Gastroenterology最新文献

{"title":"Presentation of the AGA Distinguished Achievement Award in Basic Science to Klaus H. Kaestner, PhD.","authors":"Vincent W Yang, Mitchell A Lazar, Anil K Rustgi","doi":"10.1053/j.gastro.2026.08.005","DOIUrl":"https://doi.org/10.1053/j.gastro.2026.08.005","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"171 5","pages":"968-969"},"PeriodicalIF":29.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149265772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presentation of the AGA William Beaumont Prize in Gastroenterology to Stuart Jon Spechler, MD, AGAF.","authors":"Rhonda F Souza, Gary W Falk, David Katzka","doi":"10.1053/j.gastro.2026.08.006","DOIUrl":"https://doi.org/10.1053/j.gastro.2026.08.006","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"171 5","pages":"964-967"},"PeriodicalIF":29.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149265696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TASTY AND HEALTHY DIET REDUCES FECAL CALPROTECTIN IN HIGH-RISK FIRST-DEGREE RELATIVES OF PATIENTS WITH CROHN'S DISEASE: PIONIR RANDOMIZED CROSSOVER TRIAL.","authors":"Dan Turner, Sarah Kenigsberg, Luba Plotkin, Yonat Aharoni-Frutkoff, Menachem Sokolik, Gili Focht, Sara Gasasa, Williams Turpin, Alyssa M Waslyk, Oren Ledder, Anne M Griffiths, Inez Martincevic, Hien Q Huynh, Lihi Godny, Irit Avni-Biron, Joana Torres, Remo Panaccione, Kevan Jacobson, Anthony Otley, Tali Sharar-Fischler, Qilong Li, Asaf Azulay, Rotem Sigall-Boneh, Sun-Ho Lee, Ken Croitoru","doi":"10.1053/j.gastro.2026.10.376","DOIUrl":"https://doi.org/10.1053/j.gastro.2026.10.376","url":null,"abstract":"<p><strong>Background: </strong>With the rising prevalence of inflammatory bowel disease (IBD), preventing new-onset disease becomes a priority. The PIONIR (Preventing IBD ONset in Individuals at Risk) randomized controlled trial explored whether the Tasty&Healthy (T&H) diet reduces inflammatory markers in high-risk first-degree relatives (FDRs) of patients with Crohn's disease (CD).</p><p><strong>Methods: </strong>FDRs with persistently elevated fecal calprotectin (FC, >70μg/g) and, at most, nonspecific mucosal abnormalities (edema or ≤10 aphthous ulcers) on video-capsule endoscopy or ileocolonoscopy were randomized to T&H or habitual diet (HD) for 8 weeks, followed by crossover for additional 8 weeks. Treatment effect on the primary outcome, FC response, was analyzed using generalized estimating equations for the two-period, two-sequence crossover design, following the intention-to-treat principle.</p><p><strong>Results: </strong>Twenty-nine FDRs were randomized (n=14 T&H-first, n=15 HD-first). At week 8, median FC was lower with T&H (64μg/g [IQR 44-127]) vs. HD (112μg/g [74-227]; P=.022). FC decreased by ≥50% in 71% on T&H versus 27% on HD (RR=2.68 [95%CI 1.09-6.60]; P=.016). Across both crossover periods, estimated marginal mean FC declined from 185μg/g [95%CI 144-237] by 61% to 72μg/g [95%CI 57-91] with T&H, versus 38% to 114μg/g [95%CI 93-140] with HD (ratio 0.63 [95%CI 0.51-0.80], translating to 37% overall decrease with T&H; P<0.001). Six microbial species differed between diets after FDR correction. By week 8, 79% rated T&H acceptable and 83% had good or complete adherence.</p><p><strong>Conclusion: </strong>These findings demonstrate the modifiability of low-grade intestinal inflammation in healthy high-risk FDRs with persistent FC elevation but without diagnostic endoscopic evidence of CD, supporting long-term dietary prevention trials (ClinicalTrials.gov #NCT05211518).</p>","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":""},"PeriodicalIF":29.7,"publicationDate":"2026-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149265763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Promise of POWER 2.0 Depends on Equitable Access.","authors":"Sean Rangwani, Xiaohan Ying, Arun Jesudian","doi":"10.1053/j.gastro.2026.07.043","DOIUrl":"https://doi.org/10.1053/j.gastro.2026.07.043","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":""},"PeriodicalIF":29.7,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149265752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential for GLP-1 Receptor Agonists in Irritable Bowel Syndrome.","authors":"Michael Camilleri, Alexander C Ford","doi":"10.1053/j.gastro.2026.10.378","DOIUrl":"https://doi.org/10.1053/j.gastro.2026.10.378","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":""},"PeriodicalIF":29.7,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149244220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Seo et al.","authors":"Chun-Wei Pan, Daryl Ramai","doi":"10.1053/j.gastro.2026.10.375","DOIUrl":"https://doi.org/10.1053/j.gastro.2026.10.375","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":""},"PeriodicalIF":29.7,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149244164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Men Live By: Family Ties as a Bridge to Persistent Non-Participants in Colorectal Cancer Screening.","authors":"Jeongkuk Seo, Hang-Shim Lee, Uri