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The TUNEL observation of murine follicular oocyte cleaving with repeated superovulation 重复超排卵小鼠卵泡卵母细胞分裂的TUNEL观察
Reproductive Immunology and Biology Pub Date : 1900-01-01 DOI: 10.3192/JSIRIB.21.1
K. Nariai, H. Uchiyama, Kahei Sato, S. Tsumagari, K. Kanayama
{"title":"The TUNEL observation of murine follicular oocyte cleaving with repeated superovulation","authors":"K. Nariai, H. Uchiyama, Kahei Sato, S. Tsumagari, K. Kanayama","doi":"10.3192/JSIRIB.21.1","DOIUrl":"https://doi.org/10.3192/JSIRIB.21.1","url":null,"abstract":"Ovarian follicles constantly undergo selection and sifting in the process of their development, and many ovarian follicles fall into atresia. Follicular atresia can be prevented by superovulation induction with gonadotropin (GTH), but this treatment causes ovulation of cleaved-unfertilized ova. In this study, the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) reaction was performed in the ovary of mice in which superovulation was induced repeatedly using PMSG/hCG. The TUNEL reaction was positive in oocytes that showed cleavage already in developing follicle and in surrounding granulosa cells. Ovarian follicles developed by superovulation using GTHs include abnormal oocytes with cell fragmentation. This change is remarkably similar to apoptosis.","PeriodicalId":126001,"journal":{"name":"Reproductive Immunology and Biology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127166281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental induction of immunotolerance to gonadotropin in mice 小鼠对促性腺激素免疫耐受的实验诱导
Reproductive Immunology and Biology Pub Date : 1900-01-01 DOI: 10.3192/JSIRIB.21.53
K. Nariai, H. Uchiyama, Kahei Sato, Kazuyoshi Suzuki, R. Asano, M. Yukawa, S. Tsumagari, K. Kanayama
{"title":"Experimental induction of immunotolerance to gonadotropin in mice","authors":"K. Nariai, H. Uchiyama, Kahei Sato, Kazuyoshi Suzuki, R. Asano, M. Yukawa, S. Tsumagari, K. Kanayama","doi":"10.3192/JSIRIB.21.53","DOIUrl":"https://doi.org/10.3192/JSIRIB.21.53","url":null,"abstract":"This study was conducted to induce immunotolerance to human chorionic gonadotropin (hCG) as a heterologous protein in neonatal mice. Ovulatory responses after repeated induction of superovulation were also investigated in the animals. Subcutaneous injection of hCG (100 IU) was performed in female mice within 24 hours after birth. Serum anti-hCG antibody titers were assayed and ovulatory responses were observed after the repeated superovulation with pregnant mare serum gonadotropin (PMSG) and hCG.As a result, the production of anti-hCG antibody was suppressed. Thus, tolerance induction to hCG was achieved, although it was incomplete. Compared with the control mice, the ovulatory rate was higher after the induction of immunotolerance to hCG. It was suggested that the production of anti-hCG antibody has a close relation with a decrease in the ovulatory response after the repeated induction of superovulation by gonadotropins.","PeriodicalId":126001,"journal":{"name":"Reproductive Immunology and Biology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126842517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
精子形成に必須の細胞接着分子CADM1/IGSF4A/SgIGSF 精子形成に必須の細胞接着分子CADM1/IGSF4A/SgIGSF
Reproductive Immunology and Biology Pub Date : 1900-01-01 DOI: 10.3192/JSIRIB.23.1
友彦 若山, 尚一 井関
{"title":"精子形成に必須の細胞接着分子CADM1/IGSF4A/SgIGSF","authors":"友彦 若山, 尚一 井関","doi":"10.3192/JSIRIB.23.1","DOIUrl":"https://doi.org/10.3192/JSIRIB.23.1","url":null,"abstract":"精子形成の調節において、内分泌因子や局所因子の役割はよく知られているが、造精細胞とセルトリ細胞間の直接の相互作用に関わる細胞接着分子も必須であることが明らかになってきた。造精細胞とセルトリ細胞間には複数種の細胞接着分子が発現し、異種分子間結合だけでなく同種分子間結合もする。マウス精巣の造精細胞に発現する新規の細胞接着分子として、CADM1/IGSF4A/SgIGSFをクローニングした。CADM1/IGSF4A/SgIGSFは、細胞外に3つの免疫グロブリン様ループ構造をもち、細胞膜を1回貫通する免疫グロブリンスーパーファミリーに属する細胞接着分子である。精巣において、CADM1/IGSF4A/SgIGSFは、造精細胞に発現するが、セルトリ細胞等の体細胞には発現しない。造精細胞の中で、CADM1/IGSF4A/SgIGSFは、精祖細胞から精母細胞と伸長精子細胞の細胞膜に発現するが、円形精子細胞や成熟精子には発現しない。セルトリ細胞の膜に存在するPVRは、造精細胞のCADM1/IGSF4A/SgIGSFと異種分子間結合を行う。CADM1/IGSF4A/SgIGSFのノックアウトマウスは、精子形成障害により雄性不妊を生じる。これらの結果は、造精細胞とセルトリ細胞間においてCADM1/IGSF4A/SgIGSFをはじめとする接着分子を介した特異的な細胞認識機構が存在し、精子形成の調節に必須の役割を果たしていることを示唆する。","PeriodicalId":126001,"journal":{"name":"Reproductive Immunology and Biology","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124526208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term study for the risk factors and outcomes of recurrent pregnancy loss in Japan 日本复发性流产的危险因素及结局的长期研究
