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An Unusual Cause of Acute Liver Failure Diagnosed on Organ Explant in a Patient With Ulcerative Colitis. 溃疡性结肠炎患者器官切片诊断出急性肝衰竭的不寻常原因
IF 25.7 1区 医学
Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-06-29 DOI: 10.1053/j.gastro.2024.06.021
Alessandro Pedicelli, René P Michel, Giada Sebastiani
{"title":"An Unusual Cause of Acute Liver Failure Diagnosed on Organ Explant in a Patient With Ulcerative Colitis.","authors":"Alessandro Pedicelli, René P Michel, Giada Sebastiani","doi":"10.1053/j.gastro.2024.06.021","DOIUrl":"10.1053/j.gastro.2024.06.021","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"223-226"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Brain-Gut Pathway for Stress-Induced Microbiome Changes. 压力诱导微生物群变化的大脑-肠道途径。
IF 25.7 1区 医学
Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-09-28 DOI: 10.1053/j.gastro.2024.09.025
Sarah A Najjar, Kara Gross Margolis
{"title":"A Brain-Gut Pathway for Stress-Induced Microbiome Changes.","authors":"Sarah A Najjar, Kara Gross Margolis","doi":"10.1053/j.gastro.2024.09.025","DOIUrl":"10.1053/j.gastro.2024.09.025","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"418"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High Pathological Response Rate After Neoadjuvant Immunotherapy in Locally Advanced Mismatch Repair-Deficient Colon Cancer (NICHE-2 Study). 局部晚期错配修复缺陷结肠癌接受新辅助免疫疗法后病理反应率高（NICHE-2 研究）。
IF 25.7 1区 医学
Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-08-06 DOI: 10.1053/j.gastro.2024.08.003
Ville Sallinen
{"title":"High Pathological Response Rate After Neoadjuvant Immunotherapy in Locally Advanced Mismatch Repair-Deficient Colon Cancer (NICHE-2 Study).","authors":"Ville Sallinen","doi":"10.1053/j.gastro.2024.08.003","DOIUrl":"10.1053/j.gastro.2024.08.003","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"419-420"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Mysterious Cause of Refractory Diarrhea and Weight Loss in a Young Woman. 一位年轻女性难治性腹泻和体重减轻的神秘原因。
IF 25.7 1区 医学
Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-07-09 DOI: 10.1053/j.gastro.2024.07.003
Zhenzhen Fan, Yanting Shi, Jie Liang
{"title":"The Mysterious Cause of Refractory Diarrhea and Weight Loss in a Young Woman.","authors":"Zhenzhen Fan, Yanting Shi, Jie Liang","doi":"10.1053/j.gastro.2024.07.003","DOIUrl":"10.1053/j.gastro.2024.07.003","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"227-230"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surveillance for Hepatocellular Carcinoma in Cirrhosis: End of Monopoly for Serum Alpha Fetoprotein. 肝硬化肝细胞癌监测：结束对血清甲胎蛋白的垄断。
IF 25.7 1区 医学
Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-09-28 DOI: 10.1053/j.gastro.2024.09.027
Lung-Yi Mak, Man-Fung Yuen
{"title":"Surveillance for Hepatocellular Carcinoma in Cirrhosis: End of Monopoly for Serum Alpha Fetoprotein.","authors":"Lung-Yi Mak, Man-Fung Yuen","doi":"10.1053/j.gastro.2024.09.027","DOIUrl":"10.1053/j.gastro.2024.09.027","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"217-219"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Phase 3 Biomarker Validation of GALAD for the Detection of Hepatocellular Carcinoma in Cirrhosis. GALAD 检测肝硬化肝细胞癌的 3 期生物标志物验证。
IF 25.7 1区 医学
Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-09-16 DOI: 10.1053/j.gastro.2024.09.008
Tracey L Marsh, Neehar D Parikh, Lewis R Roberts, Myron E Schwartz, Mindie H Nguyen, Alex Befeler, Stephanie Page-Lester, Nabihah Tayob, Sudhir Srivastava, Jo Ann Rinaudo, Amit G Singal, K Rajender Reddy, Jorge A Marrero
{"title":"A Phase 3 Biomarker Validation of GALAD for the Detection of Hepatocellular Carcinoma in Cirrhosis.","authors":"Tracey L Marsh, Neehar D Parikh, Lewis R Roberts, Myron E Schwartz, Mindie H Nguyen, Alex Befeler, Stephanie Page-Lester, Nabihah Tayob, Sudhir Srivastava, Jo Ann Rinaudo, Amit G Singal, K Rajender Reddy, Jorge A Marrero","doi":"10.1053/j.gastro.2024.09.008","DOIUrl":"10.1053/j.gastro.2024.09.008","url":null,"abstract":"<p><strong>Background & aims: </strong>Better surveillance tests for hepatocellular carcinoma (HCC) are needed. The GALAD score (gender, age, α-fetoprotein [AFP] L3, AFP, and des-γ carboxyprothrombin) has been shown to have excellent sensitivity and specificity for HCC in phase 2 studies. We performed a phase 3 biomarker validation study to compare GALAD with AFP in detecting HCC.