Gastroenterology Research and Practice最新文献

{"title":"RETRACTION: \"Influence of Rosiglitazone on the Expression of PPAR<i>γ</i>, NF-<i>κ</i>B,and TNF-<i>α</i> in Rat Model of Ulcerative Colitis\".","authors":"Gastroenterology Research And Practice","doi":"10.1155/grp/9859572","DOIUrl":"10.1155/grp/9859572","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2012/845672.][This retracts the article DOI: 10.1155/2012/845672.].</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"9859572"},"PeriodicalIF":1.6,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13244562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148210918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Prevalence of Sarcopenia in Noncirrhotic Women With Primary Biliary Cholangitis: A Comparative Study of Clinical Characteristics and Risk Factors.","authors":"Jingyi Zhang, Jiamin Xu, Weimin Bao, Yingmei Tang","doi":"10.1155/grp/8688776","DOIUrl":"10.1155/grp/8688776","url":null,"abstract":"<p><strong>Aim: </strong>Sarcopenia is a common complication in patients with chronic liver disease (CLD). However, most prior studies on sarcopenia in CLD have predominantly focused on viral hepatitis and cirrhosis, with limited data available on its prevalence in primary biliary cholangitis (PBC), especially at noncirrhotic stages. This study is aimed at investigating the clinical characteristics and identifying independent risk factors for sarcopenia in female PBC patients.</p><p><strong>Methods: </strong>We retrospectively enrolled 229 female patients, including 118 with chronic hepatitis B (CHB) and 111 with PBC. All patients underwent abdominal computed tomography (CT). The skeletal muscle area at the level of the third lumbar vertebra (L3) was measured using the image analysis software SliceOmatic V5.0 (TomoVision, Magog, Canada), and the skeletal muscle index (SMI) was calculated accordingly. Sarcopenia was defined based on the L3-SMI index. We compared the prevalence of sarcopenia between PBC and CHB patients at different stages of liver fibrosis and further analyzed the clinical characteristics and independent risk factors for sarcopenia in PBC patients.</p><p><strong>Results: </strong>Among the 229 female patients, 93 were noncirrhotic (45 with PBC and 48 with CHB). The prevalence of sarcopenia was significantly higher in noncirrhotic PBC patients than in noncirrhotic CHB patients (75.60% vs. 31.30%, <i>χ</i> ² = 18.29, <i>p</i> < 0.001). Among the 136 cirrhotic patients (66 with PBC and 70 with CHB), sarcopenia prevalence showed no significant difference between PBC and CHB patients (60.60% vs. 52.90%, <i>χ</i> ² = 0.83, <i>p</i> > 0.05). After propensity score matching (PSM), both cirrhotic and noncirrhotic PBC groups demonstrated a high prevalence of sarcopenia (85.30% vs. 70.60%, <i>χ</i> ² = 2.138, <i>p</i> > 0.05). Multivariate analysis identified that low body mass index (BMI) (OR = 1.342; 95<i>%</i>CI = 1.150-1.565; <i>p</i> < 0.001) and osteopenia/osteoporosis (OR = 4.2; 95<i>%</i>CI = 1.408-12.533; <i>p</i> = 0.01) were independent risk factors for sarcopenia in female PBC patients.</p><p><strong>Conclusion: </strong>Sarcopenia is highly prevalent in female PBC patients. In contrast to female CHB patients, in whom sarcopenia mainly occurs at the cirrhotic stage, female PBC patients exhibit high sarcopenia prevalence at both noncirrhotic and cirrhotic stages. Low BMI and osteopenia/osteoporosis are independent risk factors for sarcopenia in female PBC patients. Notably, sarcopenia should also be considered in PBC patients with normal or high BMI. Early and routine screening for sarcopenia and its risk factors is recommended in all PBC patients, regardless of cirrhosis stage.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"8688776"},"PeriodicalIF":1.6,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13238509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148198436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory Cytokines as Potential Inducements of Early Gastric Mucosal Lesions in <i>Helicobacter pylori</i>-Infected Patients.","authors":"Minghong Li, Chiyu Tian, Kai Guo, Wei Pan, Runhua Lv, Lipeng Jing, Dongmei Yang","doi":"10.1155/grp/9063312","DOIUrl":"10.1155/grp/9063312","url":null,"abstract":"<p><strong>Background: </strong>Chronic inflammation due to <i>Helicobacter pylori</i> infection causes the development of many gastrointestinal diseases, such as gastric ulcer and atrophic gastritis. This study is aimed at investigating the relationship between inflammatory cytokines and pepsinogen levels in <i>H. pylori</i>-infected patients.