Gastroenterology Research and Practice最新文献

{"title":"Relationship Between Blood Urea Nitrogen to Albumin Ratio and Risks of Mortality and Delirium in Pancreatitis Patients: A Retrospective Analysis of the MIMIC-IV Database.","authors":"Shuning Duan, Jie Xu, Yiwen Zu, Peicong You, Qiuyi Wang","doi":"10.1155/grp/5512602","DOIUrl":"10.1155/grp/5512602","url":null,"abstract":"<p><strong>Background and objective: </strong>This study is aimed at evaluating the predictive value of the blood urea nitrogen-to-albumin ratio (BAR) for both mortality and delirium risk in patients with pancreatitis. Pancreatitis carries a substantial mortality risk and significant long-term sequelae, with delirium being a severe neurological complication, underscoring the clinical need for effective prognostic markers.</p><p><strong>Methods: </strong>A retrospective cohort study was performed using the MIMIC-IV v3.0 database. A total of 1748 ICU patients meeting diagnostic criteria for pancreatitis (ICD-9/10 codes: 577.0, 577.1, K85) with documented baseline blood urea nitrogen (BUN) and albumin levels were included. BAR was calculated (BUN[mg/dL]/Albumin[g/dL]) and patients were stratified into quartiles (Q1: BAR < 3.0; Q2: BAR 3.0-5.0; Q3: BAR 5.0-9.2; Q4: BAR ≥ 9.2). The primary endpoints were all-cause mortality and delirium occurrence (identified using ICD-9 codes 293.0, 293.1, and ICD-10 codes F05, F05.9). Multivariable Cox proportional hazards regression (mortality) and logistic regression (delirium) were employed, adjusting for demographics, illness severity scores (GCS, SAPS II, OASIS, and Charlson Comorbidity Index), and comorbidities. Restricted cubic splines (RCS) were used to explore nonlinear associations.</p><p><strong>Results: </strong>Higher BAR levels significantly correlated with greater disease severity: compared with Q1, Q4 exhibited a higher Charlson Comorbidity Index and mortality rate. BAR was an independent predictor of delirium; each 1-unit increase in BAR was associated with a 2.7% increased risk of delirium (adjusted OR = 1.027, 95% CI: 1.009-1.044), and patients in Q4 had a significantly higher risk compared with those in Q1 (adjusted OR = 1.882, 95% CI: 1.157-3.108). After multivariable adjustment, BAR was not significantly independently associated with mortality (Q4 adjusted HR = 1.022, <i>p</i> = 0.8). RCS analysis revealed BAR > 9.0 as a high-risk threshold, characterized by delirium OR > 1.78 and mortality HR > 1.97. The BAR quartile model yielded AUCs of 0.635 and 0.599 for predicting mortality and delirium, respectively, indicating modest predictive ability.</p><p><strong>Conclusion: </strong>BAR independently predicts delirium risk and reflects disease severity in pancreatitis patients, but does not demonstrate significant independent predictive value for mortality after accounting for confounders. The identified threshold (BAR > 9.0) supports the utility of BAR as a supplementary biomarker for delirium risk stratification in this population.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"5512602"},"PeriodicalIF":1.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149215918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Research Analysis and Application Value of the Laparoscopic Retroperitoneal Approach in In Situ Splenectomy.","authors":"Dong-Fang Huang, Jian-Bo Xu, Ye-Mu Du, Ye-Bo Wang","doi":"10.1155/grp/7113085","DOIUrl":"10.1155/grp/7113085","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to compare the effects of the laparoscopic posterior approach in in situ splenectomy with those of traditional splenectomy. The primary indications for splenectomy in our cohort were splenomegaly and hypersplenism secondary to liver cirrhosis and portal hypertension, which is a common clinical scenario in our hepatobiliary surgery-centred hospital.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 58 patients who underwent splenectomy in our hospital. These were divided into 28 cases of laparoscopic posterior approach in situ splenectomy (posterior approach group) and 30 cases of traditional open splenectomy (open splenectomy group). Surgical indicators and postoperative complications were compared between the two groups.</p><p><strong>Results: </strong>Intraoperative blood loss, length of hospital stay and time to drainage clearance were substantially lower in the posterior approach group compared with the open splenectomy group. There was no significant difference in operation time. Postoperative complications in the posterior approach group included fever (7 cases), ascites (14 cases), pancreatic leakage (0 cases), rebleeding (1 case), secondary abdominal infection (0 cases) and venous thrombosis (2 cases). These were fewer than in the open splenectomy group, which presented with 18 cases of fever, 24 of ascites, 7 of pancreatic leakage, 4 of rebleeding, 3 of secondary abdominal infection and 6 of venous thrombosis. Statistically significant differences were observed in the incidence of pancreatic leakage, fever and ascites between the groups (<i>p</i> = 0.011, <i>p</i> = 0.007 and <i>p</i> = 0.016, respectively). No significant differences were found for rebleeding (<i>p</i> = 0.392), secondary abdominal infection (<i>p</i> = 0.238) or venous thrombosis (<i>p</i> = 0.299).