Global journal for research analysis最新文献

{"title":"MYASTHENIA GRAVIS IN PREGNANCY: ACHIEVING OPTIMAL OUTCOMES THROUGH PRECISION CARE – A CASE SERIES FROM SOUTH INDIA & REVIEW OF LITERATURE","authors":"Dhanya R Shenoy, N. Navakumar, Vidyalekshmy R, Brinda Sabu, Roshini Ambat, Sajitlh Mohan, Lumiya Malik, Suresh Chandran","doi":"10.36106/gjra/2506207","DOIUrl":"https://doi.org/10.36106/gjra/2506207","url":null,"abstract":"Introduction: Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder affecting skeletal\u0000muscles, particularly in women of reproductive age. Though uncommon with a prevalence of only 0.3 to\u00002.8 per 100,000, the incidence peaks during 2nd and 3rd decades of life, and can have signicant impact in pregnancy. The\u0000course of the disease in pregnancy is not entirely understood. Methodology: A retrospective case series analysis of 4 cases\u0000were carried out for a period of 5 years from 2018 in a tertiary care centre in South India to identify and describe the disease\u0000course in pregnancy and effect of disease in the pregnant women and their fetuses. From this study, we aimed to describe the\u0000disease course of MG in pregnancy and formulate an optimal management plan, learning from our experience. Results: All\u0000patients included in the study were in a state of remission prior to conception. With vigilant monitoring and collaborative\u0000multidisciplinary approach, two patients successfully carried their pregnancies to term without encountering any\u0000complications, maintaining a stable course throughout the antenatal, intrapartum, and postpartum periods. However, one\u0000patient experienced an acute exacerbation upon contracting COVID-19 category C. Subsequently, her pregnancy was\u0000complicated by late-onset fetal growth restriction, preterm premature rupture of membranes (PPROM), preterm birth and\u0000postpartum exacerbation. Despite these challenges, both maternal and fetal outcomes were favorable, attributed to\u0000meticulous surveillance and critical care interventions. Another patient experienced an exacerbation at 10 weeks of gestation\u0000but otherwise had an uneventful pregnancy, labour, and postpartum recovery. Conclusion: One third of Myasthenia gravis\u0000patients can have exacerbations in pregnancy with a small but signicant subset experiencing potentially life threatening\u0000Myasthenic crisis. All necessary precautions should be pro-actively taken to prevent factors that could trigger a myasthenic\u0000crisis, including cautious drug selection during anaesthesia and the avoidance of medications that may exacerbate MG during\u0000acute infections. Caesarean section should be for obstetric indications only. Managing myasthenia gravis in pregnancy is\u0000quite challenging and requires multidisciplinary input with close monitoring and follow up.","PeriodicalId":12664,"journal":{"name":"Global journal for research analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140456306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A CLINICO-HEMATOLOGICAL PROFILE OF MICROCYTIC HYPOCHROMIC ANEMIA IN CHILDREN: AN OBSERVATIONAL STUDY","authors":"P. C. Kalanidhi, Rakesh Rakesh, Manisha Manisha, Srujana Srujana","doi":"10.36106/gjra/6805652","DOIUrl":"https://doi.org/10.36106/gjra/6805652","url":null,"abstract":"Microcytic hypochromic anemia is anemia classication based on the morphology of anemia . The\u0000causes of microcytic hypochromic anemia may be either due to iron deciency anemia, anemia of\u0000inammation, or thalassemia. . To investigate the causes of Microcytic Hypochromic anaemia at a tertiary care centre in\u0000NALGONDA. After obtaining valid written consent, cases of microcytic hypochromic anaemia were selected from the OPD . The\u0000whole haematological and biochemical investigations were sent for anaemia workup. The study comprised 44 patients with\u0000microcytic hypochromic disorder. The study comprised subjects ranging in age from 1 TO 11 years. 42% were men and 58%\u0000were women. Anemia is not an illness in and of itself, but rather a symptom of another, hence nding the underlying cause is\u0000signicantly more important. The diagnosis of microcytic hypochromic anaemia is insufcient in the absence of an underlying\u0000cause. Special precautions will be made to determine the cause of iron decient anaemia. The thalassemia trait must also be\u0000diagnosed in order to minimise excessive iron supplementation and for family screening.","PeriodicalId":12664,"journal":{"name":"Global journal for research analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140455319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CURRENT PERSPECTIVES ON CATARACTS: A COMPREHENSIVE NARRATIVE ANALYSIS","authors":"Julian Andres León Agudelo","doi":"10.36106/gjra/8106778","DOIUrl":"https://doi.org/10.36106/gjra/8106778","url":null,"abstract":"Cataracts, a common age-related eye condition, involve the clouding of the lens, leading to visual\u0000impairment. Various risk factors, such as age, smoking, sunlight exposure, and metabolic syndrome,\u0000contribute to cataract development. Epidemiological studies explore associations between cataracts and systemic conditions\u0000like diabetes, metabolic syndrome, and HIV. Surgical interventions, specically cataract extraction, are standard treatments,\u0000with factors