</p><p><strong>Method: </strong>A total of 165 <i>H. pylori</i>-infected subjects without atrophic gastritis were recruited, and their demographic, medical, and lifestyle information were collected. Inflammatory cytokines such as IL-8, IFN-<i>γ</i>, TNF-<i>α</i>, CRP, IL-17A, IL-1<i>β</i>, IL-18, and pepsinogen (PGs I and II) levels were measured. Multiple linear regression was used to analyze the relationship between cytokines and PG levels, whereas segmental regression explored threshold or saturation effects.</p><p><strong>Result: </strong>IL-17A and IFN-<i>γ</i> were positively correlated with PG I and LNPG II, with each 1-pg/mL increase in IL-17A associated with a 2.595 (95% CI: 0.854, 4.335)-ng/mL increase in PG I and a 0.012 (95% CI: 0.002, 0.022)-ng/mL increase in LNPG II; each 1-pg/mL increase in IFN-<i>γ</i> was associated with a 1.746 (95% CI: 0.702, 2.791)-ng/mL increase in PG I and a 0.008 (95% CI: 0.002, 0.0191)-ng/mL increase in LNPG II. No significant correlation was found between inflammatory cytokines and the PG I/PG II ratio (PGR).</p><p><strong>Conclusion: </strong>In <i>H. pylori</i>-infected patients without atrophic gastritis, IL-17A and IFN-<i>γ</i> levels showed a linear correlation with PG levels. These cytokines may be closely associated with early gastric mucosal lesions. However, further research is needed to elucidate their specific mechanisms in disease pathogenesis.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"9063312"},"PeriodicalIF":1.6,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147971745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gui-Shao San Umbilical Moxibustion for Diarrhea-Predominant Irritable Bowel Syndrome With Liver Depression and Spleen Deficiency Pattern: A Randomized Controlled Trial.","authors":"Mengyan Zhou, Yulu He, Longshu Zhang, Junquan Xia, Zhentao An, Xixia Zhang","doi":"10.1155/grp/1832176","DOIUrl":"10.1155/grp/1832176","url":null,"abstract":"<p><strong>Objectives: </strong>This randomized controlled trial aimed to evaluate the effects of Gui-Shao San umbilical moxibustion on symptoms of the disease, psychological well-being, and quality of life in patients with IBS-D.</p><p><strong>Interventions: </strong>The patients were randomly assigned to three groups: One received Gui-Shao San umbilical moxibustion alongside conventional Western medicine treatment; one received placebo umbilical moxibustion alongside conventional Western medicine treatment; and one received only conventional Western medicine treatment for use as a positive control group.</p><p><strong>Outcomes: </strong>The primary outcome measures included TCM clinical symptom score, IBS-SSS, and grading criteria for TCM syndrome scores. Secondary outcome measures included SAS, SDS, and IBS-QOL. The effects of the intervention on these outcomes were measured at three time points: baseline (T0), Week 2 (T1), and Week 4 (T2). At Week 8, the recurrence of patients was measured based on whether their IBS-SSS score increased by one grade.</p><p><strong>Results: </strong>After 4 weeks of treatment, compared with the positive drug control group, both the Gui-Shao San umbilical moxibustion group and the placebo umbilical moxibustion group effectively relieved patients' symptoms, anxiety, and depression, while improving their quality of life. Significant differences were observed between groups in IBS-SSS scores (120.61 ± 30.61 vs. 128.13 ± 41.85 vs. 161.82 ± 59.87, <i>p</i> < 0.001) and TCM syndrome scores (7.88 ± 1.709 vs. 8.59 ± 2.722 vs. 9.97 ± 2.099, <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Gui-Shao San umbilical moxibustion is an effective method for treating IBS-D. Further rigorous, large-scale, long-term trials are needed to evaluate the therapeutic effects of Gui-Shao San umbilical moxibustion, focusing on interdisciplinary collaboration.</p><p><strong>Trial registration: </strong>The International Traditional Medicine Clinical Trial Registry (ITMCTR) Reg. No.: ITMCTR2025001072.