Gastroenterology最新文献

筛选
英文 中文
Shunting the Diagnosis of a Rapid Decline in Cognition 分流认知能力快速下降的诊断
IF 29.4 1区 医学
Gastroenterology Pub Date : 2025-05-31 DOI: 10.1053/j.gastro.2025.03.059
Maria Rosina Troppmair, Benedikt Schaefer, Martin Freund
{"title":"Shunting the Diagnosis of a Rapid Decline in Cognition","authors":"Maria Rosina Troppmair, Benedikt Schaefer, Martin Freund","doi":"10.1053/j.gastro.2025.03.059","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.03.059","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"26 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rare cause of abdominal distension in infancy 婴儿腹胀的罕见原因
IF 29.4 1区 医学
Gastroenterology Pub Date : 2025-05-30 DOI: 10.1053/j.gastro.2025.04.034
Yu-Syuan Chen, Jui-Hung Weng, Shan-Ming Chen
{"title":"A rare cause of abdominal distension in infancy","authors":"Yu-Syuan Chen, Jui-Hung Weng, Shan-Ming Chen","doi":"10.1053/j.gastro.2025.04.034","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.04.034","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"25 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expanding Nutrition Training in Gastroenterology: A Call to Action 扩大胃肠病学营养培训:行动呼吁
IF 29.4 1区 医学
Gastroenterology Pub Date : 2025-05-30 DOI: 10.1053/j.gastro.2025.04.035
Jason C. Lin, John C. Lin, Joy Zhao, Elizabeth G. Holt, Edwin K. McDonald, Stephanie M. Moleski
{"title":"Expanding Nutrition Training in Gastroenterology: A Call to Action","authors":"Jason C. Lin, John C. Lin, Joy Zhao, Elizabeth G. Holt, Edwin K. McDonald, Stephanie M. Moleski","doi":"10.1053/j.gastro.2025.04.035","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.04.035","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"7 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Pragmatic Trial Comparing Uptake and Cancer Mortality between Invitation to Colonoscopy and Invitation to Fecal Immunochemical Testing Approaches 一项比较邀请结肠镜检查和邀请粪便免疫化学检查方法的摄取和癌症死亡率的实用试验
IF 29.4 1区 医学
Gastroenterology Pub Date : 2025-05-28 DOI: 10.1053/j.gastro.2025.05.017
Nauzer Forbes
{"title":"A Pragmatic Trial Comparing Uptake and Cancer Mortality between Invitation to Colonoscopy and Invitation to Fecal Immunochemical Testing Approaches","authors":"Nauzer Forbes","doi":"10.1053/j.gastro.2025.05.017","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.05.017","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"4 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An International Consensus on Appropriate Management of Corticosteroids in Clinical Trials in Inflammatory Bowel Disease 炎症性肠病临床试验中皮质类固醇适当管理的国际共识
IF 29.4 1区 医学
Gastroenterology Pub Date : 2025-05-28 DOI: 10.1053/j.gastro.2025.05.015
Jurij Hanžel, Virginia Solitano, Sudheer Kumar Vuyyuru, Remo Panaccione, Bruce E. Sands, Laurent Peyrin-Biroulet, Silvio Danese, Geert R. D'Haens, Raja Atreya, Matthieu Allez, Charles N. Bernstein, Peter Bossuyt, Brian Bressler, Robert V. Bryant, Benjamin L. Cohen, Jean-Frederic Colombel, Ferdinando D’Amico, Axel Dignass, Marla Dubinsky, Phillip Fleshner, Christopher Ma
{"title":"An International Consensus on Appropriate Management of Corticosteroids in Clinical Trials in Inflammatory Bowel Disease","authors":"Jurij Hanžel, Virginia Solitano, Sudheer Kumar Vuyyuru, Remo Panaccione, Bruce E. Sands, Laurent Peyrin-Biroulet, Silvio Danese, Geert R. D'Haens, Raja Atreya, Matthieu Allez, Charles N. Bernstein, Peter Bossuyt, Brian Bressler, Robert V. Bryant, Benjamin L. Cohen, Jean-Frederic Colombel, Ferdinando D’Amico, Axel Dignass, Marla Dubinsky, Phillip Fleshner, Christopher Ma","doi":"10.1053/j.gastro.2025.05.015","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.05.015","url":null,"abstract":"<h3>Background &amp; Aims</h3>Approval of new therapies for inflammatory bowel disease (IBD) requires rigorously designed and well-executed randomized controlled trials (RCTs). Corticosteroids remain a cornerstone of IBD induction therapy and many patients in trials are enrolled while taking corticosteroids. Despite this, approaches to corticosteroid management in RCTs have been highly heterogeneous, often differing from clinical practice. This negatively impacts patients’ willingness to participate due to prolonged corticosteroid exposure and may potentially bias outcomes in the clinical trial. Our aim is to provide comprehensive standardized recommendations on key aspects of corticosteroid use in IBD clinical trials through a multi-phase, international expert consensus, with a goal to help inform and standardize practice in future RCTs.