like surgeon experience inuencing outcomes. Postoperative complications, such as endophthalmitis and\u0000hemorrhagic occlusive retinal vasculitis, are critical considerations. Intraocular lens choices, antibiotics, and prophylactic\u0000measures impact surgical success. Beyond surgery, lifestyle factors like smoking cessation, dietary patterns, and lead exposure\u0000may inuence cataract progression. Emerging areas of research include the impact of cataract surgery on comorbid conditions\u0000like macular degeneration.","PeriodicalId":12664,"journal":{"name":"Global journal for research analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140455486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A STUDY ON THE PREDICTORS OF MORTALITY IN ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE USING DYSPNEA, EOSINOPENIA, CONSOLIDATION, ACIDEMIA AND ATRIAL FIBRILLATION SCORE (DECAF)IN A TERTIARY CENTRE.","authors":"Ramdhan Somani, S. Khangarot, Anish Mittal, Qazi Faizanul Haque, Vishnu Ms, Roshni Mary Prince","doi":"10.36106/gjra/2305976","DOIUrl":"https://doi.org/10.36106/gjra/2305976","url":null,"abstract":"Introduction Chronic Obstructive Pulmonary Disease (COPD) has emerged as one of the primary causes\u0000of death globally with 90% of fatalities occurring in low- and middle-income countries. It is an enormous\u0000economic and social burden, with high morbidity and mortality. The DECAF score, a simple tool regularly employed by\u0000clinicians, is a predictive measure for in-hospital mortality and can be conveniently applied at the bedside for risk stratication\u0000during Acute Exacerbations of COPD (AECOPD). Material And Methods: A cross-sectional observational study was\u0000conducted involving 100 patients, aged between 40 and 82 years, with a mean age of 60, who presented to the OP and IP of the\u0000Department of Respiratory Medicine. Participants who met the inclusion criteria with a diagnosis of COPD were evaluated and\u0000their data was collected. Subsequently, a DECAF score was assigned to each patient. The study then observed in-hospital\u0000mortality and conducted a comparative analysis of the characteristics between survivors and non-survivors. Results: The study\u0000included 100 conrmed cases of COPD, ranging from 40 to 82 years old, with a mean age of 60.66 years. A male predominance\u0000was noted, as there were 77 males and 23 females in the study. An increase in the DECAF score corresponded to a higher\u0000utilization of ventilation. In the low-risk group (DECAF 0-1), only one patient required mechanical ventilation, while in the\u0000intermediate-risk group, 1 (6.25%) patient and in the high-risk group, 14 (87.5%) patients required mechanical ventilation.\u0000Conclusion: In patients admitted with acute exacerbation of COPD, the DECAF score is a benecial clinical tool for in-hospital\u0000prognosis. Assessing the DECAF score after admission due to AECOPD aids in decisions regarding early escalation of care,\u0000therapeutic interventions, evaluating the necessity for ICU admissions, determination of the need for assisted ventilation,\u0000decision-making in end-of-life care, and provides valuable information to clinicians for informing patients and relatives about\u0000life-threatening risks associated with exacerbation.","PeriodicalId":12664,"journal":{"name":"Global journal for research analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140455579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NEUROLOGICAL DISORDERS IN PREGNANCY AND POSTPARTUM PERIOD: AN INSTITUTIONAL EXPERIENCE","authors":"Sucheta Rajput, Dinesh Kumar Rajput, Vijendra Maurya","doi":"10.36106/gjra/2405890","DOIUrl":"https://doi.org/10.36106/gjra/2405890","url":null,"abstract":"Neurological disorders contribute signicantly, if they are present in pregnancy and postpartum period.\u0000They not only affect maternal mortality but also affect infant mortality rate. We had conducted prospective\u0000study for 02 years to know epidemiology of different neurological disease in this period and their presentation, imaging features\u0000and outcome.","PeriodicalId":12664,"journal":{"name":"Global journal for research analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140456040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF DISABILITY AND FUNCTIONING IN WOMEN WITH LOW-RISK PREGNANCY USING WORLD HEALTH ORGANISATION DISABILITY ASSESSMENT SCHEDULE 2.0 (WHODAS 2.0)","authors":"Nupur Gupta, Shipra Raj Verma, Nausheen Anis","doi":"10.36106/gjra/2806172","DOIUrl":"https://doi.org/10.36106/gjra/2806172","url":null,"abstract":"WHO developed questionnaire to quantify the level of disability and functioning called World Health\u0000Organisation Disability Assessment Schedule 2.0 36 item score (WHODAS 2.0) on background of ICF\u0000(International Classication of functioning and disability) It has six domains cognition, mobility, selfcare, getting along, life\u0000activities and participation. Each domains have variable number of questions and a score from 1 to 5 corresponding to none,\u0000mild, moderate, severe and extreme. Our objective was to evaluate disability and functioning in low-risk pregnancy using\u0000WHODAS 2.0, 36 item score in late second and third trimesters. The study was prospective observational cohort study on women\u0000with low-risk singleton pregnancy