Functional Foods in Health and Disease最新文献

{"title":"Pasteurized <i>Akkermansia muciniphila</i> AKK ONE improves aging-related phenotypes and increases lifespan in zebrafish models","authors":"Youming Ou, Haotian Feng, Nan Li","doi":"10.31989/ffhd.v16i1.1848","DOIUrl":"https://doi.org/10.31989/ffhd.v16i1.1848","url":null,"abstract":"Background: Aging is a biological process characterized by progressive compositional and functional alterations in the gut microbiota. Akkermansia muciniphila, a commensal bacterium of the human intestine, has been shown to confer significant metabolic and health benefits, particularly in the context of aging-associated physiological decline. Objective: The primary objective of this study was to further evaluate the potential anti-aging effects of pasteurized Akkermansia muciniphila AKK ONE using aged zebrafish models. Methods: Three aging models were established in zebrafish through exposure to aluminum chloride hexahydrate, D-galactose, and hydrogen peroxide, respectively. Behavioral and physiological parameters were assessed, including light-dark transition time difference, total locomotor distance, movement distance within the blue region, telomere length, relative expression of the spns1 gene, and survival rate. Results: Administration of pasteurized AKK ONE significantly improved mobility as indicated by enhanced light-dark transition time difference and increased total moving distance. Additionally, after pasteurized AKK ONE treatment, the moving distance in the blue region of aged zebrafish rose compared to that of the normal control group, showing substantial improvements in learning and memory. At the epigenetic level, both telomere length and the relative expression of the spns1 gene were significantly improved after administration of pasteurized AKK ONE. Noteworthy is the increased survival rate in the pasteurized AKK ONE group. Conclusions: Pasteurized AKK ONE effectively ameliorated aging-related phenotypes in aspects of mobility, cognition, and epigenetics, and remarkably increased lifespan in aged zebrafish models. Keywords: pasteurized Akkermansia muciniphila AKK ONE, zebrafish, lifespan, aging, mobility, cognition, telomere, spns1 gene.","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":"16 1","pages":"29-41"},"PeriodicalIF":0.0,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ffhdj.com/index.php/ffhd/article/download/1848/4894","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147890494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Active medicinal-food homologous complex nutrients (AMCN) enhance immune systems in zebrafish","authors":"Yinan Yuan, Fei Xu, Heng Liu, Xiaoze Ren, Lan Yuan","doi":"10.31989/ffhd.v15i11.1782","DOIUrl":"https://doi.org/10.31989/ffhd.v15i11.1782","url":null,"abstract":"Background: Immunosuppression, whether caused by disease, stress, or medical treatments, compromises host defense by disrupting both innate and adaptive immune responses. Natural compounds such as Ganoderma lucidum, polygonatum, and mulberry leaves have long been used in traditional medicine for their immune-enhancing properties, yet their efficacy is often limited by low bioavailability. Biotransformation offers a promising approach to enhance the bioactivity of these medicinal-food homologous substances, but its potential in restoring immune function has not been fully explored. Objective: The objective of this study was to investigate whether active medicinal-food homologous complex nutrients (AMCN) formulation containing Ganoderma lucidum, polygonatum, and mulberry leaf could restore immune function in an immunodeficient zebrafish model. Specifically, we aimed to evaluate its effects on both innate and adaptive immune cell populations, including neutrophils, macrophages, and T cells, as well as its ability to modulate key immune-related cytokines. Methods: AMCN was prepared by culturing Ganoderma lucidum mycelia, followed by enzymatic biotransformation with polygonatum and mulberry leaf powders and subsequent fermentation with Lactobacillus plantarum. Transgenic zebrafish larvae were used as an in vivo model to evaluate immunomodulatory effects. Immune suppression was induced using cyclophosphamide, and larvae were exposed to AMCN to assess immune recovery. Changes in innate and adaptive immune cell populations and key cytokine