Genetics and Molecular Biology最新文献_第7页

The inhibition of Beclin1-dependent autophagy sensitizes PTC cells to ABT737-induced death. 抑制 Beclin1 依赖性自噬使 PTC 细胞对 ABT737 诱导的死亡敏感。

IF 2.1 4区生物学

Genetics and Molecular Biology Pub Date : 2024-03-04 eCollection Date: 2024-01-01 DOI: 10.1590/1678-4685-GMB-2022-0170

Ning Hu, Yanhua Tian, Yanmei Song, Leilei Zang

{"title":"The inhibition of Beclin1-dependent autophagy sensitizes PTC cells to ABT737-induced death.","authors":"Ning Hu, Yanhua Tian, Yanmei Song, Leilei Zang","doi":"10.1590/1678-4685-GMB-2022-0170","DOIUrl":"10.1590/1678-4685-GMB-2022-0170","url":null,"abstract":"ABT737 is used as a specific BCL2 inhibitor, which can treat papillary thyroid carcinoma (PTC). However, the effect of ABT737 on PTC cell apoptosis is limited. Moreover, BCL2 inhibition causes the activation of Beclin1-dependent autophagy. Our study aimed to explore the effects of autophagy and Beclin1 on ABT737 efficacy in PTC. The experimental data showed that ABT737 synchronously enhanced autophagic activity and apoptosis level in PTC cells. ABT737 also promoted the dissociation of BCL2-Beclin1 and BCL2-Bax complexes. Autophagy inhibitors, Bafilomycin A1 and 3-MA, enhanced the inhibitory effect of ABT737 on the survival and function in PTC cells. Consistently, autophagy inhibition with Beclin1 pharmacological inhibitor (spautin-1) also enhanced the efficacy of ABT737. Additionally, ABT737 at low-dose promoted LC3 conversion in PTC cells, and did not affect PTC cell apoptosis and survival. However, The efficacy of low-dose of ABT737 in PTC cell apoptosis and survival was displayed with the addition of Bafilomycin A1, 3-MA or spautin-1. In conclusion, the limited role of ABT737 in PTC cell apoptosis is attributed to its promoting effect on Beclin1-dependent autophagy. Therefore, autophagy inhibition based on Beclin1 downregulation can enhance the sensitivity of PTC cells to ABT737-induced death.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10941729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the effects of Carpesii fructus extract on the liver transcriptome of olive flounder (Paralichthys olivaceus) as a potential antiparasitic agent. 作为一种潜在的抗寄生虫药物，研究栉水母提取物对橄榄鲽（Paralichthys olivaceus）肝脏转录组的影响。

IF 2.1 4区生物学

Genetics and Molecular Biology Pub Date : 2024-03-04 eCollection Date: 2024-01-01 DOI: 10.1590/1678-4685-GMB-2023-0146

Sang Yoon Lee, Hwa Jin Lee, Na Young Kim, Min Sun Kim

{"title":"Investigating the effects of Carpesii fructus extract on the liver transcriptome of olive flounder (Paralichthys olivaceus) as a potential antiparasitic agent.","authors":"Sang Yoon Lee, Hwa Jin Lee, Na Young Kim, Min Sun Kim","doi":"10.1590/1678-4685-GMB-2023-0146","DOIUrl":"10.1590/1678-4685-GMB-2023-0146","url":null,"abstract":"Olive flounder (Paralichthys olivaceus), a popular aquaculture species, is plagued by the disease scuticociliatosis caused by Miamiensis avidus, which has a high mortality rate and is typically treated with chemicals such as formalin and hydrogen peroxide. However, Carpesii fructus extract has shown potential as a natural therapeutic agent by reducing the motility of M. avidus. However, despite its potential importance, the effect of the extract on fish metabolism remains unknown. In this study, the effect of Carpesii fructus extract and formalin on fish metabolism was analysed by whole transcriptome analysis in the liver of P. olivaceus. A total of 37,796 transcripts were generated and differential expression genes (DEGs) were identified in the liver of P. olivaceus treated with Carpesii fructus extract or formalin. In addition, functional analysis of DEGs between treatment groups was presented using Gene Ontology. These results will be crucial for the study of scuticociliatosis in various fish species, including P. olivaceus, and for the development of therapeutic agents for other diseases.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10941726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptome data-based screening of potential host of genetic transformation for a blue-hued Bougainvillea transgene. 基于转录组数据筛选蓝花九重葛转基因的潜在基因转化宿主。

