Green Processing and Synthesis最新文献_第3页

Green synthesis and multifaceted characterization of iron oxide nanoparticles derived from Senna bicapsularis for enhanced in vitro and in vivo biological investigation 从番泻叶中提取的氧化铁纳米颗粒的绿色合成和多方面表征，用于增强体外和体内生物学研究

IF 4.3 4区工程技术

Green Processing and Synthesis Pub Date : 2024-01-01 DOI: 10.1515/gps-2024-0001

Zubair Ahmad, Abdur Rauf, Haiyuan Zhang, Muhammad Ibrahim, N. Muhammad, Yahya S. Al‐Awthan, O. Bahattab

{"title":"Green synthesis and multifaceted characterization of iron oxide nanoparticles derived from Senna bicapsularis for enhanced in vitro and in vivo biological investigation","authors":"Zubair Ahmad, Abdur Rauf, Haiyuan Zhang, Muhammad Ibrahim, N. Muhammad, Yahya S. Al‐Awthan, O. Bahattab","doi":"10.1515/gps-2024-0001","DOIUrl":"https://doi.org/10.1515/gps-2024-0001","url":null,"abstract":"\u0000 Iron oxide nanoparticles have garnered significant interest in recent years due to their diverse applications, particularly in the therapeutic field. We present a green synthesis method using the extract of Senna bicapsularis, the production of iron oxide nanoparticles (IONPs). The successful synthesis of IONPs was confirmed by UV–visible spectroscopy, revealing the characteristic peak at 295 nm. Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy were employed to elucidate the functional groups involved in the synthesis and characterize the morphological features of the nanoparticles. Subsequently, the synthesized IONPs were subjected to biological assays to assess their anticancer, enzyme inhibitory, analgesic, and sedative activities, following standardized protocols. The IONPs exhibited potent anticancer activity against the MDR 2780AD cell line, with IC50 values of 0.85 (extract) and 0.55 (iron oxide nanoparticles). Remarkable inhibitory effects were also observed against urease (IC50 = 12.98 ± 0.98) and xanthine oxidase (IC50 = 96.09 ± 0.65). Additionally, they demonstrated moderate carbonic anhydrase II inhibition, with 42.09% inhibition at a concentration of 0.25 mM. Furthermore, the extract and IONPs demonstrated a significant analgesic effect in a dose-dependent manner, while the sedative effect was also significant (p < 0.001).","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140524085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation, screening and optimization of alkaliphilic cellulolytic fungi for production of cellulase 分离、筛选和优化嗜碱性纤维素分解真菌以生产纤维素酶

IF 4.3 4区工程技术

Green Processing and Synthesis Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0153

Nor’Izzah Zainuddin, M. Z. Makhtar, Ahmad Anas Nagoor Gunny, S. Gopinath, Abdul Aziz Ahmad, Kavita Pusphanathan, M. Siddiqui, Mahboob Alam, Mohd Rafatullah

{"title":"Isolation, screening and optimization of alkaliphilic cellulolytic fungi for production of cellulase","authors":"Nor’Izzah Zainuddin, M. Z. Makhtar, Ahmad Anas Nagoor Gunny, S. Gopinath, Abdul Aziz Ahmad, Kavita Pusphanathan, M. Siddiqui, Mahboob Alam, Mohd Rafatullah","doi":"10.1515/gps-2023-0153","DOIUrl":"https://doi.org/10.1515/gps-2023-0153","url":null,"abstract":"\u0000 This study concerns with the production and partial characterization of alkaline cellulase from alkaliphilic cellulolytic (AC) fungi isolated fromsoil in Perlis, Malaysia. The best fungi strain was selected on the basis of producing the highest cellulase at high pH conditions. Cellulase from the selected fungi strain was further characterized under saccharification but varies in operating parameters. Finally, the kinetic model describing the growth of the AC fungi strain was studied by employing the logistic model. Among the tested fungi strains, Basidiomycetes strain (BK1) showed high potentiality for the production of maximum alkaline cellulase production at pH 9 after 72 h of incubation at 30°C containing 6 g·L−1 carboxyl methyl cellulose. The saccharification process showed that the enzyme favour high alkaline condition and proves thermotolerant properties, while 15% (v/v) enzyme loading and 1% substrate concentration recorded the highest glucose production at about 1.2–1.3 mg·mL−1. The novelty of the study is to identify and optimize a unique indigenous fungi that emit alkaliphilic cellulase as alternative usage in biotechnology industries due to its capacity to adapt to the extreme conditions of specific industrial processes. There are revolutionary options for use in biotechnological businesses that involve high pH and therefore have substantial biotechnological promise.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140518430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the antimicrobial potential of biogenically synthesized graphene oxide nanoparticles against targeted bacterial and fungal pathogens 探索生物合成氧化石墨烯纳米粒子对目标细菌和真菌病原体的抗菌潜力

