Functional Foods in Health and Disease最新文献

{"title":"Potential of multi-strain probiotics extract as an anti-inflammatory agent through inhibition of macrophage migration inhibitory factor activity","authors":"Denny Nyotohadi, T. Go","doi":"10.31989/ffhd.v13i1.1033","DOIUrl":"https://doi.org/10.31989/ffhd.v13i1.1033","url":null,"abstract":"Background: Probiotics are reported to have a role for improving health conditions and reduce the risk of diseases associated with inflammation. However, how they affect inflammation has not been well studied. The inflammation occurs during the progression of chronic diseases could damage the normal function of cells, tissues, and organs. Macrophage migration inhibitory factor (MIF) is recognized as a cytokine playing a key role in the inflammation process. Inhibition of its activity has been used by researchers as an approach for alleviating the inflammation. This study aims to evaluate the potential inhibitory effect of the extract of multi-strain probiotics consisting of Lactobacillus casei EMRO 002, L. casei EMRO 213, L. plantarum EMRO 009, L. fermentum EMRO 211, L. rhamnosus EMRO 014, L. bulgaricus EMRO 212,and Rhodopseudomonas palustris EMRO 201 on MIF tautomerase activity, the reversibility, and the mechanism of inhibition. Hence, the scope of this study is the evaluation of the functional characteristics of multi-strain probiotics extract on MIF activity.Methods:The multi-strain probiotics were centrifuged and the supernatant was separated from the pellet. The supernatant, i.e. the extract, was mixed with MIF and analyzed for its inhibition effect on MIF tautomerase activity. The reversibility of inhibition was evaluated by preincubation and dilution assays, and the mechanism of inhibition was determined by kinetic evaluation.Results:The multi-strain probiotics extract inhibited MIF tautomerase activity with an IC50 of 7.80 ± 1.96 mg/L. The preincubation and dilution assays showed that the inhibition is reversible, and the kinetic evaluation predicted that the extract components might bind to the enzyme active site and other site(s) of MIF.Conclusion:The findings show that the extract was able to inhibit MIF tautomerase activity reversibly and its components might bind to the enzyme active site and other site(s) of MIF suggest that the multi-strain probiotics extract has potential to be used as an anti-inflammatory agent for the treatment of chronic diseases associated with inflammation.Keywords: Multi-strain probiotics, anti-inflammatory, macrophage migration inhibitory factor, reversible inhibition, kinetic evaluation. ","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43083003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensory characteristics of selective traditional Indian sweets using agave syrup and stevia : An observatory study","authors":"R. Yargatti, Arti Muley","doi":"10.31989/ffhd.v12i12.1042","DOIUrl":"https://doi.org/10.31989/ffhd.v12i12.1042","url":null,"abstract":"Background:   Indian sweets largely contribute to the rising graph of obesity and cardiovascular diseases in India. An urgent update in lifestyle and dietary patterns has become necessary to stay risk-free. Replacement of sucrose with natural sweeteners in traditional Indian sweets is one way of dealing with the consequences of high sucrose consumption. This study tries to understand the change in sensory characteristics of selective Indian sweets on the replacement of sucrose with natural sweeteners like Agave syrup and Stevia.Objectives:In this observatory study, sensory characteristics of traditional Indian sweets (Gulab Jamun, Jalebi, and Motichoor Ladoo) are observed after sucrose replacement with natural sweeteners.Methods:In order to examine the flavour and appearance of selected Indian sweets, sucrose is substituted with agave syrup and stevia. Product characteristics namely appearance, flavour, colour, odour, aftertaste, and overall acceptability of the standardized sweets are compared with the control samples prepared with sucrose.Results: Results using the 9-point hedonic scale conclude that out of the two natural sugars used as a substitute for sucrose, stevia showed better overall acceptability for Gulab Jamun (84%) and Motichoor Ladoo (59%), but not for Jalebi (30%). Results for the paired comparison test conclude that substituting Agave syrup with sucrose had an undesirable effect on colour, taste, and mouthfeel while substituting Stevia had a detrimental effect on taste and mouthfeel only.Conclusion:The