expression were analyzed to determine the efficacy of AMCN. Results: AMCN treatment significantly restored immune cell populations in immunodeficient zebrafish, increasing neutrophils, macrophages, and T cells compared with the model group. It also upregulated key pro-inflammatory cytokines, including tnf-α, il-12a, and ifn-γ. Conclusion: AMCN effectively restores both innate and adaptive immune cell populations in an immunodeficient zebrafish model, highlighting its potential as a natural immunomodulatory agent. Novelty of the study: This study is the first to show that a biotransformed complex of AMCN can restore both innate and adaptive immune cell populations in an immunodeficient zebrafish model. AMCN exhibited broad immunostimulatory effects, upregulating key cytokines and highlighting biotransformation as a strategy to enhance the bioactivity of medicinal-food homologous substances for mitigating immunosuppression. Keywords: AMCN, biotransformation, immunomodulation, zebrafish model.","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":"15 11","pages":"796-807"},"PeriodicalIF":0.0,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ffhdj.com/index.php/ffhd/article/download/1782/4740","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147889470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative effects of an oral supplement mixture containing melon, yeast extract, and licorice on skin pigmentation reduction: Insights from a zebrafish model and a randomized double-blind controlled pilot human trial","authors":"Jiani Zheng, Jing Sun, Xinyi Zeng, Danyang Yu, Peng Chen, Weiguo Zhang","doi":"10.31989/ffhd.v15i9.1747","DOIUrl":"https://doi.org/10.31989/ffhd.v15i9.1747","url":null,"abstract":"Introduction: Intrinsic aging (e.g., genetic and metabolic changes) and extrinsic factors (e.g., sun exposure and environmental pollution) contribute to skin pigmentation and aged facial appearance. Plant extracts, known for their antioxidant properties, may influence skin pigmentation both directly and indirectly through pigment metabolism in the liver, potentially mitigating the effects of aging. Objective: This study investigates the effects of a mixture of melon, yeast extract, and licorice (Mix) oral supplement on liver metabolism and skin pigmentation. Methods: A zebrafish model of chemical liver injury was established using acetaminophen (APAP). Liver and yolk sac areas were analyzed, and uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) activity and total bilirubin content were measured to assess the supplement’s protective effects. Additionally, a zebrafish pigmentation model was induced with menadione, and yolk sac pigmentation intensity was analyzed. A pilot randomized, double-blind, placebo-controlled clinical trial was conducted with 22 healthy female volunteers randomly assigned to either the experimental or placebo group. Participants consumed 700 mg of the mixture (Mix) daily for 8 weeks. Skin brightness (L*), yellowness (b*), individual typology angle (ITA°), and melanin index (MI) were measured using a skin colorimeter (CL 400), melanin meter (MX 18), and VISIA 7 at baseline, 4 weeks, and 8 weeks. Results: In the zebrafish liver injury model, the mixture group（Mix Group）showed a significant increase in liver surface area, a decrease in yolk sac area, increased UGT1A1 activity, and reduced total bilirubin levels compared to the model control group. In the zebrafish pigmentation model, yolk sac pigmentation intensity was lower in the mixture group（Mix Group）. The pilot human trial demonstrated that participants taking the mixture (Mix) experienced significant improvements in skin brightness (L*) and ITA°, along with reductions in skin yellowness (b*) and melanin index (MI) after 4 and 8 weeks. Conclusion: An oral supplement comprising bioactive compounds from melon, yeast extract, and licorice effectively reduce skin pigmentation and supports liver pigment metabolism. This formulation, with its demonstrated functional food properties, suggests potential as an anti-aging intervention. Keywords: Skin pigmentation; Liver; Oral supplements; Plant extracts; Antioxidants; Zebrafish","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":"15 9","pages":"577-595"},"PeriodicalIF":0.