Perch essence prevents cell death to improve skeletal muscle mass and strength: Evidence from in vitro and human model

IF 1.3 Q4 FOOD SCIENCE & TECHNOLOGY
Chih-Cheng Lin, Chih-Yu Hsieh, Ling-Ni Chen, Mao-Hsiang Lee, Yi-Han Ting, Ting-Ming Wang, Jia-Feng Chang
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Abstract

Background:Fish protein supplementation may maintain muscle strength and prevent sarcopenia as it contains a complex array of macro- and micronutrients essential for building the skeletal muscle. Objective:The aim of this study was to evaluate the influence of perch essence (PE) supplementation on muscle mass and muscle function of through human and cell model. Methods:The open label clinical trial was conducted to assess the therapeutic effect of PE on muscle mass improvement. The mouse skeletal muscle cell (C2C12) model of muscle atrophy was analyzed for cell viability. Results:Our results showed PE contained abundant branched chain amino acid, taurine, hydroxyproline and collagen. After one month of supplementation with PE in our human model, there was a significant increase in muscle mass in the whole body and all parts of the body, with an increase of 1.55 % in the whole body, 1.79% in the trunk, 1.64% in the arms and 1.38% in the legs. The percentage of subcutaneous fat in the trunk, arms and legs also decreased significantly by 2.49%, 3.21% and 3.40% respectively. PE supplementation also improves muscle grip strength, especially with the dominant hand. The cell model results demonstrated that PE could effectively prevent skeletal muscle cell from death induced by dexamethasone. Conclusion:This study suggests that the branched chain amino acids, taurine, hydroxyproline and collagen in PE have the potential to serve as a good source of dietary supplements for the improvement of skeletal muscle mass and strength through cell protection.Keywords:branched chain amino acid, collagen, perch, skeletal muscle, sarcopenia
鲈鱼精华防止细胞死亡,提高骨骼肌质量和力量:来自体外和人体模型的证据
背景:补充鱼蛋白可以保持肌肉力量并预防肌肉减少症,因为它含有一系列构建骨骼肌所必需的宏量和微量营养素。目的:通过人体模型和细胞模型,探讨添加鲈鱼精(PE)对大鼠肌肉质量和肌肉功能的影响。方法:采用开放标签临床试验,评价PE对肌肉质量改善的疗效。对小鼠骨骼肌细胞(C2C12)肌萎缩模型进行细胞活力分析。结果:聚乙烯中含有丰富的支链氨基酸、牛磺酸、羟脯氨酸和胶原蛋白。在我们的人体模型中补充PE一个月后,全身和身体各部位的肌肉量都有显著增加,其中全身增加1.55%,躯干增加1.79%,手臂增加1.64%,腿部增加1.38%。躯干、手臂和腿部的皮下脂肪含量也分别显著降低了2.49%、3.21%和3.40%。补充PE还可以提高肌肉握力,特别是优势手。细胞模型结果表明,PE能有效预防地塞米松所致骨骼肌细胞死亡。结论:本研究提示PE中的支链氨基酸、牛磺酸、羟脯氨酸和胶原蛋白有潜力作为膳食补充剂的良好来源,通过保护细胞来改善骨骼肌的质量和力量。关键词:支链氨基酸,胶原蛋白,鲈鱼,骨骼肌,肌少症
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来源期刊
Functional Foods in Health and Disease
Functional Foods in Health and Disease FOOD SCIENCE & TECHNOLOGY-
CiteScore
2.20
自引率
20.00%
发文量
47
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