</p><p><strong>Conclusion: </strong>The laparoscopic retroperitoneal approach in in situ splenectomy demonstrates clear advantages over traditional splenectomy with respect to intraoperative performance and postoperative complications, offering improved safety and efficacy.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"7113085"},"PeriodicalIF":1.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Status and Prospects of <i>Helicobacter pylori</i>-associated gastritis: From Mechanisms to Traditional Chinese Medicine Treatment.","authors":"Zhongyao Fan, Ziling Jin, Caiyue Liu, Ruifan Hu, Weiqiang Li","doi":"10.1155/grp/3413458","DOIUrl":"10.1155/grp/3413458","url":null,"abstract":"<p><p><i>Helicobacter pylori</i>-associated gastritis (HPAG) is a chronic inflammatory condition of the gastric mucosa caused by <i>Helicobacter pylori</i> infection, serving as the core etiological factor for peptic ulcers and gastric precancerous lesions. Given the persistently high global infection rates and the escalating burden of antibiotic resistance, conventional eradication therapies are encountering significant challenges. This article systematically delineates the molecular pathogenic mechanisms underlying HPAG, encompassing bacterial virulence factors, host immune responses, aberrant signaling pathways, oxidative stress, epigenetic regulation, and mucosal barrier damage. Building upon this foundation and in alignment with international mainstream diagnostic and therapeutic guidelines, we summarize the research progress of traditional Chinese medicine (TCM) interventions from a novel perspective of microecological homeostasis regulation. Specifically, we clarify the multifaceted roles of TCM monomers and formulas in immunomodulation, mucosal repair, and antibacterial synergism. By systematically synthesizing existing evidence from TCM studies, we construct a whole-course TCM intervention framework for HPAG that integrates \"susceptibility prevention, active treatment, and posteradication repair.\" Furthermore, we critically analyze the current clinical translation bottlenecks and the limitations inherent in the \"black-box\" research paradigm of TCM monomers and formulas, and propose future research directions driven by multiomics technologies. This work provides both theoretical support and practical references for precise integrated Chinese and Western medicine diagnosis and treatment of HPAG.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"3413458"},"PeriodicalIF":1.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13548316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional Role of Transabdominal Ultrasonography on Esophagogastroduodenoscopy for Uninvestigated Dyspepsia: A Prospective Study.","authors":"Sapol Thepwiwatjit, Piyaporn Apisarnthanarak, Supot Pongprasobchai","doi":"10.1155/grp/1205998","DOIUrl":"10.1155/grp/1205998","url":null,"abstract":"<p><strong>Background and aim: </strong>Dyspepsia is a common issue worldwide, primarily caused by gastroduodenal disorders. Esophagogastroduodenoscopy (EGD) is the standard investigation of uninvestigated dyspepsia (UID), whereas transabdominal ultrasonography (TUS) is used to evaluate various hepatopancreatobiliary diseases that may mimic dyspeptic symptoms. TUS is widely used among physicians, even though the diagnostic yield remains unclear. This study is aimed at assessing the additional benefit of TUS on EGD in investigating the etiologies of dyspepsia.</p><p><strong>Methods: </strong>This prospective study included patients with UID indicating for EGD at the Division of Gastroenterology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. All patients underwent both EGD and TUS within 1 month. Lesions identified by both methods were recorded and classified based on their potential to explain dyspepsia. Clinical data and reasons for EGD were also collected.</p><p><strong>Results: </strong>Three hundred and seventy patients with a mean age of 59 were included in the analysis. Dyspepsia-relevant endoscopic findings were present in 24.1% with common diagnoses including erosive gastritis/duodenitis, peptic ulcer, and erosive esophagitis. <i>Helicobacter pylori</i> was detected in 23.5%. No dyspepsia-relevant ultrasonographic findings were noted, though 9.5% of patients had ultrasonographic lesions requiring further investigation. No gastroesophageal and hepatopancreatobiliary cancers were detected.