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ffhdj.com/index.php/ffhd/article/download/1747/4647","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147892750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of thyme, rosemary, and lemongrass oils on extension of the shelf life and qualitative characteristics of Iraqi soft cheese","authors":"Firas Najm Ismael, Sara Thamer Hadi","doi":"10.31989/ffhd.v14i1.1262","DOIUrl":"https://doi.org/10.31989/ffhd.v14i1.1262","url":null,"abstract":"Background: In the case of Iraqi soft cheeses, researchers have noted that the moisture content of these cheeses decreases over time in storage and reaches its maximum depletion in the final storage period. This information was found to be true for all samples that were tested. As storage times increased, this decline was followed by a rise in the ratio of fat and protein, which reached the maximum at 21 days for all samples under investigation. Additionally, research was done on the impact of thyme, rosemary, and lemongrass oil additions on the microbiological and sensory properties of the soft cheese generated during storage.     Objective: This study set out to ascertain the impact of adding oils such as thyme, rosemary, and lemongrass on the chemical, microbial, and sensory properties of Iraqi soft white cheese made from cow's milk and stored for 21 days at 1 ± 5°C.Materials and Methods: The wild thyme and rosemary were obtained from local markets in Baghdad, while the lemongrass was obtained from one of the nurseries in Abu Ghraib / Baghdad in December 2022. The essential oils were extracted by water distillation according to the method described. Results: As storage went on, the number of Staphylococcus aureus bacteria increased; on day 21, they reached 1.75, 3.54, 5.41, 6.75, 1.20, 2.14, 3.21, and 4.20 CFU / g of cheese, respectively. This was the largest rise in the count. By contrast, these values dropped when thyme oil was added, coming down to 1.54, 1.48, 2.10, and 2.88 CFU/g of cheese, respectively. In the sample to which rosemary oil was added, the quantity of Staphylococcus aureus bacteria fell as well, reaching 1.54, 1.76, 2.88, and 3.31 CFU /g cheese, respectively, despite the fact that they were not present at all. Additionally, there was no Staphylococcus aureus germs present, in contrast to the cheese sample that had lemongrass oil added, which had both Staphylococcus aureus and coliform bacteria entirely missing. The findings also demonstrated that, when compared to the cheese samples treated with wild thyme oil, rosemary oil, and the control sample, the cheese sample treated with lemongrass oil exhibited superior sensory qualities, such as flavor, color, texture, and bitterness over various storage times.Keywords: Soft Cheese, Thyme Oil, Rosemary Oil, Lemongrass Oil, Chemical composition, Storage period","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":"29 3","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139386526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety evaluation of high bioavailability curcumin in Healthy Japanese Adults: A Randomized, placebo-controlled, double-blind, parallel-group comparison study","authors":"Hyunjin Lee, Y. Kuwabara, Akiko Hirose, Toshihiro Kakinuma, Asami Baba, T. Takara","doi":"10.31989/ffhd.v13i12.1207","DOIUrl":"https://doi.org/10.31989/ffhd.v13i12.1207","url":null,"abstract":"Background:  Curcumin is the principal component responsible for the pharmacological action of Curcuma longa. It has been proven to exhibit a diverse range of functions. It has been used in many fields as a spice, coloring agent, cosmetic, and food preservative.Objective: To evaluate the safety of the intake of highly bioavailable curcumin (CR-033P and TS-P1) in humans. Methods: We conducted two trials. The participants were healthy Japanese adults.  Participants of tria1 1 (Long-term intake trial) took CR-033P or TS-P1 for 12 weeks (as curcumin 150 mg/day). Participants of Trial 2 (Excessive intake trial) took TS-P1 for 4 weeks (as curcumin 750 mg/day).  