Gastroenterology最新文献

{"title":"Reflections on the Use of Preclinical Protein Signatures for IBD Diagnosis","authors":"Lichao Yang, Caimei Yang, Jiwang Tang, Ganglei Liu, Lianwen Yuan","doi":"10.1053/j.gastro.2024.12.045","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.12.045","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"18 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on “Preclinical protein signatures of Crohn’s disease and ulcerative colitis: A nested case-control study within large population-based cohorts”","authors":"Peng Wang, Jing Wang, Pengbo Zhang, Weidong Xiao","doi":"10.1053/j.gastro.2025.01.259","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.01.259","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"45 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Yang et al, Tian and Huang, and Wang et al,","authors":"Olle Grännö, Daniel Bergemalm, Benita Salomon, Jonas Halfvarson","doi":"10.1053/j.gastro.2025.06.015","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.06.015","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"12 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elsewhere in the AGA Journals (Preview Section)","authors":"","doi":"10.1053/S0016-5085(25)00782-6","DOIUrl":"10.1053/S0016-5085(25)00782-6","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"169 1","pages":"Pages A25-A27"},"PeriodicalIF":25.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Out-of-Pocket Costs for Colonoscopy Prep Persist Despite ACA Mandate: Insights from a Large Real-World Dataset","authors":"Eric D. Shah, Audrey H. Calderwood, Kaitlyn McBride, Paul Sharaf, Daniel L. Halberg","doi":"10.1053/j.gastro.2025.05.025","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.05.025","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"70 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exam 1: Recurrent Acute Pancreatitis: Many Faces (/Facets) of a Challenging Disease","authors":"","doi":"10.1053/j.gastro.2025.05.001","DOIUrl":"10.1053/j.gastro.2025.05.001","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"169 1","pages":"Pages e12-e14"},"PeriodicalIF":25.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Senescence, aging and disease throughout the gastrointestinal system","authors":"Sofia Ferreira-Gonzalez, Tomotoro Matsumoto, Eiji Hara, Stuart J. Forbes","doi":"10.1053/j.gastro.2025.06.010","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.06.010","url":null,"abstract":"Senescence is an irreversible cell cycle arrest -characterized by morphological alterations, genomic instability and secretome changes- that profoundly affects the tissue structure and function.Accumulating evidence indicates that senescence plays a relevant role in gastrointestinal pathologies: senescence contributes to salivary gland hypofunction, is instrumental in the development of oral sub-mucous fibrosis, drives age-dependent hepatic steatosis and regulates the clinical progression of steatotic liver disease. Senescence in the biliary tract develops in response to ischemic injury in biliary complications and is characteristic of biliary conditions such as biliary atresia, primary sclerosing cholangitis and primary biliary cirrhosis. Senescence also contributes to acute pancreatitis and plays a major role in the dysfunction of pancreatic beta cells. Moreover, senescence is a hallmark of a number of gastrointestinal conditions such as inflammatory bowel disease and colorectal cancer. These examples illustrate the widespread effect of cellular senescence in the gastrointestinal tract, not just as a consequence of the disease, but as a driver of pathology and a potential therapeutic target.In this review we describe the mechanisms, hallmarks and consequences of cellular senescence, as well as the therapeutic potential of senescence-targeting interventions. We aim to highlight the importance of understanding the molecular basis of senescence in gastroenterology, whilst connecting the worlds of research and clinical practice.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"22 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144305173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole food diet induces remission in children and young adults with mild-moderate Crohn's disease and is more tolerable than exclusive enteral nutrition: a randomized controlled trial","authors":"Yonat Aharoni Frutkoff, Luba Plotkin, Daniel Pollak, Jessica Livovsky, Gili Focht, Raffi Lev-Tzion, Oren Ledder, Amit Assa, Dotan Yogev, Esther Orlanski-Meyer, Efrat Broide, Jarosław Kierkuś, Ben Kang, Batia Weiss, Marina Aloi, Tobias Schwerd, Dror S. Shouval, Matteo Bramuzzo, Anne M. Griffiths, Moran Yassour, Dan Turner","doi":"10.1053/j.gastro.2025.06.011","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.06.011","url":null,"abstract":"<h3>Background</h3>Tasty&amp;Healthy (T&amp;H) is a whole-food diet for Crohn’s disease (CD), which excludes processed food, gluten, red meat, and dairy, without requiring formula or mandatory ingredients. TASTI-MM was a clinician-blinded, randomized-controlled trial comparing tolerability and effectiveness of T&amp;H vs. exclusive enteral nutrition (EEN).<h3>Methods</h3>Patients with biologic-naive mild-moderate CD aged 6–25 years were randomized to either T&amp;H or EEN for 8 weeks, receiving weekly dietary support. Tolerability was evaluated by weekly interviews, questionnaires and intake diaries. Other outcomes included symptomatic remission, Mucosal-Inflammation Non-Invasive (MINI) index, calprotectin, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Fecal microbiome was analyzed by metagenomics at baseline, week-4 and week-8. Data were analyzed by the intention-to-treat approach unless specified otherwise.<h3>Results</h3>Among 83 included patients (41 T&amp;H, 42 EEN; mean age 14.5±3.7 years), 88% tolerated T&amp;H vs. 52% for EEN (aOR 7.7 [95%CI 2.4-25]; p&lt;0.001). Calprotectin, CRP and ESR decreased significantly in both groups, with no between-group differences. Symptomatic remission was achieved in 56% of T&amp;H group vs. 38% of the EEN group (aOR 2.5 [0.98-6.3], p=0.1; per-protocol: 67% vs. 76%; p=0.47). Calprotectin &lt;250μg/g was achieved in 34% vs. 33% (aOR 0.97 [0.37-2.6], p=0.84) and MINI&lt;8 in 44% vs. 31% (aOR 1.8 [0.7-4.5]; p=0.33). Microbiome <em>α</em>-diversity improved in the T&amp;H arm and declined in the EEN arm, showing superior species richness at both week-4 and week-8. Species associated with bowel inflammation, such as <em>Ruminococcus gnavus,</em> decreased in T&amp;H and increased in EEN (q&lt;0.001).<h3>Conclusions</h3>T&amp;H demonstrated better tolerability than EEN for inducing remission in mild-to-moderate CD, while positively affecting the microbiome (TASTI-MM, NCT#04239248).","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"145 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing the Multi-HCC Model: Implications for Clinical Decision-Making and Transplant Prioritization.","authors":"Kui Wang","doi":"10.1053/j.gastro.2024.12.043","DOIUrl":"10.1053/j.gastro.2024.12.043","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial transcriptomics of Hirschsprung disease resection margins marks differential gene expression in myenteric plexus","authors":"Isabelle A.M. van Thiel, Joris J.T.H. Roelofs, Ramon R. Gorter, L.W. Ernest van Heurn, Wouter J. de Jonge, Joep P.M. Derikx","doi":"10.1053/j.gastro.2025.06.012","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.06.012","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"28 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144296308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}