results conclude an initial understanding of sucrose replacement using natural sugars namely Stevia and Agave syrup in the context of traditional Indian sweets and Stevia is better-suited replacement in Gulab Jamun.Keywords: Natural sweeteners, Sucrose replacement, Indian sweets, Sensory evaluation, new product development, Agave syrup, Stevia","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49255446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of daily peanut consumption on cognitive function and indicators of mental health among healthy young women","authors":"N. Reeder, T. Tolar-Peterson, G. Adegoye, Erin Dickinson, Emily McFatter","doi":"10.31989/ffhd.v12i12.1010","DOIUrl":"https://doi.org/10.31989/ffhd.v12i12.1010","url":null,"abstract":"Background: Peanuts and tree nuts contain many bioactive compounds that may provide health benefits. There is some evidence to suggest that regular consumption of peanuts and peanut butter may improve cognitive function and mood, however, there are no prior studies examining whether daily intake of dry roasted, skinless peanuts improves cognition. Objective:The objective of this study was to determine the effect of consuming 49 g/day of peanuts for 12 weeks on cognitive function and mental health, compared to consuming a peanut-free diet, among healthy young women. Methods:This was a pre-post test study of 65 women (n = 32 in peanut group, n = 29 in control group). Participants in the peanut group consumed an individually portioned pack of peanuts each day for 12 weeks. Cognitive function was assessed using the CNS Vital Signs computerized neurocognitive test battery. Mental health was assessed using the Depression, Anxiety, and Stress Scale (DASS-42). Differences in endpoints between groups were assessed using ANCOVA tests. Results:There was a significant difference between the two groups in reaction time (6.9 points; p = 0.029), with the control group having a greater increase in scores. There was a significant within-group effect of peanuts on processing speed, with the peanut group increasing scores by 6.3 points (95% CI: 2.7, 9.8). There was no effect of peanut consumption on depression, anxiety, or stress scores. Conclusion:Further research is needed to fully understand the effect of different types of peanut products on cognition. Keywords: cognition, mental health, peanuts, nuts","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45695741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of probiotics for nutritional enrichment of dairy products","authors":"S. Hati, JB Prajapati","doi":"10.31989/ffhd.v12i12.1013","DOIUrl":"https://doi.org/10.31989/ffhd.v12i12.1013","url":null,"abstract":"Several food products, prepared with the help of beneficial microbes, can fit into the current definition of probiotics which have been consumed by mankind since ancient times. Beneficial microbes are the agents that produce many fermented foods and beverages, which are popular in different parts of the world. Indications about the use of products with healthy microbes are given in Vedic literature and are also depicted in ancient Egyptian and European treatises. However, systematic studies on probiotics started after the publication of the book, Prolongation of life, by Eli Metchnikoff in 1907. During the last century, the use of probiotics as food and pharma products gained substantial rise. This review intends to compile and analyze the literature pertaining to the use of probiotics as food products, especially for nutritional enrichment. The review will focus on the key issues important to establishing the requirement to re-assure the efficacy and safety after strain development, process standardization, product formulations, bioavailability of the live cells and biomolecules, and the effect of processing, etc. Current literatures addressing the mechanisms of action for probiotic function and the development of novel probiotic foods with health claims and meeting the nutritional requirement through fermentation are necessary to better understand the product and its application.Keywords: Probiotics, prebiotics, nutritional enrichment, fermented foods, bioavailability, efficacy, regulatory, safety, synbiotic, functional food","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43790837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical study of goat milk kefir as an antihyperglycemic food","authors":"S. Susanti, N. Nurwantoro, Jessen Juan Elto, Trilaksana Nugroho, A. Suryani, H. Rizqiati","doi":"10.31989/ffhd.v12i12.987","DOIUrl":"https://doi.org/10.31989/ffhd.v12i12.987","url":null,"abstract":"Background: Goat milk kefir is a functional food with numerous health benefits, including blood sugar control, cholesterol reduction, and improved digestive health. This study aims to determine the effect of kefir consumption on blood glucose levels in hyperglycaemic mice (Mus musculus) without affecting another blood chemistry.  