Future cardiologyPub Date : 2025-04-01Epub Date: 2025-03-07DOI: 10.1080/14796678.2025.2476351
Maisha Maliha, Vikyath Satish, Kuan Yu Chi, Amrin Kharawala, Sanjana Nagraj, Tinatin Saralidze, Nathaniel Abittan, Natalia Nazarenko, Gal Rubinstein, Riya Patel, Seth I Sokol, Robert T Faillaice, Leonidas Palaiodimos
{"title":"Introducing the use of AngioVac in nonbacterial thrombotic endocarditis: a systematic review.","authors":"Maisha Maliha, Vikyath Satish, Kuan Yu Chi, Amrin Kharawala, Sanjana Nagraj, Tinatin Saralidze, Nathaniel Abittan, Natalia Nazarenko, Gal Rubinstein, Riya Patel, Seth I Sokol, Robert T Faillaice, Leonidas Palaiodimos","doi":"10.1080/14796678.2025.2476351","DOIUrl":"10.1080/14796678.2025.2476351","url":null,"abstract":"<p><strong>Introduction: </strong>Nonbacterial thrombotic endocarditis (NBTE) involves vegetations on heart valves without active bloodstream infection. The AngioVac device, a vacuum-based aspiration system commonly used for infective endocarditis, has potential in managing NBTE, particularly in patients unsuitable for surgery. This study systematically reviews the literature to evaluate AngioVac's effectiveness in reducing vegetations in NBTE.</p><p><strong>Methods: </strong>A systematic literature review was conducted using PubMed, Embase, Cochrane, and Web of Science databases through February 2024. Primary outcome was procedural success, defined as a ≥ 50% reduction in vegetation size on transesophageal echocardiogram. Secondary outcomes included in-hospital mortality, hospital stay length, and procedural complications.</p><p><strong>Results: </strong>Out of 38 identified articles, 4 case reports met inclusion criteria. Patients were male with a median age of 60 years, and NBTE was associated with conditions such as lung adenocarcinoma, end-stage renal disease, and antiphospholipid syndrome. The mitral valve was the most commonly affected site. AngioVac achieved 100% procedural success, with no complications or in-hospital mortality. The average hospital stay was 2 days. Follow-up revealed one patient alive at 2 months, one deceased at 3 months and no data for two patients.</p><p><strong>Conclusion: </strong>AngioVac is a promising tool for safely reducing vegetations in NBTE, especially for high-risk surgical candidates.The study design and protocol are registered with PROSPERO International Prospective Register of Systematic Reviews (registration number CRD42024505295).</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"305-313"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment options for heart failure in individuals with overweight or obesity: a review.","authors":"Athina Nasoufidou, Panagiotis Stachteas, Paschalis Karakasis, Christos Kofos, Efstratios Karagiannidis, Aleksandra Klisic, Djordje S Popovic, Theocharis Koufakis, Nikolaos Fragakis, Dimitrios Patoulias","doi":"10.1080/14796678.2025.2479378","DOIUrl":"10.1080/14796678.2025.2479378","url":null,"abstract":"<p><p>Obesity and heart failure are interlaced global epidemics, each contributing to significant morbidity and mortality. Obesity is not only a risk-factor for heart failure, but also complicates its management, by distinctive pathophysiological mechanisms and cumulative comorbidities, requiring tailored treatment plan. To present current treatment options for heart failure in individuals with overweight/obesity, emphasizing available pharmacological therapies, non-pharmacological strategies, and the management of related comorbidities. We conducted a comprehensive literature review regarding the results of heart failure treatments in individuals with overweight/obesity, including cornerstone interventions as well as emerging therapeutic options. Specific drug classes, including angiotensin receptor-neprilysin inhibitors, mineralocorticoid receptor antagonists, and sodium-glucose cotransporter-2 inhibitors, have demonstrated consistent efficacy in heart failure irrespective of body mass index, while diuretics remain a key for fluid management. Glucagon-like peptide-1 receptor agonists have shown promising results in improving relevant outcomes and warrant further research. Non-pharmacological approaches, including weight-loss strategies and lifestyle modifications, have shown to improve symptoms, exercise tolerance and quality of life. Managing heart failure in individuals with overweight/obesity requires a multidisciplinary, individualized approach integrating pharmacological and non-pharmacological options. Emerging therapies and preventive strategies arise to address the unique challenges in this population and provide improved outcomes.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"315-329"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-04-01Epub Date: 2025-03-09DOI: 10.1080/14796678.2025.2476313
