Gastroenterology Research and Practice最新文献

{"title":"Association Between Serum PADI-4 Levels and Disease Activity in Ulcerative Colitis Patients.","authors":"Semiha Şimşek, Elvan Işık, Betül Çiğdem Yortanlı, Cem Çekiç","doi":"10.1155/grp/8211063","DOIUrl":"https://doi.org/10.1155/grp/8211063","url":null,"abstract":"<p><strong>Objectives: </strong>PADI-4 is a member of the peptidyl arginine deiminase enzyme family. This enzyme is expressed by inflammatory cells and plays an important role in inflammation and immune responses. In this study, we aimed to evaluate serum PADI-4 levels in patients with ulcerative colitis (UC) and to investigate the relationship between PADI-4 and disease activity.</p><p><strong>Material and method: </strong>Fifty-one patients with UC and 31 healthy controls were included in this observational study. First, serum PADI-4 levels in patients with UC and the control group were compared. Subsequently, serum PADI-4 levels were analyzed in UC patients with active disease and those who are in remission, separately. Finally, the impact of PADI-4 on predicting disease activity was evaluated by performing correlation analyses between serum PADI-4 and C-reactive protein (CRP) in addition to the total Mayo score (TMS) and modified Mayo Endoscopic Subscore (MESS).</p><p><strong>Results: </strong>Serum mean PADI-4 levels were found to be significantly higher in the UC group (1317 ± 818 pg/mL) compared to the control group (873 ± 622 pg/mL) (<i>p</i>: 0.009). Serum mean PADI-4 levels were significantly different between the three groups (patients with remission, mild disease, and moderate/severe disease group) (<i>p</i>: 0.015) (1076 ± 609, 1073 ± 683, and 1802 ± 943 pg/mL, respectively). In Spearman's correlation analysis, it was determined that there was a positive and significant relationship between PADI-4 and CRP levels (<i>r</i> = 0.31, <i>p</i>: 0.027) in addition to TMS (<i>r</i> = 0.419, <i>p</i>: 0.02) and MESS (<i>r</i> = 0.417, <i>p</i>: 0.002). The ideal serum PADI-4 levels for predicting disease activity were found to be 980 pg/mL.</p><p><strong>Conclusion: </strong>Our study revealed that serum PADI-4 levels were higher in patients with UC compared to healthy controls and might be an effective marker to determine disease severity.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"8211063"},"PeriodicalIF":1.4,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ERCP Performed Out-of-Working Hours Is Effective and Reliable for the Treatment of Acute Cholangitis.","authors":"Kerem Kenarlı, Bülent Ödemiş, Dilara Turan Gökçe, Orhan Coşkun, Volkan Gökbulut, Zeki Mesut Yalin Kılıç","doi":"10.1155/grp/2344299","DOIUrl":"https://doi.org/10.1155/grp/2344299","url":null,"abstract":"<p><strong>Background: </strong>Acute cholangitis is a life-threatening condition that requires prompt biliary drainage, typically achieved through endoscopic retrograde cholangiopancreatography (ERCP). However, data on outcomes of procedures performed outside of regular working hours remain limited. This study evaluates the safety and efficacy of out-of-working-hours ERCP for acute cholangitis.</p><p><strong>Methods: </strong>A retrospective analysis of 83 patients who underwent out-of-working-hours ERCP for acute cholangitis was conducted. Patients were categorized by cholangitis severity (mild, moderate, and severe) and procedure timing (< 12, 12-24, and 24-48 h). Outcomes assessed included procedural success, complications, and clinical results. Multivariate logistic regression was used to identify predictors of prolonged hospitalization.</p><p><strong>Results: </strong>Of the patients, 14.5% had mild, 19.3% moderate, and 66.3% severe cholangitis. Median time to procedure was shorter in severe cases (6.0 h) than in mild (13.5) and moderate (14.5) cases (<i>p</i> = 0.016). Technical success was 100%, with 91.6% receiving stents or nasobiliary drains. Complications occurred in 6%, and mortality (3.6%) was limited to severe cases. Early intervention (< 12 h) significantly reduced prolonged hospital stays (> 15 days, <i>p</i> = 0.006).</p><p><strong>Conclusion: </strong>Out-of-working-hours ERCP was associated with high technical success and a low complication rate in this cohort. Out-of-working-hours ERCP achieved high rates of successful biliary drainage with an acceptable safety profile, and ERCP performed within 12 h was independently associated with a lower risk of prolonged hospitalization.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"2344299"},"PeriodicalIF":1.4,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: \"H-Ras Oncogene Expression and Angiogenesis in Experimental Liver Cirrhosis\".","authors":"Gastroenterology Research And Practice","doi":"10.1155/grp/9871791","DOIUrl":"https://doi.org/10.1155/grp/9871791","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2013/868916.].