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The relationship between infertility and antiphospholopid antibody or thrombophilia 不孕症与抗磷脂抗体或血栓形成的关系
Reproductive Immunology and Biology Pub Date : 1900-01-01 DOI: 10.3192/JSIRIB.26.1
M. Itoh
{"title":"The relationship between infertility and antiphospholopid antibody or thrombophilia","authors":"M. Itoh","doi":"10.3192/JSIRIB.26.1","DOIUrl":"https://doi.org/10.3192/JSIRIB.26.1","url":null,"abstract":"最近、不妊症や反復着床不全の患者に対してスクリーニング的に抗リン脂質抗体を測定する施設が散見されるが、その意義について検証した。凝固第XII因子、抗フォスファチジールエタノールアミン抗体 (aPE抗体)、抗カルジオリピンβ2GPI抗体とループスアンチコアグラントの測定を施行した。不妊症の中にも凝固第XII因子欠乏症とaPE抗体陽性例が不育症の1/2程度の頻度で存在した。不妊症や体外受精の反復着床不成功の原因として、抗リン脂質抗体やthrombophiliaを取り上げるか否かは、さまざまな意見があり、エビデンスをあきらかにできていない。抗リン脂質抗体やthrombophiliaがあるから、即ヘパリン使用とは推奨できない。但しこれらの患者は卵巣過剰刺激症候群 (OHSS) の兆候がある際は可能な限りの回避策をとり、OHSS症状が消失するまでは、抗凝固療法を続けるべきであろう。それ以外の場合は現時点で抗凝固療法を必要とするエビデンスはまだ不十分である。","PeriodicalId":126001,"journal":{"name":"Reproductive Immunology and Biology","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126170466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gamete Immunology: Infertility and Contraception 配子免疫学:不育和避孕
Reproductive Immunology and Biology Pub Date : 1900-01-01 DOI: 10.3192/JSIRIB.24.1
K. Koyama
{"title":"Gamete Immunology: Infertility and Contraception","authors":"K. Koyama","doi":"10.3192/JSIRIB.24.1","DOIUrl":"https://doi.org/10.3192/JSIRIB.24.1","url":null,"abstract":"","PeriodicalId":126001,"journal":{"name":"Reproductive Immunology and Biology","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123743965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Fertilization capacity of oocytes by mouse round spermatids cultured in vitro and its embryo development
Reproductive Immunology and Biology Pub Date : 1900-01-01 DOI: 10.3192/JSIRIB.27.1
Kahei Sato, H. Hasegawa, N. Okamoto
{"title":"Fertilization capacity of oocytes by mouse round spermatids cultured in vitro and its embryo development","authors":"Kahei Sato, H. Hasegawa, N. Okamoto","doi":"10.3192/JSIRIB.27.1","DOIUrl":"https://doi.org/10.3192/JSIRIB.27.1","url":null,"abstract":": Intracytoplasmic sperm injection (ICSI) has been performed to the treatment method of for male infertility. Using ICSI, in the mouse or other species, round spermatid injection (ROSI) has been successful, however, its application in human is controversial. To obtain much information on round spermatids, culture of round spermatids under in vitro conditions is an effective method. Mouse round spermatids cultured in the presence of recombinant FSH and testosterone show normal differentiation into elongating spermatids, and the elongated spermatids show normal oocyte activation and fertilization.","PeriodicalId":126001,"journal":{"name":"Reproductive Immunology and Biology","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126943579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ICSI and embryo development ICSI与胚胎发育
Reproductive Immunology and Biology Pub Date : 1900-01-01 DOI: 10.3192/JSIRIB2003.20.2_79
K. Yanagida, Yoko Fujikura
{"title":"ICSI and embryo development","authors":"K. Yanagida, Yoko Fujikura","doi":"10.3192/JSIRIB2003.20.2_79","DOIUrl":"https://doi.org/10.3192/JSIRIB2003.20.2_79","url":null,"abstract":"The process of fertilization in intracytoplasmic sperm injection (ICSI) treatment is largely different from that of physiological fertilization. It is also true that the rate of development of the embryo into the blastocyst after ICSI is lower than that after in vitro fertilization (IVF) [1,2]. It is unknown whether these facts are closely related. Although it is impossible to simply compare the results of IVF and ICSI due to the difference in their indications, it has been determined that pregnancy rates, the endpoint of fertilization failure treatment, are similar between ICSI and IVF treatments. This is because negative impacts of ICSI on fertilization do not become apparent due to a considerable effect of the in vitro culture environment. In this report, we discuss causes for the low development rate of the blastocyst after ICSI.","PeriodicalId":126001,"journal":{"name":"Reproductive Immunology and Biology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122807311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interleukin-35 plays a pivotal role in maintaining the testicular immune privilege 白细胞介素-35在维持睾丸免疫特权中起着关键作用
Reproductive Immunology and Biology Pub Date : 1900-01-01 DOI: 10.3192/JSIRIB.29.13
H. Terayama, T. Yoshimoto, M. Naito, S. Hirai, N. Qu, N. Hatayama, S. Hayashi, Teruhisa Kanazawa, K. Suyama, K. Sakabe, M. Itoh
{"title":"Interleukin-35 plays a pivotal role in maintaining the testicular immune privilege","authors":"H. Terayama, T. Yoshimoto, M. Naito, S. Hirai, N. Qu, N. Hatayama, S. Hayashi, Teruhisa Kanazawa, K. Suyama, K. Sakabe, M. Itoh","doi":"10.3192/JSIRIB.29.13","DOIUrl":"https://doi.org/10.3192/JSIRIB.29.13","url":null,"abstract":"","PeriodicalId":126001,"journal":{"name":"Reproductive Immunology and Biology","volume":"152 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122042393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Future directions of investigation on gamete and gonadal immunology in the male 雄性配子和性腺免疫学研究的未来方向
Reproductive Immunology and Biology Pub Date : 1900-01-01 DOI: 10.3192/jsirib.32.1
