GMS Hygiene and Infection Control最新文献

{"title":"Assessment of the knowledge of healthcare workers on monkeypox in Nigeria.","authors":"Uche Eze, Nnenna Okafor, Gerald Ozota, Kelechi Nworie, Christian Asogwa, Ifeanyi Richard, Ann-Pearl Ilochonwu, Samuel Ezeasor, Chineye Okorie, Kenechukwu Ben-Umeh, Adaeze Ezeh, Mercy Aboh, Abdulmuminu Isah","doi":"10.3205/dgkh000493","DOIUrl":"10.3205/dgkh000493","url":null,"abstract":"<p><strong>Background: </strong>Monkeypox, a re-emerging zoonotic disease caused by the monkeypox virus (MPXV), poses a public health challenge in Nigeria. To effectively combat this disease, it is essential to assess the knowledge of healthcare workers (HCWs) in Nigeria concerning monkeypox outbreak.</p><p><strong>Methods: </strong>A cross-sectional web-based survey with 609 healthcare workers in Nigeria was conducted using a structured questionnaire to assess their knowledge of monkeypox. Data were coded and analyzed with Microsoft Excel and Python in Anaconda Jupyter Notebook.</p><p><strong>Results: </strong>The majority of respondents (n=318, 52.2%) had good knowledge of MPXV but also had knowledge gaps regarding certain symptoms and disease similarities. Interestingly, respondents were completely unaware of the possibility of sexual transmission of the disease. However, they recognized the possible significant impact of monkeypox on the social and economic lifestyle of Nigerians (n=582, 95.6%, adjOR=21.181, 95% CI: 14.450-31.051). Respondents had mixed knowledge regarding the use of smallpox vaccines and antiviral agents for monkeypox prevention and treatment. Furthermore, a significant proportion (n=526, 86.4%, adjOR=0.159, 95% CI: 0.126-0.201) attributed the outbreak to bioterrorism. The logistic regression highlighted a strong influence of academic qualification, type of healthcare provider, years of experience, and geopolitical zone of practice, on monkeypox knowledge in Nigeria.</p><p><strong>Conclusion: </strong>The study highlights the importance of continuous education for healthcare professionals in Nigeria to improve monkeypox outbreak management. Despite their moderate performance, there are knowledge gaps in critical areas among HCWs, necessitating further research to explore reasons and influencing factors for knowledge levels.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc38"},"PeriodicalIF":1.7,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virucidal activity of chlorine dioxide in combination with acetic acid or citric acid and a surfactant, in presence of interfering substances, against polio-, adeno- and murine norovirus in suspension-, carrier- and four-field tests.","authors":"Patryk Tarka, Arkadiusz Chruściel, Wiesław Hreczuch, Krzysztof Kanecki, Aneta Nitsch-Osuch","doi":"10.3205/dgkh000492","DOIUrl":"10.3205/dgkh000492","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to investigate whether the virucidal effectiveness of chlorine dioxid against adenovirus and murine norovirus can be improved by combining it with carboxylic acids and surfactants.</p><p><strong>Method: </strong>The virucidal efficacy against polio-, adeno- and murine norovirus has been tested in presence of interfering substances in the quantitative suspension test according to EN 14476, the carrier test without mechanical action according to EN 16777, and in the four-field test according to EN 16615.Three chlorine-dioxide-based surface disinfectants were tested: a two-component cleaning disinfectant concentrate for large surfaces, a ready-to-use (RTU) foam, and an RTU gel.</p><p><strong>Results: </strong>Cleaning and disinfecting preparations based on chlorine dioxide, applied at various concentrations, in combination with acetic acid or citric acid and surfactants, are virucidally active against polio-, adeno-, and norovirus after an exposure time of 5 minutes in presence of interfering substances.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc37"},"PeriodicalIF":1.7,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secapin: a promising antimicrobial peptide against multidrug-resistant Acinetobacter baumannii.","authors":"Zohreh Sadeghi Rad, Mahnaz Farahmand, Mahsa Kavousi","doi":"10.3205/dgkh000491","DOIUrl":"10.3205/dgkh000491","url":null,"abstract":"<p><strong>Introduction: </strong><i>Acinetobacter baumannii</i>, renowned for its exceptional multidrug resistance and its role as a prevalent nosocomial pathogen, poses a formidable challenge to conventional antibiotic therapies. The primary objective of this investigation was to evaluate the efficacy of Secapin, an antimicrobial peptide, against multidrug-resistant (MDR) <i>baumannii</i>. Furthermore, the mechanisms underlying Secapin's antibacterial and antibiofilm activities were elucidated.</p><p><strong>Methods: </strong>The antimicrobial and antibiofilm effectiveness of Secapin against MDR <i>A. baumannii</i> was assessed through a series of experiments. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of Secapin were determined using established protocols. Time-kill kinetic analysis was performed to assess the concentration-dependent bactericidal effect of Secapin. Additionally, the capacity of Secapin to impede biofilm formation and eradicate <i>A. b</i> <i>aumannii</i> biofilms was investigated. Hemolytic potential was evaluated using human red blood cells, while mammalian cell viability was examined at varying Secapin concentrations.