Gastroenterology最新文献

{"title":"Skipping surgery in rectal and other solid cancers with mismatch repair deficiency using immunotherapy","authors":"Maria D. Giraldez","doi":"10.1053/j.gastro.2025.05.024","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.05.024","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"81 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144202231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Chronic Gastrointestinal Symptoms: Peeling Back the Mucosal Layers","authors":"Jeffrey Liu, Katherine O. Jones, Muhammad Baraa Hammami","doi":"10.1053/j.gastro.2025.05.021","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.05.021","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"50 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shunting the Diagnosis of a Rapid Decline in Cognition","authors":"Maria Rosina Troppmair, Benedikt Schaefer, Martin Freund","doi":"10.1053/j.gastro.2025.03.059","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.03.059","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"26 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare cause of abdominal distension in infancy","authors":"Yu-Syuan Chen, Jui-Hung Weng, Shan-Ming Chen","doi":"10.1053/j.gastro.2025.04.034","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.04.034","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"25 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding Nutrition Training in Gastroenterology: A Call to Action","authors":"Jason C. Lin, John C. Lin, Joy Zhao, Elizabeth G. Holt, Edwin K. McDonald, Stephanie M. Moleski","doi":"10.1053/j.gastro.2025.04.035","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.04.035","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"7 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pragmatic Trial Comparing Uptake and Cancer Mortality between Invitation to Colonoscopy and Invitation to Fecal Immunochemical Testing Approaches","authors":"Nauzer Forbes","doi":"10.1053/j.gastro.2025.05.017","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.05.017","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"4 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An International Consensus on Appropriate Management of Corticosteroids in Clinical Trials in Inflammatory Bowel Disease","authors":"Jurij Hanžel, Virginia Solitano, Sudheer Kumar Vuyyuru, Remo Panaccione, Bruce E. Sands, Laurent Peyrin-Biroulet, Silvio Danese, Geert R. D'Haens, Raja Atreya, Matthieu Allez, Charles N. Bernstein, Peter Bossuyt, Brian Bressler, Robert V. Bryant, Benjamin L. Cohen, Jean-Frederic Colombel, Ferdinando D’Amico, Axel Dignass, Marla Dubinsky, Phillip Fleshner, Christopher Ma","doi":"10.1053/j.gastro.2025.05.015","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.05.015","url":null,"abstract":"<h3>Background &amp; Aims</h3>Approval of new therapies for inflammatory bowel disease (IBD) requires rigorously designed and well-executed randomized controlled trials (RCTs). Corticosteroids remain a cornerstone of IBD induction therapy and many patients in trials are enrolled while taking corticosteroids. Despite this, approaches to corticosteroid management in RCTs have been highly heterogeneous, often differing from clinical practice. This negatively impacts patients’ willingness to participate due to prolonged corticosteroid exposure and may potentially bias outcomes in the clinical trial. Our aim is to provide comprehensive standardized recommendations on key aspects of corticosteroid use in IBD clinical trials through a multi-phase, international expert consensus, with a goal to help inform and standardize practice in future RCTs.<h3>Methods</h3>The consensus was informed by a systematic review of MEDLINE, EMBASE, and the Cochrane CENTRAL Register of Controlled Trials, which determined the corticosteroid management rules used in placebo-controlled trials of advanced therapies in IBD. International expert consensus recommendations for all aspects of corticosteroid management in RCTs were then developed using a modified Delphi process with two rounds of survey questions and a ratification meeting.<h3>Results</h3>These recommendations propose management of corticosteroids during screening, induction, and maintenance phases of pharmacologic trials in IBD, and define corticosteroid-related endpoints. We emphasize the need for minimizing corticosteroid exposure through expedited tapering and shorter fixed-dosing periods that more closely reflect clinical care, and provide recommendations for standardized definitions of corticosteroid-free remission.<h3>Conclusions</h3>These recommendations will serve to optimize trial design and facilitate appropriate, acceptable, and standardized RCT corticosteroid handling practices.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"5 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AAV-mediated silencing of Sox4 leads to long-term amelioration of liver phenotypes in mouse models of Alagille syndrome","authors":"Duncan Fox, Jun Xie, Jennifer L. Burwinkel, Josh M. Adams, Kashish Chetal, Marzieh Keivandarian, Yaniv Faingelernt, Sanjay Subramanian, Mario F. Lopez, Anna L. Peters, Nathan Salomonis, Neda Zarrin-Khameh, Guangping Gao, Stacey S. Huppert, Hamed Jafar-Nejad","doi":"10.1053/j.gastro.2025.04.033","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.04.033","url":null,"abstract":"<h3>BACKGROUND &amp; AIMS</h3>In patients with Alagille syndrome (ALGS), bile duct paucity often leads to severe cholestatic phenotypes for which liver transplantation remains the only definitive treatment. No FDA-approved mechanism-based strategies exist to enhance biliary development in ALGS or other diseases with bile duct paucity. We aimed to identify a therapeutic target to address this unmet need.<h3>METHODS</h3>Preclinical ALGS mouse models lacking one copy of <em>Jag1</em> with or without conditional deletion of one or both copies of <em>Sox9</em> were used. <em>Sox4</em> levels were reduced genetically or with adeno-associated virus 8 (AAV8) vectors driving a <em>Sox4</em>-silencing sequence. Liver histology, biliary tree ink injection, serum chemistry, RNAscope (on mouse and human livers), mouse liver single-cell RNA-sequencing (scRNA-Seq), and reanalysis of published human liver bulk RNA-Seq were performed.<h3>RESULTS</h3>Conditional removal of one copy of <em>Sox4</em> in mouse liver significantly improved the ALGS liver phenotypes in a <em>Sox9</em>-dependent manner. An increase in <em>Sox4/SOX4</em> expression in early postnatal <em>Jag1</em>-heterozygous mouse livers and ALGS patient livers was observed. scRNA-Seq revealed the appearance of an intermediate hepatobiliary cluster co-expressing <em>Sox4</em> and <em>Sox9</em> in <em>Jag1-</em>heterozygous livers. AAV8-mediated <em>Sox4</em> knockdown, ubiquitously or driven by the hepatocyte-specific TBG promoter, led to long-term improvement of ALGS liver phenotypes upon injection at postnatal day 1 (P1). AAV8 injection at P15—after the appearance of liver necrosis—led to the incorporation of some transduced cells into bile ducts and phenotypic improvement.<h3>CONCLUSIONS</h3>Preclinical studies provide proof of principle for postnatal AAV-mediated <em>Sox4</em> knockdown in TBG⁺ cells as a therapeutic approach for ALGS liver disease.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"42 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of Intra-Pancreatic Fat Deposition With Pancreatic Cancer Differs According to Carcinoma Types","authors":"Hiroki Oyama, Tsuyoshi Hamada, Daniel Nevo, Yudai Nakai, Yousuke Nakai, Maxim S. Petrov","doi":"10.1053/j.gastro.2025.04.032","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.04.032","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"1 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Practical Guide to Incorporating a Psychologist into a Gastroenterology Practice","authors":"Jessica K. Salwen-Deremer, Sarah Ballou, Megan Petrik, Miguel Regueiro, Corey A. Siegel, Laurie Keefer","doi":"10.1053/j.gastro.2025.05.014","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.05.014","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"12 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}