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An Invisible Threat. 无形的威胁
IF 25.7 1区 医学
Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-07-04 DOI: 10.1053/j.gastro.2024.06.031
Marie-Emilie Esclangon, Maxime Henrion, Karim Gebara
{"title":"An Invisible Threat.","authors":"Marie-Emilie Esclangon, Maxime Henrion, Karim Gebara","doi":"10.1053/j.gastro.2024.06.031","DOIUrl":"10.1053/j.gastro.2024.06.031","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"e1-e3"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of DNA Methylation in Gastrointestinal Disease: An Expanded Review of Malignant and Nonmalignant Gastrointestinal Diseases. DNA 甲基化在胃肠道疾病中的作用：恶性和非恶性胃肠道疾病扩展综述》。
IF 25.7 1区 医学
Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-07-04 DOI: 10.1053/j.gastro.2024.07.001
Andrew Kalra, Stephen J Meltzer
{"title":"The Role of DNA Methylation in Gastrointestinal Disease: An Expanded Review of Malignant and Nonmalignant Gastrointestinal Diseases.","authors":"Andrew Kalra, Stephen J Meltzer","doi":"10.1053/j.gastro.2024.07.001","DOIUrl":"10.1053/j.gastro.2024.07.001","url":null,"abstract":"<p><p>Esophageal, colorectal, pancreatic, hepatocellular, and gastric cancer together impact millions of patients worldwide each year, with high overall mortality rates, and are increasing in incidence. Additionally, premalignant gastrointestinal diseases, such as Barrett's esophagus and inflammatory bowel disease, are also increasing in incidence. However, involvement of aberrant DNA methylation in these diseases is incompletely understood, especially given recent research advancements in this field. Here, we review knowledge of this epigenetic mechanism in gastrointestinal preneoplasia and neoplasia, considering mechanisms of action, genetic and environmental factors, and 5'-C-phosphate-G-3' island methylator phenotype. We also highlight developments in translational research, focusing on genomic-wide data, methylation-based biomarkers and diagnostic tests, machine learning, and therapeutic epigenetic strategies.</p>","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"245-266"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comments on “Recompensation of Chronic Hepatitis C–Related Decompensated Cirrhosis Following Direct-Acting Antiviral Therapy: Prospective Cohort Study From a Hepatitis C Virus Elimination Program”
IF 29.4 1区 医学
Gastroenterology Pub Date : 2025-02-01 DOI: 10.1053/j.gastro.2024.09.050
Niteen Kumar, Abhideep Chaudhary
{"title":"Comments on “Recompensation of Chronic Hepatitis C–Related Decompensated Cirrhosis Following Direct-Acting Antiviral Therapy: Prospective Cohort Study From a Hepatitis C Virus Elimination Program”","authors":"Niteen Kumar, Abhideep Chaudhary","doi":"10.1053/j.gastro.2024.09.050","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.09.050","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"24 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Liver Failure and a Rash
IF 29.4 1区 医学
Gastroenterology Pub Date : 2025-01-31 DOI: 10.1053/j.gastro.2025.01.225
Emily R. Gordon, Madison E. Jones, Brandon L. Adler
{"title":"Acute Liver Failure and a Rash","authors":"Emily R. Gordon, Madison E. Jones, Brandon L. Adler","doi":"10.1053/j.gastro.2025.01.225","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.01.225","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"24 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel, IBS-specific IgG ELISA-based elimination diet in irritable bowel syndrome: A randomized, sham-controlled trial
IF 29.4 1区 医学
Gastroenterology Pub Date : 2025-01-31 DOI: 10.1053/j.gastro.2025.01.223
Prashant Singh, William D. Chey, Will Takakura, Brooks D. Cash, Brian E. Lacy, Eamonn M.M. Quigley, Charles W. Randall, Anthony Lembo
{"title":"A novel, IBS-specific IgG ELISA-based elimination diet in irritable bowel syndrome: A randomized, sham-controlled trial","authors":"Prashant Singh, William D. Chey, Will Takakura, Brooks D. Cash, Brian E. Lacy, Eamonn M.M. Quigley, Charles W. Randall, Anthony Lembo","doi":"10.1053/j.gastro.2025.01.223","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.01.223","url":null,"abstract":"<h3>Background &amp; Aims</h3>Personalized dietary therapies for irritable bowel syndrome (IBS) are needed and an IgG-antibody-based elimination diet presents a potential solution. However, existing studies have serious methodological limitations. This study aimed to assess the efficacy of an elimination diet utilizing a novel IBS-specific IgG assay.