This study compared goat milk kefir products to other processed milk products considered to be capable of controlling and reducing blood sugar levels. Objective:This study aimed to compare goat milk kefir products to other processed food products considered to be capable of controlling and reducing blood sugar levels.Methods: Twenty-one mice, as experimental animals, were induced for 21 days with the high-fat and high fructose diet to increase blood sugar levels. After induction, mice were divided into 3 groups according to treatment, namely oral administration of additional distilled water (placebo), diabetasol® (positive control), and goat's milk kefir with each group consisting of 9 individuals. Results: Treatment showed significant effect on the blood glucose and β-ketone level. Diabetasol®  and Goat kefir supplemented mice had a lower blood glucose level than control (p < 0.05) and goat kefir supplemented mice had lower blood β-ketone level than control and Diabetasol® (p< 0.05). Meanwhile, hematocrit and hemoglobin levels did not show significant differences between treatments.Conclusion: The results suggested that goat milk kefir has preclinical potential as an antihyperglycemic functional food without affecting other blood chemistry profiles.Keywords: Antihyperglycemic, blood sugar, goat kefir","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45170839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-obesity effect of Microalga, Melosira nummuloieds ethanolic extract in high-fat-diet-induced obesity C57BL/6J mice","authors":"I. Yun, Jiwon Choi, Hyeonjeong Choe, Ki-ok Kim, Gyung-Min Go, Dae-Hee Lee, Mi-Yeon Kim","doi":"10.31989/ffhd.v12i12.1002","DOIUrl":"https://doi.org/10.31989/ffhd.v12i12.1002","url":null,"abstract":"Background: Melosira nummuloides is a microalga belonging to the Melosiracease diatom. The ability of the diatoms to mass-produce essential fatty acids and carotenoid pigments was reported, which has driven research and their industrial application. Melosira nummuloides mass-cultivated with Jeju Lava sea water contains fucoxanthin, which has excellent biological properties such as antioxidant, anti-inflammatory, anti-cancer, and anti-obesity activities. The effect of M. nummuloides ethanolic extract (MEE) on the reduction of fat accumulation was evaluated.Methods: C57BL/6J mice fed a high-fat diet (HFD) were treated over 8 weeks with Melosira ethanolic extract. Cholesterol in serum and triglyceride in liver after the 8-week were evaluated. The expression of SREBP-1c, FAS, PPAR-γ, SCD-1 and p-AMPK were measured by western blotting respectively.Results: The MEE-treated C57BL/6J showed significant body weight and visceral fat loss compared to HFD group. Cholesterol in serum and triglyceride levels in liver showed a significant decrease in MEE groups. Levels of SREBP-1c, FAS, PPAR-γ and SCD-1 were low in mice fed an HFD+MEE.Conclusion: These results show MEE reduces blood lipid levels by regulating the expression of factors related to lipid synthesis and adipocyte differentiation in adipose tissue and inhibiting new lipid synthesis in the liver. M. nummuloides ethanolic extract confirmed its suitability as an anti-obesity agent.Keywords: Melosira nummuloides; C57BL/6J mice; obesity: weight loss; fatty acid synthesis","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47968178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory effect of Phytomarine R-L compound against lipopolysaccharide- induced pulmonary injury in BALB/c mice","authors":"Janani Gopi, F. Marotta, Sushmitha Sriramulu, A. Banerjee, N. Kanna, Vignesh Palani, Antonio Ayala, Fang He, R. Vijayashree, S. Pathak","doi":"10.31989/ffhd.v12i11.1014","DOIUrl":"https://doi.org/10.31989/ffhd.v12i11.1014","url":null,"abstract":"Background: This study deals with the induction of lipopolysaccharide induced inflammation in animal model and treating this condition using phytomarine R-L compound (Bloomin’Age, Science of Living, Milan Italy) that is known to possess the anti-inflammatory properties and eventually determine their characteristics through the in-vivo experimentation.Objective of the study:The present study was subjected to test the therapeutic anti-inflammatory/anti-oxidative and regenerative property of this phytomarine (SBF-LF) in an LPS-induced lung injury in mice models.   