</p><p><strong>Results: </strong>Secapin exhibited robust bactericidal activity at minimal concentrations, with an MIC of 5 µg/mL and an MBC of 10 µg/mL against MDR <i>A. baumannii</i>. The time-kill kinetic analysis confirmed the concentration-dependent efficacy of Secapin in diminishing bacterial viability. Moreover, Secapin demonstrated the ability to prevent biofilm formation and eliminate established <i>A. baumannii</i> biofilms. Notably, Secapin exhibited no hemolytic activity and preserved mammalian cell viability up to a concentration of 100 µg/mL.</p><p><strong>Conclusion: </strong>These findings underscore the substantial potential of Secapin as a potent agent against multidrug-resistant <i>A. baumannii</i>, showcasing its efficacy in both antibacterial and antibiofilm capacities. The favorable attributes of Secapin, characterized by its minimal hemolytic effects and high mammalian cell viability, position it as a promising contender in the fight against antibiotic resistance.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc36"},"PeriodicalIF":1.7,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric analysis of publication trends on ocular hygiene and infections in the past two decades.","authors":"Mohsan Ali, Bisal Naseer, Rawal Alias Insaf Ahmed, Muhammad Talha, Moeez Saqib, Amar Anwar","doi":"10.3205/dgkh000489","DOIUrl":"10.3205/dgkh000489","url":null,"abstract":"<p><strong>Background: </strong>Ocular hygiene encompasses a spectrum of measures to initiate and maintain adequate ocular cleanliness to prevent eye infections and their further transmission. These infections affect all age groups and can lead to severe complications such as blindness. Nearly 1 billion cases could have been prevented out of over 2.2 billion people that are visually impaired worldwide. This bibliometric analysis focuses on the papers published on ocular hygiene and infections.</p><p><strong>Methods: </strong>We searched in the Scopus database from 2004 to 2024. After manual screening, a list of the 100 most-cited original articles was obtained, which was analysed for various factors, including temporal trends, subject areas, authorship patterns, country of origin, funding bodies, etc.</p><p><strong>Results: </strong>There has been a gradual decline over the past two decades in the number of publications. The United States was affiliated with the highest number of publications (n=61), followed by The United Kingdom (n=12) and Gambia (n=8). Several authors had 4 or more publications, with the highest number of publications by Rouse, B. T. (n=14). The American Journal of Ophthalmology takes the lead with 15 publications, while the National Eye Institute (n=23) was the leading funding body. Examination of institutional contributions shows that The University of Tennessee, Knoxville and UT College of Veterinary Medicine stand out with twelve publications each. Nearly half the publications belong to the field of medicine. However, significant publications also come from the fields Neuroscience, Microbiology and Immunology, Biochemistry, Genetics and Molecular Biology, etc. These findings highlight that there is great potential to conduct research to propagate ocular hygiene to prevent adverse effects of infections.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc34"},"PeriodicalIF":1.7,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11238425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of methicillin sensitive and resistant Staphylococcus aureus carriage among German emergency medical providers.","authors":"Aaron Weiss, Axel Kramer, Robert Taube, Frauke Mattner, Katrin Premke","doi":"10.3205/dgkh000490","DOIUrl":"10.3205/dgkh000490","url":null,"abstract":"<p><strong>Background: </strong>Health care workers (HCW) in Emergency Medical Services (EMS) frequently come into contact with carriers of methicillin-susceptible <i>Staphylococcus</i> <i>aureus</i> (MSSA) and methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) strains and may acquire and transmit them to patients. However, there is little data on MSSA and MRSA colonization of medical personnel in the emergency services. Additionally, few studies have analyzed the association between personal hygiene of staff and colonization. Therefore, we examined the prevalence of MSSA and MRSA in EMS staff of two German regions and evaluated their personal hygiene behavior.</p><p><strong>Method: </strong>Throat and nasal swabs from 300 EMS workers were analyzed. Both direct and pre-enriched cultures of the swabs were cultivated on culture media to identify MSSA and MRSA. Results were analyzed together with questionnaires about sociodemographic data and a self-assessment of hygiene behavior. Statistical analysis was done using the R statistical software.</p><p><strong>Results: </strong>Of the total 300 swabs, 55% were from paramedics, 39% were from emergency medical technicians (EMT) and 5% were from emergency physicians. With 1%, the MRSA prevalence was comparable to that of the German population, while the MSSA rate - 43.7% - was higher than expected. Colonization with MSSA was significantly associated with poor hand hygiene and male sex, and was inversely correlated to time on the job in EMS.