Green Processing and Synthesis最新文献

Simultaneous estimation of ibuprofen, caffeine, and paracetamol in commercial products using a green reverse-phase HPTLC method 采用绿色反相 HPTLC 法同时估算商业产品中的布洛芬、咖啡因和扑热息痛

IF 4.3 4区工程技术

Green Processing and Synthesis Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0220

M. Alqarni, F. Shakeel, S. Alshehri, A. Foudah, T. M. Aljarba, Fatma Abdel Bar, P. Alam

{"title":"Simultaneous estimation of ibuprofen, caffeine, and paracetamol in commercial products using a green reverse-phase HPTLC method","authors":"M. Alqarni, F. Shakeel, S. Alshehri, A. Foudah, T. M. Aljarba, Fatma Abdel Bar, P. Alam","doi":"10.1515/gps-2023-0220","DOIUrl":"https://doi.org/10.1515/gps-2023-0220","url":null,"abstract":"\u0000 A fast, sensitive, and green reverse-phase “high-performance thin-layer chromatography” approach for the simultaneous estimation of ibuprofen (IBF), caffeine (CAF), and paracetamol (PCM) in marketed formulations was established and verified in this study. The binary combination of acetone and water (80:20 v/v) was used as the green eluent system. The current method’s greenness was predicted using four different approaches, namely National Environmental Method Index, Analytical Eco-Score (89), ChlorTox (1.08 g), and the Analytical GREENness (83) approaches, which demonstrated an outstanding greener profile. The present approach was linear in the range of 25–800 ng·band−1 for the simultaneous estimation of IBF, CAF, and PCM. In addition, the current method was accurate (% recoveries = 100 ± 2), precise (%CV < 2%), robust (%CV < 2), sensitive (LOD = 1.13–2.71 ng·band−1 and LOQ = 3.39–8.10 ng·band−1), and green. The amount of IBF, CAF, and PCM in commercial tablets was determined to be 99.51%, 98.25%, and 100.64%, respectively. The present method for the simultaneous determination of IBF, CAF, and PCM in marketed tablets is supported by these data. The findings of this study suggested that the current approach may be consistently applied to analyze IBF, CAF, and PCM in marketed tablets.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140524866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and characterization of capsaicin nanoparticles: An attempt to enhance its bioavailability and pharmacological actions 辣椒素纳米颗粒的合成与表征：尝试提高辣椒素的生物利用度和药理作用

IF 4.3 4区工程技术

Green Processing and Synthesis Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0206

M. Sher, Ishtiaq Hussain, Farhat Ali Khan, Muhammad Zahoor, Wiaam Mujahid Sher, Muhammad Saqib Khalil, Muhammad Sulaiman, Riaz Ullah, Sumaira Naz, Essam A. Ali

{"title":"Synthesis and characterization of capsaicin nanoparticles: An attempt to enhance its bioavailability and pharmacological actions","authors":"M. Sher, Ishtiaq Hussain, Farhat Ali Khan, Muhammad Zahoor, Wiaam Mujahid Sher, Muhammad Saqib Khalil, Muhammad Sulaiman, Riaz Ullah, Sumaira Naz, Essam A. Ali","doi":"10.1515/gps-2023-0206","DOIUrl":"https://doi.org/10.1515/gps-2023-0206","url":null,"abstract":"\u0000 Herein, capsaicin nanoparticles (NPs) were prepared by two different methods, namely, evaporative precipitation of nanosuspension (EPN) and anti-solvent precipitation with a syringe pump (APSP). The nanoparticles of the necessary sizes were obtained after optimizing experimental parameters such as the solvent-to-anti-solvent ratio and stirring speed. They had spherical shapes and an average diameter of 171.29 ± 1.94 and 78.91 ± 0.54 nm when prepared using the EPN and APSP methods, respectively. Differential scanning calorimetry and an X-ray diffractometer showed that the capsaicin crystallinity decreased. FTIR results showed that the NPs were produced with their original configuration and did not result in the synthesis of any additional structures. The NP formulation had a desirable drug content. They surpassed the unprocessed drug in solubility and displayed the desired stability. Capsaicin NP cream showed many folds of enhanced analgesic, anti-inflammatory, and antimicrobial effects compared to unprocessed capsaicin.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140518288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green polymer electrolyte and activated charcoal-based supercapacitor for energy harvesting application: Electrochemical characteristics 基于绿色聚合物电解质和活性炭的能量收集应用超级电容器：电化学特性