Helge Haarmann, Besir Hasan, Nibras Soubh, Eva Rasenack, Simon Schlögl, Markus Zabel, Leonard Bergau
{"title":"First experience with a new tool for automatic mapping of fragmented signals in a case report of cardioneuroablation.","authors":"Helge Haarmann, Besir Hasan, Nibras Soubh, Eva Rasenack, Simon Schlögl, Markus Zabel, Leonard Bergau","doi":"10.1080/14796678.2025.2476313","DOIUrl":"10.1080/14796678.2025.2476313","url":null,"abstract":"<p><p>Cardioneuroablation is a treatment option for patients with recurrent vasovagal syncope (VVS). Ablation targets of parasympathetic ganglionated plexi (GP) adjacent to the right and left atrial walls and distal endocardial inputs of these GP can be identified both by their anatomical localization and by intracardiac mapping of fragmented electrogram signals. In this case of a successful cardioneuroablation of a 22-year-old patient suffering from recurrent VVS, a new algorithm for automatic mapping of fragmented signals (CARTO Elevate Module, Biosense Webster) was used to identify areas of GP. In this first experience, automatic tags of fragmented signals were matching well with anatomically guided ablation points. This new tool for automatic identification of fragmented signals may facilitate and improve cardioneuroablation procedures.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"265-268"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-03-01Epub Date: 2025-02-28DOI: 10.1080/14796678.2025.2472590
Bryan Tornabene, David Waldron, Hannah Short, Nicholas Duca
{"title":"An unexpected battle with peripartum cardiomyopathy: a case report.","authors":"Bryan Tornabene, David Waldron, Hannah Short, Nicholas Duca","doi":"10.1080/14796678.2025.2472590","DOIUrl":"10.1080/14796678.2025.2472590","url":null,"abstract":"<p><p>Peripartum cardiomyopathy (PPCM) is a rare cardiomyopathy marked by systolic dysfunction that presents in late pregnancy or the early postpartum period with an ejection fraction (EF) of less than 45%. Diagnosing PPCM often presents a diagnostic dilemma due to its nonspecific clinical presentation, which usually resembles physiological changes of pregnancy or peripartum pulmonary embolism. Echocardiography is frequently used as a diagnostic modality of choice with management following the GDMT guidelines and delivery. This case presents a 23-year-old patient with a delayed diagnosis of PPCM, followed by a discussion of goal-directed medical therapy (GDMT) and the benefits of early diagnosis and treatment. Common pitfalls in diagnosing PPCM are introduced to encourage clinicians to consider PPCM during late pregnancy. Currently, a new clinical trial is underway investigating the efficacy of dopamine agonists in conjunction with GDMT for treatment of peripartum cardiomyopathy.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"223-227"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-03-01Epub Date: 2025-01-30DOI: 10.1080/14796678.2025.2459542
Muhammad Hamza Shuja, Syed Hasan Shuja, Fabeeha Shaheen, Ramish Hannat, Firzah Shakil, Abeera Farooq Abbasi, Minal Hasan
{"title":"Comparative efficacy of single-coil versus dual-coil ICD leads: a meta-analysis of clinical outcomes.","authors":"Muhammad Hamza Shuja, Syed Hasan Shuja, Fabeeha Shaheen, Ramish Hannat, Firzah Shakil, Abeera Farooq Abbasi, Minal Hasan","doi":"10.1080/14796678.2025.2459542","DOIUrl":"10.1080/14796678.2025.2459542","url":null,"abstract":"<p><strong>Background: </strong>Implantable cardioverter-defibrillators (ICDs) are essential for reducing sudden cardiac death in patients at risk of ventricular arrhythmias. The choice of ICD lead - single-coil or dual-coil - can influence device performance and patient outcomes. This meta-analysis evaluates the comparative efficacy and safety of single-coil versus dual-coil ICD leads to inform clinical decision-making.</p><p><strong>Methods: </strong>A systematic search of PubMed, Cochrane Library, and Google Scholar was performed up to October 2024. Only randomized controlled trials (RCTs) comparing single-coil and dual-coil ICD leads were included. Outcomes assessed included defibrillation threshold (DFT), first-shock efficacy, all-cause mortality, cardiovascular mortality, shock impedance, and peak current.