<h3>Methods</h3>The consensus was informed by a systematic review of MEDLINE, EMBASE, and the Cochrane CENTRAL Register of Controlled Trials, which determined the corticosteroid management rules used in placebo-controlled trials of advanced therapies in IBD. International expert consensus recommendations for all aspects of corticosteroid management in RCTs were then developed using a modified Delphi process with two rounds of survey questions and a ratification meeting.<h3>Results</h3>These recommendations propose management of corticosteroids during screening, induction, and maintenance phases of pharmacologic trials in IBD, and define corticosteroid-related endpoints. We emphasize the need for minimizing corticosteroid exposure through expedited tapering and shorter fixed-dosing periods that more closely reflect clinical care, and provide recommendations for standardized definitions of corticosteroid-free remission.<h3>Conclusions</h3>These recommendations will serve to optimize trial design and facilitate appropriate, acceptable, and standardized RCT corticosteroid handling practices.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"5 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AAV-mediated silencing of Sox4 leads to long-term amelioration of liver phenotypes in mouse models of Alagille syndrome aav介导的Sox4沉默导致Alagille综合征小鼠模型肝脏表型的长期改善
IF 29.4 1区 医学
Gastroenterology Pub Date : 2025-05-28 DOI: 10.1053/j.gastro.2025.04.033
Duncan Fox, Jun Xie, Jennifer L. Burwinkel, Josh M. Adams, Kashish Chetal, Marzieh Keivandarian, Yaniv Faingelernt, Sanjay Subramanian, Mario F. Lopez, Anna L. Peters, Nathan Salomonis, Neda Zarrin-Khameh, Guangping Gao, Stacey S. Huppert, Hamed Jafar-Nejad
{"title":"AAV-mediated silencing of Sox4 leads to long-term amelioration of liver phenotypes in mouse models of Alagille syndrome","authors":"Duncan Fox, Jun Xie, Jennifer L. Burwinkel, Josh M. Adams, Kashish Chetal, Marzieh Keivandarian, Yaniv Faingelernt, Sanjay Subramanian, Mario F. Lopez, Anna L. Peters, Nathan Salomonis, Neda Zarrin-Khameh, Guangping Gao, Stacey S. Huppert, Hamed Jafar-Nejad","doi":"10.1053/j.gastro.2025.04.033","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.04.033","url":null,"abstract":"<h3>BACKGROUND &amp; AIMS</h3>In patients with Alagille syndrome (ALGS), bile duct paucity often leads to severe cholestatic phenotypes for which liver transplantation remains the only definitive treatment. No FDA-approved mechanism-based strategies exist to enhance biliary development in ALGS or other diseases with bile duct paucity. We aimed to identify a therapeutic target to address this unmet need.<h3>METHODS</h3>Preclinical ALGS mouse models lacking one copy of <em>Jag1</em> with or without conditional deletion of one or both copies of <em>Sox9</em> were used. <em>Sox4</em> levels were reduced genetically or with adeno-associated virus 8 (AAV8) vectors driving a <em>Sox4</em>-silencing sequence. Liver histology, biliary tree ink injection, serum chemistry, RNAscope (on mouse and human livers), mouse liver single-cell RNA-sequencing (scRNA-Seq), and reanalysis of published human liver bulk RNA-Seq were performed.<h3>RESULTS</h3>Conditional removal of one copy of <em>Sox4</em> in mouse liver significantly improved the ALGS liver phenotypes in a <em>Sox9</em>-dependent manner. An increase in <em>Sox4/SOX4</em> expression in early postnatal <em>Jag1</em>-heterozygous mouse livers and ALGS patient livers was observed. scRNA-Seq revealed the appearance of an intermediate hepatobiliary cluster co-expressing <em>Sox4</em> and <em>Sox9</em> in <em>Jag1-</em>heterozygous livers. AAV8-mediated <em>Sox4</em> knockdown, ubiquitously or driven by the hepatocyte-specific TBG promoter, led to long-term improvement of ALGS liver phenotypes upon injection at postnatal day 1 (P1). AAV8 injection at P15—after the appearance of liver necrosis—led to the incorporation of some transduced cells into bile ducts and phenotypic improvement.<h3>CONCLUSIONS</h3>Preclinical studies provide proof of principle for postnatal AAV-mediated <em>Sox4</em> knockdown in TBG<sup>+</sup> cells as a therapeutic approach for ALGS liver disease.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"42 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship of Intra-Pancreatic Fat Deposition With Pancreatic Cancer Differs According to Carcinoma Types 胰腺内脂肪沉积与胰腺癌的关系因癌而异