IF 4.3 4区工程技术

Green Processing and Synthesis Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0109

S. B. Aziz, M. H. Hamsan, Rebar T. Abdulwahid, N. A. Halim, Jamal Hassan, Ahmed F. Abdulrahman, Sameerah I. Al-Saeedi, Jihad M. Hadi, M. Kadir, Samir M. Hamad, Salah R. Saeed

{"title":"Green polymer electrolyte and activated charcoal-based supercapacitor for energy harvesting application: Electrochemical characteristics","authors":"S. B. Aziz, M. H. Hamsan, Rebar T. Abdulwahid, N. A. Halim, Jamal Hassan, Ahmed F. Abdulrahman, Sameerah I. Al-Saeedi, Jihad M. Hadi, M. Kadir, Samir M. Hamad, Salah R. Saeed","doi":"10.1515/gps-2023-0109","DOIUrl":"https://doi.org/10.1515/gps-2023-0109","url":null,"abstract":"\u0000 The aim of this study is to address the growing concern about microplastics in the ocean and their potential harm to human health through ingestion. The MPs issue is largely a result of the increasing demand for electronic devices and their components. To tackle this challenge, the research aimed to develop a green polymer electrolyte that used glycerol as a plasticizing agent to improve ionic conductivity. The polymer host included chitosan and polyvinyl alcohol and was composed of sodium acetate. To evaluate the performance of the polymer electrolyte, various analytical techniques were used, including impedance and electrochemical studies. The ionic conductivity of 7.56 × 10−5 S·cm−1 was recorded. The dielectric property study confirmed the ionic conduction process in the system and revealed the existence of non-Debye type relaxation, as indicated by asymmetric peaks of tanδ spectra. The alternating conductivity exhibits three distinguished regions. The polymer electrolyte was discovered to be electrochemically stable up to 2.33 V and capable of storing energy as a non-Faradaic electrochemical double-layer capacitor (EDLC). The cyclic voltammetry pattern is a leaf like shape. The EDLC was able to be charged and discharged up to 1 V, and it showed cyclability and could be used in low-voltage applications.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139639935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Membrane distillation of synthetic urine for use in space structural habitat systems 膜蒸馏合成尿液，用于太空结构栖息地系统

IF 4.3 4区工程技术

Green Processing and Synthesis Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0197

V. Sagar, Lauren M. Mekalip, J. Lynam

引用次数: 0

Investigation on mechanical properties of the green synthesis bamboo fiber/eggshell/coconut shell powder-based hybrid biocomposites under NaOH conditions NaOH 条件下绿色合成竹纤维/蛋壳/椰壳粉基混合生物复合材料力学性能的研究

IF 4.3 4区工程技术

Green Processing and Synthesis Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0185

L. Natrayan, Neelima Devi Chinta, Balakrishna Gogulamudi, V. Swamy Nadh, G. Muthu, S. Kaliappan, Chidurala Srinivas

{"title":"Investigation on mechanical properties of the green synthesis bamboo fiber/eggshell/coconut shell powder-based hybrid biocomposites under NaOH conditions","authors":"L. Natrayan, Neelima Devi Chinta, Balakrishna Gogulamudi, V. Swamy Nadh, G. Muthu, S. Kaliappan, Chidurala Srinivas","doi":"10.1515/gps-2023-0185","DOIUrl":"https://doi.org/10.1515/gps-2023-0185","url":null,"abstract":"\u0000 This research delves into the effects of different alkalization treatment approaches on the mechanical characteristics of epoxy matrix composites that are reinforced with natural bamboo fibers and enriched with egg and coconut shell powders as fillers. Various weight ratios of fibers and fillers were investigated, specifically at 5%, 10%, 15%, 20%, 25%, and 30%. The study assessed mechanical properties such as tensile strength, flexural behavior, microhardness, and impact resilience. Findings indicate that composites with alkali-treated fibers demonstrate superior mechanical performance (49.28 MPa of tensile, 57.33 MPa of flexural 89 HV of hardness, and 1.3 kJ·m−2 of impact) compared to untreated counterparts. Particularly noteworthy is the significant improvement in fracture toughness observed with the inclusion of 20% hybrid laminates, surpassing the performance of existing biomaterial-based composites. This heightened toughness is attributed to the optimized composition of fibers and enhanced water absorption capabilities. Conversely, the incorporation of 25% and 30% hybrid composites led to a decrease in mechanical strength (38.65 MPa of tensile, 46.7 MPa of flexural, 72 HV of hardness, and 1.19 kJ·m−2 of impact) due to the formation of additional interfacial contacts, pores, and voids within the polymeric matrix.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140521404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile, polyherbal drug-mediated green synthesis of CuO nanoparticles and their potent biological applications 多草药介导的 CuO 纳米粒子的简便绿色合成及其强效生物应用