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"1832176"},"PeriodicalIF":1.6,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147971729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prognostic Nutritional Scoring System Integrating Inflammatory Markers and Body Composition in Gastric Cancer Patients Undergoing Curative Resection With Prophylactic HIPEC.","authors":"Ruiqing Liu, Zhibo Wang, Jingnong Liu, Yahya Ahmed, Yuandi Wang, Dongsheng Wang, Duo Li","doi":"10.1155/grp/7959410","DOIUrl":"10.1155/grp/7959410","url":null,"abstract":"<p><strong>Background and objectives: </strong>Nutrition- and inflammation-related indicators have been shown the prognostic value in cancer patients; however, few studies focus on gastric cancer (GC) patients who underwent prophylactic intraperitoneal hyperthermic chemotherapy (p-HIPEC) following radical gastrectomy. This study is aimed at developing and validating a prognostic nutritional scoring system (PNSS) integrating systemic inflammatory markers and body composition parameters specifically for these patients.</p><p><strong>Methods and results: </strong>Body composition was assessed via computed tomography, and systemic inflammatory markers were recorded preoperatively. A total of 267 patients with GC who received p-HIPEC were included, and the incidences of sarcopenia, myosteatosis, and sarcopenic obesity were 32.6%, 27.3%, and 18.7%, respectively. Logistic regression analysis identified that platelet-to-lymphocyte ratio (PLR) is a significant risk factor for sarcopenia and myosteatosis. The PNSS was constructed using PLR, systemic immune-inflammation index (SII), lymphocyte-to-monocyte ratio (LMR), skeletal muscle index (SMI), and sarcopenia-myosteatosis risk (SMR) score which further integrates skeletal muscle attenuation (MA). This model demonstrated superior predictive accuracy for overall survival (OS) compared to the classic TNM model (<i>C</i>-index: 0.76 vs. 0.71 for 3-year OS in the primary cohort and 0.68 vs. 0.64 for 5-year OS in the validation cohort).</p><p><strong>Conclusions: </strong>The PNSS, incorporating both body composition and systemic inflammatory markers, provides robust prognostic value for predicting OS in GC patients undergoing curative resection with p-HIPEC.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"7959410"},"PeriodicalIF":1.6,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13173548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147963257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and Disparities in <i>Clostridioides difficile</i> Infection Mortality in the United States From 1999 to 2020: A Nationwide Perspective.","authors":"Mohamed H Eldesouki, Abdul-Rahman Abusalim, Mohammad Kloub, Muhammed Umer, Mohamed Ahmed Ali, Ahmed Yasser Shaban, Ahmed Salem, Anas Almoghrabi, Jihad Slim, Yatinder Bains, Theodore Dacosta","doi":"10.1155/grp/9981233","DOIUrl":"10.1155/grp/9981233","url":null,"abstract":"<p><strong>Background: </strong><i>Clostridioides difficile</i> infection (CDI) is one of the most prevalent infections in the United States, with rising mortality and disease severity in the early 2000s, followed by a steady decline after 2010. This study analyzes national trends in CDI mortality across different demographic and regional groups from 1999 to 2020.</p><p><strong>Methods: </strong>We used CDC WONDER (Wide-ranging Online Data for Epidemiologic Research) to analyze CDI-related deaths among adults aged ≥ 35 years. Age-adjusted mortality rates (AAMRs) per 100,000 individuals, along with annual percent change (APC) and average annual percent change (AAPC), were calculated and stratified by year, sex, race, and region. Statistical significance was assessed using Joinpoint regression analysis.</p><p><strong>Results: </strong>During the study period, 191,653 CDI-related deaths were reported. The AAMR for CDI-related mortality increased from 1.1 in 1999 to 7.3 in 2011 (AAPC: 33.60). However, from 2011 to 2020, there was a notable decline in CDI mortality (AAPC: -10.48; 95% CI: -13.31 to -7.52). Mortality increased significantly with age, and females had a higher total number of deaths, while males maintained a higher AAMR throughout the study period. Among different racial groups, non-Hispanic White individuals recorded the highest AAMR (6.1) in 2011, while Asian individuals had the lowest AAMR (2.3). Geographically, the Northeastern census region reported the highest AAMR (4.8) in 2008, while the Southern census region had the lowest AAMR (3.1). The majority of CDI-related deaths (78%) occurred in hospitals, with nursing homes accounting for 17.7% of fatalities.