Gastroenterology and Hepatology From Bed to Bench最新文献_第7页

The possible role of viral infections in acute pancreatitis: a review of literature. 病毒感染在急性胰腺炎中的可能作用：文献综述。

Gastroenterology and Hepatology From Bed to Bench Pub Date : 2023-01-01 DOI: 10.22037/ghfbb.v16i2.2582

Behrang Sarshari, Raziyeh Zareh-Khoshchehreh, Mohsen Keshavarz, Seyed Ali Dehghan Manshadi, SeyedAhmad SeyedAlinaghi, Hamid Asadzadeh Aghdaei, Seyed Reza Mohebbi

{"title":"The possible role of viral infections in acute pancreatitis: a review of literature.","authors":"Behrang Sarshari, Raziyeh Zareh-Khoshchehreh, Mohsen Keshavarz, Seyed Ali Dehghan Manshadi, SeyedAhmad SeyedAlinaghi, Hamid Asadzadeh Aghdaei, Seyed Reza Mohebbi","doi":"10.22037/ghfbb.v16i2.2582","DOIUrl":"https://doi.org/10.22037/ghfbb.v16i2.2582","url":null,"abstract":"Acute pancreatitis, a potentially fatal disease, with symptoms including nausea and/or vomiting, indigestion, and abdominal pain, is known to range from a mild self-limiting state up to a more severe and lethal form. This review aims to provide a clearer picture to improve understanding the role of viral agents in the development of acute pancreatitis. Common databases including PubMed, Google Scholar, and Scopus were used for the literature search. In this review search terms including virus, viral, infection, and specific descriptive terms for a virus were considered in different combinations. Various causative agents are recognized in the development of acute pancreatitis as one of the most frequent gastrointestinal diseases, such as gallstones, alcoholism, and hypertriglyceridemia. Microbial pathogens with about 10% of acute pancreatitis cases, mainly viruses, among other factors, are thought to play a role in this regard. Once the pancreatitis diagnosis has been made, depending on the causative agent, the management approach and specific interventions affect the final outcome. Virus-induced acute pancreatitis in patients should be considered. Advanced diagnostic tests such as PCR, in situ hybridization, and biopsy can help for a better understanding of the role of viruses in causing acute pancreatitis. Improvement in the tests will lead to timely diagnosis, treatment, and better management of pancreatitis.","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"16 3","pages":"270-281"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/99/e0/GHFBB-16-270.PMC10520394.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41112062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel stop codon mutation in STK11 gene is associated with Peutz-Jeghers Syndrome and elevated cancer risk: a case study. STK11基因中一种新的终止密码子突变与Peutz-Eghers综合征和癌症风险升高有关：一项病例研究。

Gastroenterology and Hepatology From Bed to Bench Pub Date : 2023-01-01 DOI: 10.22037/ghfbb.v16i2.2751

Binazir Khanabadi, Diba Najafgholizadeh Seyfi, Leili Rejali, Mohammad Yaghoob Taleghani, Mehdi Tavallaei, Shabnam Shahrokh, Elahe Daskar Abkenar, Fatemeh Naderi Noukabadi, Hamid Asadzadeh Aghdaei, Ehsan Nazemalhosseini Mojarad

{"title":"A novel stop codon mutation in STK11 gene is associated with Peutz-Jeghers Syndrome and elevated cancer risk: a case study.","authors":"Binazir Khanabadi, Diba Najafgholizadeh Seyfi, Leili Rejali, Mohammad Yaghoob Taleghani, Mehdi Tavallaei, Shabnam Shahrokh, Elahe Daskar Abkenar, Fatemeh Naderi Noukabadi, Hamid Asadzadeh Aghdaei, Ehsan Nazemalhosseini Mojarad","doi":"10.22037/ghfbb.v16i2.2751","DOIUrl":"https://doi.org/10.22037/ghfbb.v16i2.2751","url":null,"abstract":"Based on the analysis of patients with Peutz-Jeghers syndrome (PJS), Serine threonine kinase11 (STK11) is known as a tumor suppressor gene, which is involved in cell polarization, regulation of apoptosis, and DNA damage response. In this case report study, we examined STK11 gene sequencing in a 42-year-old woman with mucocuta neous pigmentation and positive family history. Endoscopy and colonoscopy showed >1000 polyps throughout the stomach/colon (PJ-type hamartomas). The larger polyp in the stomach was resected and the small bowel imaging detected multiple jejunum/ileum small polyps. The data released from the sequencing results revealed five alterations in exons 1 to 5. The major mutation in stop codon was reported as converted to the amino acid tryptophan (TRP) to tyrosine (TER). The TGG codon was converted to TAG by mutation. Finally, another novel mutation in STK11 stop codon as a 'de novo' variant was seen. It is predicted that stop codon mutations make the affected person susceptible to developing colorectal cancer.","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"16 3","pages":"341-346"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/fa/GHFBB-16-341.PMC10520397.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41116607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ChatGPT and authorship list. ChatGPT 和作者列表。

Gastroenterology and Hepatology From Bed to Bench Pub Date : 2023-01-01 DOI: 10.22037/ghfbb.v16i4.2801