The safety assessment involved monitoring the occurrence of side effects or adverse events, along with the analysis of urinalysis and blood parameters.Results: The safety analysis population of Trial 1 included 33 participants in the CR-033P group, 32 participants TS-P1, and 30 participants in the Placebo group. The safety analysis population of trial 2 included 22 participants in TS-P1 and 20 participants in the Placebo group. In both Trial 1 and Trial 2, few participants were observed to experience adverse events and  however these were not adverse events related to the CR-033P or TS-P1. Results of urinalysis and blood analysis were confirmed to not exhibit medically problematic changes related to the CR-033P or TS-P1.Conclusions: These trials proved the safety of the long-term intake of CR-033P or TS-PI- (as curcumin 150mg/ day) and the safety of the excessive intake of TS- P1 for four weeks (as curcumin 750mg/ day). TS-P1 and CR-033P can be considered a safe curcumin supplement based on these results.     Keywords: Curcumin, bioavailability, safety, high dose, long term dose, Healthy Japanese Adults, BMI, Blood pressure Trial registration: Trial 1: UMIN000046160, Trial 2: UMIN000048797. Foundation:Theravalues Corporation","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":"22 7","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138955717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kombucha: Probiotic beverage or ultra-processed food: A global review using nutritional classification","authors":"Carlos Aulesa, Carmen Gongora","doi":"10.31989/ffhd.v13i12.1236","DOIUrl":"https://doi.org/10.31989/ffhd.v13i12.1236","url":null,"abstract":"Aim/Objectives: The aim of this work is, to know the true essence and content of kombucha through the statistical analysis of the food classification and nutritional component of the world database of kombucha-registered trademarks, which has been provided to us by the OpenFoodFact Foundation.Method: To gain an understanding of kombucha, a study on the global market for this beverage has been conducted. A total of 2,818 kombucha brands are currently marketed and registered as of April 1, 2023.This research has been made possible thanks to the fact that OpenFoodFact. App provides us with detailed descriptions of the products, nutritional components, as well as Nutri-Score, Nova, and Eco-Score classifications for each registered trademark.Results: The statistical analysis of 2,673 brands from the 13 main Kombucha-producing countries reveals that, based on the Nutri-Score classification, 57% are deemed healthy (categories A, B, and C), while 43% are categorized as unhealthy (categories D and E). In terms of the Nova classification, 70% fall under the healthy categories (1, 2, 3), with the remaining 30% classified as unhealthy, specifically falling into category 4 as ultra-processed.Conclusions: The world market kombucha study shows contradictory results depending on the chosen food classification and the country. Global basic advice for its consumption and specific tips for groups such as people with diabetes or cardiovascular disease are proposed.Running Title: Global analysis market shows us kombucha´s distribution worldwide brands through the statistical analysis of OpenFoodFact database.Keywords: Kombucha, Probiotic fermented food, SCOBY, Nutri-Score food classification, Nova food classification, ultra-processed food.","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":"13 4","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138995376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of the effect of fermented derivatives from Bactrian milk on the gut microbiome","authors":"Kozhakhmetov Samat, Tultabayeva Tamara, Suieubayev Maxat, Muhanbetganov Nurislam, Pernebek Zhanel, Tarzhanova Dinar, Uyzbayeva Indira, Khassenbekova Zhanagul, Zhantureyeva Akmaral, Jarmukhanov Zharkyn, Kozhakhmetova Saniya, Kushugulova Almagul","doi":"10.31989/ffhd.v13i12.1247","DOIUrl":"https://doi.org/10.31989/ffhd.v13i12.1247","url":null,"abstract":"Background:The gut microbiome plays a vital role in maintaining intestinal homeostasis, and its modulation through dietary interventions has garnered considerable interest in improving human health. In this study, we investigated the effect of traditional Kazakh fermented milk products derived from camel milk on the gut microbiome of rats. Objective:The animals were divided into three groups: the Bactrian milk group (BCM), the camel yogurt group (CMY), and the camel cheese group (CMC). Results:After 4 weeks of intervention, the relative abundance of bacterial taxa varied significantly in the BCM and Bactrian milk derivative groups. The CMY group demonstrated a 2-fold increase in the relative abundance of