</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"9871791"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13042329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors and Predictive Modeling of Occult Choledocholithiasis in Patients with Cholecystolithiasis.","authors":"Ping Zhang, Long-Jiang Chen, Dan-Feng Liu","doi":"10.1155/grp/9419737","DOIUrl":"10.1155/grp/9419737","url":null,"abstract":"<p><strong>Background: </strong>Occult choledocholithiasis, if not diagnosed and treated in a timely manner, can have severe consequences. The purpose of this study is to construct a predictive model to assist in the diagnosis.</p><p><strong>Methods: </strong>A total of 988 case datasets were included. Data were analyzed using chi-square tests and multivariate logistic regression. Ultimately, a predictive model for gallstones combined with occult choledocholithiasis was constructed.</p><p><strong>Results: </strong>Multivariate logistic regression analysis revealed that age, alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), direct bilirubin (DBIL), location of gallstones, and ultrasonographic indication of common bile duct dilation are independent risk factors for gallstones combined with occult choledocholithiasis. A predictive model was constructed based on these factors: logit(P) = -5.109 + 2.007x1 + 1.175x2 + 3.479x3 + 1.412x4 + 2.199x5 + 2.473x6 (where x1-x6 represent age, location of gallstones, ultrasonographic indication of common bile duct dilation, ALT, GGT, DBIL, respectively). The model demonstrated a sensitivity of 0.839, specificity of 0.891, accuracy of 0.885, 95% CI of 0.913-0.967, and an AUC of 0.940.</p><p><strong>Conclusion: </strong>Age, ALT, GGT, DBIL, gallstone location, and sonographic common bile duct dilation constitute independent risk factors for gallstones with occult choledocholithiasis. The prediction model based on these indicators provides a valuable tool for the diagnosis of occult choledocholithiasis.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"9419737"},"PeriodicalIF":1.4,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12961351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147376931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil Extracellular Traps and Intestinal Diseases: A Narrative Review.","authors":"Zhe Wang, Binni Yang, Zhenghong Li, Chen Gao","doi":"10.1155/grp/5908301","DOIUrl":"https://doi.org/10.1155/grp/5908301","url":null,"abstract":"<p><p>Neutrophil extracellular traps (NETs) are a network-like structure released by neutrophils into the extracellular space in response to various stimuli, with DNA as the main component, to which histones, granulins, cytoplasmic proteins, and other proteins are attached. Previous studies have shown that NETs are involved in the development of immune diseases, inflammation, tumors, etc. NETs are associated with the development of several intestinal diseases, including inflammatory bowel disease and intestinal ischemia-reperfusion injury. NETs may also interact with microorganisms to contribute to the development of inflammatory bowel disease and participate in the proliferation, metastasis, and thrombosis of colorectal cancer cells. This review comprehensively summarizes the latest research progress on NETs and intestinal diseases, providing a valuable reference for further investigations in this field.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"5908301"},"PeriodicalIF":1.4,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12957777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147364786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Value of Serum Pepsinogen and <i>Helicobacter pylori</i> Infection in Gastric Cancer Screening in Western Zhejiang.","authors":"Dong-Hai Yan, Yu-Fang Li","doi":"10.1155/grp/9113753","DOIUrl":"https://doi.org/10.1155/grp/9113753","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to assess the screening value of serum pepsinogen (PG) expression and <i>Helicobacter pylori</i> (<i>Hp</i>) infection for gastric cancer (GC) in western Zhejiang.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on patients who underwent gastroscopy at the First People's Hospital of Jiande between July 2020 and July 2023. Participants were classified into four groups: chronic nonatrophic gastritis, chronic atrophic gastritis, peptic ulcer, and GC, which included early gastric cancer (EGC) and advanced GC. Serum pepsinogen I (PGI), pepsinogen II (PGII), pepsinogen ratio (PGR), and anti-<i>Helicobacter pylori</i> immunoglobulin G (Hp-IgG) levels were measured. Group differences were assessed, and receiver operating characteristic (ROC) curve analysis was used to assess the diagnostic performance of PG alone and in combination with Hp-IgG, age, and sex for GC and EGC.</p><p><strong>Results: </strong>Significant differences were observed among the four groups in PGI, PGII, PGR, <i>Hp</i> infection rate, age, and sex (<i>p</i> < 0.01). In benign gastric diseases, PGI and PGII levels increased with the severity and activity of gastric mucosal inflammation (<i>p</i> < 0.05). PGII levels were associated with tumor size and Lauren classification (<i>p</i> < 0.05), while PGR was associated with GC stage (<i>p</i> = 0.021). The area under the ROC curve (AUC) for PG alone in differentiating GC/EGC from benign gastric diseases ranged from 0.598 to 0.813, whereas the model incorporating PG, Hp-IgG, age, and sex achieved an AUC of 0.851.