IF 2.1 4区生物学

Genetics and Molecular Biology Pub Date : 2024-03-04 eCollection Date: 2024-01-01 DOI: 10.1590/1678-4685-GMB-2023-0099

Rong Sun, Shan Liu, Jia Long, Jinglei Gao, Yi Diao

{"title":"Transcriptome data-based screening of potential host of genetic transformation for a blue-hued Bougainvillea transgene.","authors":"Rong Sun, Shan Liu, Jia Long, Jinglei Gao, Yi Diao","doi":"10.1590/1678-4685-GMB-2023-0099","DOIUrl":"10.1590/1678-4685-GMB-2023-0099","url":null,"abstract":"Bougainvillea is a popular ornamental plant. Although Bougainvillea is abundant in germplasm resources, cultivars and flower colors, there is no rare blue colour varieties, due to the absence of delphinidin-based anthocyanins. This study analyzed the Bougainvillea leaf and bract transcriptome to select hosts of genetic transformation that would be suitable for the accumulation of delphinidin. A total of 36 gigabyte (GB) of raw data was obtained by transcriptome sequencing, with 4,058 significantly differentially expressed genes, including 1,854 upregulated and 2,204 downregulated genes. Annotation of these genes was performed using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases. Through annotation, two CHS genes, one F3H gene, one DFR gene, and one F3'H gene involved in the delphinidin biosynthesis pathway were identified. The expression levels of these genes and total flavonoid content in the bracts of six Bougainvillea varieties were examined through quantitative real-time PCR and spectrophotometry, respectively. Through the comprehensive evaluation based on membership function method, the suitable host order for a blue-hued Bougainvillea transgene is Singapore White>Elizabeth Angus>Ratana Yellow>China Beauty>Orange King>Brilliant Variegata. Thus, Singapore White variety was the most appropriate transgene host for blue-hued Bougainvillea. The results of this study provide a reference for the directed breeding of blue-hued Bougainvillea.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10941975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prostate tumor markers: diagnosis, prognosis and management. 前列腺肿瘤标志物：诊断、预后和管理。

IF 2.1 4区生物学

Genetics and Molecular Biology Pub Date : 2024-02-26 eCollection Date: 2024-01-01 DOI: 10.1590/1678-4685-GMB-2023-0136

Gabriela Kniphoff da Silva Lawisch, Geórgia Muccillo Dexheimer, Vanderlei Biolchi, Rafael Armando Seewald, José Artur Bogo Chies

{"title":"Prostate tumor markers: diagnosis, prognosis and management.","authors":"Gabriela Kniphoff da Silva Lawisch, Geórgia Muccillo Dexheimer, Vanderlei Biolchi, Rafael Armando Seewald, José Artur Bogo Chies","doi":"10.1590/1678-4685-GMB-2023-0136","DOIUrl":"10.1590/1678-4685-GMB-2023-0136","url":null,"abstract":"Prostate cancer (PCA) is the second most common type of cancer in the world. Nevertheless, diagnosis is still based on nonspecific methods, or invasive methods which makes clinical decision and diagnosis difficult, generating risk of both underdiagnosis and overdiagnosis. Given the high prevalence, morbidity and mortality of PCA, new strategies are needed for its diagnosis. A review of the literature on available biomarkers for PCA was performed, using the following terms: prostate cancer AND marker OR biomarker. The search was carried out in Pubmed, Science Direct, Web of Science and Clinical Trial. A total of 35 articles were used, and PHI (Prostate Health Index) and the 4Kscore tests were identified as the best well-established serum markers. These tests are based on the evaluation of expression levels of several molecules. For analysis of urine samples, Progensa, ExoDXProstate, and Mi Prostate Score Urine Test are available. All these tests have the potential to help diagnosis, avoiding unnecessary biopsies, but they are used only in association with digital rectal examination and PSA level data. The search for biomarkers that can help in the diagnosis and therapeutic management of PCA is still in its initial phase, requiring more efforts for an effective clinical application.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The good, the bad and the ugly of transposable elements annotation tools. 转座元件注释工具的好坏和丑陋。

