genesis最新文献

{"title":"Mechanisms of self-incompatibility in ascidians","authors":"Takako Saito","doi":"10.1002/dvg.23556","DOIUrl":"10.1002/dvg.23556","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41138233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giuseppina Ortolani (1951–2009): A “grande dame” in ascidian embryology","authors":"Fiorenza De Bernardi","doi":"10.1002/dvg.23559","DOIUrl":"10.1002/dvg.23559","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41167065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor dormancy: EMT beyond invasion and metastasis","authors":"Patrick Aouad,&nbsp;Hazel M. Quinn,&nbsp;Adeline Berger,&nbsp;Cathrin Brisken","doi":"10.1002/dvg.23552","DOIUrl":"10.1002/dvg.23552","url":null,"abstract":"<p>More than two-thirds of cancer-related deaths are attributable to metastases. In some tumor types metastasis can occur up to 20 years after diagnosis and successful treatment of the primary tumor, a phenomenon termed late recurrence. Metastases arise from disseminated tumor cells (DTCs) that leave the primary tumor early on in tumor development, either as single cells or clusters, adapt to new environments, and reduce or shut down their proliferation entering a state of dormancy for prolonged periods of time. Dormancy has been difficult to track clinically and study experimentally. Recent advances in technology and disease modeling have provided new insights into the molecular mechanisms orchestrating dormancy and the switch to a proliferative state. A new role for epithelial-mesenchymal transition (EMT) in inducing plasticity and maintaining a dormant state in several cancer models has been revealed. In this review, we summarize the major findings linking EMT to dormancy control and highlight the importance of pre-clinical models and tumor/tissue context when designing studies. Understanding of the cellular and molecular mechanisms controlling dormant DTCs is pivotal in developing new therapeutic agents that prevent distant recurrence by maintaining a dormant state.</p>","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvg.23552","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41135064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two Ciona sister species are not just complex, but wonderful: A study of maternal mRNAs to safeguard life on earth","authors":"Atsuko Sato","doi":"10.1002/dvg.23555","DOIUrl":"10.1002/dvg.23555","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41160085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidences of differential methylation in the genome during development in the cactophilic Drosophila species","authors":"Adriano S. Santos,&nbsp;Ester S. Ramos,&nbsp;Vera L. S. Valente-Gaiesky,&nbsp;Fábio de Melo Sene,&nbsp;Maura H. Manfrin","doi":"10.1002/dvg.23554","DOIUrl":"10.1002/dvg.23554","url":null,"abstract":"<div>\u0000 \u0000 <p>DNA methylation with 5-methylcytosine (5mC) has been reported in the genome of several eukaryotes, with marked differences between vertebrates and invertebrates. DNA methylation is poorly understood as its role in evolution in insects. <i>Drosophila gouveai</i> (cluster <i>Drosophila buzzatii</i>) presents larvae that develop obligatorily in necrotic tissues of cacti in nature, with the distribution of populations in South America, and plasticity of phenotypes in insect–plant interaction. We characterize organisms at developmental stages and analyze variations at multiple methylation-sensitive <i>loci</i> in pupae, and adult flies using methylation sensitive amplification polymorphism. We obtained 326 <i>loci</i> with CCGG targets in the genome of <i>D. gouveai</i>. Genomic regions with molecular lengths from 100 to 700 pb were most informative about methylation states. Multiple <i>loci</i> show differences in methylation-sensitive sites (MSL) concerning developmental stages, such as in pupae (MSL = 40), female reproductive tissue (MSL = 76), and male reproductive tissues (MSL = 58). Our results are the first evidence of genome-wide methylation in <i>D. gouveai</i> organisms.</p>\u0000 </div>","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41149647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A long and winding but exciting road: Biodiversity, phylogenetic, and biogeographic relationships of ascidians in the Southwest Atlantic","authors":"M. Carla de Aranzamendi","doi":"10.1002/dvg.23551","DOIUrl":"10.1002/dvg.23551","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41155241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The story of my research with ascidians","authors":"Fiorenza De Bernardi","doi":"10.1002/dvg.23550","DOIUrl":"10.1002/dvg.23550","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41148568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"V. K. Meenakshi: The first lady of ascidian research in India. Active: 1994–present","authors":"Jhimli