</p><p><strong>Conclusion: </strong>EGD provides some diagnostic information for dyspeptic patients, with additional TUS offering limited benefit. TUS findings rarely contributed to the diagnosis or necessitated further intervention, indicating that it does not enhance the diagnostic yield of EGD in this study.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"1205998"},"PeriodicalIF":1.6,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the GLIM Malnutrition Criteria in Patients With Gastric Cancer at the Time of Diagnosis.","authors":"Paola Sánchez-Corrales, Yazmín Hernández-Murillo, Luis Enrique Orozco-Rivera, Vanessa Fuchs-Tarlovsky, Gabriela Gutiérrez-Salmeán","doi":"10.1155/grp/6636000","DOIUrl":"10.1155/grp/6636000","url":null,"abstract":"<p><p>Gastric cancer is a major global public health challenge, with high incidence and mortality rates, particularly in Costa Rica. Like most oncological diseases, it significantly wastes nutritional status, often leading to malnutrition, which in turn worsens prognosis and survival. Early identification of malnutrition is therefore critical. The Global Leadership Initiative on Malnutrition (GLIM) has proposed standardized diagnostic criteria to systematically diagnose malnutrition across diverse clinical settings. However, validation has not been performed versus reference methods in many conditions, such as gastric cancer, although it is essential before widespread adoption. This study is aimed at validating the GLIM criteria for the timely detection of malnutrition in patients newly diagnosed with gastric cancer. We conducted a cross-sectional analysis in which GLIM-based assessments were compared against the Patient-Generated Subjective Global Assessment (PG-SGA) as the gold standard. Diagnostic performance was evaluated through sensitivity, specificity, and positive and negative predictive values; agreement was assessed with kappa statistics. Survival probability was further examined using Kaplan-Meier curves to estimate the prognostic relevance of nutritional status. A total of 72 patients were included. GLIM criteria demonstrated a sensitivity of 81.9% and specificity of 81.8% compared with PG-SGA, with moderate agreement (kappa = 0.48). Survival analysis revealed that both GLIM and PG-SGA consistently identified better outcomes among patients with preserved nutritional status. In conclusion, the GLIM criteria represent a valid and practical tool for the early detection of malnutrition in gastric cancer patients at diagnosis, supporting their integration into routine clinical practice to improve patient management and survival outcomes.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"6636000"},"PeriodicalIF":1.6,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13478726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148791710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of TIMP1 as a Key Regulator of Ferroptosis in Ulcerative Colitis Through Bioinformatics and Functional Experiments.","authors":"Xuan Zhou, Qiao Qiao, Jie Yang, Huiming Tu","doi":"10.1155/grp/6894499","DOIUrl":"10.1155/grp/6894499","url":null,"abstract":"<p><strong>Background: </strong>Ferroptosis is an iron-dependent form of regulated cell death, whereas the precise mechanism of ferroptosis in the pathogenesis of ulcerative colitis (UC) remains to be elucidated. The tissue inhibitor Metalloproteinase 1 (TIMP1) is involved in ferroptosis of UC, whereas its regulatory function remains unclear. This study is aimed at exploring the potential effect on ferroptosis in UC.</p><p><strong>Methods: </strong>Gene expression profiling data of colonic biopsies from UC patients and healthy controls were acquired from the GSE87466 dataset. The expression of TIMP1, GPX4, and SLC7A11 was determined using western blot. The mRNA levels of TIMP1, PGRMC1, IL-1<i>β</i>, and IL-6 were measured using reverse transcription quantitative PCR (RT-qPCR). The Fe²⁺ and malondialdehyde (MDA) contents were detected with commercial kits. The reactive oxygen species (ROS) production was analyzed via flow cytometry. The integrity of the intestinal epithelium was evaluated using a fluorescein isothiocyanate (FITC)-dextran permeability assay and transepithelial electrical resistance (TEER) measurements.</p><p><strong>Results: </strong>Bioinformatics identified TIMP1 and PGRMC1 as core genes related to ferroptosis of UC. Both TIMP1 and PGRMC1 were upregulated in colonic biopsies from UC patients in the GSE87466 dataset. The mRNA expression was induced after LPS treatment, whereas PGRMC1 was not significantly altered. TIMP1 knockdown inhibited the expression of IL-1<i>β</i> and IL-6; reduced Fe²⁺, MDA, and ROS levels; and upregulated the expression of GPX4 and SLC7A11 in LPS-induced intestinal epithelial cells. Furthermore, TIMP1 knockdown reduced the intestinal epithelial leakage in vitro.