Gastroenterology最新文献

{"title":"A Microbiome-directed therapy for malnutrition that performs better than standard nutritional interventions.","authors":"Alain J. Benitez, Kara Gross Margolis","doi":"10.1053/j.gastro.2025.01.231","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.01.231","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"10 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Microbiome Signature in Predisease Phase of Inflammatory Bowel Disease: Prediction to Pathogenesis to Prevention","authors":"Williams Turpin, Sun-Ho Lee, Ken Croitoru","doi":"10.1053/j.gastro.2025.01.004","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.01.004","url":null,"abstract":"Advances in understanding the pathogenesis of inflammatory bowel disease (IBD) point toward a key role of the gut microbiome. We review the data describing the changes in the gut microbiome from IBD case-control studies and compare these findings with emerging data from studies of the preclinical phase of IBD. What is apparent is that assessing changes in the composition and function of the gut microbiome during the preclinical phase helps address confounding factors, such as disease activity and drug therapy, which can directly influence the gut microbiome. Understanding these changes in the predisease phase provides a means of predicting IBD in high-risk populations and offers insights into possible mechanisms involved in disease pathogenesis. Finally, we discuss strategies to use this information to design interventions aimed at modulating the microbiome as a means of preventing or delaying the onset of IBD.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"168 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reevaluating Stemness in the Intestinal Crypt.","authors":"Samuel Asfaha, Nicola L Jones","doi":"10.1053/j.gastro.2024.09.010","DOIUrl":"10.1053/j.gastro.2024.09.010","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"417"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142283936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Names matter: a call to neurogastroenterologists to examine how we can improve the nomenclature we use to describe the disorders our patients experience","authors":"Pankaj J. Pasricha, Nicholas J. Talley, Linda Nguyen, Thomas Abell, John Furness, Mark Pimentel","doi":"10.1053/j.gastro.2024.12.040","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.12.040","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"8 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new tool to study the DREADDed peripheral nervous system","authors":"Amber L. Alhadeff, Brian J. DeBosch","doi":"10.1053/j.gastro.2025.01.230","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.01.230","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"10 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity-Facilitated Colon Cancer Progression Is Mediated by Increased Diacylglycerol O-Acyltransferases 1 and 2 Levels.","authors":"Jenisha Ghimire, Morgan E Collins, Patricia Snarski, Angelle N King, Emmanuelle Ruiz, Rida Iftikhar, Harrison M Penrose, Krzysztof Moroz, Tyler Rorison, Melody Baddoo, Muhammad Anas Naeem, Arnold H Zea, Scott T Magness, Erik F Flemington, Susan E Crawford, Suzana D Savkovic","doi":"10.1053/j.gastro.2024.09.011","DOIUrl":"10.1053/j.gastro.2024.09.011","url":null,"abstract":"<p><strong>Background & aims: </strong>The obesity epidemic is associated with increased colon cancer progression. As lipid droplets (LDs) fuel tumor growth, we aimed to determine the significance of diacyltransferases (diacylglycerol o-acyltransferases 1 and 2 [DGAT1/2]), responsible for LDs biogenesis, in obesity-mediated colonic tumorigenesis.</p><p><strong>Methods: </strong>Human colon cancer samples, colon cancer cells, colonospheres, and Apc^Min/+ colon cancer mouse model on a high-fat diet were employed. For DGAT1/2 inhibition, enzymatic inhibitors and small interfering RNA were used. Expression, pathways, cell cycle, and growth were assessed. Bioinformatic analyses of CUT&RUN and RNA sequencing data were performed.</p><p><strong>Results: </strong>DGAT1/2 levels in human colon cancer tissue are significantly elevated with disease severity and obesity (vs normal). Their levels are increased in human colon cancer cells (vs nontransformed) and further enhanced by fatty acids prevalent in obesity; augmented DGAT2 expression is MYC-dependent. Inhibition of DGAT1/2 improves FOXO3 activity by attenuating PI3K, resulting in reduced MYC-dependent DGAT2 expression and accumulation of LDs, suggesting feedback. This inhibition attenuated growth in colon cancer cells and colonospheres via FOXO3/p27kip1 cell cycle arrest and reduced colonic tumors in Apc^Min/+ mice on a high-fat diet. Transcriptomic analysis revealed that DGAT1/2 inhibition targeted metabolic and tumorigenic pathways in human colon cancer and colon cancer crypts, stratifying human colon cancer samples from normal. Further analysis revealed that this inhibition is predictive of advanced disease-free state and survival in patients with colon cancer.