in late second and third trimester using World Health Organisation Disability Assessment\u0000Schedule 2.0, 36 item score. On comparing the scores of both trimesters and total scores statistically signicant results were\u0000obtained p value < 0.001. The rst domain cognition had signicant decrease in scores in third trimester while rest ve domains\u0000had an increase in disability in third trimester. Low risk pregnancy causes signicant reduction in functioning and increased\u0000disability than that normally perceived.","PeriodicalId":12664,"journal":{"name":"Global journal for research analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140456197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIAS AND PRE-EXCITATION SYNDROMES: COMPREHENSIVE NARRATIVE REVIEW","authors":"Camilo Andres Neisa Morales","doi":"10.36106/gjra/3207039","DOIUrl":"https://doi.org/10.36106/gjra/3207039","url":null,"abstract":"This comprehensive review explores the management of supraventricular paroxysmal tachycardias\u0000(SVTs) and preexcitation syndromes, providing a synthesis of 15 selected studies. A meticulous literature\u0000search in prominent databases guided our review, yielding 15 relevant articles. Etiology and pathogenesis, clinical\u0000manifestations, diagnostic strategies, and treatment modalities are extensively discussed. The etiology of SVTs and\u0000preexcitation involves accessory pathways, and their manifestation varies from asymptomatic cases to life-threatening\u0000arrhythmias. Diagnosis relies on electrocardiography, electrophysiological studies, and imaging. Ablation is the preferred\u0000treatment for symptomatic cases, with catheter-based procedures demonstrating efcacy. Prognosis is generally favorable,\u0000with low recurrence rates post-ablation. In conclusion, this narrative review emphasizes the signicance of tailored therapeutic\u0000approaches and the need for vigilant follow-up in SVTs and preexcitation syndromes. The wealth of evidence presented\u0000underscores the role of catheter ablation as a pivotal intervention, ensuring improved patient outcomes and highlighting the\u0000nuanced nature of these arrhythmias.","PeriodicalId":12664,"journal":{"name":"Global journal for research analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140455182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ROLE OF IMAGING IN DIAGNOSIS OF PULMONARY EMBOLISM","authors":"Abhishek Choudhury, Anjani Kumar","doi":"10.36106/gjra/6300104","DOIUrl":"https://doi.org/10.36106/gjra/6300104","url":null,"abstract":"Acute pulmonary embolism may occur rapidly and unpredictably and may be difcult to diagnose. Early\u0000detection and treatment can reduce the risk of death, and appropriate primary prophylaxis is usually\u0000effective. The current diagnostic measures for acute pulmonary embolism consist of autopsy results, clinical data, laboratory\u0000testing, and imaging studies. Clinical and laboratory diagnosis of pulmonary embolism remains arduous and the issues\u0000regarding the imaging diagnosis are many. The purpose of this article was to review the role of imaging in diagnosis of\u0000pulmonary embolism.","PeriodicalId":12664,"journal":{"name":"Global journal for research analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140455971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A STUDY ON SUSTAINABLE CSR INITIATIVES FOR QUALITY EDUCATION AT HEI'S","authors":"V. S. D. Himabindu","doi":"10.36106/gjra/9803142","DOIUrl":"https://doi.org/10.36106/gjra/9803142","url":null,"abstract":"Education is the backbone of every nation in this world. And quality education is a dream for many. The\u0000role of CSR is crucial in improving the educational condition in India especially in higher educational\u0000institutions (HEI'S) and out of this urgent need necessities the philanthropic CSR. This is an emerging concept widely accepted\u0000among all universities. Business Donations and contributions made to education are enriching the scope of quality education.\u0000Corporates should commit initiatives to contribute through CSR for sustainable developments in Higher education. CSR in\u0000universities, strengthens the education, business and Society relationships","PeriodicalId":12664,"journal":{"name":"Global journal for research analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140456090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A CASE STUDY ON THE EFFICACY OF TRANSOBTURATOR TAPE FOR THE TREATMENT OF STRESS URINARY INCONTINENCE","authors":"Shubhi Shubhi, Geeta J Doppa, Anil S Baipadithaya, R. G O, B. H U","doi":"10.36106/gjra/2706069","DOIUrl":"https://doi.org/10.36106/gjra/2706069","url":null,"abstract":"Stress urinary incontinence (SUI) has a signicant impact on\u0000the quality of life for many women, although estimates of\u0000prevalence vary widely due to inconsistencies in the\u0000denitions of SUI and differences in populations studied.[1]\u0000An estimated prevalence for urinary incontinence is nearly\u000030% in women aged 30–60 years, with approximately half of\u0000the cases attributed to SUI.[2,3] Seen in reproductive and\u0000menopausal age group women.","PeriodicalId":12664,"journal":{"name":"Global journal for research analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140456283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}