Gastroenterology最新文献

{"title":"A Rare Cause of Abdominal Pain and Melena","authors":"Boying Liu, Fu Guan","doi":"10.1053/j.gastro.2025.03.031","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.03.031","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"59 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remodeling the colon with ileal properties to treat short bowel syndrome","authors":"Tao Liu, Shiri Li, Jorge Múnera, Ramesh A. Shivdasani, Xiaofeng Huang, Qiao Zhou","doi":"10.1053/j.gastro.2025.03.026","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.03.026","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"57 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A learner’s guide to optical diagnosis in endoscopy: training strategies and practical applications","authors":"Robert Bechara, Michael A. Scaffidi, Samir C. Grover","doi":"10.1053/j.gastro.2025.03.027","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.03.027","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"73 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FUT7 improves intestinal immune homeostasis in IBD by enhancing Treg intestinal homing and immunosuppression","authors":"Ke Liu, Bingxia Chen, Xinlong Lin, Qian Zhou, Teng Ben, Jiahui Xu, Yin Zhang, Xinyue Zhang, Yeling Chen, Sheng Li, Fangqing Zhu, Yuexin Ren, Fachao Zhi, Gao Tan","doi":"10.1053/j.gastro.2025.02.041","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.02.041","url":null,"abstract":"<h3>Background &amp; Aims</h3>Tregs play a critical role in maintaining tissue immune homeostasis, but they are relatively insufficient at inflammatory intestinal sites in patients with IBD. However, what controls Treg homing to the intestine in IBD is unknown.<h3>Methods</h3>FUT7 expression in Tregs from patients with active IBD was detected by RNA sequencing. To determine whether FUT7 controls Treg intestinal homing in IBD, Treg-specific Fut7 conditional knockout (CKO) mice were constructed and used in an IBD model induced by dextran sulfate sodium. To investigate whether upregulating FUT7 expression in Tregs plays a therapeutic role in IBD, the nanocarrier CD4-LDP-Fut7, which specifically targets Tregs to express Fut7, was constructed and used in the IBD model. In addition, whether Fut7 regulates other Treg functions was explored by mass cytometry.<h3>Results</h3>Compared with healthy controls, patients with active IBD had significantly decreased FUT7 expression in Tregs. In the IBD model, CKO mice had a lower frequency of colonic Tregs among CD4⁺ T cells and a lower ratio of colonic to splenic Tregs from the same mouse than their littermate controls did, indicating that Fut7 deficiency impaired the ability of Tregs to home to the intestine. Consistently, CKO mice had severe colitis, while CD4-LDP-Fut7 alleviated it in the IBD model. Mass cytometry analysis revealed that Fut7 downregulated PD1 expression in Tregs via competition with Fut8 for the substrate GDP-fucose, thereby increasing the immunosuppressive capacity of Tregs.<h3>Conclusion</h3>FUT7 enhances Treg intestinal homing and immunosuppression. Thus, upregulating FUT7 expression in Tregs could be a novel therapeutic strategy for IBD.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"107 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barrett’s Oesophagus Surveillance versus endoscopy at need Study (BOSS): a randomized controlled trial","authors":"Oliver Old, Janusz Jankowski, Stephen Attwood, Clive Stokes, Catherine Kendall, Cathryn Rasdell, Alex Zimmermann, M Sofia Massa, Sharon Love, Scott Sanders, Manuela Deidda, Andrew Briggs, Julie Hapeshi, Chris Foy, Paul Moayyedi, Hugh Barr","doi":"10.1053/j.gastro.2025.03.021","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.03.021","url":null,"abstract":"<h3>Background and aims</h3>Barrett’s esophagus (BE) is a precursor lesion for esophageal adenocarcinoma (EA). Surveillance endoscopy aims to detect early malignant progression: though widely practised it has not previously been tested in a randomized trial.<h3>Methods</h3>BOSS was a randomized controlled trial at 109 centres in the UK. Patients with BE were randomized to two-yearly surveillance endoscopy or ‘at need’ endoscopy, offered only for symptoms. Follow up was a minimum of 10 years. The primary outcome was overall survival in the intention-to-treat population. Secondary outcomes included cancer-specific survival; time to diagnosis of EA; stage of EA at diagnosis; frequency of endoscopy and serious adverse events related to interventions.<h3>Results</h3>3453 patients were recruited. 