Gastroenterology最新文献_第2页

Impact of Behavioral Interventions on Fecal Immunochemical Testing Uptake from a Randomized Trial 随机试验中行为干预对粪便免疫化学测试吸收的影响

IF 29.4 1区医学

Gastroenterology Pub Date : 2025-07-05 DOI: 10.1053/j.gastro.2025.07.002

Nauzer Forbes

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Scrotal swelling in a patient with Crohn’s disease: More than meets the eye 克罗恩病患者的阴囊肿胀：不仅仅是眼睛看到的

IF 29.4 1区医学

Gastroenterology Pub Date : 2025-07-03 DOI: 10.1053/j.gastro.2025.07.001

Ashkan Rezazadeh Ardabili, Alexandros D. Polydorides, Jean-Frederic Colombel

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Dietary Patterns and Incident Chronic Constipation in Three Prospective Cohorts of Middle- and Older-aged Adults 三个前瞻性中老年人群的饮食模式和慢性便秘发生率

IF 29.4 1区医学

Gastroenterology Pub Date : 2025-07-03 DOI: 10.1053/j.gastro.2025.06.020

Yiqing Wang, Braden Kuo, Madeline Berschback, Curtis Huttenhower, Andrew T. Chan, Kyle Staller

{"title":"Dietary Patterns and Incident Chronic Constipation in Three Prospective Cohorts of Middle- and Older-aged Adults","authors":"Yiqing Wang, Braden Kuo, Madeline Berschback, Curtis Huttenhower, Andrew T. Chan, Kyle Staller","doi":"10.1053/j.gastro.2025.06.020","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.06.020","url":null,"abstract":"<h3>Background and Aims</h3>Current literature on diet-constipation associations is limited by small sample sizes and cross-sectional designs. We aimed to comprehensively examine the associations between five dietary patterns, their components, and incident constipation.<h3>Methods</h3>In three large cohorts, the Nurses’ Health Study (NHS), NHSII, and the Health Professional Follow-up Study (HPFS), we identified chronic constipation based on repeatedly-measured self-reported constipation symptoms for ≥12 weeks in the past year. We assessed long-term adherence to five dietary patterns (alternate Mediterranean diet (aMED), low-carbohydrate diet (LCD), Western diet (WD)) and indices (plant-based dietary index (PDI), empirical dietary inflammatory pattern (EDIP)) using validated quadrennial food frequency questionnaires. We used a log-binomial model adjusted for a wide range of confounders, including fiber or ultra-processed food (UPF) intake, to estimate relative risk (95% confidence interval) for constipation.<h3>Results</h3>In the pooled cohort of 27,774 (78.4±5.6y) NHS, 55,906 (60.5±4.6y) NHSII, and 12,237 (78.6±5.6y) HPFS participants, we documented 7,519 incident constipation cases after 2-4 years of follow-up. Compared to the lowest quintiles, the top quintiles of aMED and PDI were associated with 16% (9-22%) and 20% (14-27%) reduced risk for constipation, whereas the top quintiles of EDIP, WD, and LCD were associated with 24% (15-33%), 22% (11-33%), and 3% (-3-11%) increased risk for constipation, respectively. These associations were independent of total fiber or UPF intake. Vegetable and nut intake, which are enriched in aMED and PDI, were associated with decreased constipation risks.<h3>Conclusion</h3>Our findings suggest that dietary patterns emphasizing plant-based foods and healthy fats may protect against constipation, informing future dietary interventions and treatments for chronic constipation.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"27 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Serotonin’s New Frontier: SSRIs Unveiled as Cancer Immunotherapy 5 -羟色胺的新领域：SSRIs被揭露为癌症免疫疗法

IF 29.4 1区医学

Gastroenterology Pub Date : 2025-07-03 DOI: 10.1053/j.gastro.2025.06.024

Rajan Singh, Kara Gross Margolis

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Reply to Zhao and Peppelenbosch 回复赵和Peppelenbosch

