Gastroenterology最新文献

{"title":"Exploring the Potential of Real-Time Audio-Visual Interactions of ChatGPT-4o in Endoscopy Training and Practice","authors":"Qiqi Wu","doi":"10.1053/j.gastro.2024.06.042","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.06.042","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":null,"pages":null},"PeriodicalIF":29.4,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sucrase isomaltase dysfunction reduces sucrose intake in mice and humans","authors":"Peter Aldiss, Leire Torices, Stina Ramne, Marit Eika Jørgensen, Mauro D’Amato, Mette K. Andersen","doi":"10.1053/j.gastro.2024.10.040","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.10.040","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":null,"pages":null},"PeriodicalIF":29.4,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unexpected Cause of Fistulizing Small Intestinal Disease","authors":"Saam Dilmaghani, Rondell P. Graham, Seth Sweetser","doi":"10.1053/j.gastro.2024.10.039","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.10.039","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":null,"pages":null},"PeriodicalIF":29.4,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142598090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase 3 validation of PAaM for hepatocellular carcinoma risk stratification in cirrhosis","authors":"Naoto Fujiwara, Camden Lopez, Tracey L. Marsh, Indu Raman, Cesia A. Marquez, Subhojit Paul, Sumit K. Mishra, Naoto Kubota, Courtney Katz, Hiroaki Kanzaki, Michael Gonzalez, Lisa Quirk, Sneha Deodhar, Pratibha Selvakumar, Prithvi Raj, Neehar D. Parikh, Lewis R. Roberts, Myron E. Schwartz, Mindie H. Nguyen, Alex S. Befeler, Yujin Hoshida","doi":"10.1053/j.gastro.2024.10.035","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.10.035","url":null,"abstract":"<h3>Background and aims</h3>Hepatocellular carcinoma (HCC) risk stratification is an urgent unmet need for cost-effective HCC screening and early detection in patients with cirrhosis to improve poor HCC prognosis.<h3>Methods</h3>Molecular (Prognostic Liver Secretome signature with alpha-fetoprotein) and clinical (aMAP score) variable-based scores were integrated to develop PAaM, which was subsequently validated in two phase 3 biomarker validation studies: the statewide Texas HCC Consortium (THCCC) and nationwide HCC Early Detection Strategy (HEDS) prospective cohorts, following the prospective specimen collection, retrospective blinded evaluation (PRoBE) design. The associations between baseline PAaM and incident HCC were assessed using Fine-Gray regression, with overall death and liver transplantation as competing events.<h3>Results</h3>Of 2,156 cirrhosis patients in THCCC, PAaM identified 404 (19%) high-risk, 903 (42%) intermediate-risk, and 849 (39%) low-risk patients with annual HCC incidence rates of 5.3%, 2.7%, and 0.6%, respectively. Compared to low-risk patients, high- and intermediate-risk groups had sub-distribution hazard ratios (sHRs) for incident HCC of 7.51 (95% confidence interval [CI], 4.42-12.8) and 4.20 (95%CI, 2.52-7.01), respectively. Of 1,328 cirrhosis patients in HEDS, PAaM identified 201 (15%) high-risk, 540 (41%) intermediate-risk, and 587 (44%) low-risk patients, with annual HCC incidence rates of 6.2%, 1.8%, and 0.8%, respectively. High- and intermediate risk groups were associated with sHRs for incident HCC of 6.54 (95%CI, 3.85-11.1) and 1.77 (95%CI, 1.02-3.08), respectively. Subgroup analysis showed robust risk stratification across HCC etiologies, including metabolic dysfunction-associated steatotic liver disease (MASLD) and cured hepatitis C infection.<h3>Conclusion</h3>PAaM enables accurate HCC risk stratification in patients with cirrhosis from contemporary etiologies.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":null,"pages":null},"PeriodicalIF":29.4,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CREEPING FAT-DERIVED FREE FATTY ACIDS INDUCE HYPERPLASIA OF INTESTINAL MUSCULARIS PROPRIA MUSCLE CELLS – A NOVEL LINK BETWEEN FAT AND INTESTINAL STRICTURE FORMATION IN CROHN’S DISEASE","authors":"Weiwei Liu, Ren Mao, Thi Hong Nga Le, Gail West, Venkateshwari Varadharajan, Rakhee Banerjee, Genevieve Doyon, Pranab Mukherjee, Quang Tam Nguyen, Anny Mulya, Julie H. Rennison, Ilyssa O. Gordon, Michael Cruise, Shaomin Hu, Doug Czarnecki, Thomas Plesec, Jyotsna Chandra, Suhanti Banerjee, Jie Wang, William J. Massey, Florian Rieder","doi":"10.1053/j.gastro.2024.10.034","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.10.034","url":null,"abstract":"<h3>Background</h3>In Crohn’s disease (CD) wrapping of mesenteric fat around the bowel wall, so called ‘creeping fat’, is highly associated with strictures. The strongest contributor to luminal narrowing in strictures is a thickening of the human intestinal muscularis propria (MP). We hence investigated creeping fat derived factors and their effect on mechanisms of human intestinal MP smooth muscle cell (HIMC) hyperplasia.<h3>Methods</h3>Free fatty acids (FFA) in creeping fat or non-creeping mesenteric fat organ cultures were measured via lipidomic mass spectrometry. Primary HIMC were exposed to FFA and cell proliferation was assessed. Intracellular FFA metabolism pathways and reactive oxygen species were functionally evaluated. Muscle thickness was investigated in dextran sodium sulfate (DSS) colitis with small molecule inhibition of FFA transport and a novel fat deletion mouse model.