<h3>Methods</h3>We conducted a randomized, double-blind, sham-controlled trial enrolling subjects with IBS from 8 centers. Subjects positive for ≥1 food on an 18-food IgG assay and an average daily abdominal pain intensity (API) score between 3-7.5 on an 11-point scale during a 2-week run-in period were randomized to either an experimental antibody-guided diet or sham diet for 8 weeks. The primary outcome was a ≥30% decrease in API for ≥2 of the last 4 weeks of the treatment period.<h3>Results</h3>Among 238 randomized IBS subjects, 223 were included in the modified intention-to-treat analysis. A significantly greater proportion of subjects in the experimental diet group met the primary outcome than those in the sham diet group (59.6% vs. 42.1%, P=0.02). Subgroup analysis revealed that a higher proportion of IBS-C and IBS-M subjects in the experimental diet group met the primary endpoint vs. the sham group (67.1% vs. 35.8% and 66% vs. 29.5%, respectively).<h3>Conclusions</h3>Subjects on an IgG-guided elimination diet were more likely to achieve the primary endpoint than those on a sham elimination diet. Subgroup analysis suggests a more robust benefit for subjects with IBS-C and IBS-M. This highlights the potential effectiveness of a personalized elimination diet based on a novel IBS-specific IgG assay. A larger study is warranted to validate these observations.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"20 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The safety and efficacy of guselkumab for the treatment of moderate to severely active ulcerative colitis
IF 29.4 1区 医学
Gastroenterology Pub Date : 2025-01-31 DOI: 10.1053/j.gastro.2025.01.227
Reena Khanna
{"title":"The safety and efficacy of guselkumab for the treatment of moderate to severely active ulcerative colitis","authors":"Reena Khanna","doi":"10.1053/j.gastro.2025.01.227","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.01.227","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"11 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Unexpected Adverse Event of Radiofrequency Ablation for Intraductal Papillary Mucinous Neoplasm
IF 29.4 1区 医学
Gastroenterology Pub Date : 2025-01-31 DOI: 10.1053/j.gastro.2025.01.226
Ahmed Abdelbaki, Fadi Hawa, Somashekar G. Krishna
{"title":"An Unexpected Adverse Event of Radiofrequency Ablation for Intraductal Papillary Mucinous Neoplasm","authors":"Ahmed Abdelbaki, Fadi Hawa, Somashekar G. Krishna","doi":"10.1053/j.gastro.2025.01.226","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.01.226","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"8 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to Kumar and Chaudhary
IF 29.4 1区 医学
Gastroenterology Pub Date : 2025-01-31 DOI: 10.1053/j.gastro.2025.01.222
Madhumita Premkumar, Radha K. Dhiman
{"title":"Reply to Kumar and Chaudhary","authors":"Madhumita Premkumar, Radha K. Dhiman","doi":"10.1053/j.gastro.2025.01.222","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.01.222","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"121 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to Li, Wang et al, and Xu et al
IF 29.4 1区 医学
Gastroenterology Pub Date : 2025-01-30 DOI: 10.1053/j.gastro.2025.01.221
Kai Wang, Mingyang Song
{"title":"Reply to Li, Wang et al, and Xu et al","authors":"Kai Wang, Mingyang Song","doi":"10.1053/j.gastro.2025.01.221","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.01.221","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"16 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143056259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regarding "An Empirical Dietary Pattern Associated With the Gut Microbial Features in Relation to Colorectal Cancer Risk"
IF 29.4 1区 医学
Gastroenterology Pub Date : 2025-01-30 DOI: 10.1053/j.gastro.2024.12.038
Wei Wang, Yan Geng, Jie Pan, Xian-hui Zhang
{"title":"Regarding \"An Empirical Dietary Pattern Associated With the Gut Microbial Features in Relation to Colorectal Cancer Risk\"","authors":"Wei Wang, Yan Geng, Jie Pan, Xian-hui Zhang","doi":"10.1053/j.gastro.2024.12.038","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.12.038","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"78 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143056324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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