the genus Ligilactobacillus (p=0.032), whereas the CMC group showed a 3-fold decrease (p=0.009). Prevotella_9 exhibited an inverse abundance vector in the CMY (p=0.0005) and CMC (p=0.0001) groups compared to the BCM group. Additionally, 53 metabolic pathways were predicted, each showing varying relative abundances in response to dietary interventions. Notably, the metabolic pathways associated with amines, polyamines, cell structure, fatty acids, and nucleoside and nucleotide biosynthesis underwent the greatest changes. Conclusion:Consumption of camel milk yogurt led to an increase in biodiversity and abundance in the gut microbiota (p<0.01), as evidenced by Shannon and Simpson's indices. In summary, our study demonstrates that fermented camel milk products significantly influence the gut microbiome and metabolic pathways.Keywords: Bactrian camel milk, gut microbiota, rats, yogurt, soft cheese","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":"10 5","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138979129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of daily peanut consumption on indicators of metabolic health among healthy young women","authors":"N. Reeder, T. Tolar-Peterson, G. Adegoye, Erin Dickinson, Emily McFatter","doi":"10.31989/ffhd.v13i12.1193","DOIUrl":"https://doi.org/10.31989/ffhd.v13i12.1193","url":null,"abstract":"Background:Regular consumption of nuts and peanuts may reduce the risk of cardiovascular disease due to the bioactive compounds found within them. Previous research suggests that including nuts and seeds as part of an overall healthy dietary pattern may help manage blood pressure, cholesterol, triglyceride, and fasting blood glucose levels, but few studies have examined the specific effect of dry-roasted, skinless peanuts on these outcomes. Objective:The objective was to examine the effect of regular consumption of dry-roasted, skinless peanuts on markers of metabolic health among women. Methods:This was a pre-post test study. Eligible women were randomized into either the intervention group (49 g peanuts/day, n=30) or the control group (participants’ usual diet minus peanuts, n=28) for 12 weeks. Anthropometrics, cholesterol, triglyceride, fasting blood glucose, and blood pressure levels were measured at baseline and end-line. Results:There were no significant between-group differences for any of the outcomes of interest. For the peanut group, there was a significant within-group decrease in systolic blood pressure (-7.0 mmHg; 95% CI: 1.3, 12.6), and a significant increase in total: HDL cholesterol ratio from baseline to endline (0.2; 95% CI: -0.3, 0.02). There was a significant within-group decrease in diastolic blood pressure for the control group (-6.3 mmHg; 95% CI: 2.0, 10.6). Conclusion:Among healthy young women, the addition of daily peanuts to a usual diet does not appear to negatively affect body composition as measured by BMI, waist circumference, and body fat percentage. Further research is needed to fully elucidate the effect of peanut consumption on indicators of cardiovascular health in different populations. Keywords: Nuts, Peanuts, Blood Pressure, Cholesterol, Metabolic Health, Women","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":"8 8","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138590382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of dietary fiber-enriched brown rice crackers on suppressing elevation of blood glucose level","authors":"Hiroshi Suzuki, Kenichi Watanabe, Izumi Ikeda, Yasunaga Takeda, Mariko Hatta, Chika Horikawa, Efrem D’Avila Ferreira, Wu Sijia, Khin Laymon, Hirohito Sone","doi":"10.31989/ffhd.v13i11.1231","DOIUrl":"https://doi.org/10.31989/ffhd.v13i11.1231","url":null,"abstract":"Background: Rice crackers are composed of carbohydrates refined from rice and enjoyed as a snack in Japan. Most rice crackers are crafted from white rice, and the potential postprandial blood glucose rise following their consumption may pose a clinical concern. Brown rice contains more dietary fiber than white rice and has been reported to suppress elevations of blood glucose. Dietary fiber-enhanced brown rice crackers have a significantly higher dietary fiber content than regular brown rice crackers and can be expected to suppress blood glucose elevations more reliably.Methods: We conducted a crossover trial in