IF 4.3 4区工程技术

Green Processing and Synthesis Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0174

Mohammad Azam Ansari, Hassan Nassr Al Dhneem, S. G. Ali, Yahya F. Jamous, M. Alomary, Banan Atwah, Maryam S. Alhumaidi, Umme Hani, Nazima Haider, S. Asiri, F. A. Khan

{"title":"Facile, polyherbal drug-mediated green synthesis of CuO nanoparticles and their potent biological applications","authors":"Mohammad Azam Ansari, Hassan Nassr Al Dhneem, S. G. Ali, Yahya F. Jamous, M. Alomary, Banan Atwah, Maryam S. Alhumaidi, Umme Hani, Nazima Haider, S. Asiri, F. A. Khan","doi":"10.1515/gps-2023-0174","DOIUrl":"https://doi.org/10.1515/gps-2023-0174","url":null,"abstract":"\u0000 Copper oxide nanoparticles (CuO NPs) were synthesized using ayurvedic medicine septilin. The septilin-mediated CuO NPs were characterized using UV–Vis, fourier-transform infrared spectroscopy, X-ray diffraction (XRD), scanning electron microscope (SEM), and transmission electron microscope (TEM). The average particle size of CuO NPs was 8 nm as evident from TEM. Minimum inhibitory concentration of CuO NPs against Escherichia coli, Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans was found in the range of 1–2.5 mg·mL−1. CuO NPs dose-dependently decreased the biofilm formation from 0.0315 to 2 mg·mL−1, at the highest dose of 2 mg·mL−1 of CuO NPs; 92.91%, 79.84%, and 71.57% decrease in biofilm was observed for P. aeruginosa, MRSA, and C. albicans, respectively. Down-regulation of biofilm upon treatment with nanoparticles (NPs) was also observed by SEM analysis. SEM analysis also showed the change in morphological structure, and deformities in bacterial and fungal cells upon treatment of NPs. Furthermore, the anticancer efficacy of NPs was assessed using colon cancer (HCT-116). The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay clearly showed the anticancer potential of NPs, as the concentration of CuO NPs increased, the number of viable cells decreased. The produced CuO NPs have promise for future investigations in many biological and therapeutic domains, including the treatment of microbial biofilm infections, as well as the inhibition of cancer cell growth.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140516870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biofabrication of silver nanoparticles using Uncaria tomentosa L.: Insight into characterization, antibacterial activities combined with antibiotics, and effect on Triticum aestivum germination 利用云杉生物制造银纳米粒子：深入了解其特性、与抗生素结合的抗菌活性以及对小麦发芽的影响

IF 4.3 4区工程技术

Green Processing and Synthesis Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0207