Methods:Mice received an intra-nasal administration of LPS at a concentration of 1 mg/ml weekly per day in a week for four consecutive weeks followed by the oral administration of R-L compound at a concentration of 50 mg/kg body weight intermittently. Broncho-alveolar lavage fluids (BALF) as well as the lung tissues were periodically collected from the control and experimental groups for histological examination. Likewise, the lung tissue homogenate obtained from induction and treatment groups was assayed for myeloperoxidase (MPO) assay, superoxide dismutase (SOD) activity and elastase assay. Results: The results illustrated that LPS- induced mice group demonstrated an increased inflammatory cell infiltration causing an acute and persisting neutrophilic accumulation in the lung parenchyma with alveolar congestion. Furthermore, the influx of macrophages, lymphocytes as well as inflammatory mediators was observed during the BALF analysis. The treatment with R-L compound resulted in a significant decline in the permeation of inflammatory cells as observed by lung histology and BALF analysis. Conclusion: Thus, the exploitation of R-L compound with the experimental groups along with other assay methods confirmed its robust anti-inflammatory and antioxidant properties and suggested epithelial regenerative capacity. Further analyzing the efficacy of the R-L compound might help understanding its potential as a therapeutic option in clinical settings.Keywords:Lungs, BALB/c mice, Lipopolysaccharide, anti-inflammatory, R-L compound","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48072148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maltose consumption exacerbates high-fat diet-induced overweight and related parameters in mice","authors":"Nanaka Shibazaki, Wataru Tanaka, Yusuke Suzuki, H. Matsuyama, Hibiki Kubota, Kenjirou Ogawa, Daigo Yokoyama, H. Sakakibara","doi":"10.31989/ffhd.v12i11.997","DOIUrl":"https://doi.org/10.31989/ffhd.v12i11.997","url":null,"abstract":"Background: Maltose is a disaccharide formed from two units of glucose. The amount of maltose in raw sweet potatoes reportedly increased by more than 40-fold after baking. We aimed to investigate the effects of maltose consumption on diet-induced obesity using a mouse model.Methods: Male C57BL/6J mice were divided into three dietary groups: a control diet of American Institute of Nutrition (AIN)-93 (CD), an AIN-93-based 30% high-fat diet (HFD), or an HFD diet containing 7.0% maltose (HFD+Mal). After 13 weeks, body mass index, blood glucose, lipid parameters, including total cholesterol and triglyceride, and hepatic fatty acid content were evaluated. Results: After 6 weeks on the special diet, weight gain was significantly higher in the HFD+Mal group than in the HFD group. The body mass index rose steadily and was significantly higher in the HFD+Mal group (5.03 ± 0.22), compared to the CD (3.32 ± 0.30) and HFD (4.57 ± 0.40) groups at 12 weeks. The relative liver weight per weight was also significantly higher in the HFD+Mal group than in the other two groups. The increases in blood glucose levels were more significant in the HFD+Mal group compared to the HFD group, as were the plasma levels of total cholesterol, high-density lipoprotein (HDL)-cholesterol and non-HDL-cholesterol. In the liver, levels of the following fatty acids increased in both the HFD and HFD+Mal groups relative to those in the CD group: C14:0 (myristic acid), C16:0 (palmitic acid), C18:0 (stearic acid), C18:1 (oleic acid), C18:2 (linoleic acid) and C18:3 (α-linolenic acid). Additionally, the C16:0 content in the HFD+Mal group was significantly higher than that in the HFD group.  