</p><p><strong>Conclusions: </strong>The sharp decline in CDI mortality starting in 2010 aligns with the implementation of strict guidelines and collaborative efforts between professional societies (IDSA/SHEA), the ACG, and government agencies (CDC). This underscores the success of coordinated public health initiatives in reducing healthcare-associated infections and improving patient outcomes. However, disparities in mortality rates persist across different age, sex, ethnic, and geographic groups, emphasizing the need to further study disease trends and explore strategies to address these disparities in high-risk populations.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"9981233"},"PeriodicalIF":1.6,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13162000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147928483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Cytomegalovirus Infection Affecting the Stomach.","authors":"Yang Diao, Ye Zong, Rui Xu, Guangyong Chen, Xun Yang, Haiying Zhao","doi":"10.1155/grp/4842972","DOIUrl":"10.1155/grp/4842972","url":null,"abstract":"<p><strong>Background: </strong>The incidence of cytomegalovirus (CMV) infection is increasing. This study explored the clinical characteristics, diagnosis, treatments, and prognosis of gastric lesions caused by CMV infection.</p><p><strong>Methods: </strong>This is a systematic review of the literature on CMV infection involving the stomach.</p><p><strong>Results: </strong>A total of 39 English publications reporting 44 cases of CMV gastritis were identified through literature retrieval. Clinically, patients with CMV gastritis commonly presented with gastrointestinal symptoms, including abdominal pain, nausea and/or vomiting, and gastrointestinal bleeding. Endoscopic findings most frequently included mucosal ulcers (54.55%), erosions (27.27%), and erythema (20.45%). Most patients had a history of immunosuppression, such as AIDS, postorgan transplantation, cancer chemotherapy, or long-term use of corticosteroids and immunosuppressants. The diagnosis was primarily confirmed by endoscopic biopsy combined with CMV DNA quantitative testing. The majority of patients improved after antiviral therapy, while a small subset experienced spontaneous resolution. However, a few cases (2.27%) progressed to gastric cancer, and some (4.55%) resulted in death.</p><p><strong>Conclusion: </strong>In patients with a history of immunosuppression presenting with gastrointestinal symptoms such as abdominal pain, nausea, vomiting, or gastrointestinal bleeding, CMV gastritis should be considered in the differential diagnosis. Endoscopic biopsy with histopathological examination plays a crucial role in confirming the diagnosis.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"4842972"},"PeriodicalIF":1.6,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"S1 Guideline of the German Society for Neurogastroenterology and Motility (DGNM) on Functional Dyspepsia (FD), a Disorder of Gut-Brain Interaction (DGBI) [English Language Edition].","authors":"M Storr, V Andresen, T Frieling, J M Gschossmann, J Keller, J Langhorst, C Pehl, A Stengel, J Tebbe, K Wiemer, A Madisch, M Stengel","doi":"10.1155/grp/2610765","DOIUrl":"10.1155/grp/2610765","url":null,"abstract":"<p><p>Functional dyspepsia (FD) is common and classified as a disorder of gut-brain interaction (DGBI). The prevalence is estimated around 10% of the population. Diagnosis is based on symptoms, which are classified according to the Rome IV criteria, in combination with diagnostic procedures that may include laboratory testing, <i>Helicobacter pylori</i> testing, upper gastrointestinal endoscopy, abdominal ultrasound, and other examinations, depending on the severity, duration, and presence of alarm symptoms. Therapeutic procedures include psychoeducation, dietary counseling, mind-body procedures, psychotherapy, and medication. The S1 guideline summarizes the current state of knowledge and allows a targeted approach based on the currently available medical evidence.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"2610765"},"PeriodicalIF":1.