IF 4.3 4区工程技术

Green Processing and Synthesis Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0130

Anila Ashraf, Muhammad Altaf, Fozia Abasi, Muhammad Shahbaz, Tanveer Hussain, Md. Arshad Ali, J. Seelan, Baber Ali, M. Mahmoud, Steve Harakeh, Muhammad Hamzah Saleem

{"title":"Exploring the antimicrobial potential of biogenically synthesized graphene oxide nanoparticles against targeted bacterial and fungal pathogens","authors":"Anila Ashraf, Muhammad Altaf, Fozia Abasi, Muhammad Shahbaz, Tanveer Hussain, Md. Arshad Ali, J. Seelan, Baber Ali, M. Mahmoud, Steve Harakeh, Muhammad Hamzah Saleem","doi":"10.1515/gps-2023-0130","DOIUrl":"https://doi.org/10.1515/gps-2023-0130","url":null,"abstract":"\u0000 Graphene oxide (GO) and reduced graphene oxide (rGO) nanoparticles were synthesized using 40 mL of lemon juice extract as a reducing agent. The synthesized nanoparticles were characterized using various analytical techniques, including UV–visible spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction. The results confirmed the successful synthesis of GO and rGO nanoparticles with varied sizes and shapes. The synthesized nanoparticles were tested for their antimicrobial activity against a range of bacterial and fungal strains, including Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Candida albicans, Fusarium oxysporum, and Aspergillus flavus. Multiple concentrations of GO and rGO nanoparticles were tested, and it was observed that 100 µg·mL−1 of both GO and rGO showed the highest inhibitory effect against bacterial and produced zones of inhibition of 17.66 mm, 18.67 mm, and 17.88 for E. coli, S. aureus, K. pneumoniae and 20.33, 22.45, and 21.34 mm for C. albicans, F. oxysporum, and A. flavus. Comparatively, GO performed well as compared to rGO regarding antimicrobial activity. The synthesized nanoparticles exhibited significant antimicrobial activity against various bacterial and fungal strains and have the potential to be developed as novel antimicrobial agents.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140519185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Materials-based drug delivery approaches: Recent advances and future perspectives 基于材料的给药方法：最新进展与未来展望

IF 4.3 4区工程技术

Green Processing and Synthesis Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0094

Jinjin Pei, Yuqiang Yan, C. Palanisamy, Selvaraj Jayaraman, P. Natarajan, V. Umapathy, S. Gopathy, J. R. Roy, Janaki Coimbatore Sadagopan, Dwarakesh Thalamati, Monica Mironescu

{"title":"Materials-based drug delivery approaches: Recent advances and future perspectives","authors":"Jinjin Pei, Yuqiang Yan, C. Palanisamy, Selvaraj Jayaraman, P. Natarajan, V. Umapathy, S. Gopathy, J. R. Roy, Janaki Coimbatore Sadagopan, Dwarakesh Thalamati, Monica Mironescu","doi":"10.1515/gps-2023-0094","DOIUrl":"https://doi.org/10.1515/gps-2023-0094","url":null,"abstract":"\u0000 Materials-based drug delivery approaches have garnered substantial attention in recent years due to their potential to revolutionize pharmaceutical interventions. This abstract provides a concise overview of recent advancements and future prospects in this rapidly evolving field. Materials such as nanoparticles, liposomes, polymers, and hydrogels have emerged as versatile carriers for drug delivery. These materials facilitate precise control over drug release kinetics, enabling targeted and sustained therapeutic effects. Smart materials with responsiveness to external stimuli or physiological conditions have further enhanced drug delivery precision. Personalized medicine approaches are gaining traction, tailoring drug delivery systems to individual patient profiles and needs. The horizon for materials-based drug delivery is bright. Ongoing research is focused on refining material design, streamlining production processes, and ensuring safety profiles. Collaborative efforts among researchers, clinicians, and industry stakeholders are crucial for translating these advancements into clinical practice. Additionally, the convergence of drug delivery with diagnostics and imaging holds immense potential for personalized and efficient healthcare solutions. As materials-based drug delivery continues to evolve, it stands poised to reshape the landscape of pharmaceuticals, offering the promise of more effective and patient-centered therapies for a wide range of medical conditions.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140517228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Manganese and copper-coated nickel oxide nanoparticles synthesized from Carica papaya leaf extract induce antimicrobial activity and breast cancer cell death by triggering mitochondrial caspases and p53 从木瓜叶提取物中合成的锰和铜包覆氧化镍纳米颗粒通过触发线粒体卡巴酶和 p53 诱导抗菌活性和乳腺癌细胞死亡

