Stem cell-mediated development, regeneration, chimerism, and aging in the colonial chordate Botryllus schlosseri.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-11-01 Epub Date: 2023-10-27 DOI:10.1002/dvg.23542

Ayelet Voskoboynik

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Abstract

Stem cells are units of biological organization, responsible for tissue and organ development and regeneration. I study stem cell biology, aging, and the evolution of immunity using the colonial chordate Botryllus schlosseri as a model system. This organism is uniquely suited for this study because it is closely related to vertebrates, undergoes weekly cycles of stem cell mediated regeneration, is long lived and has a recognition system and robust immune system. I have led the Botryllus genome project and developed a novel method to obtain a synthetic long read sequence, identified Botryllus stem cells and stem cell niches, isolated the gene that controls self/non self-recognition and characterized its immune system on the cellular and molecular levels. Recently, I led the Botryllus atlas project to characterize the two developmental pathways, embryogenesis (sexual) and blastogenesis (asexual), revealing the unique molecular landscapes for each developmental mode and investigated the molecular clock and neurodegeneration pathways in young and old colonies and investigated the molecular clock and neurodegeneration pathways in young and old colonies. These results and the resources we developed are used by my lab and others to further study stem cell and immune cell properties during development, regeneration, transplantation, and aging.

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施洛塞氏博氏脊索动物的干细胞介导的发育、再生、嵌合和衰老。

干细胞是生物组织的单位，负责组织和器官的发育和再生。我研究干细胞生物学、衰老和免疫进化，使用殖民脊索动物Botryllus schlosseri作为模型系统。这种生物特别适合这项研究，因为它与脊椎动物密切相关，每周经历干细胞介导的再生周期，寿命长，具有识别系统和强大的免疫系统。我领导了Botryllus基因组项目，并开发了一种获得合成长读序列的新方法，鉴定了Botryellus干细胞和干细胞小生境，分离了控制自我/非自我识别的基因，并在细胞和分子水平上表征了其免疫系统。最近，我领导了Botryllus图谱项目，以表征两种发育途径，胚胎发生（有性）和胚泡发生（无性），揭示了每种发育模式的独特分子景观，研究了年轻和老年群体的分子时钟和神经退行性变途径，研究了青年和老年群体中的分子时钟与神经退行性变性途径。这些结果和我们开发的资源被我的实验室和其他人用来进一步研究干细胞和免疫细胞在发育、再生、移植和衰老过程中的特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.