joon Lee, Changbaig Hyun","doi":"10.3389/fvets.2025.1687939","DOIUrl":"https://doi.org/10.3389/fvets.2025.1687939","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fvets.2025.1622383.].</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1687939"},"PeriodicalIF":2.9,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Idiopathic calvarial hyperostosis and concurrent nasal discharge in a 22-week-old Staffordshire bull terrier.","authors":"Victoria Travail, Beatriz Moreno-Aguado, Claudio Motta, Beatriz Garcia, Darren Kelly","doi":"10.3389/fvets.2025.1616797","DOIUrl":"10.3389/fvets.2025.1616797","url":null,"abstract":"<p><p>A 22-week-old Staffordshire bull terrier presented with acute onset of bilateral mucopurulent nasal discharge and lethargy. Clinical examination revealed pyrexia and pain upon palpation of the head, accompanied by marked asymmetrical swelling. Computed tomography (CT) of the head showed severe thickening of multiple calvarial bones with periosteal reaction, with small defined areas of fluid accumulation and contrast enhancement of the osteopenic areas. There was mild thickening of the mucosa of the frontal sinuses suggestive of sinusitis, fluid in the left nasal passage, choanae, and nasopharynx. Histological examination of biopsies of the bone revealed periosteal reaction with fibrosis, neutrophilic and histiocytic inflammation, and necrosis. Culture yielded negative results. The dog was diagnosed with idiopathic calvarial hyperostosis and medically managed with methadone, paracetamol, and meloxicam. At recheck 10 days later, all clinical signs had resolved except for mild persistence of skull asymmetry. To the authors' knowledge, this is the first report of idiopathic calvarial hyperostosis in a Staffordshire bull terrier. The presence of bilateral purulent nasal discharge represents a novel clinical sign not previously reported.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1616797"},"PeriodicalIF":2.9,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Risk assessment in equine anesthesia: a first evaluation of the usability, utility and predictivity of the two-part CHARIOT.","authors":"Lisa Brumund, Liza Wittenberg-Voges, Karl Rohn, Sabine B R Kästner","doi":"10.3389/fvets.2025.1685121","DOIUrl":"https://doi.org/10.3389/fvets.2025.1685121","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fvets.2024.1384525.].</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1685121"},"PeriodicalIF":2.9,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of neutral detergent fiber levels on apparent nutrient digestibility and intestinal microbiota composition and function in forest musk deer.","authors":"Qindan Dai, Yu He, Jie Wu, Lei Zhou, Guimei Jiang, Feng Chen","doi":"10.3389/fvets.2025.1658189","DOIUrl":"10.3389/fvets.2025.1658189","url":null,"abstract":"<p><p>This experiment was conducted to explore the effects of different neutral detergent fiber (NDF) levels on nutrient apparent digestibility and intestinal microbiota composition and function in adult male forest musk deer (FMD) (<i>Moschus berezovskii</i>). A total of 18 adult male forest musk deer (FMD) (aged 4-10 years) with an initial average body weight of 7.09 ± 0.82 kg were selected and randomly divided into three groups with different NDF levels: L: 21.60%, M: 25.14%, and H: 28.47%. The FMD were used in a 50-day trial. The results showed that the apparent digestibility of NDF and acid detergent fiber (ADF) first increased and then decreased as NDF levels rose, with the M group showing the highest digestibility (<i>p</i> < 0.05). The H group exhibited significantly higher (<i>p</i> < 0.05) Chao1 and ACE indices compared to the L group. In addition, at the phylum level (the relative abundance > 0.5%), no significant differences were observed among the three groups, except for Mycoplasmatota, which showed higher (<i>p</i> < 0.05) relative abundance in the M group compared to the L group. At the genus level (the relative abundance > 1%), the three groups did not change (<i>p</i> > 0.05) significantly. In the KEGG function analysis, differentially expressed genes were primarily enriched in pathways related to organismal systems and human diseases. In the CAZy functional analysis, significant differences (<i>p</i> < 0.05) were observed in glycoside hydrolases (GHs) and carbohydrate-binding modules (CBMs), with the M group showing clear enrichment in fiber-degrading enzymes. Overall, the M group demonstrated superior NDF apparent digestibility and enhanced fiber degradation capacity. Therefore, a dietary NDF level of approximately 25% is recommended as optimal for adult male FMD.