humans using white rice crackers and dietary fiber-enhanced brown rice crackers to investigate the effect of dietary fiber-enhanced brown rice crackers on postprandial blood glucose elevations. Participants ingested the 100 g rice crackers with 200 mL water for 10 min, and blood was collected from the fingertip at 7 time points: baseline, and at 15, 30, 45, 60, 90, and 120 min after ingestion of the rice cracker. The primary outcome measure was the blood glucose levels, and the secondary outcome measure was the incremental area under curve of blood glucose.Results: Glucose levels and incremental areas under curve at 60 min and 120 min after intake were significantly lower with dietary fiber-enhanced brown rice crackers than with white rice crackers. Incremental area under curves at 60 min and 120 min after intake of rice crackers were also significantly lower in dietary fiber-enhanced brown rice crackers than white rice crackers.Conclusions: Ingesting dietary fiber-enhanced brown rice crackers instead of white rice crackers could be useful for achieving better glycemic control.Keywords: Brown rice crackers, Dietary fiber, Postprandial blood glucose","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":"118 13","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134957741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of bioactive substances accumulation during cauliflower maturation as a way to ensure functional crop properties","authors":"Laura Tadevosyan, Gayane Martirosyan, Irina Tsereteli, Irina Vardanyan, Merujan Zadayan, Alvina Avagyan","doi":"10.31989/ffhd.v13i11.1197","DOIUrl":"https://doi.org/10.31989/ffhd.v13i11.1197","url":null,"abstract":"Background: Cauliflower heads are recognized as a rich sources of proteins, unsaturated fatty acids, numerous mineral elements, vitamins, and a high content of bioactive substances. Some studies report that the dynamics of accumulation of bioactive substances in cauliflower can be influenced by various factors. Objective: To determine the dependence of the content of bioactive components (ascorbic acid, B vitamins, macronutrients) on the stage of maturity of cauliflower heads and on the growing period.Methods: The study investigated the variation in vitamin C, B group vitamins (thiamine, pyridoxine, pantothenic acid, nicotinic acid, inositol), and seven macronutrients (silicon, aluminum, calcium, magnesium, sodium, phosphorus, potassium) during different stages of head ripening and cultivation periods in medium-ripening hybrids of cauliflower, specifically ‘Rocky F1’ and ‘Unibotra F1’. Ascorbic acid content in cauliflower heads was determined by the titration method. Quantitative analysis of the water-soluble B group vitamins was performed spectrophotometrically. The content of macronutrients was determined by the chemical-spectral method.Results: The maximum content of ascorbic acid in cauliflower Rocky F1 hybrid was observed at the stage of the heads technical ripening in spring cultivation conditions, and in Unibotra F1 hybrid - in the phase of new head formation in summer growing conditions. The content of group B vitamins, with the exception of pantothenic acid, was high in newly formed heads in both studied hybrids. In the conditions of spring cultivation, most of the studied macronutrients were high for Rocky F1 hybrid in the stage of technical ripening of heads, and for Unibotra F1 hybrid in the phase of new head formation (Si, Al, Na, P) and in middle ripening stage (Ca, Mg). Under the conditions of summer cultivation, most of the macronutrients were high for Rocky F1 hybrid in the phase of new head formation, and in Unibotra F1 hybrid - Si, Al, P were high in the phase of new head formation, and Ca, Mg, K - in middle ripening stage. Conclusion: The content of bioactive components (ascorbic acid, B vitamins, macronutrients) in cauliflower heads is influenced by the stage of cauliflower maturity and the cultivation period (spring, summer). This should be taken into account when developing targeting diets and growing cauliflower in semi-desert zones of the Republic of Armenia.Keywords: ascorbic acid, B vitamins, macronutrients, cauliflower head ripening stage","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":"55 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135092874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}