IF 4.3 4区工程技术

Green Processing and Synthesis Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0087

Badr Alzahrani, Abozer Y. Elderdery, Abdullah Falleh Alsrhani, N. Alzerwi, M. M. Althobiti, Musaed Rayzah, Bandar Idrees, Ahmed M. E. Elkhalifa, Abdulrahim AlAbdulsalam, A. Alsultan, Ebtisam Bakhsh, Naif Alsuhaymi, Suresh S. Kumar, P. Mok

{"title":"Manganese and copper-coated nickel oxide nanoparticles synthesized from Carica papaya leaf extract induce antimicrobial activity and breast cancer cell death by triggering mitochondrial caspases and p53","authors":"Badr Alzahrani, Abozer Y. Elderdery, Abdullah Falleh Alsrhani, N. Alzerwi, M. M. Althobiti, Musaed Rayzah, Bandar Idrees, Ahmed M. E. Elkhalifa, Abdulrahim AlAbdulsalam, A. Alsultan, Ebtisam Bakhsh, Naif Alsuhaymi, Suresh S. Kumar, P. Mok","doi":"10.1515/gps-2023-0087","DOIUrl":"https://doi.org/10.1515/gps-2023-0087","url":null,"abstract":"\u0000 In the present work, manganese–copper co-infused nickel oxide nanoparticles (MnCu co-doped NiO NPs) were formulated via a green process using Carica papaya extract. The MnCu co-doped NiO NPs were characterized by X-ray diffraction (XRD), UV–Vis, Fourier transform infrared, field emission scanning electron microscope, energy dispersive X-ray analysis, and photoluminescence (PL) spectrum. The XRD pattern demonstrated that synthesized MnCu co-doped NiO NPs exhibit cubic structure. On the PL spectrum, various surface defects were identified. MnCu co-doped NiO NPs exhibited ferromagnetic properties at 37°C. The antimicrobial activity of green synthesis MnCu co-doped NiO NPs against human pathogens (Escherichia coli, Streptococcus pneumoniae, Bacillus megaterium, Bacillus subtilis, Shigella dysenteriae, Pseudomonas aeruginosa) and Candida albicans as fungal strains were demonstrated. The MnCu co-doped NiO NPs treatment considerably reduced MDA-MB-231 cell viability while not disturbing HBL-100 cell viability. Different fluorescent staining analyses revealed that MnCu co-doped NiO NPs induced nuclear and mitochondrial damage to improve free radical production, altering mitochondrial membrane protein potential, which led to apoptotic cell death in MDA-MB-231 cells. The MnCu co-doped NiO NP treatment enhanced pro-apoptotic protein expression and inhibited the cell cycle at the S phase in MDA-MB-231 cells. This makes it easy, cheap, and environmentally friendly to make MnCu co-doped NiO NPs using C. papaya extract, which has excellent antimicrobial properties.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140525259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insight into heating method and Mozafari method as green processing techniques for the synthesis of micro- and nano-drug carriers 加热法和 Mozafari 法作为合成微纳米药物载体的绿色加工技术的启示

IF 4.3 4区工程技术

Green Processing and Synthesis Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0136

Zahra Jalilian, M. R. Mozafari, sargol aminnezhad, Elham Taghavi

{"title":"Insight into heating method and Mozafari method as green processing techniques for the synthesis of micro- and nano-drug carriers","authors":"Zahra Jalilian, M. R. Mozafari, sargol aminnezhad, Elham Taghavi","doi":"10.1515/gps-2023-0136","DOIUrl":"https://doi.org/10.1515/gps-2023-0136","url":null,"abstract":"\u0000 Drug delivery systems, also known as bioactive carriers, are currently an important contribution to the pharmaceutical and biomedical industries. A leading category of these drug carriers is lipid- and phospholipid-based systems including liposomes, nanoliposomes, solid lipid nanoparticles, nanostructured lipid vesicles, archaeosomes, and tocosomes. At present, there are several methods available for the preparation of the lipidic drug carriers at the micro- and nanoscales. There are some misunderstandings and confusion in the literature regarding two of the scalable and environment-friendly (green) techniques developed in our laboratory, namely the heating method and the Mozafari method. These methods are superior to conventional procedures used in the synthesis of drug carriers due to the fact that they do not involve utilization of potentially toxic solvents, detergents, or high-shear homogenizations. This entry is aimed to clarify differences between these methods to the peers and colleagues in academia as well as relevant industries. Some details of the industrially applied patented instrument used in the manufacturing of lipidic carriers are also provided.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140524445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of humic acid with the obtaining of potassium humate based on coal waste from the Lenger deposit, Kazakhstan 利用哈萨克斯坦伦格矿床的煤炭废料合成腐殖酸并获得腐殖酸钾