Mondal","doi":"10.1002/dvg.23547","DOIUrl":"10.1002/dvg.23547","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41173881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Beyond transcription: How post-transcriptional mechanisms drive neural crest EMT”","authors":"Mariann Guzman-Espinoza,&nbsp;Minyoung Kim,&nbsp;Cindy Ow,&nbsp;Erica J. Hutchins","doi":"10.1002/dvg.23553","DOIUrl":"10.1002/dvg.23553","url":null,"abstract":"<p>The neural crest is a stem cell population that originates from the ectoderm during the initial steps of nervous system development. Neural crest cells delaminate from the neuroepithelium by undergoing a spatiotemporally regulated epithelial-mesenchymal transition (EMT) that proceeds in a coordinated wave head-to-tail to exit from the neural tube. While much is known about the transcriptional programs and membrane changes that promote EMT, there are additional levels of gene expression control that neural crest cells exert at the level of RNA to control EMT and migration. Yet, the role of post-transcriptional regulation, and how it drives and contributes to neural crest EMT, is not well understood. In this mini-review, we explore recent advances in our understanding of the role of post-transcriptional regulation during neural crest EMT.</p>","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvg.23553","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41171052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Signals, grids, and geometry: In pursuit of understanding cell fate switches","authors":"Clare Hudson","doi":"10.1002/dvg.23546","DOIUrl":"10.1002/dvg.23546","url":null,"abstract":"&lt;p&gt;After a degree in Biology at the University of Nottingham in the early 90s, I studied for a PhD focusing on frog endoderm formation with Prof. Hugh Woodland at the University of Warwick (Hudson et al., &lt;span&gt;1997&lt;/span&gt;). When I was looking for a lab to do postdoctoral studies, I was undecided whether to continue with &lt;i&gt;Xenopus&lt;/i&gt; or switch to a different system. My fate was sealed at a postdoc interview with Patrick Lemaire at the IBDM in Marseille when I caught his enthusiasm for ascidian embryos, although at that time his lab was still working only with &lt;i&gt;Xenopus&lt;/i&gt;. I accepted the challenge to help him establish ascidians as a model in the lab, but with hindsight I was a little naive, not realizing how much of a challenge it was going to be! During this period, we were fortunate to also have help from experienced ascidian embryologists Hitoyoshi Yasuo and Sébastien Darras. What attracted me most about ascidian embryos, as a developmental biologist, was the invariant cell division pattern and lineage, which is extremely useful, as it allows one to identify and name the same cell in every embryo and thus to know the embryonic origin and eventual fate of cells as they progress through each developmental transition. In that pre-genomic era, I started off looking for homologues of vertebrate regulatory genes using degenerate PCR. A breakthrough came when I isolated a couple of genes expressed in neural tissue (&lt;i&gt;Otx&lt;/i&gt; and &lt;i&gt;Gsx&lt;/i&gt;) and the next step of my adventure with ascidians began. In Patrick's lab, I focused mainly on neural induction in ectoderm cells (“brain” induction) and the role of the FGF-ERK signaling pathway, work which contributed to a more molecular understanding of this process (Hudson &amp; Lemaire, &lt;span&gt;2001&lt;/span&gt;). In 2003, I became a staff scientist of the Centre National de Recherche Scientifique (CNRS), joining the “Cell Fate” team led by Hitoyoshi Yasuo (“Yas”) in the Laboratoire de Biologie du Développement de Villefranche-sur-mer (LBDV).&lt;/p&gt;&lt;p&gt;My studies were greatly inspired by beautiful descriptions from the laboratory of Dr. Ian Meinertzhagen, showing the regular grid-like organization of the developing neural plate and the ordered pattern of neural plate cell divisions (Nicol &amp; Meinertzhagen, &lt;span&gt;1988&lt;/span&gt;). These neural plate maps helped us show that each neural plate cell is characterized by a unique gene expression profile (Esposito et al., &lt;span&gt;2016&lt;/span&gt;; Hudson et al., &lt;span&gt;2007&lt;/span&gt;; Hudson &amp; Lemaire, &lt;span&gt;2001&lt;/span&gt;; Hudson &amp; Yasuo, &lt;span&gt;2005&lt;/span&gt;). We could then show how the neural plate is patterned across the medial-lateral axis by Nodal and Delta/Notch signals and along the anterior–posterior axis by differential ERK activity (Esposito et al., &lt;span&gt;2016&lt;/span&gt;; Haupaix et al., &lt;span&gt;2014&lt;/span&gt;; Hudson et al., &lt;span&gt;2007&lt;/span&gt;; Hudson &amp; Yasuo, &lt;span&gt;2005&lt;/span&gt;; Figure 1a). Remarkably, within each neural lineage, each precursor receives a unique combination of","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvg.23546","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10264138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}