Gastroenterology最新文献_第5页

Spatial transcriptomics of Hirschsprung disease resection margins marks differential gene expression in myenteric plexus 先天性巨结肠切除边缘的空间转录组学标记了肌丛基因的差异表达

IF 29.4 1区医学

Gastroenterology Pub Date : 2025-06-16 DOI: 10.1053/j.gastro.2025.06.012

Isabelle A.M. van Thiel, Joris J.T.H. Roelofs, Ramon R. Gorter, L.W. Ernest van Heurn, Wouter J. de Jonge, Joep P.M. Derikx

引用次数: 0

Leveraging Professional Networking For Career Advancement - Tips for Early Career Faculty 利用专业网络促进职业发展——给早期职业教师的建议

IF 29.4 1区医学

Gastroenterology Pub Date : 2025-06-14 DOI: 10.1053/j.gastro.2025.06.008

Joseph Sleiman, Laura S. Chiu, James Connolly, Shifa Umar

引用次数: 0

Potential and challenges of glepaglutide for SBS-IF 格列鲁肽治疗SBS-IF的潜力和挑战

IF 29.4 1区医学

Gastroenterology Pub Date : 2025-06-14 DOI: 10.1053/j.gastro.2025.04.039

Shiyu Yang, Ying Lu

引用次数: 0

Total Pancreatectomy and Islet Auto Transplant for Chronic Pancreatitis 全胰切除术和胰岛自体移植治疗慢性胰腺炎

IF 29.4 1区医学

Gastroenterology Pub Date : 2025-06-14 DOI: 10.1053/j.gastro.2025.04.040

Guru Trikudanathan, Anne Eaton, Martin L. Freeman, Vikesh K. Singh, Sarah J. Schwarzenberg, Jaimie D. Nathan, Gregory J. Beilman, Maisam Abu-El-Haija, David Adams, Syed A. Ahmad, Srinath Chinnakotla, Elissa M. Downs, Mayha Faghih, Timothy B. Gardner, Luis F. Lara, Katherine Morgan, Sri Prakash Mokshagundam, Bashoo Naziruddin, Andrew Posselt, Timothy L. Pruett, Melena D. Bellin

{"title":"Total Pancreatectomy and Islet Auto Transplant for Chronic Pancreatitis","authors":"Guru Trikudanathan, Anne Eaton, Martin L. Freeman, Vikesh K. Singh, Sarah J. Schwarzenberg, Jaimie D. Nathan, Gregory J. Beilman, Maisam Abu-El-Haija, David Adams, Syed A. Ahmad, Srinath Chinnakotla, Elissa M. Downs, Mayha Faghih, Timothy B. Gardner, Luis F. Lara, Katherine Morgan, Sri Prakash Mokshagundam, Bashoo Naziruddin, Andrew Posselt, Timothy L. Pruett, Melena D. Bellin","doi":"10.1053/j.gastro.2025.04.040","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.04.040","url":null,"abstract":"<h3>Background and Aims</h3>Total pancreatectomy with islet autotransplantation (TPIAT) is an emerging but controversial therapy for patients with intractably painful chronic pancreatitis (CP) and recurrent acute pancreatitis (RAP). Outcomes of TPIAT have not been validated in multicenter studies.<h3>Methods</h3>384 participants (mean age 30 (SD 17) years, 34% pediatric, 62% female) with painful CP and/or RAP undergoing TPIAT were prospectively enrolled at 12 centers. Numeric pain scores, opioid use, and health-related QOL, including physical component summary (PCS) and mental component summary (MCS), were collected at baseline and at 6 months and 1 year post TPIAT. Predictors of outcomes were evaluated with regression modeling.<h3>Results</h3>Opioid use, assessed over a 14 day interval, decreased from 61% before to 24% at 1 year after TPIAT (p<0.001). Daily abdominal pain decreased from 65% to 23%, while the mean (SD) pain score decreased from 4.9 (2.3) to 2.3 (2.5) (both p<0.001). In a multivariable model, opioid use at 1 year was associated with older age and opioid use pre-TPIAT (odds ratio 9.21 [95% confidence interval 3.93-25.7]). PCS and MCS score improved by ≥10 points in 58% and 35% respectively. Higher QOL scores at 1 year were associated with higher scores pre-surgery and younger age. Mean (SD) HbA1c was 7 (1.9%) with 20% insulin independent at 1 year. Duration of disease, pancreas morphology, and etiology did not predict response to TPIAT.<h3>Conclusion</h3>In this prospective multicenter study of patients with intractably painful CP or RAP, TPIAT significantly reduced pain burden and improved QOL. While young age predicted better outcomes, duration and etiology of disease did not.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"13 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Adenoma Detection Rate and Prevalent Colorectal Cancer Detection Rate in a National Colonoscopy Registry Subtitle: Association Between Adenoma and Colorectal Cancer Detection 国家结肠镜检查登记中腺瘤检出率与结直肠癌检出率的关系（副标题：腺瘤与结直肠癌检出率的关系）