Amnuay Kleebayoon, Viroj Wiwanitkit

引用次数: 0

Frailty as a predictor of poor outcomes among patients awaiting liver transplant: a systematic review and meta-analysis. 虚弱是肝移植等待患者不良预后的预测因素：系统综述和荟萃分析。

Gastroenterology and Hepatology From Bed to Bench Pub Date : 2023-01-01 DOI: 10.22037/ghfbb.v16i4.2795

Seyed Ali Moosavi, Amirali Mashhadiagha, Erfan Taherifard, Mohammad Amin Fallahzadeh, Nasrin Motazedian, Mehrab Sayadi, Negar Azarpira, Robert S Rahimi

{"title":"Frailty as a predictor of poor outcomes among patients awaiting liver transplant: a systematic review and meta-analysis.","authors":"Seyed Ali Moosavi, Amirali Mashhadiagha, Erfan Taherifard, Mohammad Amin Fallahzadeh, Nasrin Motazedian, Mehrab Sayadi, Negar Azarpira, Robert S Rahimi","doi":"10.22037/ghfbb.v16i4.2795","DOIUrl":"10.22037/ghfbb.v16i4.2795","url":null,"abstract":"Aim: This review sought to evaluate the significance of a functional assessment for liver transplant candidates, i.e., frailty, in the pre-transplant setting and its association with mortality and morbidities.Background: Liver transplantation (LT) remains the treatment of choice for patients with end-stage liver disease. Due to the shortage of organs for LT, a careful selection of suitable recipients is essential. Frailty, a measure of physiologic reserve and increased vulnerability to stressors, was initially used in geriatrics and then introduced to the field of transplantation for better patient selection.Methods: PubMed, Scopus, and Web of Science databases were reviewed up until January 2023. The search terms included: \"frail*\", \"liver\", and \"transplant*\". A Meta-analysis was conducted for the hazard ratios (HRs) obtained from the COX regression models. Fifty-five studies were included in this review; ten were included in the meta-analysis.Results: The prevalence of frailty varied from 2.82% to 70.09% in the studies. Meta-analysis showed that overall frailty had a significant association with mortality (pooled adjusted HR [95%CI]: 2.66 [1.96-3.63]). Subgroup analyses revealed that both the Liver Frailty Index and Fried Frailty Index were significantly associated with mortality. Furthermore, these studies have demonstrated that this population's frailty is associated with ascites, hepatic encephalopathy, and esophageal varices.Conclusion: According to emerging evidence, frailty is associated with increased morbidity and mortality of the patients on the LT waiting list. Further randomized trials are required to determine the efficacy and safety of variable interventions in the frail population.","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"16 4","pages":"364-377"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10835093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139681006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marsh's legacy and persistency in subjective interpretation of coeliac disease's histology. 马什在乳糜泻组织学主观解释中的遗产和持久性。

Gastroenterology and Hepatology From Bed to Bench Pub Date : 2023-01-01 DOI: 10.22037/ghfbb.v16i2.2783

Kamran Rostami, Mihai Danciu

{"title":"Marsh's legacy and persistency in subjective interpretation of coeliac disease's histology.","authors":"Kamran Rostami, Mihai Danciu","doi":"10.22037/ghfbb.v16i2.2783","DOIUrl":"https://doi.org/10.22037/ghfbb.v16i2.2783","url":null,"abstract":"1 This issue of GHFBB is dedicated to Professor Michael N Marsh who passed away on 12 July 2021. Professor Marsh was a pioneering figure in basic immune-histopathology of small intestine, in particular coeliac disease (CeD). As Professor Ensari highlighted, great minds deserve to be acknowledged while still alive though their true recognition usually takes place afterwards (1). Even though he personally may not have received the attention he deserved during his lifetime, but his name become inseparable from CeD as reflected in most of publications on CeD since late 1960s (1). He defined the gluten induced inflammation and the spectrum of enteropathy in distinctive phenotypes. His pioneering work funded the platform of quantitative histology (2-5) by development of a computerized methodology for accurate measurement of mucosal specimens and reporting histology in clinical practice. This was an enormous advance in understanding the damaged intestinal tissues seen in gluten sensitivity – both in comparison with “normal” tissues, and during the progress of these abnormal specimens – from","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"16 2","pages":"108-109"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c2/fa/GHFBB-16-108.PMC10404832.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10575705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Not all enteropathies are coeliac disease! Report of an infant with microvillus inclusion disease. 不是所有的肠道疾病都是乳糜泻!婴儿微绒毛包涵性疾病1例报告。

Gastroenterology and Hepatology From Bed to Bench Pub Date : 2023-01-01 DOI: 10.22037/ghfbb.v16i2.2735

Eda Nur Kozan, Ceyda Tuna Kırsaçlıoğlu, Zarife Kuloğlu, Aydan Kansu, Berna Savas, Arzu Ensari

