GastroenterologyPub Date : 2025-05-02DOI: 10.1053/j.gastro.2025.04.016
Naoto Fujiwara, Amit G. Singal, Yujin Hoshida
{"title":"Reply to Zheng and Shan and to Bao et al","authors":"Naoto Fujiwara, Amit G. Singal, Yujin Hoshida","doi":"10.1053/j.gastro.2025.04.016","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.04.016","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"50 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GastroenterologyPub Date : 2025-05-02DOI: 10.1053/j.gastro.2025.04.019
Danica M.N. van den Berg, Lucie de Jonge, Esther Toes-Zoutendijk
{"title":"Reply to Antonelli et al, Wang et al, and He et al","authors":"Danica M.N. van den Berg, Lucie de Jonge, Esther Toes-Zoutendijk","doi":"10.1053/j.gastro.2025.04.019","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.04.019","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"8 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GastroenterologyPub Date : 2025-05-02DOI: 10.1053/j.gastro.2025.04.018
Weiwei Liu, Florian Rieder
{"title":"Reply to Kelm and Flemming and to Zhang et al","authors":"Weiwei Liu, Florian Rieder","doi":"10.1053/j.gastro.2025.04.018","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.04.018","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"13 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GastroenterologyPub Date : 2025-05-02DOI: 10.1053/j.gastro.2025.04.014
Tianhui Li, Olabisi Oluwabukola Coker, Jun Yu
{"title":"Reply to Zuo et al, Takefuji, and Bu et al","authors":"Tianhui Li, Olabisi Oluwabukola Coker, Jun Yu","doi":"10.1053/j.gastro.2025.04.014","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.04.014","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"275 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GastroenterologyPub Date : 2025-05-02DOI: 10.1053/j.gastro.2025.03.043
Yoshiyasu Takefuji
{"title":"Critical Analysis of Random Forest Feature Selection: Implications for Gut Microbiome Cancer Research","authors":"Yoshiyasu Takefuji","doi":"10.1053/j.gastro.2025.03.043","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.03.043","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"18 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GastroenterologyPub Date : 2025-05-02DOI: 10.1053/j.gastro.2025.03.047
Amit G. Singal, Riad Salem, David J. Pinato, Anjana Pillai
{"title":"Advances in Locoregional and Systemic Treatments for HCC","authors":"Amit G. Singal, Riad Salem, David J. Pinato, Anjana Pillai","doi":"10.1053/j.gastro.2025.03.047","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.03.047","url":null,"abstract":"There have been significant advances in the locoregional and systemic therapy landscape for hepatocellular carcinoma (HCC), with the most notable being the introduction of immune checkpoint inhibitor (ICI) combinations. ICI combinations have significantly improved the overall survival of patients with unresectable HCC, affording median survival over 2 years and long-term survival exceeding 5 years in a subset of patients. Accordingly, there has been increased interest in the earlier application of systemic therapies, including (neo)adjuvant therapy in the peri-operative setting or in combination with intra-arterial therapies. However, recent data failed to demonstrate improved recurrence-free survival with use of adjuvant ICI therapy. Conversely, two trials showed improved progression-free-survival when ICI therapies were combined with transarterial chemoembolization, although data regarding the impact on overall survival are still immature. These improved outcomes raise several new questions including which patients with liver-localized HCC should receive systemic therapy, how should this be sequenced or combined with other available therapies, and how to manage those patients with marked responses, including consideration of liver transplantation. These questions are often determined on a case-by-case basis and best made in a multidisciplinary manner, considering several factors including tumor burden, degree of liver dysfunction, performance status, and patient’s long-term goals of care.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"10 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GastroenterologyPub Date : 2025-05-02DOI: 10.1053/j.gastro.2025.01.255
Matthias Kelm, Sven Flemming
{"title":"The importance of the mesentery in the pathophysiology of Crohn’s disease","authors":"Matthias Kelm, Sven Flemming","doi":"10.1053/j.gastro.2025.01.255","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.01.255","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"2 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GastroenterologyPub Date : 2025-05-02DOI: 10.1053/j.gastro.2025.03.044
Jiawen Bu, Xudong Zhu, Hong Zhang
{"title":"Methanogens in Colorectal Cancer: Association or Causation?","authors":"Jiawen Bu, Xudong Zhu, Hong Zhang","doi":"10.1053/j.gastro.2025.03.044","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.03.044","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"89 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}