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Risk Factors for Short-Term Outcomes in Acute Small Bowel Obstruction: A Retrospective Study.","authors":"Yong Cai, Wei-Xuan Xu, Can-Hong Zhan, Qi-Hong Zhong, Shuai Chen, Hui Wang, Peng-Sheng Tu, Wen-Xuan Chen, Xian-Qiang Chen, Jun-Rong Zhang","doi":"10.1155/grp/8871353","DOIUrl":"10.1155/grp/8871353","url":null,"abstract":"<p><strong>Background: </strong>As the lack of analysis on risk factors for the short-term outcomes of acute small bowel obstruction (ASBO), the current high readmission rate and severe postoperative complications of ASBO seriously affect the quality of life of patients. Risk-scoring models for evaluating the short-term outcomes of ASBO are still urgently needed.</p><p><strong>Methods: </strong>A total of 278 patients diagnosed with complete ASBO were included in this study. Cox proportional hazards regression analysis was used to construct predictive models for the length of stay (LOS) and the length of short-term recurrence (LOR). The receiver operating characteristic (ROC) curves and the area under the curve (AUC) were calculated to assess the performance.</p><p><strong>Results: </strong>The mean LOS of 278 patients was 11.19 days, and 17 patients (6.1%) were readmitted. Multivariate analysis showed that longer duration of disease (Hazard ratio, HR = 1.551), low albumin (HR = 1.681), high lumen diameter(max) (HR = 1.477), low chlorine (HR = 1.046), and operation (HR = 7.456) were risk factors for LOS. Calcium (HR = 29.391) was an independent risk factor for LOR. Operation is not a risk factor for LOR. A risk-scoring model of LOS (RS_LOS) was constructed to predict the posttreatment recovery (AUC, 30 days = 0.859). In the high-risk group, the severe adverse events (SAE) rate reached 17.1%, exceeding 1.4% in the low-risk group. The performance of RS_LOR was also satisfactory (AUC, 12 months = 0.802). In the high-risk group, the recurrence rate reached 14.3%, nearly triple that in the low-risk group (3.4%).</p><p><strong>Conclusion: </strong>The risk-scoring models of LOS and LOR provide a comprehensive evaluation on the short-term outcomes of ASBO treatment.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"8871353"},"PeriodicalIF":1.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features and Factors Contributing to Preoperative Misdiagnosis of Gastric Gastrointestinal Stromal Tumors: A Retrospective Analysis of 27 Cases.","authors":"Jianming Xie, Jiabin Yang, Zhilong Yan","doi":"10.1155/grp/6634495","DOIUrl":"10.1155/grp/6634495","url":null,"abstract":"<p><strong>Objective: </strong>Gastrointestinal stromal tumors (GISTs) lack specific clinical manifestations and are challenging to distinguish from other gastric submucosal tumors (SMTs). This study is aimed at illustrating the atypical manifestations of non-GISTs mimicking gastric GISTs and determining whether objective preoperative factors can help differentiate gastric GISTs from non-GISTs in patients.</p><p><strong>Methods: </strong>We included 29 GIST patients and 27 patients preoperatively misdiagnosed with GIST located in the stomach. We compared demographic data and tumor characteristics based on endoscopic ultrasound (EUS) and computed tomography (CT) findings between GIST and non-GIST groups.</p><p><strong>Results: </strong>Clinical symptoms in the extragastric compressions group were significantly more common (100%) than in the GISTs group (35.7%) (<i>p</i> < 0.05). Gastrointestinal stromal tumors more commonly exhibited an exophytic growth pattern than gastric non-GISTs SMTs (<i>p</i> < 0.05). Mean arterial phase attenuation was significantly lower in gastric non-GISTs SMTs (54.3 HU) compared with GISTs (59 HU, <i>p</i> = 0.003), with an optimal cutoff value of < 28.9 HU and an AUC of 0.689. There was a significant difference in lesion size between the GIST and gastric non-GIST groups, with GISTs presenting larger lesions (4.2 vs. 3.3 cm, <i>p</i> = 0.038). Additionally, necrosis was more frequently observed in the GISTs.</p><p><strong>Conclusions: </strong>For gastric submucosal protuberant lesions, a comprehensive EUS and CT imaging examination is necessary for accurate diagnosis to avoid misdiagnosis and inappropriate treatment, which may affect patient prognosis.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"6634495"},"PeriodicalIF":1.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147769027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}