Reproductive Immunology and Biology Pub Date : 1900-01-01 DOI: 10.3192/jsirib.35.16
K. Moritaa, Yosuke Onob, Sayaka Tsudaa, A. Nakashima, S. Saito
{"title":"Long-term study for the risk factors and outcomes of recurrent pregnancy loss in Japan","authors":"K. Moritaa, Yosuke Onob, Sayaka Tsudaa, A. Nakashima, S. Saito","doi":"10.3192/jsirib.35.16","DOIUrl":"https://doi.org/10.3192/jsirib.35.16","url":null,"abstract":"Recurrent pregnancy loss (RPL) is one of the major concerns in Japan. We performed a long-term multicenter prospective study to reveal the risk factors and pregnancy outcomes of RPL in Japan. Antiphospholipid antibodies (aPL), malformation of the uterus, thyroid dysfunction, parental karyotype abnormality, factor XII deficiency, and protein S deficiency were defined as the risk factors of RPL. The prevalence of each risk factor was similar to previous studies except aPL positive rate. No risk factors were detected in more than half of RPL patients (65.2%). In transiently aPL-positive patients, the live birth rates with LDA were comparable to that with heparin + LDA. Despite that factor XII deficiency and protein S deficiency are not recognized as risk factors for RPL in general, low-dose aspirin (LDA) or unfractionated heparin + LDA therapy improved live birth rates. However, the live birth rate treated with LDA and that with unfractionated heparin + LDA were comparable in factor XII deficiency and protein S deficiency. Factor XII deficiency and protein S deficiency might be considered to be the risk factors of RPL and LDA therapy might be recommended in Factor XII deficiency, protein S deficiency, and transiently aPL-positive patients. We have discussed the risk factors and the live birth rate after treatment between Japan and worldwide.","PeriodicalId":126001,"journal":{"name":"Reproductive Immunology and Biology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123772339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oocyte growth and ovarian tissue differentiation in organ culture of mouse fetal gonads 小鼠胎儿性腺器官培养中卵母细胞生长和卵巢组织分化
Reproductive Immunology and Biology Pub Date : 1900-01-01 DOI: 10.3192/JSIRIB.21.48
H. Kada, H. Motohashi, H. Motohashi, Sakiko Kobayashi, Kahei Sato
{"title":"Oocyte growth and ovarian tissue differentiation in organ culture of mouse fetal gonads","authors":"H. Kada, H. Motohashi, H. Motohashi, Sakiko Kobayashi, Kahei Sato","doi":"10.3192/JSIRIB.21.48","DOIUrl":"https://doi.org/10.3192/JSIRIB.21.48","url":null,"abstract":"Mammalian oocytes undergo growth and development through prenatal and postnatal periods. This is an investigation of development in vitro of oocytes and ovarian tissues from fetal gonads of the 12.5 days post coitus. Cultured tissues survived and the oocytes entered the growth phase, subsequently achieving long-term (14-30 days) culture. Growing oocytes were observed in their general morphology and were enclosed within 1-2 layers of granulosa cells, which resembled primary or secondary follicles. However, no follicular structures were also found in the cultures despite the existence of growing oocytes. The oocytes enclosed in very flattened cells were detected as in histological structure on day 18 of culture. The oocyte diameter became approximately 50 μm under culture conditions supplemented with 15% fetal bovine serum or Ehrlich ascites tumor fluid. These results indicate that the maximum culture period for oocyte growth in this organ culture is approximately 3 weeks and that the oocytes can grow in vitro to at least a medium size even if normal follicular structure is not formed.","PeriodicalId":126001,"journal":{"name":"Reproductive Immunology and Biology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130919712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Clinical characteristics in spontaneous preterm delivery and novel strategy for preterm labor, and for prevention of spontaneous preterm delivery 自发性早产的临床特点和新策略，以及预防自发性早产
Reproductive Immunology and Biology Pub Date : 1900-01-01 DOI: 10.3192/jsirib.35.1
S. Yoneda