IF 1.7 4区生物学

Genetics and Molecular Biology Pub Date : 2024-02-19 eCollection Date: 2024-01-01 DOI: 10.1590/1678-4685-GMB-2023-0138

Elgion L S Loreto, Elverson S de Melo, Gabriel L Wallau, Tiago M F F Gomes

引用次数: 0

Reduced gene flow and bottleneck in the threatened giant armadillo (Priodontes maximus): implications for its conservation. 濒危巨型犰狳（Priodontes maximus）基因流动的减少和瓶颈：对其保护的影响。

IF 2.1 4区生物学

Genetics and Molecular Biology Pub Date : 2024-02-19 eCollection Date: 2024-01-01 DOI: 10.1590/1678-4685-GMB-2023-0252

Nayra T Rodrigues, Bruno H Saranholi, Alexandre R Inforzato, Leandro Silveira, Arnaud Leonard Jean Desbiez, Pedro M Galetti

{"title":"Reduced gene flow and bottleneck in the threatened giant armadillo (Priodontes maximus): implications for its conservation.","authors":"Nayra T Rodrigues, Bruno H Saranholi, Alexandre R Inforzato, Leandro Silveira, Arnaud Leonard Jean Desbiez, Pedro M Galetti","doi":"10.1590/1678-4685-GMB-2023-0252","DOIUrl":"10.1590/1678-4685-GMB-2023-0252","url":null,"abstract":"The progressive fragmentation and loss of habitats represent the main threats for endangered species, causing genetic consequences that may have potential implications for a population's long-term persistence. Large mammals are the most affected species among vertebrates. The giant armadillo Priodontes maximus is a large South American mammal threatened species, showing nocturnal, solitary and fossorial behavior, occurring at low population densities, and its population dynamics are still poorly known. In this study, we carried out the first assessment of genetic variability and population genetic structure of the species, using a panel of 15 polymorphic microsatellites developed by high-throughput genome sequencing. The spatial Bayesian clustering, Fst and Dest results indicated the presence of two genetic clusters (K = 2) in the study area. These results suggest a reduction in gene flow between individuals inhabiting the Brazilian savanna (Cerrado) and the Pantanal wetlands, with the increased human-driven habitat modifications possibly contributing for this scenario. A bottleneck signal was detected in both populations, and a subpopulation structuring in the Cerrado may also be reflecting consequences of the extensive habitat modifications. Findings from this study provide important and useful information for the future maintenance of genetic diversity and long-term conservation of this flagship species.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10917080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140049218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

bHLH-regulated routes in anther development in rice and Arabidopsis. 水稻和拟南芥花药发育过程中的 bHLH 调控途径。

IF 2.1 4区生物学

Genetics and Molecular Biology Pub Date : 2024-02-19 eCollection Date: 2024-01-01 DOI: 10.1590/1678-4685-GMB-2023-0171

Francieli Ortolan, Thomaz Stumpf Trenz, Camila Luiza Delaix, Fernanda Lazzarotto, Marcia Margis-Pinheiro