</p><p><strong>Conclusion: </strong>Serum PG expression and <i>Hp</i> infection rates differed between patients with GC and those with benign gastric diseases in western Zhejiang. Models combining PG with demographic variables demonstrated a good diagnostic value for GC, including EGC, supporting their potential application in noninvasive GC screening.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"9113753"},"PeriodicalIF":1.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12950352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory Bowel Disease in Vietnam: Insights From a Retrospective Study at Bach Mai Hospital.","authors":"Nam Hoai Nguyen, Hien Thi-Thu Nguyen, Trang Thu Khuc, Yen Thi Lo, Ha Thi-Ngoc Doan, Hieu Van Nguyen, Long Cong Nguyen","doi":"10.1155/grp/1618547","DOIUrl":"https://doi.org/10.1155/grp/1618547","url":null,"abstract":"<p><strong>Introduction: </strong>Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is an emerging disease in Southeast Asian countries, including Vietnam. This study was conducted to characterize patients with IBD who were managed as inpatients.</p><p><strong>Populations and methods: </strong>This is a retrospective study at the Gastroenterology and Hepatology Center, Bach Mai Hospital, from January 1, 2022 to December 31, 2024. Medical records from clinical information of all patients admitted for inpatient treatment were used.</p><p><strong>Results: </strong>There were 242 patients with IBD, of whom 143 had CD and 99 had UC. In patients with UC, disease extent was classified as E1 (24.0%), E2 (62.2%), and E3 (23.8%). For patients with CD, the disease location was L1 (9.1%), L2 (48.3%), L3 (32.9%), and L4 (2.1%), and the disease phenotype was B1 (49.0%), B2 (16.8%), B3 (34.2%), with 16.0% having perianal lesions. A total of 81.8% of patients were treated with the step-up therapy; 18.2% were treated with the top-down strategy, and there was a difference between CD and UC. After 12 months of follow-up, 20% of patients required therapy escalation, including 18.2% with CD and 23.2% with UC.</p><p><strong>Conclusions: </strong>Inpatients with IBD at Bach Mai Hospital often present with severe manifestations and poor prognostic factors. Although biologic agents are increasingly used in CD, most patients are still managed with a step-up approach due to limited access to advanced treatments.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"1618547"},"PeriodicalIF":1.4,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12949386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147325596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leucine Aminopeptidase to Spleen Length Ratio: A Novel Noninvasive Model for Predicting Esophageal Gastric Variceal Bleeding in Patients With Liver Cirrhosis.","authors":"Chen Zhu, Ying Jiang, Yicun Liu, Zhaolian Bian, Lin Luo","doi":"10.1155/grp/9637489","DOIUrl":"https://doi.org/10.1155/grp/9637489","url":null,"abstract":"<p><strong>Background: </strong>Esophageal gastric variceal bleeding (EGVB) is a common complication of liver cirrhosis. However, esophagogastroduodenoscopy (EGD) for detecting venous pressure is invasive, limiting its clinical application. To reduce unnecessary EGD screening, here we screened multiple commonly used noninvasive examination indicators and evaluated their potential for predicting the risk of EGVB in patients with cirrhosis.</p><p><strong>Methods: </strong>Patients with liver cirrhosis who were diagnosed with esophageal gastric varices (EGVs) for the first time were divided into groups with and without bleeding. All patients underwent serum biochemical and hematological tests, EGD, and splenic ultrasound examination. The relationships among these indices and EGVB were analyzed using logistic regression models and receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>The neutrophil-to-leukocyte ratio (NEU%) and splenic vein diameter were identified as independent risk factors for EGVB, while total protein (TP), total biliary acid (TBA), leucine aminopeptidase (LAP), and platelet (PLT) count were protective factors. TP, TBA, NEU%, LAP/spleen length ratio (LSR), and PLT/spleen length ratio (PSR) were all significantly correlated with the maximum diameter of EGV blood vessels. Compared to their individual applications, the combination of TP and LSR demonstrated the highest diagnostic accuracy for EGVB.</p><p><strong>Conclusion: </strong>LSR and the combination application of LSR and TP could help predict bleeding events in patients with EGV.