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1658189"},"PeriodicalIF":2.9,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of the novel Pictor PictVet™ <i>Mycoplasma bovis</i> IgG multiplex ELISA for the detection of <i>Mycoplasma bovis</i> infections in cattle.","authors":"Yoichi Furuya, Piyush Bugde, Bhoopika Shetty, Farina Nor Hashimi, Hamideh Gholizadeh, Dave Whittaker, Jimena Tejerina, Natasha Gordon, Kelly A Tivendale, Nadeeka K Wawegama, Glenn F Browning, Andrea Kinga","doi":"10.3389/fvets.2025.1664919","DOIUrl":"10.3389/fvets.2025.1664919","url":null,"abstract":"<p><p>Early and accurate detection of infection with <i>Mycoplasma bovis (M. bovis)</i> is critical for managing disease caused by this pathogen, particularly in eradication campaigns, such as New Zealand's National <i>M. bovis</i> Eradication Programme. In response to the launch of the eradication programme, we developed and evaluated a novel multiplex ELISA assay-the Pictor PictVet™ <i>M. bovis</i> IgG Multiplex ELISA. Two <i>M. bovis</i> antigens, MilA and K310, were incorporated into the Pictor PictVet™ <i>M. bovis</i> Multiplex ELISA to detect <i>M. bovis</i>-specific serum IgG. Studies were conducted to determine the assay agreement with the ID Screen® <i>Mycoplasma bovis</i> Indirect ELISA (IDvet). A collection of sera from New Zealand cattle, previously characterized as IDvet-positive (+) and IDvet-negative (-), was used for these evaluations. Binding to the two different <i>M. bovis</i> antigens, MilA and K310, had high estimates of agreement, with PPAs of 89.3 and 96.4%, and a NPA of 99.2%. When the results from both the MilA and K310 components of the assay were combined to determine the assay outcome, the PPA increased to 100%, while the NPA remained high, at 98.4%, with an overall agreement of 98.9%. Multiplexing of two <i>M. bovis</i> antigens enhanced the diagnostic performance of the indirect ELISA in detecting <i>M. bovis</i>-specific IgG in serum samples. These findings suggest that the Pictor PictVet™ <i>M. bovis</i> IgG Multiplex ELISA could be a valuable tool for early detection and surveillance for infection with <i>M. bovis</i> in cattle.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1664919"},"PeriodicalIF":2.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breeding values and index creation for health and behavior traits in Labrador Retriever guide dogs.","authors":"Joseph A Thorsrud, Katy M Evans, C Kyle Quigley, Krishnamoorthy Srikanth, Antonio Reverter, Laercio R Porto-Neto, Heather J Huson","doi":"10.3389/fvets.2025.1628161","DOIUrl":"10.3389/fvets.2025.1628161","url":null,"abstract":"<p><strong>Introduction: </strong>Genomic breeding values and multi-trait selection indices have significantly advanced genetic improvement in livestock but remain underutilized in guide dog breeding. This study developed a genomically informed selection framework for a population of Labrador Retrievers by integrating health (e.g., dental, ocular, and dermatological conditions) and behavioral (e.g., trainability, distraction level, pace) traits into a \"Behavior Score,\" \"Health Score,\" and \"Total Score\" index by applying Genomic Best Linear Unbiased Prediction (GBLUP) to estimate breeding values.</p><p><strong>Results: </strong>Phenotypic and genotypic data were collected from 844 dogs over 26 years at The Seeing Eye guide dog school. Predictive performance was evaluated via five-fold cross-validation and correlation-based metrics. Results showed that some dentition related health traits exhibited moderate to high Area Under Receiving Operating Characteristic (AUROC) values (0.79-0.87), indicating potential for immediate use for genetic improvement. In contrast, most other health traits demonstrated weak to moderate predictive accuracy. Behavioral traits exhibited lower predictive accuracy but showed a stronger association with training success. Models were commonly unable to correctly classify individuals for binary or ordinal traits yet performed well in ranking individuals, likely due to lower heritability or strong environmental influences of traits or limitations of the dataset itself. The behavior-focused Total Score (AUROC ~0.72) outperformed health-based indices as a fixed effect in predicting breeding success despite the weaker predictive ability of individual behavioral traits. Incorporating parental scores as fixed effects modestly improved breeding values for success, indicating the importance of integrating additional data sources where available.