Gastroenterology最新文献

{"title":"FIT-positive individuals: is timely upper GI endoscopy necessary?","authors":"Yunmeng Nie, Jianyu Lv, Junbin Yan","doi":"10.1053/j.gastro.2024.08.045","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.08.045","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"16 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A HIGH-RESOLUTION MICROENDOSCOPE IMPROVES ESOPHAGEAL CANCER SCREENING AND SURVEILLANCE: IMPLICATIONS FOR UNDERSERVED GLOBAL SETTINGS BASED ON AN INTERNATIONAL, RANDOMIZED CONTROLLED TRIAL","authors":"Mimi C. Tan, Zhengqi Li, Kalpesh K. Patel, Fan Zhang, Xinying Yu, Xueshan Wang, Daniel G. Rosen, Sanford M. Dawsey, Liyan Xue, Chin Hur, Richard A. Schwarz, Imran Vohra, Yubo Tang, Mengfen Wu, Tao Wang, Jennifer Carns, Hong Xu, Rebecca R. Richards-Kortum, Guiqi Wang, Sharmila Anandasabapathy","doi":"10.1053/j.gastro.2024.10.025","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.10.025","url":null,"abstract":"<h3>Background and Aims</h3>Lugol’s chromoendoscopy (LCE)-based detection of esophageal squamous cell neoplasia (ESCN) is limited by low specificity. High-resolution microendoscopy (HRME) was shown to improve specificity and reduce unnecessary biopsies when used by academic endoscopists. In this international, randomized controlled trial, we determined the clinical impact, efficiency, and performance of HRME in true global health contexts with a range of providers.<h3>Methods</h3>Subjects undergoing screening or surveillance for ESCN by expert and novice endoscopists were enrolled in China and the U.S. from diverse clinical settings. Subjects were randomized to LCE (standard-of-care) or LCE+HRME (experimental). Primary outcomes were <em>efficiency</em> and <em>clinical impact</em> of LCE vs. LCE+HRME, using gold-standard, consensus pathology.<h3>Results</h3>Among 916 consented subjects, 859 (93.8%) were recruited in China and 36 (3.9%) in the U.S.; 21 (2.3%) were excluded due to incomplete procedure or data. In the screening arm, 217 subjects were randomized to LCE, 204 to LCE+HRME; in the surveillance arm, 236 were randomized to LCE, 238 to LCE+HRME. HRME increased efficiency in screening: diagnostic yield (neoplastic/total biopsies) improved from 20.0% (95% confidence interval [CI] 12.7-29.2%) to 51.7% (95% CI 32.5-70.6%) with 65.2% (95% CI 54.6-74.9%) of biopsies potentially saved and 59.7% (95% CI 47.5-71.1%) of subjects potentially spared <em>any</em> biopsy. Six subjects (0.7%) had neoplasia missed by the endoscopist on HRME (false negatives); of these, 3 were moderate or high-grade dysplasia missed by novices.<h3>Conclusion</h3>A low-cost microendoscope improves the efficiency and clinical impact of ESCN screening and surveillance when combined with LCE. HRME may spare unnecessary biopsies leading to cost savings in underserved global settings where the disease is prevalent. <span><span>ClinicalTrials.gov</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>, Number NCT02029937.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"13 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The management of internal fistulizing Crohn’s disease in a child: more than meets the eye","authors":"Kelsey Jones, Luba Plotkin, Stavros Loukogeorgakis, Ruth Cytter-Kuint, Austen Worth, Dan Turner","doi":"10.1053/j.gastro.2024.10.026","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.10.026","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"18 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-cohort analysis reveals altered archaea in colorectal cancer fecal samples across populations","authors":"Tianhui Li, Olabisi Oluwabukola Coker, Yang Sun, Shiyu Li, Chuanfa Liu, Yufeng Lin, Sunny H. Wong, Yinglei Miao, Joseph JY. Sung, Jun Yu","doi":"10.1053/j.gastro.2024.10.023","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.10.023","url":null,"abstract":"<h3>Background and aim</h3>Archaea are important components of the host microbiome, but their roles in colorectal cancer (CRC) remain largely unclear. We aimed to elucidate the contribution of gut archaea to CRC across multiple populations.<h3>Methods</h3>This study incorporated fecal metagenomic data from 10 independent cohorts from 7 countries and an additional in-house cohort, totaling 2101 metagenomes (748 CRC, 471 adenoma, and 882 healthy controls (HC)). Taxonomic profiling was performed using Kraken2 against the Genome Taxonomy Database. Alterations of archaeal communities and their interactions with bacteria and methanogenic functions were analyzed. Random Forest model was used to identify multicohort diagnostic microbial biomarkers in CRC.