GastroenterologyPub Date : 2025-04-07DOI: 10.1053/j.gastro.2025.01.003
Seamus O’Mahony
{"title":"How Will the Future Judge Us?","authors":"Seamus O’Mahony","doi":"10.1053/j.gastro.2025.01.003","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.01.003","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"1360 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GastroenterologyPub Date : 2025-04-07DOI: 10.1053/j.gastro.2025.02.042
Beatriz Salvador-Barbero, Markella Alatsatianos, Jennifer P. Morton, Owen J. Sansom, Catherine Hogan
{"title":"KRASG12D cells override homeostatic cell elimination mechanisms in adult pancreas via Wnt5a and cell dormancy.","authors":"Beatriz Salvador-Barbero, Markella Alatsatianos, Jennifer P. Morton, Owen J. Sansom, Catherine Hogan","doi":"10.1053/j.gastro.2025.02.042","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.02.042","url":null,"abstract":"<h3>Background and Aims</h3>PaperClipThe adult pancreas protects against cancer by actively expelling genetically mutated cells. Pancreatic cancer starts with cells carrying KRAS mutations; however, it is not clear how some KRAS mutant cells override cell elimination mechanisms to survive in tissues.MethodsWe used an <em>in vivo</em> mouse model of sporadic tumorigenesis to induce <em>Kras</em> and/or <em>Tp53</em> mutations in low numbers of cells in the adult pancreas. We monitored mutant cell fate over time using quantitative fluorescence imaging. Gene signatures of non-eliminated mutant cell populations were identified using bulk RNA sequencing. Differential gene expression was overlapped with publicly available datasets. Key molecular pathways were validated in murine pancreas using immunofluorescence and functionally tested using inhibitor studies <em>in vivo</em> and epithelial co-culture systems <em>in vitro</em>.ResultsWhile most genetically mutant cells are eliminated from the adult pancreas, a population of KRASG12D- or p53R172H-expressing cells are stably retained. We identify Wnt5a signalling, cell dormancy and stemness as key features of surviving KrasG12D cells <em>in vivo</em>. Wnt5a specifically inhibits apical extrusion of RasV12 cells by promoting stable E-cadherin-based cell-cell adhesions at RasV12: normal cell-cell boundaries <em>in vitro</em>. In the pancreas, Wnt signalling, E-cadherin and β-catenin are increased at cell-cell contacts between non-eliminated KrasG12D cells and normal neighbours. Active Wnt signalling is a general mechanism required to promote KrasG12D and p53R172H cell retention and cell survival <em>in vivo</em>.ConclusionsRAS mutant cells activate Wnt5a and cell dormancy to avoid cell expulsion and to survive in the adult pancreas.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"37 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GastroenterologyPub Date : 2025-04-04DOI: 10.1053/j.gastro.2025.03.030
Vedant Acharya, Shivan Mehta, Amar R. Deshpande
{"title":"Reply to Pellegrino and Gravina and to Campion et al","authors":"Vedant Acharya, Shivan Mehta, Amar R. Deshpande","doi":"10.1053/j.gastro.2025.03.030","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.03.030","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"24 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GastroenterologyPub Date : 2025-04-04DOI: 10.1053/j.gastro.2025.03.032
Pieterjan Perremans, Gert De Hertogh, Bram Verstockt
{"title":"Gastro Curbside Consult: A rare case of ileocolitis","authors":"Pieterjan Perremans, Gert De Hertogh, Bram Verstockt","doi":"10.1053/j.gastro.2025.03.032","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.03.032","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"33 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GastroenterologyPub Date : 2025-04-04DOI: 10.1053/j.gastro.2025.03.029
John R. Campion, Conor Lahiff, Gayle Bennett
{"title":"Comments on \"Use of Large Language Models to Identify Surveillance Colonoscopy Intervals—A Feasibility Study\"","authors":"John R. Campion, Conor Lahiff, Gayle Bennett","doi":"10.1053/j.gastro.2025.03.029","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.03.029","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"183 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GastroenterologyPub Date : 2025-04-04DOI: 10.1053/j.gastro.2024.10.051
Raffaele Pellegrino, Antonietta Gerarda Gravina
{"title":"A large language model chatbot would only be as intelligent as the mind that uses it!","authors":"Raffaele Pellegrino, Antonietta Gerarda Gravina","doi":"10.1053/j.gastro.2024.10.051","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.10.051","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"58 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GastroenterologyPub Date : 2025-04-04DOI: 10.1053/j.gastro.2025.03.028
Jamie Robertson, Andrew D.F. Ross, Samuel Nurko
{"title":"Ethical considerations for the use of deception in pediatric research: Reflections on the use of deceptive placebo in children with DGBI","authors":"Jamie Robertson, Andrew D.F. Ross, Samuel Nurko","doi":"10.1053/j.gastro.2025.03.028","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.03.028","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"66 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GastroenterologyPub Date : 2025-04-04DOI: 10.1053/j.gastro.2025.03.031
Boying Liu, Fu Guan
{"title":"A Rare Cause of Abdominal Pain and Melena","authors":"Boying Liu, Fu Guan","doi":"10.1053/j.gastro.2025.03.031","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.03.031","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"59 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}