</p><p><strong>Conclusion: </strong>The sample size of 300 and a MRSA prevalence of 1% made a meaningful analysis of potential influencing factors on the prevalence of MRSA infeasible. The comparatively high prevalence of MSSA and the association with decreasing frequency of hand antisepsis suggests an influence of personal hygiene on MSSA colonization. HCW in EMS should be encouraged to make use of their personal protective equipment and practice frequent hand hygiene. The implementation of diagnostic tools such as the Hand Hygiene Self-Assessment Framework of the WHO could be utilized to reveal problems in organizations, followed by an individual program to promote hand hygiene.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc35"},"PeriodicalIF":1.7,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11238403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can toothbrushing reduce the intraoral viral load of SARS-CoV-2? A pilot study with a dentifrice containing an antimicrobial phthalocyanine derivative.","authors":"Marcelo Lupion Poleti, Danielle Gregório, Alisson Gabriel Idelfonso Bistaffa, Fabiano Vieira Vilhena, Andréa Name Colado Simão, Mayara Tiemi Enokida Mori, Nicole Perugini Stadtlober, Marcell Alysson Batisti Lozovoy, Paulo Sérgio da Silva Santos, Berenice Tomoko Tatibana, Thais Maria Freire Fernandes","doi":"10.3205/dgkh000487","DOIUrl":"10.3205/dgkh000487","url":null,"abstract":"<p><p>The aim of this study was to assess whether toothbrushing with a dentifrice containing an antimicrobial phthalocyanine derivative (APD) can reduce the intraoral viral load of SARS-CoV-2. Twenty COVID-19-positive dentate patients aged ≥18 years were selected instructed to brush their teeth for 2 min with a dentifrice containing APD. Self-collected samples of unstimulated saliva were carried out three times: T0 (baseline), T5 (5 min after toothbrushing), and T30 (30 min after toothbrushing). The analysis of viral RNA was performed by RT-qPCR for detection of three viral genes (ORF1ab, N and S genes). Results were statistically tested using Friedman's test and pairwise comparison with Bonferroni corrections, with a significance level of 5%. There was an increase in the cycle threshold (Ct) value from T0 to T5 in 13 patients (72.2%), and from T0 to T30 in 14 patients (77.8%). In two patients (11.1%) no SARS-CoV-2 was detected at T5 and five patients (27.8%) at T30. The Ct values were statistically significantly higher (p=0.020) at T30 in comparison to T0 and T5. This pilot study suggests that toothbrushing with a dentifrice containing APD could reduce the SARS-CoV-2 viral load in the oral cavity. However, further studies are needed to confirm this possible beneficial effect against SARS-CoV-2.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc32"},"PeriodicalIF":1.7,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11238404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective manual cleaning as the first step of reprocessing glass probes of a medical device for non-invasive physical plasma therapy.","authors":"Roland Röcker, Benedikt Eggers, Axel Kramer, Matthias B Stope","doi":"10.3205/dgkh000486","DOIUrl":"10.3205/dgkh000486","url":null,"abstract":"<p><strong>Background: </strong>For reusable devices and device components, effective reprocessing is essential to prevent nosocomial infections.</p><p><strong>Aim: </strong>The objective of the study was to evaluate manual cleaning as the first step of reprocessing reusable glass probes of a device for generation of non-invasive physical plasma, in accordance with regulations.</p><p><strong>Methods: </strong>Two glass probes of the device were contaminated with human blood. For manual cleaning, both probes were cleaned with instrument cleaning agent and instrument brushes. Cleaning efficacy was evaluated by total protein measurement in the rinsing solution.</p><p><strong>Results: </strong>After manual cleaning of the two test glass probes, no protein from the test contamination with human blood could be detected. Neither the different design of the two probes nor the use of a hard or a soft instrument brush demonstrated any difference.</p><p><strong>Conclusion: </strong>Our data suggest that manual cleaning of glass probes achieves complete removal of organic contaminants. This should enable safe applications in clinical practice.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc31"},"PeriodicalIF":1.7,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11238430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary ovarian hydatid cyst mimicking cyst adenoma: a rare case report.","authors":"Ensiyeh Bahadoran, Fatemeh Samieerad, Simindokht Molaverdikhani, Saeideh Gholamzadeh Khoei","doi":"10.3205/dgkh000488","DOIUrl":"10.3205/dgkh000488","url":null,"abstract":"<p><strong>Background: </strong>Hydatid cysts (HC) are zoonotic diseases that are mainly caused by <i>Echinococcus granulosus</i>. Ovarian HC is a rare condition with different and unspecified presentations. Here we report a rare case of primary ovarian HC.