Gastroenterology最新文献_第10页

Preventive effect of Helicobacter pylori treatment on gastric cancer incidence and mortality: A Korean population study 幽门螺杆菌治疗对胃癌发病率和死亡率的预防作用：一项韩国人口研究

IF 29.4 1区医学

Gastroenterology Pub Date : 2025-04-08 DOI: 10.1053/j.gastro.2025.03.036

Yoon Suk Jung, Mai Thi Xuan Tran, Boyoung Park, Chang Mo Moon

{"title":"Preventive effect of Helicobacter pylori treatment on gastric cancer incidence and mortality: A Korean population study","authors":"Yoon Suk Jung, Mai Thi Xuan Tran, Boyoung Park, Chang Mo Moon","doi":"10.1053/j.gastro.2025.03.036","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.03.036","url":null,"abstract":"<h3>BACKGROUND & AIMS</h3><em>Helicobacter pylori</em> (<em>H. pylori</em>) infection is a major risk factor for gastric cancer (GC); however, whether <em>H. pylori</em> eradication (HPE) benefits the older population remains unclear. We compared GC incidence and mortality between <em>H. pylori</em>-treated individuals and the general population, stratified by age.<h3>METHODS</h3>We conducted a population-based study in South Korea involving 916,438 individuals aged ≥20 years who underwent HPE therapy between 2009 and 2011, with follow-up until 2021. Standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs) for GC were calculated, comparing <em>H. pylori</em>-treated individuals with the general population.<h3>RESULTS</h3>The mean follow-up period was 12.4±1.1 years. GC incidence and mortality rates were significantly lower in <em>H. pylori</em>-treated individuals than in the general population across all age groups (30–39, 40–49, 50–59, 60–69, and ≥70 years), except for the 20–29 years age group. Notably, in the 70–74, 75–79, and ≥80 years age groups, GC incidence and mortality in <em>H. pylori</em>-treated individuals remained significantly lower. The SIRs (95% confidence intervals [CIs]) for these groups were 0.56 (0.52–0.61), 0.48 (0.42–0.54), and 0.36 (0.28–0.46), respectively, and the SMRs (95% CIs) were 0.30 (0.25–0.35), 0.38 (0.31–0.47), and 0.43 (0.30–0.59), respectively.<h3>CONCLUSIONS</h3>HPE may help prevent GC and improve survival in adults of all ages, including those aged ≥70 years. These findings suggest that HPE benefits not only younger adults but also older adults. HPE treatment is preferable at a younger age, but older age may not be a limiting factor for the treatment.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"32 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143798177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Will the Future Judge Us? 未来将如何评判我们？

IF 25.7 1区医学

Gastroenterology Pub Date : 2025-04-07 DOI: 10.1053/j.gastro.2025.01.003

Seamus O’Mahony

引用次数: 0

KRASG12D cells override homeostatic cell elimination mechanisms in adult pancreas via Wnt5a and cell dormancy. KRASG12D细胞通过Wnt5a和细胞休眠覆盖成人胰腺的稳态细胞消除机制。

IF 29.4 1区医学

Gastroenterology Pub Date : 2025-04-07 DOI: 10.1053/j.gastro.2025.02.042

Beatriz Salvador-Barbero, Markella Alatsatianos, Jennifer P. Morton, Owen J. Sansom, Catherine Hogan

{"title":"KRASG12D cells override homeostatic cell elimination mechanisms in adult pancreas via Wnt5a and cell dormancy.","authors":"Beatriz Salvador-Barbero, Markella Alatsatianos, Jennifer P. Morton, Owen J. Sansom, Catherine Hogan","doi":"10.1053/j.gastro.2025.02.042","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.02.042","url":null,"abstract":"<h3>Background and Aims</h3>PaperClipThe adult pancreas protects against cancer by actively expelling genetically mutated cells. Pancreatic cancer starts with cells carrying KRAS mutations; however, it is not clear how some KRAS mutant cells override cell elimination mechanisms to survive in tissues.MethodsWe used an <em>in vivo</em> mouse model of sporadic tumorigenesis to induce <em>Kras</em> and/or <em>Tp53</em> mutations in low numbers of cells in the adult pancreas. We monitored mutant cell fate over time using quantitative fluorescence imaging. Gene signatures of non-eliminated mutant cell populations were identified using bulk RNA sequencing. Differential gene expression was overlapped with publicly available datasets. Key molecular pathways were validated in murine pancreas using immunofluorescence and functionally tested using inhibitor studies <em>in vivo</em> and epithelial co-culture systems <em>in vitro</em>.ResultsWhile most genetically mutant cells are eliminated from the adult pancreas, a population of KRASG12D- or p53R172H-expressing cells are stably retained. We identify Wnt5a signalling, cell dormancy and stemness as key features of surviving KrasG12D cells <em>in vivo</em>. Wnt5a specifically inhibits apical extrusion of RasV12 cells by promoting stable E-cadherin-based cell-cell adhesions at RasV12: normal cell-cell boundaries <em>in vitro</em>. In the pancreas, Wnt signalling, E-cadherin and β-catenin are increased at cell-cell contacts between non-eliminated KrasG12D cells and normal neighbours. Active Wnt signalling is a general mechanism required to promote KrasG12D and p53R172H cell retention and cell survival <em>in vivo</em>.ConclusionsRAS mutant cells activate Wnt5a and cell dormancy to avoid cell expulsion and to survive in the adult pancreas.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"37 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large Language Model-supported Systematic Reviews to Augment Clinical Guideline Development: An AGA Pilot 大型语言模型支持的系统评价以增加临床指南的制定：AGA试点

IF 29.4 1区医学

Gastroenterology Pub Date : 2025-04-06 DOI: 10.1053/j.gastro.2025.03.034

Sunny Chung, Bahar Saberzadeh-Ardestani, Gaurav Nigam, Yuhong Yuan, Siddharth Singh, Dennis Shung

引用次数: 0

Reply to Pellegrino and Gravina and to Campion et al 对 Pellegrino 和 Gravina 以及 Campion 等人的答复

IF 29.4 1区医学

Gastroenterology Pub Date : 2025-04-04 DOI: 10.1053/j.gastro.2025.03.030

Vedant Acharya, Shivan Mehta, Amar R. Deshpande

引用次数: 0

Gastro Curbside Consult: A rare case of ileocolitis 胃旁会诊：一例罕见的回肠结肠炎