R. M. Alghanmi, R. Hamouda, A. Al-Moubaraki, Afnan A. Allouzi, Muhammad A. Abuelmagd

{"title":"Biofabrication of silver nanoparticles using Uncaria tomentosa L.: Insight into characterization, antibacterial activities combined with antibiotics, and effect on Triticum aestivum germination","authors":"R. M. Alghanmi, R. Hamouda, A. Al-Moubaraki, Afnan A. Allouzi, Muhammad A. Abuelmagd","doi":"10.1515/gps-2023-0207","DOIUrl":"https://doi.org/10.1515/gps-2023-0207","url":null,"abstract":"\u0000 Herein, we used the aqueous extract of Uncaria tomentosa L. barks (Cat’s claw bark [CCb]) for the biofabrication of silver nanoparticles (CCb-Ag-NPs). The effects of different parameters (Uncaria tomentosa L. aqueous extract, silver nitrate [AgNO3] ratio, temperature, and pH) on the formation of the nanoparticles were investigated using UV scan as a preliminary tool for the detection of surface plasmon resonance of CCb-Ag-NPs. The optimal ratio was 1:7 (Uncaria tomentosa L. extract: 1 mM AgNO3 solution). Fourier-transform infrared spectroscopy revealed the functional groups of both CCb extract and the CCb-Ag-NPs, whose dispersion and quasispherical morphologies were characterized using scanning electron microscopy and transmission electron microscopy. Particle sizes ranged from 19.2 to 38.5 nm. The zeta potential of CCb-Ag-NPs was −34.44 mV. According to energy-dispersive X-ray analysis, the CCb-Ag-NPs contained 28.87% silver. The formation of Ag-NPs was also confirmed by X-ray diffraction pattern analysis. Pristine CCb-Ag-NPs showed antibacterial activity against three pathogenic bacterial strains: Escherichia coli (ATCC 25922), E. coli (ATCC 8739), and Pseudomonas aeruginosa (ATCC 90274). Antibacterial activity increased significantly after loading CCb-Ag-NPs on antibiotic discs containing meropenem and cefoxitin. Low concentrations of CCb-Ag-NPs also enhanced the germination percentage, coleoptile length, and radical root length of Triticum aestivum.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140517110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosynthesis of silver nanoparticles on yellow phosphorus slag and its application in organic coatings 黄磷渣上银纳米粒子的生物合成及其在有机涂料中的应用

IF 4.3 4区工程技术

Green Processing and Synthesis Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0204

Nguyen Tien Dung, Duong Tra My, Nguyen Thuy Chinh, Nguyen Quy Dai, Vu Dinh Hieu, Tran Thanh Thuy, Nguyen Kim Thoa, T. Hoang

{"title":"Biosynthesis of silver nanoparticles on yellow phosphorus slag and its application in organic coatings","authors":"Nguyen Tien Dung, Duong Tra My, Nguyen Thuy Chinh, Nguyen Quy Dai, Vu Dinh Hieu, Tran Thanh Thuy, Nguyen Kim Thoa, T. Hoang","doi":"10.1515/gps-2023-0204","DOIUrl":"https://doi.org/10.1515/gps-2023-0204","url":null,"abstract":"\u0000 This work concentrated on the decoration of AgNPs to yellow phosphorus slag (YPS) using both chemical (NaBH4) and biological (Areca catechu nut and Jasminum subtriplinerve leaf extracts) reducing agents, as well as its use as antibacterial and enhancement additives for organic coatings based on acrylic emulsion resin. It is the first study about the decoration of AgNPs on the surface of YPS using bio-reduction agents (A. catechu nut and J. subtriplinerve leaf extracts). The characteristics of YPS decorated by AgNPs (YPS@AgNPs) were determined using attenuated total reflectance infrared spectroscopy, scanning electron microscopy, X-ray diffraction, ultraviolet-visible spectroscopy and dynamic light scattering methods. To quantify the amount of AgNPs in YPS@AgNPs, atomic absorption spectroscopy was used. The results of YPS@AgNPs fabrication confirmed that the above green reduction agents had a higher efficiency and were more suitable than the chemical reduction agent (NaBH4). Moreover, the ability to inhibit the growth of bacteria strains of YPS@AgNPs using the J. subtriplinerve leaf extract as a reducing agent gave the best result among the three agents. In particular, the bactericidal activity of YPS@AgNPs against the new marine bacterium, Pseudomonas stutzeri B27, was evaluated, and it was found that YPS@AgNPs can inhibit the growth of an antibiotic-resistant bacterium, P. stutzeri B27. They enhance not only the mechanical properties but also the bactericidal ability of the water-borne acrylic resin coating.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140524540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zinc oxide-manganese oxide/carboxymethyl cellulose-folic acid-sesamol hybrid nanomaterials: A molecularly targeted strategy for advanced triple-negative breast cancer therapy 氧化锌-氧化锰/羧甲基纤维素-叶酸-芝麻酚混合纳米材料：治疗晚期三阴性乳腺癌的分子靶向策略

IF 4.3 4区工程技术

Green Processing and Synthesis Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0179