<h3>Results</h3>The overall archaeal alpha diversity shifted from HC, adenoma patients to CRC patients with <em>Methanobacteriota</em> phylum enriched while order <em>Methanomassiliicoccales</em> depleted. At the species level, <em>Methanobrevibacter_A smithii</em> and <em>Methanobrevibacter_A sp002496065</em> were enriched, while 8 species, including <em>Methanosphaera stadtmanae</em> and <em>Methanomassiliicoccus_A intestinalis</em>, were depleted in CRC patients across multiple cohorts. Among them, <em>M. stadmanae, Methanobrevibacter_A sp900314695 and Methanocorpusculum sp001940805</em> exhibited a progressive decrease in the HC-adenoma-CRC sequence. CRC-depleted methanogenic archaea exhibited enhanced co-occurring interactions with butyrate-producing bacteria. Consistently, methanogenesis-related genes and pathways were enriched in CRC patients. A model incorporating archaeal and bacterial biomarkers outperformed single-kingdom models in discriminating CRC patients from healthy individuals with AUC ranging from 0.744 to 0.931 in leave-one-cohort-out analysis.<h3>Conclusions</h3>This multicohort analysis uncovered significant alterations in gut archaea and their interactions with bacteria in healthy individuals, adenoma patients and CRC patients. Archaeal biomarkers, combined with bacterial features, have potential as non-invasive diagnostic biomarkers for CRC.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"67 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142519988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differing Epithelial and Immunologic Activation Patterns Following Food Reintroduction Reveal Different Transcriptional Profiles in Active Eosinophilic Esophagitis","authors":"Ashley L. Pyne, Amiko M. Uchida, Mark W. Hazel, Maria A. Pletneva, Kristina Allen-Brady, Kathryn A. Peterson","doi":"10.1053/j.gastro.2024.10.024","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.10.024","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"75 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142519447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Tiwari, Nakajima et al, Xu and Tang, and Yang et al","authors":"Ingo Steinbrück","doi":"10.1053/j.gastro.2024.10.017","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.10.017","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"125 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142489139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol-Associated Liver Disease: Managing the Dual Pathology of Liver Disease and of Alcohol Use Disorder","authors":"Juan Pablo Arab, Alexandre Louvet, Maja Thiele, Gerald S. Winder, Robert J. Wong, Ashwani K. Singal","doi":"10.1053/j.gastro.2024.09.042","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.09.042","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"31 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142488043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Cold Versus Hot Snare Endoscopic Resection of Large Nonpedunculated Colorectal Polyps in the German CHRONICLE Trial","authors":"Yu Yang, Yaling Li, Chengzi Huang, Ting Yu, Jun Li","doi":"10.1053/j.gastro.2024.09.044","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.09.044","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"4 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142489142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burn the fat: colon cancer tumors are skilled at lipid storage during obesity","authors":"Arianne L. Theiss, Christopher S. Williams","doi":"10.1053/j.gastro.2024.10.021","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.10.021","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"31 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Faecalibacterium prausnitzii is associated with clinical response to immune checkpoint inhibitors in patients with advanced gastric adenocarcinoma: results of microbiota analysis of PRODIGE 59-FFCD 1707-DURIGAST trial","authors":"Marius Bredon, Karine le Malicot, Christophe Louvet, Ludovic Evesque, Daniel Gonzalez, David Tougeron, Harry Sokol","doi":"10.1053/j.gastro.2024.10.020","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.10.020","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"27 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}