IF 29.4 1区医学

Gastroenterology Pub Date : 2025-07-01 DOI: 10.1053/j.gastro.2025.06.022

Jonathan D. Windster, Kaushal Parikh, Maria M. Alves

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Describing rates of post-colonoscopy colorectal cancer: potential risks as well as benefits? 描述结肠镜检查后结直肠癌的发病率：潜在的风险和益处？

IF 29.4 1区医学

Gastroenterology Pub Date : 2025-07-01 DOI: 10.1053/j.gastro.2025.05.030

Arun Gupta, Andrew Metz, Finlay Macrae

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Peyer’s patch B cells sample transglutaminase-gluten complexes and drive celiac disease autoimmunity Peyer’s patch B细胞样品转谷氨酰胺酶-谷蛋白复合物和驱动乳糜泻自身免疫

IF 29.4 1区医学

Gastroenterology Pub Date : 2025-07-01 DOI: 10.1053/j.gastro.2025.06.021

M. Fleur du Pré, Liv Kleppa, Alisa E. Dewan, Maureen T. Meling, Lene S. Høydahl, Harrison A. Besser, Chaitan Khosla, Ludvig M. Sollid

{"title":"Peyer’s patch B cells sample transglutaminase-gluten complexes and drive celiac disease autoimmunity","authors":"M. Fleur du Pré, Liv Kleppa, Alisa E. Dewan, Maureen T. Meling, Lene S. Høydahl, Harrison A. Besser, Chaitan Khosla, Ludvig M. Sollid","doi":"10.1053/j.gastro.2025.06.021","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.06.021","url":null,"abstract":"<h3>Background and aims</h3>The production of autoantibodies against the enzyme transglutaminase 2 (TG2) in celiac disease likely results from TG2-specific B cells receiving help from gluten-specific CD4<sup>+</sup> T cells in gut-associated lymphoid tissues (GALT) via the formation of transient enzyme-substrate complexes formed between TG2 and gluten. Where in the body enzymatically active TG2 encounters gluten peptides remains unknown.<h3>Methods</h3>A model to study the celiac disease-relevant T cell-B cell interactions in GALT has been developed. Mice expressing HLA-DQ2.5 received TG2-specific B cells and gluten-specific T cells by adoptive transfer and were subsequently orally immunized with a model antigen containing the the B-cell and T-cell epitopes.<h3>Results</h3>Orally immunized HLA-DQ2.5 knock-in mice developed TG2-specific gut IgA and serum IgG responses. Activated TG2-specific B cells were present in Peyer’s patches and in gut-draining mesenteric lymph nodes, resembling what is seen in human celiac disease. We demonstrate that TG2-specific B cells in Peyer’s patches sample TG2 when the protein is perfused into the gut lumen.<h3>Conclusion</h3>The model supports a mechanism where TG2-gluten complexes formed in the gut lumen are taken up by TG2-specific B cells in GALT. We propose that this pathway plays an important role in driving the anti-TG2 IgA autoantibody response in celiac disease patients. The model provides a platform to explore novel approaches for celiac disease therapies.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"41 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Mechanistic Insights into Prucalopride's Role in IBS Treatment: Schwann-like Enteric Glial Cells as Therapeutic Targets 普芦卡必利在肠易激综合征治疗中的作用机制：雪旺样肠胶质细胞作为治疗靶点

IF 29.4 1区医学

Gastroenterology Pub Date : 2025-07-01 DOI: 10.1053/j.gastro.2025.01.261

Yilan Zhao, Maikel P. Peppelenbosch

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Reply to Gupta et al 回复Gupta等人

IF 29.4 1区医学

Gastroenterology Pub Date : 2025-07-01 DOI: 10.1053/j.gastro.2025.06.023

Nanette S. van Roermund, Joep E.G. Ijspeert, Evelien Dekker

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Endoscopic Surveillance for Non-Dysplastic Barrett’s Esophagus: Are We Violating “Primum Non Nocere”? 非发育不良巴雷特食管的内窥镜监测：我们是否违反了“非无创性原则”？