Conclusion: The results of this study suggest that daily consumption of maltose exacerbated the development of obesity and related parameters, including body mass index and plasma cholesterol levels, under the high-fat diet consumption. It is possible that the consumption of maltose-rich cooked sweet potatoes, as part of an overall HFD, might exacerbate HFD-induced overweight.Keywords: high-fat diet-induced obesity, maltose, mice, roasting, sweet potato","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42009963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness in the short-term of a novel nutraceutical for the management of hypercholesterolemia: an observational multicenter primary care experience","authors":"F. Natale, R. Molinari, S. Covino, G. Piccinocchi, A. Salvetti, E. Monda, G. Limongelli, G. Cimmino","doi":"10.31989/ffhd.v12i11.1023","DOIUrl":"https://doi.org/10.31989/ffhd.v12i11.1023","url":null,"abstract":"Purpose: Increasing evidence reinforces the benefits of reduction of low-density lipoprotein (LDL-C) levels on cardiovascular outcomes. Different targets are suggested based on cardiovascular risk (CVR). According to the current European guidelines, a goal of LDL-C≤ 115mg/dL is desirable for patients with low-moderate CVR. However, a high percentage of these patients are far from this target. Nutraceuticals are “food supplements” that may help to achieve this goal in this population. In this retrospective analysis, we evaluate the effects of dietary supplementation with a novel monacolin/berberine/bergamot nutraceutical formulation on plasma lipid levels of subjects with low-moderate hypercholesterolemia who are not treated with conventional drug or other dietary supplements. Patients and Methods:526 adult patients with hypercholesterolemia were retrospectively selected from the database of participant family practitioners according to prespecified criteria. All selected patients had a baseline and 30-day value of total cholesterol (TC), LDL-C, high-density lipoprotein cholesterol, triglycerides, C-reactive protein, and transaminases and have started a dietary supplementation with this novel nutraceutical. Similarly, 104 subjects with comparable clinical features but not treated with any supplements were also selected. Results:At 30-day, the administration of nutraceuticals was associated with a significant reduction of LDL-C (124 ± 14 vs. 100 ± 13 mg/dL, Δ 24.5mg, p-value <0.0001) and TC levels (210 ± 56 vs. 187 ± 60, p-value < 0.0001), in the absence of a significant change of transaminase levels. No side effects were reported in the database during the observation period. Conclusion: This novel nutraceutical is an effective dietary supplement to achieve a significant and early  LDL-C reduction in patients with hypercholesterolemia at low-moderate CVR.Keywords:Cardiovascular Risk; Hypercholesterolemia; Nutraceuticals","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45390095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Nut Consumption on Cardiovascular Risk Factors and Coronary Heart Diseases","authors":"M. Zibaeenezhad, Zahra Elyaspour","doi":"10.31989/ffhd.v12i11.1022","DOIUrl":"https://doi.org/10.31989/ffhd.v12i11.1022","url":null,"abstract":"Background: Intervention and epidemiological studies have shown that nut consumption has beneficial effects on cardiovascular risk factors, such as hypertension, type 2 diabetes, body mass index, and hyperlipidemia. The aim of this review is to investigate the effects of nut consumption on cardiovascular risk factors and coronary heart diseases. In addition, we investigated possible mediating mechanisms through which nuts act with health protective effects, which could have a preventive effect on cardiovascular risk factors and coronary artery diseases.Method: We collected accredited international investigations, whether original, review, meta-analysis that published data in Google Scholar, PubMed/Medline, Wiley Online Library, Web of Science, Science Direct, Scopus, and Research Gate databases.Result:Some human studies and most animal and laboratory studies reported that favorable effects of nut consumption on cardiovascular risk factors and diseases are through their nutrient profile including polyphenols, unsaturated fatty acid, vitamins, phytosterols, minerals, fibers, and protein. Nut nutrient profile could act through reduction inflammation, inhibition oxidative stress, gut microbiota modification, improvement of endothelial function, modulating gene expression, miRNA, adipokines, insulin secretion, lipid and glucose metabolism, and decreasing cholesterol absorption.Conclusion:Nuts have favorably acted on lipid profile, glucose homeostasis, vascular health, and weight control. Furthermore, human clinical trials are needed to find the exact and most effective pathways by which nuts prevent or reduce cardiovascular risk factors.Keywords: Nut Consumption, hypertension, type 2 diabetes, body mass index, hyperlipidemia","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44938605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}