{"title":"Clinical characteristics in spontaneous preterm delivery and novel strategy for preterm labor, and for prevention of spontaneous preterm delivery","authors":"S. Yoneda","doi":"10.3192/jsirib.35.1","DOIUrl":"https://doi.org/10.3192/jsirib.35.1","url":null,"abstract":": Preterm birth (PTB) is divided into spontaneous and artificial PTB, and spontaneous PTB (SPTB) occurs in about 70 %. And history of SPTB itself is a risk factor for SPTB in next pregnancy. The rate of repeated SPTB in Japan is 22.3% according to a recent report. Although there are a lot of causes for SPTB, intra-uterine inflammation (histological chorioamnionitis: hCAM) is the main reason. So, intra-uterine inflammation/infection in preterm labor (PTL) is the most important marker as same as clinical symptom such as genital bleeding and maturation of cervix. In particular, super-infection (bacteria and Ureaplasma/Mycoplasma) in amnion is strongly related with earlier According to the intra-amniotic environment of PTL, antibiotics and/or progesterone (17- α -hydroxyprogesterone caproate: 17OHP-C) are selected with maintenance tocolysis, the pregnant period prolong for about 4 weeks. However, in cases with severe intra-amniotic inflammation/infection, there is a limitation not","PeriodicalId":126001,"journal":{"name":"Reproductive Immunology and Biology","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130042592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of bone morphogenetic protein(BMP)cytokine family in folliculogenesis 骨形态发生蛋白(BMP)细胞因子家族在卵泡发生中的作用
Reproductive Immunology and Biology Pub Date : 1900-01-01 DOI: 10.3192/jsirib.32.7
O. Yoshino, Ikumi Akiyama, Y. Osuga, S. Saito
{"title":"The role of bone morphogenetic protein(BMP)cytokine family in folliculogenesis","authors":"O. Yoshino, Ikumi Akiyama, Y. Osuga, S. Saito","doi":"10.3192/jsirib.32.7","DOIUrl":"https://doi.org/10.3192/jsirib.32.7","url":null,"abstract":"","PeriodicalId":126001,"journal":{"name":"Reproductive Immunology and Biology","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125495816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregnancy and soluble VEGF receptor 1(sFlt-1) 妊娠与可溶性VEGF受体1(sFlt-1)的关系
Reproductive Immunology and Biology Pub Date : 1900-01-01 DOI: 10.3192/jsirib.34.9
K. Kumasawa, T. Iriyama, T. Nagamatsu, Y. Osuga, T. Fujii
{"title":"Pregnancy and soluble VEGF receptor 1(sFlt-1)","authors":"K. Kumasawa, T. Iriyama, T. Nagamatsu, Y. Osuga, T. Fujii","doi":"10.3192/jsirib.34.9","DOIUrl":"https://doi.org/10.3192/jsirib.34.9","url":null,"abstract":": the of rapidly in the ‘Two Step Theory’ been proposed and widely the soluble receptor crucial roles. HDP model and the HDP In the research of HDP, many Japanese researchers have occupied important parts in both in vitro and in vivo experiments, in addition to clinical discoveries. In this review, we explain about the relations between HDP and sFlt-1, and then introduce mainly two kinds of model mice of HDP by our groups.","PeriodicalId":126001,"journal":{"name":"Reproductive Immunology and Biology","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115629989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Testicular autoimmunity in men ^|^mdash; its suggestion that a Japanese pathologist left ^|^mdash; 男性睾丸自身免疫的研究它暗示一位日本病理学家留下了^|^mdash;
Reproductive Immunology and Biology Pub Date : 1900-01-01 DOI: 10.3192/JSIRIB.27.7
S. Hirai, M. Itoh
{"title":"Testicular autoimmunity in men ^|^mdash; its suggestion that a Japanese pathologist left ^|^mdash;","authors":"S. Hirai, M. Itoh","doi":"10.3192/JSIRIB.27.7","DOIUrl":"https://doi.org/10.3192/JSIRIB.27.7","url":null,"abstract":"","PeriodicalId":126001,"journal":{"name":"Reproductive Immunology and Biology","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129076839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A new variant of glucose regulated protein 78 present in human sperm membrane originating from epididymis 源自附睾的人精子膜中葡萄糖调节蛋白78的新变体
Reproductive Immunology and Biology Pub Date : 1900-01-01 DOI: 10.3192/JSIRIB2003.20.2_65
P. Adoyo, A. Hasegawa, Nozomi Kanazawa, K. Koyama
{"title":"A new variant of glucose regulated protein 78 present in human sperm membrane originating from epididymis","authors":"P. Adoyo, A. Hasegawa, Nozomi Kanazawa, K. Koyama","doi":"10.3192/JSIRIB2003.20.2_65","DOIUrl":"https://doi.org/10.3192/JSIRIB2003.20.2_65","url":null,"abstract":"","PeriodicalId":126001,"journal":{"name":"Reproductive Immunology and Biology","volume":" 1267","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113946459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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