</p><p><strong>Results: </strong>Seven RCTs involving 1,614 patients were analyzed. Single-coil leads demonstrated superior first-shock efficacy (OR: 1.60; <i>p</i> = 0.05), reduced all-cause mortality (RR: 0.63; <i>p</i> = 0.02), and better peak current (MD: -2.29; <i>p</i> = 0.02). DFT and cardiovascular mortality were comparable between groups, while dual-coil leads exhibited lower shock impedance (MD: 18.26; <i>p</i> < 0.00001).</p><p><strong>Conclusions: </strong>Single-coil ICD leads are associated with improved first-shock efficacy and reduced all-cause mortality, suggesting their potential superiority in certain patient populations. Further research is warranted to refine lead selection criteria.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"167-175"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-03-01Epub Date: 2025-02-08DOI: 10.1080/14796678.2025.2463271
Alice Bottussi, Jacopo D'Andria Ursoleo, Viviana Teresa Agosta, Monica De Luca, Fabrizio Monaco
{"title":"The role of amino acids and protein administration in preventing cardiac surgery-associated acute kidney injury.","authors":"Alice Bottussi, Jacopo D'Andria Ursoleo, Viviana Teresa Agosta, Monica De Luca, Fabrizio Monaco","doi":"10.1080/14796678.2025.2463271","DOIUrl":"10.1080/14796678.2025.2463271","url":null,"abstract":"<p><p>Acute kidney injury (AKI) persists as one of the most common complications after cardiac surgery. Beyond being burdened by high morbidity and mortality rates, effective therapeutic options are still lacking. To date, the management of cardiac surgery-associated AKI (CSA-AKI) mainly focuses on preventive strategies, e.g. the implementation of standardized care bundles. Interestingly, recent experimental studies have suggested a potential nephroprotective role for both amino acids (AA) and proteins. As such, these compounds show multiple beneficial renal effects, spanning enhancement of renal blood flow, improved oxygenation, and recruitment of renal functional reserve. Moreover, clinical studies have investigated the therapeutic potential of single AA, AA combinations, and proteins. A recent large multicenter randomized controlled trial showed reduced AKI incidence in cardiac surgery patients receiving intravenous AA supplementation. However, these interventions have not yet demonstrated beneficial effects on major clinical outcomes, such as survival. Given the well-established AA safety profile and the underlying biological rationale supporting their use, this review summarizes the existing literature on the effects of various formulations and combinations of perioperative AA and protein on renal outcomes when administered in cardiac surgery patients.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"191-202"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-03-01Epub Date: 2025-02-11DOI: 10.1080/14796678.2025.2461425
Albert Wiegman, Robert Pordy
{"title":"Evinacumab for children with homozygous familial hypercholesterolemia: a plain language summary.","authors":"Albert Wiegman, Robert Pordy","doi":"10.1080/14796678.2025.2461425","DOIUrl":"10.1080/14796678.2025.2461425","url":null,"abstract":"","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"139-147"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-03-01Epub Date: 2025-02-14DOI: 10.1080/14796678.2025.2465214
Sidra Kalsoom, Muhammad Adnan Zaman
{"title":"Reconsidering the role of beta-blockers in post-myocardial infarction patients with preserved ejection fraction.","authors":"Sidra Kalsoom, Muhammad Adnan Zaman","doi":"10.1080/14796678.2025.2465214","DOIUrl":"10.1080/14796678.2025.2465214","url":null,"abstract":"","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"207-209"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-03-01Epub Date: 2025-01-08DOI: 10.1080/14796678.2025.2451530
Anna Vittoria Mattioli, Valentina Bucciarelli, Sabina Gallina
{"title":"The role of physical exercise in cancer therapy-related CV toxicity.","authors":"Anna Vittoria Mattioli, Valentina Bucciarelli, Sabina Gallina","doi":"10.1080/14796678.2025.2451530","DOIUrl":"10.1080/14796678.2025.2451530","url":null,"abstract":"","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"131-134"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142947497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}