IF 29.4 1区医学

Gastroenterology Pub Date : 2025-06-14 DOI: 10.1053/j.gastro.2025.06.009

Jason A. Dominitz, Uri Ladabaum, Jennifer L. Holub, Rachel B. Issaka, Cynthia W. Ko, Douglas J. Robertson

{"title":"Association Between Adenoma Detection Rate and Prevalent Colorectal Cancer Detection Rate in a National Colonoscopy Registry Subtitle: Association Between Adenoma and Colorectal Cancer Detection","authors":"Jason A. Dominitz, Uri Ladabaum, Jennifer L. Holub, Rachel B. Issaka, Cynthia W. Ko, Douglas J. Robertson","doi":"10.1053/j.gastro.2025.06.009","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.06.009","url":null,"abstract":"<h3>BACKGROUND</h3>While the adenoma detection rate (ADR) is associated with post-colonoscopy colorectal cancer (PCCRC) risk, it is unknown to what extent this reflects missed colorectal cancer (CRC) versus missed pre-cancerous lesions. We evaluated the association between physician ADR and prevalent CRC detection during colonoscopy.<h3>METHODS</h3>We used cross-sectional 2019-2022 GI Quality Improvement Consortium (GIQuIC) data for >1.73 million colonoscopies performed by 3567 endoscopists for screening or abnormal fecal test (AFT) follow-up from 683 US endoscopy units. Endoscopist ADR and sessile serrated lesion detection rate (SSLDR) were determined based on screening exams.<h3>RESULTS</h3>CRC was detected in 0.3% of screening and 1.5% of follow-up colonoscopies. From lowest to highest endoscopist ADR quintile, CRC detection increased from 26.6 (95% confidence interval (CI) 24.4-27.9) to 33.1 (95%CI 29.7-33.7), and from 107.8 (95%CI 96.2–129.4) to 164.7 (95% CI 140.8–188.6) per 10,000 screening and AFT follow-up colonoscopies, respectively. In multivariable models with lowest ADR quintile as reference, the odds ratios (ORs) of CRC detection in the highest ADR quintile were 1.27 (95% CI 1.14-1.41) for screening and 1.50 (95% CI 1.16-1.93) for AFT follow-up colonoscopies. Compared to high-ADR/high-SSLDR endoscopists, the ORs of CRC detection were lower for low-ADR endoscopists irrespective of SSLDR (high-SSLDR, 0.87, 95% CI 0.80-0.96; low-SSLDR 0.92, 95% CI 0.85-0.98), but similar for high-ADR/low-SSLDR endoscopists.<h3>CONCLUSIONS</h3>ADR reflects prevalent CRC detection as well as detection and removal of CRC precursors. Our findings suggest that PCCRC is not uncommonly due to missed CRC, especially among endoscopists with low ADR.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"90 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Curious Culprit Behind Biliary Pus: What’s the Diagnosis? 胆汁液背后的奇怪罪魁祸首：如何诊断？

IF 29.4 1区医学

Gastroenterology Pub Date : 2025-06-13 DOI: 10.1053/j.gastro.2025.06.007

Partha Pal, Uday Kumar Marri, D Nageshwar Reddy

引用次数: 0

Glepaglutide in Short Bowel Syndrome: Promising, but Questions Remain 格列鲁肽治疗短肠综合征：有希望，但问题仍然存在

IF 29.4 1区医学

Gastroenterology Pub Date : 2025-06-12 DOI: 10.1053/j.gastro.2025.04.038

Gaurav Sharma

引用次数: 0

Refining Multi-HCC for Balanced Urgency and Utility 为平衡急迫性和实用性而改进多发性hcc