</p><p><strong>Discussion: </strong>While these findings underscore the utility of genomic selection for guide dog breeding, they also highlight constraints stemming from small, genetically homogeneous populations and variable phenotyping. Ultimately, we provide the first usable individual and multi-trait genomic approaches to enhance both health and performance outcomes in working dog programs and a foundation to expand upon the reference population and behavioral trait assessment to improve prediction accuracy in the future.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1628161"},"PeriodicalIF":2.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case series: effects of an induced molting protocol using levothyroxine in five captive banded penguins (genus <i>Spheniscus</i>).","authors":"Ji-Hyung Park, Seung-Hyun Seo, Sang Wha Kim, Yeong-Hun Kang","doi":"10.3389/fvets.2025.1544599","DOIUrl":"10.3389/fvets.2025.1544599","url":null,"abstract":"<p><p>Penguin molts occur annually after breeding, allowing effective waterproofing and temperature regulation. However, aberrant molts frequently occur in penguins, which can lead to health problems if prolonged. Although the exact mechanisms underlying molting in birds remain unclear, some studies have focused on the roles of thyroid and sex hormones in penguins. Previous studies on forced molting using hormonal treatments have shown both success and failure. In particular, the use of synthetic thyroxine (levothyroxine) has mostly not been successful. This study aimed to induce molting by administering commercial levothyroxine to one Humboldt penguin (<i>Spheniscus humboldti</i>) and four African penguins (<i>Spheniscus demersus</i>) with abnormal molting, housed in aquaria. The planned levothyroxine dosing protocol was to start with 25 μg/kg PO q24h for 7 d, then increase it gradually to 50 μg/kg PO q24h for the next 7 d and 75 μg/kg PO q24h for 7 d, followed by a gradual decrease to 50 μg/kg PO q24h for 7 d, and 25 μg/kg PO q24h for the final 7 d. Three penguins received treatment according to this scheduled protocol, two of which initiated molting during the dosing period, while the third began to molt approximately 3 months post-treatment. Another penguin was administered the maximum dose for an additional week, which led to molting in the final week of treatment. In the remaining penguin, the medication was deemed to be insufficiently absorbed because of inadequate drug delivery methods. Consequently, the drug delivery strategy was changed during the 5^th week of treatment, and the treatment was extended for an additional 3 weeks beyond the original plan, after which the penguin began to molt. Therefore, all five penguins in this study exhibited molting following oral levothyroxine treatment, suggesting that this is a potential option for inducing molting in banded penguins (<i>Spheniscus</i> sp.) experiencing aberrant molt.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1544599"},"PeriodicalIF":2.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Trilostane therapy in a dog with recurrent adrenocortical carcinoma producing an array of steroid hormones.","authors":"Chloe Cheung, Luca Giori, Christine Griebsch, Natalie Courtman, Juan Podadera, Mary Thompson","doi":"10.3389/fvets.2025.1632432","DOIUrl":"10.3389/fvets.2025.1632432","url":null,"abstract":"<p><strong>Case summary: </strong>A 10-year-old neutered male poodle-cross was presented with signs of progressive hyporexia and marked polyuria and polydipsia (PU/PD) of 2 months' duration. Right unilateral adrenalectomy was performed 24 months prior, and adrenocortical carcinoma with no evidence of metastatic disease was diagnosed. Tumor aldosterone secretion was suspected