IF 4.3 4区工程技术

Green Processing and Synthesis Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0150

Bakyt Smailov, U. Aravind

{"title":"Synthesis of humic acid with the obtaining of potassium humate based on coal waste from the Lenger deposit, Kazakhstan","authors":"Bakyt Smailov, U. Aravind","doi":"10.1515/gps-2023-0150","DOIUrl":"https://doi.org/10.1515/gps-2023-0150","url":null,"abstract":"\u0000 This article a synthesis of humic acid with the obtaining of potassium humate based on coal waste from the Lenger deposit. Accumulated industrial waste heavily pollutes the environment and has a direct impact on all living things. The accumulation of waste in landfills increases the pollution level of the atmosphere, soil, groundwater, and surface water, destroys the functioning of ecosystems, and damages agriculture and construction. A sieve analysis was carried out to study the fine fractions of coal waste, and a scanning electron microscope analysis was performed to study the mineralogical, structural state and X-ray chemical phase composition. The chemical composition of coal waste was studied using differential thermal analysis during heat treatment. The optimal parameters of the process for obtaining humic acids are established, and the results of experimental work are presented. The results are confirmed by mathematical planning of the experiment using the method of orthogonal plan of the second order. The mathematical planning results were tested according to the Student and Fischer criteria. Based on the conducted studies, it was identified that the degree of extraction of humic acid reaches up to 95.90% in terms of the organic phase, and the concentration of humic acid is 49.13%. From the humic acids obtained using potassium hydroxide, potassium humate was synthesized. The potassium humate obtained in its composition has fertilizer properties. Therefore, the obtained potassium humate will be used for the production of humic fertilizers to improve soil fertility and crop yields. The synthesis of humic acids with the production of potassium humate is aimed at reducing the accumulated industrial waste, which in turn allows you to regulate and improve the ecological situation and green ecology in the region.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140525479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Lawsonia inermis-encased silver–copper bimetallic nanoparticles with antioxidant, antibacterial, and cytotoxic activity 具有抗氧化、抗菌和细胞毒性活性的银铜双金属纳米粒子的合成

IF 4.3 4区工程技术

Green Processing and Synthesis Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0194

C. Ragavendran, C. Kamaraj, Devarajan Natarajan, Khalid A. Al-Ghanim, Mohan Magesh, Marcello Nicoletti, M. Govindarajan

{"title":"Synthesis of Lawsonia inermis-encased silver–copper bimetallic nanoparticles with antioxidant, antibacterial, and cytotoxic activity","authors":"C. Ragavendran, C. Kamaraj, Devarajan Natarajan, Khalid A. Al-Ghanim, Mohan Magesh, Marcello Nicoletti, M. Govindarajan","doi":"10.1515/gps-2023-0194","DOIUrl":"https://doi.org/10.1515/gps-2023-0194","url":null,"abstract":"\u0000 The extract of the medicinal plant Lawsonia inermis, known as henna, was employed to synthesize silver–copper bimetallic nanoparticles (Ag–Cu NPs) in a unique, efficient, and cost-effective method. The shape, size, and structural features of synthesized Ag–Cu NPs were determined by ultra–visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffractometer, field emission scanning electron microscopy, transmission electron microscopy, and energy dispersive X-ray spectroscopy methods. The rod-shaped Ag–Cu nanoparticles, averaging 41.66 ± 17.18 nm in size, synthesized from L. inermis, exhibited potent antioxidant activity by inhibiting 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) free radicals. They also displayed significant antibacterial effects against Pseudomonas aeruginosa (28 mm), Staphylococcus aureus (27 mm), Bacillus cereus (26 mm), and Escherichia coli (24 mm). Additionally, these nanoparticles induced notable morphological changes in cancer cells and demonstrated promising cytotoxicity against MDA-MB-231 tumor cells (IC50 = 37.40 µg·mL−1). However, they exhibited biotoxicity in Artemia nauplii, resulting in mortality rates ranging from 3.0% to 32.5%. The LC50 and LC90 values recorded for a 48-h exposure were 1.51 mg·L−1 and 2.59 mg·L−1, respectively. These findings highlight the potential application of L. inermis-derived Ag–Cu NPs in pharmacology and bio-nanomedicine.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140521095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role and the importance of green approach in biosynthesis of nanopropolis and effectiveness of propolis in the treatment of COVID-19 pandemic 绿色方法在纳米蜂胶生物合成中的作用和重要性以及蜂胶在治疗新冠肺炎大流行中的有效性