<h3>Results</h3>Subserosal creeping fat is associated with a markedly thickened MP. Experimental deletion of mesenteric fat (FAT-ATTAC mouse) reduced MP thickness. Human creeping fat conditioned medium strongly upregulated HIMC proliferation. Creeping fat released higher amounts of five long-chain FFA, including palmitate. Inhibition of HIMC long-chain FFA metabolism or FFA uptake into mitochondria through carnitine palmitoyltransferase (CPT)-1 reduced the palmitate induced HIMC proliferation. Blockade of conversion of palmitate into phospholipids reduced HIMC proliferation. Prophylactic inhibition of CPT-1 in experimental DSS colitis did not ameliorate inflammation, but reduced MP thickness.<h3>Conclusion</h3>Creeping fat released long-chain FFA induce a selective proliferative response by HIMC. These results point to creeping fat as a novel contributor to stricture formation in CD.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":null,"pages":null},"PeriodicalIF":29.4,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Enterocolitis with a Rare Cause","authors":"Hirotaka Nakamura, Daisuke Watanabe, Yuzo Kodama","doi":"10.1053/j.gastro.2024.10.037","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.10.037","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":null,"pages":null},"PeriodicalIF":29.4,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142594207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An intriguing case of hepatosplenic lesions and pneumonia during anti-TNF therapy for IBD.","authors":"Gabriel Luiz de Almeida Souza, Vinicius Andrade Chebli, Julio Maria Fonseca Chebli","doi":"10.1053/j.gastro.2024.10.036","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.10.036","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":null,"pages":null},"PeriodicalIF":29.4,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142594210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Events Associated with Endoscopic Retrograde Cholangiopancreatography: Systematic Review and Meta-analysis","authors":"Kirles Bishay, Zhao Wu Meng, Rishad Khan, Mehul Gupta, Yibing Ruan, Marcus Vaska, Jordan Iannuzzi, Dylan E. O’Sullivan, Brittany Mah, Arun C.R. Partridge, Amanda M. Henderson, Howard Guo, Sunil Samnani, Max DeMarco, Yuhong Yuan, B. Joseph Elmunzer, Rajesh N. Keswani, Sachin Wani, Zachary L. Smith, Ronald J. Bridges, Nauzer Forbes","doi":"10.1053/j.gastro.2024.10.033","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.10.033","url":null,"abstract":"<h3>Background &amp; Aims</h3>Endoscopic retrograde cholangiopancreatography (ERCP)-related adverse events (AEs) are associated with morbidity, mortality, and healthcare expenditure. We aimed to assess incidences and comparisons of ERCP AEs.<h3>Methods</h3>We included studies performed after 2000 reporting on ERCP AEs from database inception through March 12, 2024. Outcomes included pancreatitis, bleeding, cholangitis, cholecystitis, perforation, and death. DerSimonian and Laird random effects meta-analyses were performed to calculate incidences of AEs. Subgroup and pairwise meta-analyses were performed. Meta-regression was performed on median recruitment year to assess temporal trends in pancreatitis incidence.<h3>Results</h3>A total of 380 studies were included. The incidence of death attributable to ERCP was 0.2% (95% confidence intervals, CI, 0.1-0.3%, <em>I</em>² 44%, n=47,258) in all-comers. The overall incidence of pancreatitis was 4.6% (95% CI 4.0-5.1%, <em>I</em>² 96%, n=293,378) among all-comers and 6.5% (95% CI 5.9-7.1%, <em>I</em>² 89%, n=88,809) among first-time patients. Pancreatitis incidence remained stable between 2000-2023 (average annual percent change 0.06, 95%CI -0.27 to 0.39). The overall incidences of the following AEs for all-comers were: bleeding (1.5%, 95% CI 1.2-1.7%, <em>I</em>² 93%, n=229,655), cholangitis (2.5%, 95%CI 1.9-3.3%, <em>I</em>² 96%, n=121,619), cholecystitis (0.8%, 95%CI 0.5-1.2%, <em>I</em>² 39%, n=7,799), and perforation (0.5%, 95%CI 0.4-0.6%, <em>I</em>² 90%, n=306,378).<h3>Conclusions</h3>ERCP-associated AEs remain common. Incidence of post-ERCP pancreatitis remained static despite improvements in techniques, prevention, and recognition. These results are important to patients, endoscopists, and policy makers to inform consent and to encourage implementation of available risk mitigation strategies.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":null,"pages":null},"PeriodicalIF":29.4,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142594218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum.","authors":"","doi":"10.1053/j.gastro.2024.10.027","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.10.027","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":null,"pages":null},"PeriodicalIF":25.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hacking Death in Dublin.","authors":"Seamus O'Mahony","doi":"10.1053/j.gastro.2024.09.019","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.09.019","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":null,"pages":null},"PeriodicalIF":25.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}