</p><p><strong>Conclusion: </strong>TIMP1 regulated ferroptosis, inflammatory response, and intestinal epithelial permeability in LPS-induced intestinal epithelial cells, suggesting TIMP1 as a potential therapeutic target for UC.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"6894499"},"PeriodicalIF":1.6,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13463132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148720156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Endoscopic Retrograde Appendicitis Therapy on Postoperative Gastrointestinal Function in Patients With Chronic Fecalith Appendicitis.","authors":"Yao Wu, Peichen Xia, Jing Chen, Yao Liu, Yan Yang, Yanyan Wang, Wenzhuo Jiang, Yu Fan, Hong Zhu, Xiaomeng Jiang","doi":"10.1155/grp/4306502","DOIUrl":"10.1155/grp/4306502","url":null,"abstract":"<p><strong>Background: </strong>This study compared postoperative gastrointestinal function recovery between endoscopic retrograde appendicitis therapy (ERAT) and laparoscopic appendectomy (LA) in patients diagnosed with chronic fecalith appendicitis.</p><p><strong>Methods: </strong>This was a retrospective study enrolling patients with chronic fecalith appendicitis, who were divided into the ERAT group and the LA group. Gastrointestinal manifestations were recorded, and the Gastrointestinal Symptom Rating Scale (GSRS) score was applied to evaluate gastrointestinal function. Preoperative and postoperative symptomatic improvement and GSRS scores were compared across groups.</p><p><strong>Result: </strong>A total of 101 eligible patients were recruited and divided into the ERAT group (<i>n</i> = 40, 39.60%) and the LA group (<i>n</i> = 61, 60.40%). All ERAT procedures were completed successfully, with 100% rates of successful intubation and fecalith removal. No severe adverse events were reported postoperatively in either cohort. Compared with LA, ERAT presented significantly shorter operative duration and postoperative hospital stay (statistically significant differences). For GSRS score assessment, the median preoperative, postoperative scores and score reduction were 5 (4), 1 (1.75), and 3.5 (1) in the ERAT group, versus 4 (2), 3 (3), and 1 (2) in the LA group. The ERAT group exhibited a significantly larger magnitude of symptom improvement (<i>p</i> < 0.001, <i>z</i> = -5.484). Multivariate logistic regression analysis indicated that patients undergoing ERAT obtained a significantly higher degree of GSRS score improvement (<i>p</i> < 0.001, odds ratio = 2.137, 95% confidence interval: 1.461-3.126). Analysis of individual GSRS domains demonstrated that improvements in abdominal pain, dyspepsia and diarrhea were significantly more prominent in the ERAT group.</p><p><strong>Conclusion: </strong>As an organ-preserving endoscopic procedure, ERAT retains appendiceal function and protects gastrointestinal physiological function. Our findings offer meaningful clinical references of treatment strategies for chronic fecalith appendicitis.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"4306502"},"PeriodicalIF":1.6,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13307183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148344989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Divergent Trajectories of the Burden of MASLD Attributable to High Fasting Plasma Glucose in China and Globally: A GBD Study 1990-2021 and Projections to 2046.","authors":"Xun Wu, Wei-Wei Zhang, Bo-Hu Wang, Yong-Feng Tang","doi":"10.1155/grp/1090542","DOIUrl":"10.1155/grp/1090542","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern. High fasting plasma glucose (HFPG) is a major metabolic driver, yet its long-term burden and future trends in China versus globally remain unclear.</p><p><strong>Methods: </strong>Data from the Global Burden of Disease Study 2021 were analyzed. Deaths and disability-adjusted life years (DALYs) were assessed using counts and age-standardized rates (ASRs). Temporal trends were evaluated using estimated annual percentage change (EAPC). An age-period-cohort (APC) model was used to project the burden through 2046.</p><p><strong>Results: </strong>In 2021, HFPG-attributable MASLD caused 10,021 deaths and 213,481 DALYs worldwide. From 1990 to 2021, global age-standardized death and DALY rates increased significantly (EAPC, 2.22% and 2.02%, respectively). The burden was higher in males and increased with age, peaking in those aged ≥ 80 years. Projections suggest that absolute deaths and DALYs will continue to rise globally and in China through 2046, whereas ASRs are expected to decline, particularly among females. China showed a lower increase in age-standardized death rate (EAPC, 1.28%) compared with the global average.