IF 29.4 1区 医学
Gastroenterology Pub Date : 2025-05-28 DOI: 10.1053/j.gastro.2025.04.032
Hiroki Oyama, Tsuyoshi Hamada, Daniel Nevo, Yudai Nakai, Yousuke Nakai, Maxim S. Petrov
{"title":"Relationship of Intra-Pancreatic Fat Deposition With Pancreatic Cancer Differs According to Carcinoma Types","authors":"Hiroki Oyama, Tsuyoshi Hamada, Daniel Nevo, Yudai Nakai, Yousuke Nakai, Maxim S. Petrov","doi":"10.1053/j.gastro.2025.04.032","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.04.032","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"1 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Practical Guide to Incorporating a Psychologist into a Gastroenterology Practice 将心理学家纳入胃肠病学实践的实用指南
IF 29.4 1区 医学
Gastroenterology Pub Date : 2025-05-28 DOI: 10.1053/j.gastro.2025.05.014
Jessica K. Salwen-Deremer, Sarah Ballou, Megan Petrik, Miguel Regueiro, Corey A. Siegel, Laurie Keefer
{"title":"A Practical Guide to Incorporating a Psychologist into a Gastroenterology Practice","authors":"Jessica K. Salwen-Deremer, Sarah Ballou, Megan Petrik, Miguel Regueiro, Corey A. Siegel, Laurie Keefer","doi":"10.1053/j.gastro.2025.05.014","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.05.014","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"12 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of ACupuncTure in Irritable bOwel syNdrome (ACTION): a multi-centre randomized controlled trial 针灸治疗肠易激综合征的疗效(ACTION):一项多中心随机对照试验
IF 29.4 1区 医学
Gastroenterology Pub Date : 2025-05-27 DOI: 10.1053/j.gastro.2025.05.016
Jing-Wen Yang, Ling-Yu Qi, Shi-Yan Yan, Yan-Fen She, Ying Li, Li-Li Chi, Hui Hu, Li-Qiong Wang, Chang-Chun Ji, Bang-Qi Wu, Zi-Tong Fu, Shuang-Jing Li, Na-Na Yang, Yu Wang, Cun-Zhi Liu
{"title":"Efficacy of ACupuncTure in Irritable bOwel syNdrome (ACTION): a multi-centre randomized controlled trial","authors":"Jing-Wen Yang, Ling-Yu Qi, Shi-Yan Yan, Yan-Fen She, Ying Li, Li-Li Chi, Hui Hu, Li-Qiong Wang, Chang-Chun Ji, Bang-Qi Wu, Zi-Tong Fu, Shuang-Jing Li, Na-Na Yang, Yu Wang, Cun-Zhi Liu","doi":"10.1053/j.gastro.2025.05.016","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.05.016","url":null,"abstract":"<h3>BACKGROUND &amp; AIMS</h3>Irritable bowel syndrome (IBS) affects 4.1% of the adult population, with many reporting ongoing symptoms despite first-line therapies. Acupuncture is widely used for IBS, but without sufficient evidence. We aim to assess the efficacy of acupuncture in patients with diarrhea-predominant IBS (IBS-D).<h3>METHODS</h3>This was a multi-center randomized controlled trial in six hospitals in China. Patients aged 18-75 years with IBS-D per Rome IV diagnostic criteria were randomly allocated (1:1) to receive 15 sessions of acupuncture or sham acupuncture (blunt-tipped needle at non-acupoints) over 6 weeks with a 12-week follow-up. The primary outcome was the composite response rate at week 6, defined as at least a 30% improvement in the mean worst abdominal pain and a 50% or more reduction in the number of days with diarrhea from baseline during week 6.<h3>RESULTS</h3>Between May 2021 and Aug 2022, 584 patients were assessed for eligibility, of whom 280 were randomly allocated. The primary outcome was reached by 71 (57.9%) patients in the acupuncture group compared with 47 (41.4%) patients in the sham acupuncture group (risk ratio 1.40; p=0.008). The between-group difference became significant from week 3 and maintained throughout the study except week 16. No severe adverse event was reported.<h3>CONCLUSIONS</h3>Acupuncture improved abdominal pain and stool consistency in patients with IBS-D, with sustained efficacy over 18 weeks. The results of this trial suggest that acupuncture may serve as an alternative treatment for IBS-D. <strong>(</strong>ACTION Chinese Clinical Trial Registry number, ChiCTR2100044762)","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"4 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to He et al and to Wang et al 回复He et al和Wang et al
IF 29.4 1区 医学
Gastroenterology Pub Date : 2025-05-23 DOI: 10.1053/j.gastro.2025.05.013
Kara Gross Margolis, Lin Y. Hung, Mark Ansorge
{"title":"Reply to He et al and to Wang et al","authors":"Kara Gross Margolis, Lin Y. Hung, Mark Ansorge","doi":"10.1053/j.gastro.2025.05.013","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.05.013","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"144 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信