Gastroenterology最新文献

{"title":"Personalized Dosing Strategies: The Missing Link in Glepaglutide Therapy for Short Bowel Syndrome","authors":"Xinjun Hu, Xinyu Gu, Jiachun Sun","doi":"10.1053/j.gastro.2025.01.258","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.01.258","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"7 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Hu et al, Sharma, and Yang and Lu","authors":"Palle B. Jeppesen","doi":"10.1053/j.gastro.2025.06.006","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.06.006","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"56 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Disparities in Recurrent Clostridioides difficile Infection (CDI) and Fecal Microbiota Transplant (FMT) Treatment using Geospatial and Social Vulnerability Analytic Tools","authors":"Nirja Mehta, Keighly Little, Michael H. Woodworth, Dana Goodenough, Robin Dhonau, Scott K. Fridkin","doi":"10.1053/j.gastro.2025.05.028","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.05.028","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"585 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on “Multi-HCC: A Practical Model to Prioritize Patients With Hepatocellular Carcinoma on the Liver Transplant Waiting List”","authors":"Saisai Jing, Jiazhao Song","doi":"10.1053/j.gastro.2024.12.044","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.12.044","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"21 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Wang, Jing and Song, and Pan and Zhou","authors":"Vivek Charu, Allison J. Kwong, Joshua S. Norman","doi":"10.1053/j.gastro.2025.06.005","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.06.005","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"217 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum.","authors":"","doi":"10.1053/j.gastro.2025.05.018","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.05.018","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum.","authors":"","doi":"10.1053/j.gastro.2025.05.019","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.05.019","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining Organ Failures in Patients with Cirrhosis: Consensus Statements","authors":"Jasmohan S. Bajaj, Debbie L. Shawcross, Ashok Choudhury, Constantine J. Karvellas, Jacqueline G. O’Leary, Jonel Trebicka, Anand V. Kulkarni, Sebastian Marciano, Sumeet K. Asrani, Madhumita Premkumar, Dominique Thabut, Qing Xie, Mark Sonderup, Simone I. Strasser, Alberto Queiroz Faria, Mario R. Alvares-da-Silva, Aldo Torre, Jennifer C. Lai, Qin Ning, Nipun Verma, Patrick S. Kamath","doi":"10.1053/j.gastro.2025.05.026","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.05.026","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"82 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucagon-like peptide-1 Receptor Agonists and Gastrointestinal Adverse Events: a Systematic Review and Meta-analysis","authors":"Cho-Hung Chiang, Aunchalee Jaroenlapnopparat, Sena Cakir Colak, Chun-Chiao Yu, Nutchapon Xanthavanij, Tsu-Hsien Wang, Xin Ya See, Shao-Wei Lo, Albert Ko, Yu-Cheng Chang, Junmin Song, Yuan Ping Hsia, Cho-Han Chiang","doi":"10.1053/j.gastro.2025.06.003","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.06.003","url":null,"abstract":"<h3>Background and aims</h3>Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used for glycemic control or weight management in patients with type 2 diabetes mellitus (T2DM) or overweight/obesity. However, there are concerns regarding their association with serious gastrointestinal adverse events though findings have been inconsistent.<h3>Methods</h3>We systematically searched 5 databases for placebo-controlled randomized controlled trials (RCTs) assessing GLP-1RAs in patients with T2DM, overweight/obesity, or Non-Alcoholic Steatohepatitis (NASH)/Metabolic dysfunction-associated steatotic liver disease (MASLD). We included trials that reported cholecystitis, cholelithiasis, cholangitis, cholestasis, pancreatitis, gastroesophageal reflux disease (GERD), gastritis, esophagitis, gastrointestinal ischemia, gastrointestinal hemorrhage, intestinal obstruction, paralytic ileus, gastrointestinal ulceration, gastrointestinal perforation, or gastroparesis. Meta-analyses were performed using a random-effects model, with subgroup analyses evaluating risks based on patient population, GLP-1RA versus dual agonist formulation, weight loss profile, dosing, and duration of action.<h3>Results</h3>We included 55 randomized controlled trials involving 106,395 participants. GLP-1RAs increased the risk of cholelithiasis (RR 1.46, 95% CI 1.09–1.97; 2 more cases per 1,000) and probably increased the risk of GERD (RR 2.19, 95% CI 1.48–3.25; 4 more cases per 1,000) compared to placebo. GLP-1RAs probably have little or no effect on the risk of other gastrointestinal or biliary events. Subgroup analyses showed that the increased risks of cholelithiasis and GERD were more pronounced in trials including individuals with overweight/obesity or NASH/MASLD, weight-loss-inducing GLP-1RAs, or high-dose formulations, although these subgroup effects were not statistically significant.<h3>Conclusions</h3>GLP-1RAs are associated with an increased risk of cholelithiasis and GERD but do not appear to increase the risk of other gastrointestinal or biliary adverse events.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"5 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144252552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Liu and to Tian et al","authors":"Camilla Pilati, Julien Taïeb, Pierre Laurent-Puig","doi":"10.1053/j.gastro.2025.05.027","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.05.027","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"2 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144252553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}