due to persistent hypokalaemia and systemic hypertension. Upon re-presentation, the dog had a pot-bellied appearance, dermatological changes (symmetrical alopecia along the trunk, elbows, and hocks, with decubital ulcers), systemic hypertension, and marked hypokalaemia unresponsive to oral potassium supplementation, raising concerns for an endocrine disorder. Abdominal CT confirmed mass lesions in multiple liver lobes near the previous adrenalectomy site, and cytology confirmed adrenocortical carcinoma metastases. Regional and cranial mediastinal lymphadenomegaly, as well as prostatomegaly, were observed, while no abnormalities were detected in the left adrenal gland. A serum adrenal profile identified marked elevations in progesterone, androstenedione, estradiol, and testosterone concentrations pre- and post-ACTH. Serum aldosterone and cortisol concentrations pre- and post-ACTH were within reference intervals, noting the dog had been treated with spironolactone for 8 weeks at measurement. Trilostane therapy was initiated with an initial positive response, including reduced PU/PD and resolution of pot-bellied appearance. A significant reduction of steroid hormones was documented later. Signs returned about 4 months into trilostane treatment with evidence of progressive disease on repeat CT and adrenal profile. The dog is managed with palliative trilostane, 14 months since liver metastasis diagnosis.</p><p><strong>Relevance and novel information: </strong>This case highlights an initial clinical response to trilostane in a dog with metastatic, functional adrenocortical carcinoma (ACC), demonstrating short-term control of clinical signs. The variation in presentation between initial diagnosis and relapse prompted a hypothesis of a shift in tumor steroidogenic activity-a phenomenon rarely documented in veterinary literature. It underscores the diverse manifestations arising from excess production of multiple steroid hormones, including precursors. It also supports adrenal profiling in complex cases and confirms trilostane's utility as a palliative therapy in non-resectable or metastatic ACC.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1632432"},"PeriodicalIF":2.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constellation-based classification of avian reovirus in turkeys reveals shared virus origins among different meat-type farms.","authors":"Cheng-Shun Hsueh, Michael Zeller, Amro Hashish, Olufemi Fasina, Pablo Piñeyro, Oluwatobiloba Aminu, Mohamed El-Gazzar, Yuko Sato","doi":"10.3389/fvets.2025.1648247","DOIUrl":"10.3389/fvets.2025.1648247","url":null,"abstract":"<p><p>The US poultry industry suffers significant economic losses due to Avian Reovirus (ARV) infections, which mainly cause arthritis/tenosynovitis in turkeys and chickens. The emergence of outbreaks since 2012 highlights the urgent need for improved epidemiological tools. Given the distinct evolutionary history of each segment of the virus and limited resolution of existing typing methods for ARV based on a single gene, a novel genotyping scheme was developed utilizing a constellation-based genotyping approach to enhance source tracing and control strategies especially for ARV in turkeys. A dataset of 199 ARV sequences from turkey hosts was curated and organized based on branch distances from maximum likelihood phylogenetic trees using TreeCluster. The grouping performance was evaluated and optimized according to established criteria described in this study. The proposed methods selected the M2, S1 σC-encoding region, and L3 genomic segments due to their non-random reassortment and biological significance. The novel scheme identified 8 major genotypes and revealed clear epidemiological links between turkey breeder and meat-type farms, as well as common shared sources among different meat-type farms, suggesting both vertical and horizontal transmission pathways. Additionally, reassortment events were detected using our novel typing scheme, highlighting the complex evolutionary dynamics of ARV. By correlating genotypic patterns with epidemiological data, this study provides a foundation for improved ARV monitoring and disease management.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1648247"},"PeriodicalIF":2.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}