</p><p><strong>Case presentation: </strong>A 47-year-old woman with chronic abdominal pain and left hemipelvic fullness was referred to the Obstetrics Clinic of the Kowsar Hospital of Qazvin. Abdominopelvic sonography revealed a cystic mass, which primarily suggested a cyst adenoma. The tumor marker levels were within normal limits. After surgical resection, histopathological examination showed a cystic mass with dimensions of 10×6×3 cm, smooth external and internal aspects, wall thickness of 0.3 cm, and multiple pieces of irregular gray membranous tissue. The patient was treated with albendazole 3 months after surgery, and a 6-month follow-up sonogram revealed no signs of recurrence.</p><p><strong>Discussion: </strong>HC has non-specific presentations. Radiologists, pathologists, and surgeons should consider HC as a differential diagnosis for any cystic mass in the pelvic cavity, especially in endemic areas. Surgical resection and albendazole administration are the chosen treatments.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc33"},"PeriodicalIF":1.7,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11238422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of stethoscope disinfection: an observational study on nursing staff practice and knowledge.","authors":"Seda Şahan, Sevil Güler, Emine Korkmaz","doi":"10.3205/dgkh000485","DOIUrl":"10.3205/dgkh000485","url":null,"abstract":"<p><strong>Background: </strong>Healthcare-associated infections cause high mortality and morbidity, and lack of stethoscope disinfection is one of the reasons for healthcare-associated infections. Nurses who frequently use stethoscopes in the clinic do not disinfect stethoscopes at high rates. This study aimed to identify the frequency of stethoscope disinfection by nurses and their knowledge about the same.</p><p><strong>Methods: </strong>This was a mixed-methods observational study. The quantitative part of the study included 202 nurses, the qualitative part included 12. Two researchers who made observations during stethoscope use recorded the procedures the nurses performed on the \"Observation Form\". Semi-structured in-depth interviews were conducted based on phenomenological methods.</p><p><strong>Results: </strong>23.7% of the nurses disinfected their stethoscopes before contact with patients, 11.8% after contact with patients and 6.4% before and after contact with patients. The nurses used a stethoscope on an average of 7.42 patients without disinfecting it. In the qualitative interview, some nurses stated that they did not have information about the disinfectants to be used for stethoscopes and their effectiveness. Some of the participants in the present study stated that they did not receive training on stethoscope disinfection and that they did not know that there were guidelines about it.</p><p><strong>Conclusion: </strong>Since there were deficiencies in the implementation of stethoscope disinfection as well as knowledge, the transfer of knowledge in this context must receive more attention in education and training.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc30"},"PeriodicalIF":3.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11177224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of side effects of antituberculosis drugs and their related factors in northern Iran: a retrospective cohort study.","authors":"Motahareh Kheradmand, Mahdi Afshari, Mohsen Aarabi, Siavosh Abedi, Mohammadreza Parsaee, Asghar Nezammahalleh, Mahmood Moosazadeh","doi":"10.3205/dgkh000482","DOIUrl":"10.3205/dgkh000482","url":null,"abstract":"<p><strong>Background: </strong>Antituberculosis drugs may cause mild, moderate or severe adverse drug reactions (ADR) leading to poor compliance. Description of the pattern of ADR and their related factors can help tuberculosis (TB) control program as part of the WHO programs. This study aims to investigate the incidence of ADR and associated factors among TB patients in northern Iran.</p><p><strong>Methods: </strong>This is a retrospective cohort study. The required information, including year of diagnosis, age, gender, residence area, nationality, HIV co-morbidity, history of anti TB treatment and ADR, was obtained from the Deputy of Health, Mazandaran University of Medical Sciences, Iran. All data were analyzed using SPSS version 21 software.</p><p><strong>Results: </strong>Out of 3903 TB patients, 136 (3.5%) experienced major ADR. The incidence of ADR for men and women as well as for those with and without previous treatment history were 3.9% vs. 3.3% and 5.3% vs. 3.4%, respectively (p>0.05). Multiple logistic regression models showed a higher chance of ADR among those aged over 59 compared with those aged under 29 (OR=2.63, 95% confidence interval: 1.54-4.49).</p><p><strong>Conclusions: </strong>Age over 59 can be considered a risk factor for ADR with anti-TB drug administration.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc27"},"PeriodicalIF":3.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11177222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141332900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}