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"9637489"},"PeriodicalIF":1.4,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12946649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147325598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of EGFRvIII Presence in Gastric Adenocarcinoma.","authors":"Ali Zare-Mirzaie, Narjes Safari, Amirhosein Mehrtash, Nasrin Shayanfar, Ensieh Jafari, Elmira Gheytanchi","doi":"10.1155/grp/5870339","DOIUrl":"https://doi.org/10.1155/grp/5870339","url":null,"abstract":"<p><strong>Background: </strong>The significance of epidermal growth factor receptor (EGFR) gene variants, particularly the variant known as EGFRvIII, which arises from the deletion of exons 2-8, has been extensively studied in various human carcinomas. In contrast, studies into the role of EGFRvIII in gastric cancer remain limited. The current study aims to evaluate the expression levels of EGFRvIII in patients suffering from gastric adenocarcinoma.</p><p><strong>Material and methods: </strong>In this descriptive cross-sectional study, 21 patients with gastric adenocarcinoma who referred to the university-based referral hospital, Rasoul-Akram, in Tehran, Iran, during 2018-2019, were included. The patients' characteristics including demographic features, medical archives, type and location of tumor mass, and histopathological type were recorded. In order to evaluate the expression of EGFRvIII variant, RT-PCR and sequencing techniques were used.</p><p><strong>Results: </strong>In patients with gastric adenocarcinoma, 14 cases (66.7%) were males and seven cases (33.3%) were females, and the average age of the patients was 66.62 ± 10.79 years, ranging from 45 to 89 years. In terms of the histopathological type, six cases (28.6%) were moderately differentiated (MD), four cases (19.0%) were poorly differentiated (PD), five cases (23.8%) were SIG adenocarcinoma, and six cases (28.6%) were well differentiated (WD). A total of 18 samples (85.7%) were obtained from the biopsy, while three cases (14.3%) were derived from total gastrectomy and necrosis was seen in eight cases (38.1%). Two out of 21 cases (9.5%) were EGFRvIII positive in both RT-PCR and sequencing test. The first case was an 86-year-old woman with a signet-ring cell (SIG) adenocarcinoma tumor subtype with tissue from the antrum and without necrosis. The second case was a 67-year-old man with a tumor subtype of SIG adenocarcinoma with necrotic tissue sample from the gastric cavity. The location of the mutation, two genes on ex1 and ex8, which were connected to each other, was detected in samples of both cases.</p><p><strong>Conclusion: </strong>Our findings showed detection of EGFRvIII in 9.5% of gastric adenocarcinoma cases. Although the sample size presents a limitation, the increase in expression of this variant appears to be independent of the patients' gender and age. Notably, the association of this variant with the signet-ring cell adenocarcinoma subtype is a significant finding that warrants further investigation.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"5870339"},"PeriodicalIF":1.4,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12929646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147304763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the Accuracy of Endoscopic Measurements of the Size of Gastrointestinal Lesions by a Guidewire Scale.","authors":"Nanthawat Talalak, Saritphat Orrapin, Sittichock Wattanarochanaporn, Teerawat Sotananan, Thanakorn Likidkarnchanakornkij, Prasit Mahawongkajit","doi":"10.1155/grp/3466541","DOIUrl":"https://doi.org/10.1155/grp/3466541","url":null,"abstract":"<p><strong>Objectives: </strong>Using an endoscope to accurately measure the size of a lesion is crucial for assessing the healing process and determining the treatment strategies for the stage of the cancer. Visual estimation of the lesion size is commonly used, but this is often inaccurate. To address this issue, a guidewire scale was developed to measure lesion size and improve accuracy at a practical level.</p><p><strong>Methods: </strong>Four endoscopists estimated the size of artificial lesions in the gastric model by visual comparison with the guidewire measurements. The endoscopists used a guidewire scale to determine the size of the lesion and rated their satisfaction after the procedure using a numeral rating scale (NRS).</p><p><strong>Results: </strong>Fifty-two patients were recruited and assessed for the size of their lesions using a guidewire scale. Overall, the endoscopists reported good satisfaction levels (NRS ≥ 8), with satisfaction significantly higher in the dyspepsia group (<i>p</i> = 0.03). The mean lesion size was 10.7 ± 8.9 mm, with smaller lesions (≤ 1 cm) resulting in higher satisfaction levels. On average, it took 39.4 ± 13.6 s to measure the lesion, with a procedure time of ≤ 30 s resulting in very high satisfaction levels.</p><p><strong>Conclusions: </strong>The accuracy of endoscopic measurements was improved using the guidewire scale, allowing clinical studies to safely and easily estimate lesion sizes.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2026 ","pages":"3466541"},"PeriodicalIF":1.4,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12907985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146212999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}