6-(4-(丁胺)-6-(二乙胺)-1,3,5-三嗪-2-基)氧吡啶衍生物的超声辅助绿色合成及硅研究

IF 3.8 4区工程技术 Q2 CHEMISTRY, MULTIDISCIPLINARY

Green Processing and Synthesis Pub Date : 2023-01-01 DOI:10.1515/gps-2023-0088

Tiruhi Gomktsyan, Angelina Khachatryan, Diana Avakyan, Lernik Hunanyan, Roza Shainova, Armen Karapetyan, Emma Ghazaryan, Asya Vorskanyan, Margarita Dovlatyan, Yana Gharibyan, Aleksandr Yengoyan, Vergush Pivazyan

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引用次数: 0

摘要

摘要采用超声波辅助合成了一系列3- N -取代的6-((4-(丁胺)-6-(二乙基胺)-1,3,5-三嗪-2-基)氧)吡啶嗪-3(2h)-1衍生物，并对其生物活性进行了预测。测定了其理化性质和药动学性质。计算吸收、分布、代谢、排泄和毒性特性及生物利用度指数。基于谷本系数对结构相似性进行了比较分析。

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Ultrasound-assisted green synthesis and in silico study of 6-(4-(butylamino)-6-(diethylamino)-1,3,5-triazin-2-yl)oxypyridazine derivatives

Abstract Eco-friendly ultrasound-assisted synthesis of a series of 3- N -substituted 6-((4-(butylamino)-6-(diethylamino)-1,3,5-triazin-2-yl)oxy)pyridazin-3(2 H )-one derivatives and in silico study to predict their biological activities were carried out. Physicochemical and pharmacokinetic properties were obtained. Absorption, distribution, metabolism, excretion and toxicity properties and bioavailability index were calculated. A comparative analysis of structural similarity based on the Tanimoto coefficient was carried out.

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来源期刊

Green Processing and Synthesis CHEMISTRY, MULTIDISCIPLINARY-ENGINEERING, CHEMICAL

CiteScore

6.70

自引率

9.30%

发文量

审稿时长

7 weeks

期刊介绍： Green Processing and Synthesis is a bimonthly, peer-reviewed journal that provides up-to-date research both on fundamental as well as applied aspects of innovative green process development and chemical synthesis, giving an appropriate share to industrial views. The contributions are cutting edge, high-impact, authoritative, and provide both pros and cons of potential technologies. Green Processing and Synthesis provides a platform for scientists and engineers, especially chemists and chemical engineers, but is also open for interdisciplinary research from other areas such as physics, materials science, or catalysis.