Gastroenterology最新文献

{"title":"Methodology of Study on GLP-1 Receptor Agonists and Hepatocellular Carcinoma Risk","authors":"James Cheng-Chung Wei, Poi Kuo, Qi Mei","doi":"10.1053/j.gastro.2024.09.037","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.09.037","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"17 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on “Association of GLP-1 Receptor Agonists and Hepatocellular Carcinoma Incidence and Hepatic Decompensation in Patients With Type 2 Diabetes”","authors":"James Cheng-Chung Wei, Ching-Nung Wu, Wei-Chun Cheng","doi":"10.1053/j.gastro.2024.09.039","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.09.039","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"23 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective Analysis of Liver Stiffness Measurement by Vibration Controlled Transient Elastography as a Predictor of Outcomes in Biliary Atresia","authors":"Jean P. Molleston, Nathan P. Goodrich, Wen Ye, Daniel H. Leung, Ronald J. Sokol, Benjamin L. Shneider","doi":"10.1053/j.gastro.2024.09.035","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.09.035","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"20 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Efficacy of Advanced Therapies for Management of Moderate-to-Severe Ulcerative Colitis: 2024 American Gastroenterological Association Evidence Synthesis","authors":"Ashwin N. Ananthakrishnan, M. Hassan Murad, Frank I. Scott, Manasi Agrawal, John P. Haydek, Berkeley N. Limketkai, Edward V. Loftus, Siddharth Singh","doi":"10.1053/j.gastro.2024.07.046","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.07.046","url":null,"abstract":"<h3>Background &amp; Aims</h3>We performed an updated systematic review and network meta-analysis to inform the 2024 American Gastroenterological Association (AGA) Clinical Guidelines on the management of moderate-to-severe ulcerative colitis (UC).<h3>Methods</h3>We searched multiple electronic databases through November 21, 2023, to identify randomized controlled trials in adults with moderate-to-severe UC, comparing different advanced therapies (tumor necrosis factor antagonists, vedolizumab, sphingosine-1-phosphate receptor modulators, interleukin 12/23 or selective interleukin 23 antagonists, and Janus kinase [JAK] inhibitors) against placebo or another active comparator. Our primary outcomes were induction and maintenance of clinical remission, and our secondary outcome was endoscopic improvement. We performed a network meta-analysis using a frequentist approach and applied Grading of Recommendations, Assessment, Development and Evaluation (GRADE) to appraise certainty of evidence.<h3>Results</h3>After excluding JAK inhibitors as potential first-line treatment (in accordance with the United States Food and Drug Administration), low-certainty evidence supports clinically important benefit with infliximab, ozanimod, risankizumab, and guselkumab over adalimumab and mirikizumab for achieving remission with induction therapy in biologically naïve patients with moderate-to-severe UC, with risankizumab and ozanimod being ranked the highest for induction of clinical remission. With the inclusion of JAK inhibitors as first-line therapy, upadacitinib was more efficacious compared with all other medications except ozanimod and risankizumab, with low- to moderate-certainty evidence. In patients with prior biologic exposure, upadacitinib, tofacitinib, and ustekinumab were ranked highest for achieving remission.<h3>Conclusions</h3>Using Grading of Recommendations, Assessment, Development and Evaluation to appraise quality of evidence, this updated network meta-analysis will be used to inform comparative efficacy and positioning of advanced therapies for the treatment of biologic-naïve and biologic-exposed patients with moderate-to-severe UC.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"23 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLP-1 Receptor Agonists' Role in Reducing Hepatocellular Carcinoma Risk","authors":"Zaoqu Liu, Dan Shan, Xinwei Han","doi":"10.1053/j.gastro.2024.09.038","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.09.038","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"17 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities in Gastrointestinal Health for US Immigrant Populations, and Strategies to Address These Disparities","authors":"Miguel Malespin,&nbsp;Saikiran M. Kilaru","doi":"10.1053/j.gastro.2024.09.004","DOIUrl":"10.1053/j.gastro.2024.09.004","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"167 6","pages":"Pages 1071-1074"},"PeriodicalIF":25.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into the protective role of GLP-1RAs in the treatment of type 2 diabetes mellitus: implications for hepatocellular carcinoma and hepatic dysfunction","authors":"Ziyi Wang, Jun Li, Yaling Li","doi":"10.1053/j.gastro.2024.09.036","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.09.036","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"81 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolutionary Medicine for Chronic Inflammatory Diseases of the Gut: More than a Clinical Fantasy?","authors":"Nadia Andrea Andreani, Daniel Unterweger, Stefan Schreiber, John F. Baines","doi":"10.1053/j.gastro.2024.10.016","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.10.016","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"8 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A “How-to” Guide For Establishing an Effective Trainee Mentorship Program","authors":"Kirstie Lithgow, Jordan Iannuzzi, Kelle Hurd, Suqing Li","doi":"10.1053/j.gastro.2024.10.014","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.10.014","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"8 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CME Exam 1: Gastrointestinal Biofilms: Endoscopic Detection, Disease Relevance, and Therapeutic Strategies","authors":"","doi":"10.1053/j.gastro.2024.08.019","DOIUrl":"10.1053/j.gastro.2024.08.019","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"167 6","pages":"Pages e1-e3"},"PeriodicalIF":25.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}