IF 4.3 4区工程技术

Green Processing and Synthesis Pub Date : 2023-01-01 DOI: 10.1515/gps-2022-8106

Bindiya Barsola, Shivani Saklani, P. Kumari, A. K. Sidhu, Anjoo Dhar

{"title":"Role and the importance of green approach in biosynthesis of nanopropolis and effectiveness of propolis in the treatment of COVID-19 pandemic","authors":"Bindiya Barsola, Shivani Saklani, P. Kumari, A. K. Sidhu, Anjoo Dhar","doi":"10.1515/gps-2022-8106","DOIUrl":"https://doi.org/10.1515/gps-2022-8106","url":null,"abstract":"Abstract The most fascinating product of honeybee is propolis. It has an immense role in dentistry, dermatology, and otorhinolaryngology. The increased popularity of propolis as an important remedy is due to its constituents, which have anti-inflammatory, immunomodulatory, antihepatotoxic, anti-cancerous, antifungal, antioxidant, antidiabetic, and antiviral activities. The diverse biological and pharmacological activities of propolis have piqued the interest of many scientists. Many techniques like gas chromatography-mass spectrometry, chromatography, and spectroscopy are being used to identify different propolis constituents. Flavonoids, phenolic acids, and their esters are the most pharmacologically active molecules of propolis and are known to disrupt the replication machinery of the virus corroborating the anti-coronavirus activity of propolis. The main aim of this article is to provide an insight of the increasing theragnostic uses of propolis and its nanoparticles, including their chemical analysis, diverse biological activities, and the necessity for chemical standardization. In this review, we have focused at the promising effects of propolis, its optimization, and its liposomal formulation as a therapeutic intervention for COVID-19 and its accompanying comorbidities. Graphical abstract","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44952782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Environmentally friendly synthesis and computational studies of novel class of acridinedione integrated spirothiopyrrolizidines/indolizidines 新型吖啶二酮-螺硫基吡咯烷/中氮茚类化合物的环保合成及计算研究

IF 4.3 4区工程技术

Green Processing and Synthesis Pub Date : 2023-01-01 DOI: 10.1515/gps-2023-0036

R. Raju, R. Raghunathan, N. Arumugam, A. Almansour, Raju Suresh Kumar, P. Vivekanand, C. Ebenezer, R. V. Solomon, Karthikeyan Perumal

{"title":"Environmentally friendly synthesis and computational studies of novel class of acridinedione integrated spirothiopyrrolizidines/indolizidines","authors":"R. Raju, R. Raghunathan, N. Arumugam, A. Almansour, Raju Suresh Kumar, P. Vivekanand, C. Ebenezer, R. V. Solomon, Karthikeyan Perumal","doi":"10.1515/gps-2023-0036","DOIUrl":"https://doi.org/10.1515/gps-2023-0036","url":null,"abstract":"Abstract An efficient and environmentally benign synthesis of a new class of acridinedione embedded spirooxindolo/acenaphthenothiopyrrolizidines and spirooxindolo/acenathenoindolizidines has been synthesized in good to excellent yields employing ionic liquid accelerated one-pot [3 + 2]-cycloaddition strategy. The pre-requisite starting substrates, O-acryloyl acridinediones were prepared from dimedone in three good yielding steps, while the 1,3-dipole was derived in situ from isatin/acenaphthenequinone and thiazolidine-4-carboxylc acid/l-pipecolinic acid via decarboxylative condensation. The cycloadduct possesses three stereogenic carbons, one of which is a spiro carbon through the formation of two C–C and one C–N bonds in one-pot synthetic transformation. Geometrical parameters of the synthesized compounds were calculated using the B3LYP/6-311g(d,p) level of theory. The activity of these molecules was evaluated against main protease of COVID-19 to screen them for their inhibitor efficiency. In order to get a broad understanding of the interactions of these synthesized ligands, a detailed molecular docking analysis was performed. Molecular docking analysis shows that compound 8b has the highest binding affinity toward the protein. The compound can be a potential candidate for the treatment of COVID-19.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43253887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0