M. Itoh
{"title":"Future directions of investigation on gamete and gonadal immunology in the male","authors":"M. Itoh","doi":"10.3192/jsirib.32.1","DOIUrl":"https://doi.org/10.3192/jsirib.32.1","url":null,"abstract":"clinical data, investigation using experimental models of testicular autoimmunity is quite helpful to estimate physiopathology and epidemiology of the spermatogenic disturbance of autoimmune origin. From various results from experimental animals, it appears that although the testis is regarded as an immunologically privileged organ and resistant to inflammation, it is also immunologically fragile and highly susceptible to autoimmune inflammation. In the present review, the author will present future subjects in the field of male reproductive immunology.","PeriodicalId":126001,"journal":{"name":"Reproductive Immunology and Biology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117315809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contribution of protease system on human placentation 蛋白酶系统对人胎盘的贡献
Reproductive Immunology and Biology Pub Date : 1900-01-01 DOI: 10.3192/JSIRIB.30.7
K. Naruse, A. Onogi, T. Sado, Hiroshi Kobayashi
{"title":"Contribution of protease system on human placentation","authors":"K. Naruse, A. Onogi, T. Sado, Hiroshi Kobayashi","doi":"10.3192/JSIRIB.30.7","DOIUrl":"https://doi.org/10.3192/JSIRIB.30.7","url":null,"abstract":": Protease system is an essential mechanism for human body which contains various molecule including its inhibitors. In human pregnancy, this system takes an important role on trophoblast invasion, spiral artery remodeling and the maintenance of the course of pregnancy. In this review, we describe roles of proteases (matrix metalloproteinases, plasminogen activators and inhibitors) in early pregnancy, especially on placentation. A radical switch of the placentation process from invasive trophoblast invasion (until 10w GA) to spiral artery remodeling (12 to 15w GA, which now regarded as a key pathophysiology of the complicated human pregnancy if it failed) is considered to be owe to the protease system alteration on invasive trophoblast and uterine natural killer cells. Further research into protease system in human reproduction is needed for understanding of mysterious establishment of early human pregnancy.","PeriodicalId":126001,"journal":{"name":"Reproductive Immunology and Biology","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124380030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The 25 years history of JAPAN SOCIETY for IMMUNOLOGY of REPRODUCTION (JSIR) 日本生殖免疫学学会(JSIR) 25年历史
Reproductive Immunology and Biology Pub Date : 1900-01-01 DOI: 10.3192/JSIRIB.25.93
S. Isojima
{"title":"The 25 years history of JAPAN SOCIETY for IMMUNOLOGY of REPRODUCTION (JSIR)","authors":"S. Isojima","doi":"10.3192/JSIRIB.25.93","DOIUrl":"https://doi.org/10.3192/JSIRIB.25.93","url":null,"abstract":"","PeriodicalId":126001,"journal":{"name":"Reproductive Immunology and Biology","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126203748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-vitro development of early preantral ovarian follicles from postpuberal mice in a simplified culture system 青春期后小鼠早期腔前卵泡在简化培养系统中的体外发育
Reproductive Immunology and Biology Pub Date : 1900-01-01 DOI: 10.3192/JSIRIB2003.20.1_1
H. Kada
{"title":"In-vitro development of early preantral ovarian follicles from postpuberal mice in a simplified culture system","authors":"H. Kada","doi":"10.3192/JSIRIB2003.20.1_1","DOIUrl":"https://doi.org/10.3192/JSIRIB2003.20.1_1","url":null,"abstract":"The developmental competence in vitro of immature oocytes from mouse early preantral follicles in a simplified culture was investigated. The follicles ware obtained from 4-10 weeks and 14 days old mice, respectively. On day 12 of culture, most of cultured follicles ware survived (100% vs 97%) in this culture system. The granulosa cell outgrowth was observed in all of surviving follicles. The oocytes grown in vitro ware leaded to GVBD (84% vs 96%), and 44% of them reached Metaphase II, respectively. This results show that this culture system is valid in not only preantaral follicles from prepuberal mouse but also that of postpuberal periods.","PeriodicalId":126001,"journal":{"name":"Reproductive Immunology and Biology","volume":"71 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128014122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CD73-mediated increased placental adenosine signaling via A 2B adenosine receptor contributes to the pathogenesis of preeclampsia cd73介导的胎盘腺苷信号通过a2b腺苷受体增加参与子痫前期的发病机制
Reproductive Immunology and Biology Pub Date : 1900-01-01 DOI: 10.3192/JSIRIB.31.16
T. Iriyama, Y. Osuga, T. Fujii
{"title":"CD73-mediated increased placental adenosine signaling via A 2B adenosine receptor contributes to the pathogenesis of preeclampsia","authors":"T. Iriyama, Y. Osuga, T. Fujii","doi":"10.3192/JSIRIB.31.16","DOIUrl":"https://doi.org/10.3192/JSIRIB.31.16","url":null,"abstract":"","PeriodicalId":126001,"journal":{"name":"Reproductive Immunology and Biology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132866083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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