</p><p><strong>Methods: </strong>This is a prospective study of patients with cirrhosis enrolled at 7 centers. Surveillance for HCC was performed every 6 months at each site, and HCC diagnosis was confirmed per American Association for the Study of Liver Diseases guidelines. Blood for biomarker research was obtained at each follow-up visit and stored in a biorepository. Measurements of AFP, AFP-L3, and des-γ carboxyprothrombin) were performed in a FujiFilm laboratory by staff blinded to clinical data. The performance of GALAD in detecting HCC was retrospectively evaluated within 12 months before the clinical diagnosis. All analyses were conducted by an unblinded statistician in the Early Detection Research Network data management and coordinating center.</p><p><strong>Results: </strong>A total of 1,558 patients with cirrhosis were enrolled and followed for a median of 2.2 years. A total of 109 patients developed HCC (76 very early or early stage), with an annual incident rate of 2.4%. The areas under the curve for AFP and GALAD within 12 months before HCC were 0.66 and 0.78 (P < .001), respectively. Using a cutoff for GALAD of -1.36, the specificity was 82%, and the sensitivity at 12 months before HCC diagnosis was 62%. For comparison, performance of AFP at 82% specificity showed 41% sensitivity at 12 months before HCC diagnosis (P = .001).</p><p><strong>Conclusions: </strong>GALAD score, compared to AFP, improves the detection of HCC within 12 months before the actual diagnosis.</p>","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"316-326.e6"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142283919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Taming Lynch Syndrome: The Remarkable Power of Prevention for One Family. 驯服林奇综合征：一个家庭预防的非凡力量》。
IF 25.7 1区 医学
Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-07-20 DOI: 10.1053/j.gastro.2024.06.037
Matthew B Yurgelun, Jennifer Rhees, Nickolas Papadopoulos, Bert Vogelstein, C Richard Boland
{"title":"Taming Lynch Syndrome: The Remarkable Power of Prevention for One Family.","authors":"Matthew B Yurgelun, Jennifer Rhees, Nickolas Papadopoulos, Bert Vogelstein, C Richard Boland","doi":"10.1053/j.gastro.2024.06.037","DOIUrl":"10.1053/j.gastro.2024.06.037","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"195-199"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First-line dual immunotherapy to checkmate metastasic colorectal cancer with high microsatellite instability
IF 29.4 1区 医学
Gastroenterology Pub Date : 2025-02-01 DOI: 10.1053/j.gastro.2025.01.228
Maria D. Giraldez
{"title":"First-line dual immunotherapy to checkmate metastasic colorectal cancer with high microsatellite instability","authors":"Maria D. Giraldez","doi":"10.1053/j.gastro.2025.01.228","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.01.228","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"55 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenging Conventional Care: Ethical Considerations of De-intensification of Therapy in IBD. 挑战传统护理：IBD去强化治疗的伦理考虑。
IF 25.7 1区 医学
Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-12-18 DOI: 10.1053/j.gastro.2024.09.031
Joëlle St-Pierre, David T Rubin
{"title":"Challenging Conventional Care: Ethical Considerations of De-intensification of Therapy in IBD.","authors":"Joëlle St-Pierre, David T Rubin","doi":"10.1053/j.gastro.2024.09.031","DOIUrl":"10.1053/j.gastro.2024.09.031","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"200-204"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Unexpected Cause of Dysphagia. 胃路边咨询--吞咽困难的意外原因。
IF 25.7 1区 医学
Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-07-23 DOI: 10.1053/j.gastro.2024.07.020
Mehul Gupta, Stephen E Congly, Yasmin Nasser
{"title":"An Unexpected Cause of Dysphagia.","authors":"Mehul Gupta, Stephen E Congly, Yasmin Nasser","doi":"10.1053/j.gastro.2024.07.020","DOIUrl":"10.1053/j.gastro.2024.07.020","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"e4-e6"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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