Chunming Zhao, Xueqiang Pan, Xiao Li, Meixia Li, Rui Jiang, Yuyang Li

{"title":"Zinc oxide-manganese oxide/carboxymethyl cellulose-folic acid-sesamol hybrid nanomaterials: A molecularly targeted strategy for advanced triple-negative breast cancer therapy","authors":"Chunming Zhao, Xueqiang Pan, Xiao Li, Meixia Li, Rui Jiang, Yuyang Li","doi":"10.1515/gps-2023-0179","DOIUrl":"https://doi.org/10.1515/gps-2023-0179","url":null,"abstract":"\u0000 Multifunctional nanocomposites (NC) can greatly enhance therapy outcomes by reducing tumor proliferative potential. We created a novel class of Zn_Mn_CMC_FA_sesamol NC in the current work to combat breast cancer (MDA-MB-231) cells. To understand how zinc (Zn), manganese (Mn), carboxymethylcellulose, and folic acid (FA) interact with sesamol, UV-Visible spectrophotometer and Fourier Transform Infrared spectroscopy were used to analyze the absorption behavior of the synthesized NC. The particle size of NC was confirmed by X-ray diffraction and dynamic light scattering. Scanning electron microscopy was used to assess the morphological features of these NCs. photoluminescence spectrum was used to analyze the optical and electron transition molecules of the sample. In addition to MTT analysis, acridine orange/ethidium bromide (AO/EtBr) analysis of reactive oxygen species (ROS) and nuclear staining with 4′,6-diamidino-2-phenylindole as well as flow cytometry were used to confirm the apoptotic activity of Zn_Mn_CMC_FA_sesamol NC on MDA-MB-231 cells. The results showed significant cytotoxicity, apoptosis induction on AO/EtBr, and increased ROS production in treated cells compared to control cells. The cell cycle analysis revealed that NCs triggered apoptosis and arrested the cell cycle in G0/G1 phases. As a conclusion, the created NC serves as a versatile platform for the successful molecularly targeted chemotherapeutic treatment of cancer.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140525757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ascorbic acid-mediated selenium nanoparticles as potential antihyperuricemic, antioxidant, anticoagulant, and thrombolytic agents 抗坏血酸介导的硒纳米粒子作为潜在的抗高尿酸血症、抗氧化、抗凝血和溶栓药物

IF 4.3 4区工程技术

Green Processing and Synthesis Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0158

Muhammad Aamir Ramzan Siddique, Muhammad Aslam Khan, Syed Ali Imran Bokhari, Muhammad Ismail, Khurshid Ahmad, H. A. Haseeb, Mustafa Mubin Kayani, Suleman Khan, Nafeesa Zahid, Sher Bahadar Khan

{"title":"Ascorbic acid-mediated selenium nanoparticles as potential antihyperuricemic, antioxidant, anticoagulant, and thrombolytic agents","authors":"Muhammad Aamir Ramzan Siddique, Muhammad Aslam Khan, Syed Ali Imran Bokhari, Muhammad Ismail, Khurshid Ahmad, H. A. Haseeb, Mustafa Mubin Kayani, Suleman Khan, Nafeesa Zahid, Sher Bahadar Khan","doi":"10.1515/gps-2023-0158","DOIUrl":"https://doi.org/10.1515/gps-2023-0158","url":null,"abstract":"\u0000 Selenium (Se) is an important trace element that is involved in controlling oxidative stress and inflammatory disorders. Gouty arthritis is the inflammation and pain within the joints and tissues caused due to the accumulation of monosodium urate (MSU) crystals. This study aimed to investigate the antigout, antioxidant, anticoagulant, and thrombolytic potential of ascorbic acid-mediated Se nanoparticles (A-SeNPs). Different analytical techniques were used to investigate the formation of A-SeNPs. The antigout potential of the nanoparticles was carried out using MSU crystal dissolution, uric acid (UA) degradation assay, and xanthine oxidase inhibition (XOI). A-SeNPs exhibited excellent antihyperurecemic activity in a concentration-dependent manner. It was observed that at the tested concentration of 20 mg·mL−1, the A-SeNPs demonstrated significant breakage and dissolution of MSU crystals and resulted in UA degradation of 67.76%. Similarly, A-SeNPs resulted in 76% XOI with an excellent IC50 of 140 µg·mL−1. Furthermore, considerable antioxidant activity was noted for the A-SeNPs as evaluated with multiple antioxidant assays. Finally, the NPs were found to have significant anticoagulant and thrombolytic potential. Thus, it was concluded that A-SeNPs have potent antihyperuricemic, antioxidant, anticoagulant, and thrombolytic activities, making them an ideal choice for future biomedical applications.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140516280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0