1733 patients were randomized to surveillance and 1719 to ‘at need’ endoscopy. Median follow up time was 12·8 years for the primary outcome. There was no evidence of a difference in overall survival between surveillance (333 deaths in 1733 patients) versus ‘at need’ arms (356 deaths in 1719 patients), hazard ratio 0·95 (95% CI 0·82-1·10), stratified log-rank p=0·503). There was no evidence of a difference for surveillance versus ‘at need’ endoscopy in cancer-specific survival (108 vs. 106 deaths from any cancer, HR 1·01 (95% CI 0·77-1·33), p=0·926), time to diagnosis of EA (40 vs. 31 patients had a diagnosis of EA, HR 1·32 (95% CI 0·82-2·11), p=0·254), or cancer stage at diagnosis. 8 (0·46%) surveillance patients and 7 (0·41%) ‘at need’ patients reported serious adverse events.<h3>Conclusion</h3>Surveillance did not improve overall survival or cancer-specific survival. ‘At need’ endoscopy may be a safe alternative for low-risk patients.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"3 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Parental Crohn’s Disease on Offspring’s Gut Health and Disease Vulnerability","authors":"Liqi Li","doi":"10.1053/j.gastro.2024.10.050","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.10.050","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"216 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Li","authors":"Sun-Ho Lee, Maham Bushra, Kenneth Croitoru","doi":"10.1053/j.gastro.2025.03.023","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.03.023","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"38 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Tang","authors":"Ahmed N. Hegazy","doi":"10.1053/j.gastro.2025.03.022","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.03.022","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"19 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on \"Multimodal Profiling of Peripheral Blood Identifies Proliferating Circulating Effector CD4+ T Cells as Predictors for Response to Integrin α4β7–Blocking Therapy in Inflammatory Bowel Disease\"","authors":"Liu Tang","doi":"10.1053/j.gastro.2025.02.040","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.02.040","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"37 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stromal Stiffness-Regulated IGF2BP2 in Pancreatic Cancer Drives Immune Evasion via Sphingomyelin Metabolism","authors":"Rong Tang, Zifeng Zhang, Xiaomeng Liu, Yingna Liao, , Mingming Xiao, Yangyi Li, Cong Zhou, Zhen Tan, Chaoyi Zhang, Chen Chen, Zeyin Rong, Yuan Liu, Pengcheng Li, Qiong Du, Qing He, Yubin Lei, Zijian Wu, Siyuan Lu, Jin Xu, Xianjun Yu","doi":"10.1053/j.gastro.2025.03.019","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.03.019","url":null,"abstract":"<h3>Background &amp; aims</h3>Immunotherapy has shown promising results in cancer treatment; however, it remains largely ineffective for pancreatic ductal adenocarcinoma (PDAC). N6-methyladenosine (m6A), known for its crucial role in cancer biology, is not yet fully understood regarding immune evasion. This study aims to elucidate the associations and mechanisms linking m6A modification with immune evasion in PDAC and propose strategies for clinical intervention.<h3>Methods</h3>A multimodal PDAC cohort of 122 patients was developed, integrating transcriptomic profiling, imaging mass cytometry, and m6A quantification to identify m6A regulators associated with immunosuppressive tumor microenvironment (TME) and clinical outcomes. Findings were validated across six independent PDAC cohorts. Assays including MeRIP, RIP, and RNA pull-down confirmed that IGF2BP2 binds to targets, while scRNA-seq, flow cytometry, and mIHC profiled the TME. Preclinical interventions were tested in PDAC organoids, patient-derived tissue fragments, and humanized mouse models.<h3>Results</h3>Our comprehensive analysis identified the m6A reader protein IGF2BP2 as a critical factor associated with poor prognosis in PDAC, linked to reduced effector cell infiltration and a fibrotic TME. High matrix stiffness in PDAC stabilized IGF2BP2, which subsequently promoted sphingomyelin synthesis via SGMS2 upregulation. This pathway facilitates PD-L1 localization on membrane lipid rafts, enhancing immune evasion. The elastographic properties of PDAC enabled noninvasive screening of patients with overexpressed IGF2BP2/SGMS2. Disrupting sphingomyelin synthesis improved antitumor immunity and suppressed PDAC growth in humanized mice, highlighting immunotherapeutic opportunities for PDAC.<h3>Conclusion</h3>These findings emphasize the critical interplay between extrinsic matrix stiffness and intrinsic IGF2BP2-regulated sphingomyelin synthesis, identifying a promising target for immunotherapeutic strategies in PDAC.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"31 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}