</p><p><strong>Conclusions: </strong>This is a novel mechanism of DGAT1/2-dependent metabolic and tumorigenic remodeling in obesity-facilitated colon cancer, providing a platform for future development of effective treatments for patients with colon cancer.</p>","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"286-299.e6"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142283933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“A rose by any other name”? — Beyond Diagnostic Nomenclature in Neurogastroenterology","authors":"Daniel Keszthelyi, Laurie Keefer","doi":"10.1053/j.gastro.2025.01.229","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.01.229","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"11 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal Profiling of Peripheral Blood Identifies Proliferating Circulating Effector CD4⁺ T Cells as Predictors for Response to Integrin α4β7-Blocking Therapy in Inflammatory Bowel Disease.","authors":"Veronika Horn, Camila A Cancino, Lisa M Steinheuer, Benedikt Obermayer, Konstantin Fritz, Anke L Nguyen, Kim Susan Juhran, Christina Plattner, Diana Bösel, Lotte Oldenburg, Marie Burns, Axel Ronald Schulz, Mariia Saliutina, Eleni Mantzivi, Donata Lissner, Thomas Conrad, Mir-Farzin Mashreghi, Sebastian Zundler, Elena Sonnenberg, Michael Schumann, Lea-Maxie Haag, Dieter Beule, Lukas Flatz, Zlatko Trajanoski, Geert D'Haens, Carl Weidinger, Henrik E Mei, Britta Siegmund, Kevin Thurley, Ahmed N Hegazy","doi":"10.1053/j.gastro.2024.09.021","DOIUrl":"10.1053/j.gastro.2024.09.021","url":null,"abstract":"<p><strong>Background & aims: </strong>Despite the success of biological therapies in treating inflammatory bowel disease, managing patients remains challenging due to the absence of reliable predictors of therapy response.</p><p><strong>Methods: </strong>In this study, we prospectively sampled 2 cohorts of patients with inflammatory bowel disease receiving the anti-integrin α4β7 antibody vedolizumab. Samples were subjected to mass cytometry; single-cell RNA sequencing; single-cell B and T cell receptor sequencing (BCR/TCR-seq); serum proteomics; and multiparametric flow cytometry to comprehensively assess vedolizumab-induced immunologic changes in the peripheral blood and their potential associations with treatment response.</p><p><strong>Results: </strong>Vedolizumab treatment led to substantial alterations in the abundance of circulating immune cell lineages and modified the T-cell receptor diversity of gut-homing CD4⁺ memory T cells. Through integration of multimodal parameters and machine learning, we identified a significant increase in proliferating CD4⁺ memory T cells among nonresponders before treatment compared with responders. This predictive T-cell signature demonstrated an activated T-helper 1/T-helper 17 cell phenotype and exhibited elevated levels of integrin α4β1, potentially making these cells less susceptible to direct targeting by vedolizumab.</p><p><strong>Conclusions: </strong>These findings provide a reliable predictive classifier with significant implications for personalized inflammatory bowel disease management.</p>","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"327-343"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Life Exposure to Parental Crohn's Disease Is Associated With Offspring's Gut Microbiome, Gut Permeability, and Increased Risk of Future Crohn's Disease.","authors":"Sun-Ho Lee, Maham Bushra, Lanhui Qiu, Anne M Griffiths, Williams Turpin, Kenneth Croitoru, Sun-Ho Lee, Maham Bushra, Lanhui Qiu, Jincheng Shao, Pablo A Olivera, Haim Leibovitzh, Mingyue Xue, Wei Xu, Osvaldo Espin-Garcia, Guy L Amuais, Hien Q Huynh, Remo Panaccione, A Hillary Steinhart, Maria Cino, David Mack, John Marshall, Mark Ropeleski, Alain Bitton, Kevan Jacobson, Jerry McGrath, Baruch Yerushalmi, Maria T Abreu, Charles N Bernstein, Graham Radford-Smith, Charlie Lees, Dan Turner, Karen Madsen, David S Guttman, Mark Silverberg, Anne M Griffiths, Paul Moayyedi, Williams Turpin, Paul Beck, Levinus Dieleman, Brian G Feagan, Gilaad Kaplan, Denis O Krause, Ernest Seidman, Scott Snapper, Andy Stadnyk, Michael Surette, Thomas Walters, Bruce Vallance, Jeff Critch, Lee Denson, Colette Deslandres, Wael El-Matary, Hans Herfarth, Peter Higgins, Jeff Hyams, Anthony Otley, Charlotte Hedin, Seamus Hussey, David Keljo, David Kevans, Sanjay Murthy, Nimisha Parekh, Sophie Plamondon, Joel Rosh, David Rubin, Michael Schultz, Corey Siegel, Kenneth Croitoru","doi":"10.1053/j.gastro.2024.09.033","DOIUrl":"10.1053/j.gastro.2024.09.033","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"385-388.e3"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142389693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimal Incremental Benefits of Computer-Aided Optical Diagnosis of Colorectal Polyp Histology in a Large Prospective Cohort.","authors":"Nauzer Forbes","doi":"10.1053/j.gastro.2024.07.037","DOIUrl":"10.1053/j.gastro.2024.07.037","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"418-419"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}