</p><p><strong>Conclusion: </strong>The burden of HFPG-attributable MASLD continues to increase globally and remains substantial in China. Although ASRs may stabilize or decline, population aging is expected to sustain growth in the absolute burden. These findings highlight the need for early metabolic screening, integrated management of metabolic and liver diseases, and targeted interventions for older adults and other high-risk populations.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"1090542"},"PeriodicalIF":1.6,"publicationDate":"2026-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13282686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148294343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From \"Monarch, Minister, Assistant, and Envoy\" to \"Microbial Dialogue\": A Review of Novel Mechanisms by Which Chinese Herb Pairs Improve Metabolic Diseases Through Gut Microbiota Metabolic Regulation.","authors":"Zeyu Wang","doi":"10.1155/grp/8226799","DOIUrl":"10.1155/grp/8226799","url":null,"abstract":"<p><p>Metabolic diseases, including obesity, Type 2 diabetes, and nonalcoholic fatty liver disease, have become a severe global health burden, and their pathogenesis is closely associated with gut microbiota dysbiosis. As the core unit of traditional Chinese medicine (TCM) compatibility theory, Chinese herb pairs possess unique advantages in metabolic regulation due to their multicomponent and multitarget characteristics. Recent studies have confirmed that herb pairs can improve host metabolic homeostasis by reshaping gut microbial community structure, regulating microbial metabolites (e.g., short-chain fatty acids, bile acids, and tryptophan metabolites), and repairing intestinal barrier function. This review systematically summarizes the latest research progress regarding the intervention of Chinese herb pairs in metabolic diseases by modulating the gut microbiota metabolic network, provides an in-depth analysis of their action mechanisms based on the \"microbiota-gut-organ axis,\" and discusses the current research challenges and future translational directions.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"8226799"},"PeriodicalIF":1.6,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Aging on Correlation of Striated Esophageal and Pharyngeal Deglutitive Motor Function.","authors":"Mark Kern, Francis Edeani, Ling Mei, Patrick Sanvanson, Reza Shaker","doi":"10.1155/grp/9920130","DOIUrl":"10.1155/grp/9920130","url":null,"abstract":"<p><strong>Introduction: </strong>Effects of aging on the relationship of striated esophagus (StEso) motor function with pharyngeal deglutitive biomechanics has not been systematically studied.</p><p><strong>Objective: </strong>The aim of this study is to characterize the effects of aging on the correlation of deglutitive StEso with pharyngeal function.</p><p><strong>Materials and methods: </strong>We studied 33 healthy subjects. Fifteen elderly (age: 75 ± 7 years, 8 female) and 18 nonelderly (age: 50 ± 14 years, 9 F) were evaluated using high resolution manometry/impedance. Nine elderly (73 ± 7 years, 5 F) and eight young (24 ± 3 years, 4 F) were further evaluated by digital videofluoroscopy.</p><p><strong>Results and discussion: </strong>Duration of StEso excursion averaged 2.56 ± 0.65 s in elderly and 2.33 ± 0.41 in young. We identified four periods in StEso motor function during deglutitive excursion: (a) anterosuperior ascent without bolus/peristaltic activity, (b) nonperistaltic bolus receiving function at apogee of StEso excursion during UES opening and pharyngeal peristalsis, (c) peristaltic bolus transport as StEso descends, (d) continued peristalsis in resting position. Apart from the final period described, the periods are significantly different in the elderly compared with the young subjects (<i>p</i> < 0.04). Furthermore, the interaction of striated esophageal flow dynamics and peristaltic contractile vigor showed that a significant correlation (<i>r</i> = -0.71, <i>p</i> = 0.0009) was found when comparing the average bolus injection length to the average SECI in young subjects. This correlation was muted in the elderly and did not reach statistical significance (<i>r</i> = -0.41, <i>p</i> = 0.13).</p><p><strong>Conclusions: </strong>Sequencing of StEso/pharyngeal deglutitive motor function is preserved in the elderly. The differences observed in early stages of spatiotemporal mapping of StEso deglutitive motor function when comparing healthy elderly to young populations may be due to age-related suprahyoid muscle weakness since the affected periods are those associated with the active StEso ascent and descent. Like young individuals, elderly pressure signatures currently attributed to the StEso deglutitive motor activity do not represent the entirety of StEso peristalsis.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"9920130"},"PeriodicalIF":1.6,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13250628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148224571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}