Ladabaum","doi":"10.1053/j.gastro.2026.10.374","DOIUrl":"https://doi.org/10.1053/j.gastro.2026.10.374","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":""},"PeriodicalIF":29.7,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149244210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coaching Language to Improve Endoscopy Training Quality (CLIEnT): A Randomized Controlled Trial.","authors":"Aayush Gabrani, Laurel Smith Stvan, Allan Puran, Emily Finley, Wenly Ruan, David Troendle, Roopa Vemulapalli, Catharine M Walsh","doi":"10.1053/j.gastro.2026.10.003","DOIUrl":"https://doi.org/10.1053/j.gastro.2026.10.003","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":""},"PeriodicalIF":29.7,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149238024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiota–Taurine Pathway Links Dietary Fiber to Mucosal Healing","authors":"Rina Odakura, Natsumi Seki, Kei Nomura, Yukinobu Inoue, Kyosuke Yakabe, Masahiro Akiyama, Takashi Yao, Soh Okano, Wataru Suda, Hiroaki Masuoka, Xiaochen Zhang, Masayuki Orikasa, Masashi Omori, Masao Koma, Takafumi Maruyama, Naotake Yanagisawa, Takumi Murakami, Hiroshi Mori, Atsushi Toyoda, Junto Suzuki, Honoka Izuta, Tanakorn Srirat, Takeshi Haneda, Tsuyoshi Miki, Masahiro Ito, Takashi Ito, Tomoyoshi Shibuya, Ryo Katsumata, Gaku Nakato, Sayaka Mizutani, Takuji Yamada, Nobuo Sasaki, Koji Hase, Shinji Fukuda, Akihito Nagahara, Dai Ishikawa, Yun-Gi Kim","doi":"10.1053/j.gastro.2026.09.028","DOIUrl":"https://doi.org/10.1053/j.gastro.2026.09.028","url":null,"abstract":"Dietary fibers modulate host–microbiota interactions. Whether fiber promotes epithelial repair through microbiota-dependent mechanisms remains unclear. We determined how alginate influences colitis recovery and whether the pathway is relevant to ulcerative colitis (UC).","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"43 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149236216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mevalonate Biosynthesis is a Metabolic Vulnerability of Gemcitabine-resistant Pancreatic Cancer.","authors":"Alica K Michels, Sabrina Calderon, Ethan Nghiem, Eleni Zimmer, Leonor Schubert Santana, Rima Singh, Tim Eiseler, Chantal Allgöwer, Gregory Tong, Sharon Wu, Kevin Gulay, Mumina Sadullozoda, Austin Silva, Cecily Anaraki, Natalie Yousefian, Devon F Pendlebury, Cameron Geller, Alina Chao, Dennis Juarez, Thomas Seufferlein, Cholsoon Jang, Aimee L Edinger, Marcus Seldin, Alexander Muir, Thomas F Martinez, Alexander Kleger, David K Chang, Herve Tiriac, Jennifer B Valerin, David A Fruman, Christopher J Halbrook","doi":"10.1053/j.gastro.2026.09.027","DOIUrl":"10.1053/j.gastro.2026.09.027","url":null,"abstract":"<p><strong>Background & aims: </strong>Gemcitabine remains a cornerstone of systemic therapy for pancreatic ductal adenocarcinoma (PDAC) but acquired resistance limits its efficacy. While both microenvironment-derived metabolites and intrinsic metabolic reprogramming have been implicated in gemcitabine resistance, the relationship between these mechanisms remains poorly understood. We investigated the metabolic adaptations accompanying acquired gemcitabine resistance and identified therapeutically actionable vulnerabilities.</p><p><strong>Methods: </strong>Acquired gemcitabine-resistant PDAC models were generated and characterized. The effects of physiological pyrimidines on gemcitabine response were evaluated alongside changes in pyrimidine metabolism. Sensitivity to inhibition of the mevalonate pathway was assessed in vitro and in immunocompetent mouse models. Metabolite rescue experiments were performed to identify critical downstream mediators of statin activity and HMGCR expression was analyzed for its association with clinical response to gemcitabine.</p><p><strong>Results: </strong>PDAC cells with acquired gemcitabine resistance exhibited diminished sensitivity to physiological extracellular pyrimidines due to suppression of the pyrimidine salvage pathway. This metabolic rewiring created a selective dependency on the mevalonate biosynthesis pathway, rendering gemcitabine resistant cells highly sensitive to statins. Statin treatment selectively inhibited the growth of gemcitabine-resistant tumors in mice. Metabolite rescue studies identified geranylgeranyl pyrophosphate depletion, not cholesterol limitation, as a principal mediator of statin sensitivity. HMGCR expression declined progressively during the acquisition of gemcitabine resistance and low HMGCR expression levels predicted poor response to gemcitabine-based therapy in PDAC patients.</p><p><strong>Conclusions: </strong>Acquired gemcitabine resistance drives metabolic reprogramming that suppresses pyrimidine salvage while creating a therapeutically exploitable dependence on the mevalonate pathway. These findings identify pharmacological inhibition of HMGCR as a metabolic vulnerability in gemcitabine resistance and support HMGCR expression as a candidate biomarker for treatment stratification in PDAC patients.</p>","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":""},"PeriodicalIF":29.7,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149238056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}