Gastroenterology最新文献

{"title":"Burden and social determinants of health in pediatric IBD: Lessons learned from epidemiologic studies using health administrative data","authors":"Eric I. Benchimol, Maria Oliva-Hemker","doi":"10.1053/j.gastro.2025.01.011","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.01.011","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"34 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic encephalopathy – when lactulose and rifaximin are not working","authors":"Victoria T. Kronsten, Ellis K. Paintsil, Steven Rodrigues, Matthew J. Seager, William Bernal, Debbie L. Shawcross","doi":"10.1053/j.gastro.2025.01.010","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.01.010","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"29 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AGA Clinical Practice Guideline on the Prevention and Treatment of Hepatitis B Virus Reactivation in At-Risk Individuals","authors":"Faisal S. Ali, Mindie H. Nguyen, Ruben Hernaez, Daniel Q. Huang, Julius Wilder, Alejandro Piscoya, Tracey G. Simon, Yngve Falck-Ytter","doi":"10.1053/j.gastro.2024.11.008","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.11.008","url":null,"abstract":"<h3>Background &amp; Aims</h3>Hepatitis B reactivation (HBVr) can occur due to a variety of immune-modulating exposures, including multiple drug classes and disease states. Antiviral prophylaxis can be effective in mitigating the risk of HBVr. In select cases, clinical monitoring without antiviral prophylaxis is sufficient for managing the risk of HBVr. This clinical practice guideline update aims to inform frontline health care practitioners by providing evidence-based practice recommendation for the management of HBVr in at-risk individuals.<h3>Methods</h3>The Grading of Recommendations Assessment, Development and Evaluation framework was used to assess evidence and make recommendations. The panel conducted a systematic evidence review to identify new studies since publication of the first version of this clinical practice guideline in 2014. The Evidence to Decision framework was used to develop recommendations regarding the role of antiviral prophylaxis and monitoring without antiviral prophylaxis for management of HBVr. Clinical recommendations were based on the balance between desirable and undesirable effects, patient values, costs, and health equity considerations.<h3>Results</h3>The panel agreed on 4 recommendations. Based on evidence and baseline risk assessment, the panel made a strong recommendation in favor of antiviral prophylaxis for individuals at high risk of HBVr. For individuals at moderate risk of HBVr, a conditional recommendation was made in favor of antiviral prophylaxis. For individuals at low risk of HBVr, a conditional recommendation was made in favor of monitoring alone without antiviral prophylaxis. Monitoring should be performed at 1- to 3-month intervals, and must include assessment of hepatitis B viral load in addition to assessment of alanine aminotransferase. For individuals deemed to be at-risk of HBVr, the panel agreed on a strong recommendation in favor of testing for HBV; given universal Centers for Disease Control and Prevention screening guidance for hepatitis B for all adults 18 years and older by testing for HBV surface antigen, hepatitis B surface antibody, and total hepatitis B core antibody, stratifying screening practices by magnitude of HBVr risk is no longer needed.<h3>Conclusions</h3>This document provides updated guidance for the management of HBVr in at-risk individuals. Limitations and gaps in the evidence are highlighted. This guideline is expected to require updating in 5 years from publication.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"32 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143020914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spotlight: Prevention and Treatment of Hepatitis B Virus Reactivation in At-Risk Individuals","authors":"","doi":"10.1053/s0016-5085(24)05813-x","DOIUrl":"https://doi.org/10.1053/s0016-5085(24)05813-x","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"8 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143020917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elsewhere in The AGA Journals (Preview Section)","authors":"","doi":"10.1053/s0016-5085(24)05811-6","DOIUrl":"https://doi.org/10.1053/s0016-5085(24)05811-6","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"33 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuing the Commitment to Diversity, Equity, and Inclusion Within AGA Journals","authors":"Sandra M. Quezada, Folasade P. May","doi":"10.1053/j.gastro.2024.12.006","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.12.006","url":null,"abstract":"&lt;h2&gt;Section snippets&lt;/h2&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;Over 2 Years Covering a Broad Range of DEI Topics&lt;/h2&gt;In our time as DEI section editors, we published 27 manuscripts in the DEI sections for &lt;em&gt;Gastroenterology&lt;/em&gt; and &lt;em&gt;CGH&lt;/em&gt; between July 2022 and September 2024. Most pieces (23) were copublished in the two journals, with 1 additional manuscript published solely in &lt;em&gt;Gastroenterology&lt;/em&gt; and 3 published solely in &lt;em&gt;CGH&lt;/em&gt;.As intended, the range of topics covered has been broad, encompassing subjects in both gastroenterology and hepatology. While most pieces are commentaries, the DEI section has also housed&lt;/section&gt;&lt;/section&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;Views, Downloads, and Citations&lt;/h2&gt;Between July 2022 and September 2024, the 27 published DEI section manuscripts were viewed or downloaded a total of 68,150 times combined for &lt;em&gt;Gastroenterology&lt;/em&gt; and &lt;em&gt;CGH&lt;/em&gt; (mean 1434 [range 231–3242]). Views and downloads per article ranged from 303 to 3242 for &lt;em&gt;Gastroenterology&lt;/em&gt; (compared with 71 to 19,586 for non-DEI articles) and from 231 to 1577 for &lt;em&gt;CGH&lt;/em&gt; (compared with 18 to 4928 for non-DEI articles). Articles in the DEI section were cited an average of 2.1 times (both journals combined) with a&lt;/section&gt;&lt;/section&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;Social Media Engagement&lt;/h2&gt;As section editors, we use social media to promote each accepted manuscript at the time of online publication. On the platform X (formerly known as Twitter), the average engagement rate for DEI posts from October 2022 to September 2024 was 1.97% (Hootsuite/X; data were current as of September 10, 2024). For context, Adobe’s 2022 guide to social media rates explains that, while goals might vary depending on the platform and size of the business, an engagement rate greater than 1% on X is&lt;/section&gt;&lt;/section&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;DEI Within the AGA Journal Boards of Editors and Editorial Boards&lt;/h2&gt;The AGA journals routinely monitor metrics for efforts related to DEI, including the diversity of each journal’s board of editors (BOE) and editorial board (EB). All data are self-reported by individuals in their AGA member profile and maintained in the AGA member database. Of note, data for sex, race, and ethnicity are not reported by many individuals, and geographic location is manually assigned based on the individual’s institution when missing.The BOE refers to the group of editors, led by&lt;/section&gt;&lt;/section&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;Author Survey Results&lt;/h2&gt;In addition to promoting content focused on GI health equity and equity in the GI workforce, another goal of the section was to amplify work created by underrepresented authors with expertise in these areas. Authors comprise a prestigious and broad cohort, including physicians and scientists in gastroenterology and hepatology subspecializing in colorectal cancer, liver disease, and inflammatory bowel disease among other areas, with overlapping foci on health disparities. We sought to learn from&lt;/section&gt;&lt;/section&gt;&lt;secti","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"4 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143020915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-contrast magnetic resonance imaging versus ultrasonography for hepatocellular carcinoma surveillance: A randomized, single-center trial","authors":"Hyungjin Rhee, Myeong-Jin Kim, Do Young Kim, Chansik An, Wonseok Kang, Kyunghwa Han, Yun Ho Roh, Kwang-Hyub Han, Sang Hoon Ahn, Jin-Young Choi, Jun Yong Park, Yong Eun Chung, Seung Up Kim, Beom Kyung Kim, Sunyoung Lee, Hye Won Lee, Jae Seung Lee","doi":"10.1053/j.gastro.2024.12.035","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.12.035","url":null,"abstract":"<h3>Background &amp; Aims</h3>This study aimed to compare ultrasonography (US) and non-contrast magnetic resonance imaging (MRI) in the surveillance of hepatic malignancy.<h3>Methods</h3>We conducted a randomized, non-blinded, single-center trial at a single center in South Korea. Eligible individuals were aged 20–70 years with liver cirrhosis, Child–Pugh class A, and no history of liver cancer or other recent malignancy. Participants were randomized 1:1 to receive up to ten semiannual surveillance using US or non-contrast MRI with serum alpha-fetoprotein testing. The primary endpoints were the detection rates of Barcelona Clinic Liver Cancer [BCLC] stage 0 or A tumors, stage distribution at initial diagnosis, and false-positive referral rates.<h3>Results</h3>From June 2015 to November 2017, 416 patients were screened, and 414 were enrolled and assigned to the US (n=207) or MRI (n=207) group. In total, 23 participants in US group and 25 in MRI group were diagnosed with liver cancer by November 2022. The detection rates of BCLC stage 0 or A tumors were not different between the US and MRI groups (8% [95% confidence interval (CI), 5 – 13%] versus 12% [8 – 17%]). BCLC stage 0 tumors were more prevalent in the MRI group than in the US group (8% versus 3%). The MRI group had earlier BCLC stage (<em>P</em>=0.014) and lower false-positive referral rate (0.7% [95% CI, 0.4 – 1.2%] versus 3.1% [2.3 – 4.1%], <em>P</em> &lt;0.001) compared to the US group.<h3>Conclusions</h3>Non-contrast MRI is a better alternative to US for the surveillance of cirrhotic patients offering earlier stage at initial diagnosis and lower false-positive referral rate. <span><span>ClincalTrials.gov</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>, NCT02514434.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"28 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regarding the AGA Clinical Practice Update on Integrating Vonoprazan Into Clinical Practice","authors":"David Y. Graham","doi":"10.1053/j.gastro.2024.12.022","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.12.022","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"31 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142990250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Amit Patel, Loren Laine, Paul Moayyedi","doi":"10.1053/j.gastro.2025.01.001","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.01.001","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pouch Crohn's-like Disease: Mucosal Single-Cell Profiling Uncovers Pathogenesis and Targets","authors":"Liqi Li","doi":"10.1053/j.gastro.2024.08.048","DOIUrl":"https://doi.org/10.1053/j.gastro.2024.08.048","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"83 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}