{"title":"Not all enteropathies are coeliac disease! Report of an infant with microvillus inclusion disease.","authors":"Eda Nur Kozan, Ceyda Tuna Kırsaçlıoğlu, Zarife Kuloğlu, Aydan Kansu, Berna Savas, Arzu Ensari","doi":"10.22037/ghfbb.v16i2.2735","DOIUrl":"https://doi.org/10.22037/ghfbb.v16i2.2735","url":null,"abstract":"Primary enteropathies of infancy comprise of epithelial defects including microvillus inclusion disease, tufting enteropathy, and enteroendocrine cell dysgenesis and autoimmune enteropathies. The diseases in this group cause severe chronic (>2-3 weeks) diarrhoea starting in the first weeks of life and resulting in failure to thrive in the infant. Duodenal biopsies show moderate villous shortening together with crypt hyperplasia which are the main features causing resemblance to coeliac disease. We, hereby, report a term-born male infant of consanguineous parents. His two siblings died during infancy. He developed watery, urine-like diarrhea on the 3rd day of his life. On the postnatal 6th day he weighed 2750 grams, became dehydrated and had metabolic acidosis. Upper GI endoscopy performed on the postnatal 20th day appeared normal. Light microscopic examination of the duodenal biopsy showed moderate villous blunting, with mildly increased inflammatory cells in the lamina propria or and intraepithelial lymphocytosis. Enterocytes at the villous tips showed an irregular vacuolated appearance in the apical cytoplasm with patchy absence of the brush border demonstared by PAS and CD10. Electron microscopy revealed intracytoplasmic inclusions that were lined by intact microvilli in the apical cytoplasm of enterocytes. As he was dependent on TPN and aggressive intravenous fluid replacement he was hospitalized throughout his life. He died when he was 3 years and 4 months old. Paediatric coeliac disease is in the differential diagnosis of primary enteropathies of childhood. The differentiation lies on duodenal biopsy interpretation together with genetic analysis to detect the underlying genetic defect in childhood enteropathies.","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"16 2","pages":"234-239"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7a/41/GHFBB-16-234.PMC10404822.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9965715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-cultural adaptation, validity, and reliability of the pediatric constipation score-parent report in pediatric functional constipation in an Iranian population. 小儿便秘评分--家长报告在伊朗小儿功能性便秘中的跨文化适应性、有效性和可靠性。

Gastroenterology and Hepatology From Bed to Bench Pub Date : 2023-01-01 DOI: 10.22037/ghfbb.v16i1.2616

Fariba Ghaderi, Masoud Jamshidi, Parvin Sarbakhsh, Ghazal Kharaji

{"title":"Cross-cultural adaptation, validity, and reliability of the pediatric constipation score-parent report in pediatric functional constipation in an Iranian population.","authors":"Fariba Ghaderi, Masoud Jamshidi, Parvin Sarbakhsh, Ghazal Kharaji","doi":"10.22037/ghfbb.v16i1.2616","DOIUrl":"10.22037/ghfbb.v16i1.2616","url":null,"abstract":"Aim: We evaluated the Persian version of the pediatric constipation score-parent report (PCS) validity and reliability.Background: Functional constipation in children results in physical and psychological problems. Therefore, it is necessary to utilize a questionnaire to assess the health-related quality of life in children with chronic constipation.Methods: First, our team translated the English version of the questionnaire into the Persian language. Second, the psychometric properties of the Persian version were collected in 149 children with functional constipation referred to a pediatrics hospital by an expert team. We assessed content validity (CV) through the CV index (CVI) and CV ratio (CVR). The construct validity was evaluated by exploratory factor analysis, and reproducibility was tested based on test-retest reliability using the intra-class correlation coefficient (ICC). Internal consistency was calculated using Cronbach's α. we also evaluated the ceiling or floor.Results: Results showed acceptable CVI in relevancy, clarity, and simplicity, acceptable CVR for all items, moderate internal consistency (Cronbach's alpha=0.548), and almost perfect reproducibility (ICC=0.93). No ceiling or floor effect was seen.Conclusion: The Persian version of PCS showed good validity and reliability in children with functional constipation in Iran. Therefore, we can use it in clinical and research domains in Persian-speaking countries.","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"16 1","pages":"486-491"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e9/62/GHFBB-16-486.PMC10105497.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9679454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An unusual cause of failure to thrive. 一种不寻常的失败原因。

Gastroenterology and Hepatology From Bed to Bench Pub Date : 2023-01-01 DOI: 10.22037/ghfbb.v16i2.2683

Saeed Abdi, Naghmeh Salarieh, Pardis Ketabi Moghadam

引用次数: 0

An unusual shape of ampulla secondary to impaction of hydatid membrane. 一种由棘球蚴膜嵌塞引起的壶腹部畸形。

Gastroenterology and Hepatology From Bed to Bench Pub Date : 2023-01-01 DOI: 10.22037/ghfbb.v16i2.2644

Amir Sadeghi, Najmeh Radgoodarzi, Dlnya Aminzade

引用次数: 0

What does not look like celiac disease and instead it is. 看起来不像乳糜泻，但实际上是。

Gastroenterology and Hepatology From Bed to Bench Pub Date : 2023-01-01 DOI: 10.22037/ghfbb.v16i1.2686

Vincenzo Villanacci, Rachele Del Sordo, Orsola Setti, Barbara Zanini, Giovanni Casella

引用次数: 0