{"title":"bHLH-regulated routes in anther development in rice and Arabidopsis.","authors":"Francieli Ortolan, Thomaz Stumpf Trenz, Camila Luiza Delaix, Fernanda Lazzarotto, Marcia Margis-Pinheiro","doi":"10.1590/1678-4685-GMB-2023-0171","DOIUrl":"10.1590/1678-4685-GMB-2023-0171","url":null,"abstract":"Anther development is a complex process essential for plant reproduction and crop yields. In recent years, significant progress has been made in the identification and characterization of the bHLH transcription factor family involved in anther regulation in rice and Arabidopsis, two extensively studied model plants. Research on bHLH transcription factors has unveiled their crucial function in controlling tapetum development, pollen wall formation, and other anther-specific processes. By exploring deeper into regulatory mechanisms governing anther development and bHLH transcription factors, we can gain important insights into plant reproduction, thereby accelerating crop yield improvement and the development of new plant breeding strategies. This review provides an overview of the current knowledge on anther development in rice and Arabidopsis, emphasizing the critical roles played by bHLH transcription factors in this process. Recent advances in gene expression analysis and functional studies are highlighted, as they have significantly enhanced our understanding of the regulatory networks involved in anther development.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10875983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139899652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Boosting life sciences research in Brazil: building a case for a local Drosophila stock center. 促进巴西的生命科学研究：建立当地果蝇种群中心。

IF 2.1 4区生物学

Genetics and Molecular Biology Pub Date : 2024-02-19 eCollection Date: 2024-01-01 DOI: 10.1590/1678-4685-GMB-2023-0202

Marcos T Oliveira, Lucas Anhezini, Helena M Araujo, Marcus F Oliveira, Carlos A Couto-Lima

{"title":"Boosting life sciences research in Brazil: building a case for a local Drosophila stock center.","authors":"Marcos T Oliveira, Lucas Anhezini, Helena M Araujo, Marcus F Oliveira, Carlos A Couto-Lima","doi":"10.1590/1678-4685-GMB-2023-0202","DOIUrl":"10.1590/1678-4685-GMB-2023-0202","url":null,"abstract":"Drosophila melanogaster is undoubtedly one of the most useful model organisms in biology. Initially used in solidifying the principles of heredity, and establishing the basic concepts of population genetics and of the synthetic theory of evolution, it can currently offer scientists much more: the possibility of investigating a plethora of cellular and biological mechanisms, from development and function of the immune system to animal neurogenesis, tumorigenesis and beyond. Extensive resources are available for the community of Drosophila researchers worldwide, including an ever-growing number of mutant, transgenic and genomically-edited lines currently carried by stock centers in North America, Europe and Asia. Here, we provide evidence for the importance of stock centers in sustaining the substantial increase in the output of Drosophila research worldwide in recent decades. We also discuss the challenges that Brazilian Drosophila scientists face to keep their research projects internationally competitive, and argue that difficulties in importing fly lines from international stock centers have significantly stalled the progression of all Drosophila research areas in the country. Establishing a local stock center might be the first step towards building a strong local Drosophila community that will likely contribute to all areas of life sciences research.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10917079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140049200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview of actionable and potentially actionable TSC1 and TSC2 germline variants in an online Database. 在线数据库中可操作和潜在可操作的 TSC1 和 TSC2 基因变异概述。

IF 2.1 4区生物学

Genetics and Molecular Biology Pub Date : 2024-02-19 eCollection Date: 2024-01-01 DOI: 10.1590/1678-4685-GMB-2023-0132

Arthur Bandeira de Mello Garcia, Guilherme Danielski Viola, Bruno da Silveira Corrêa, Taís da Silveira Fischer, Maria Clara de Freitas Pinho, Grazielle Motta Rodrigues, Patricia Ashton-Prolla, Clévia Rosset

{"title":"An overview of actionable and potentially actionable TSC1 and TSC2 germline variants in an online Database.","authors":"Arthur Bandeira de Mello Garcia, Guilherme Danielski Viola, Bruno da Silveira Corrêa, Taís da Silveira Fischer, Maria Clara de Freitas Pinho, Grazielle Motta Rodrigues, Patricia Ashton-Prolla, Clévia Rosset","doi":"10.1590/1678-4685-GMB-2023-0132","DOIUrl":"10.1590/1678-4685-GMB-2023-0132","url":null,"abstract":"Tuberous Sclerosis Complex (TSC) is caused by loss of function germline variants in the TSC1 or TSC2 tumor suppressor genes. Genetic testing for the detection of pathogenic variants in either TSC1 or TSC2 was implemented as a diagnostic criterion for TSC. However, TSC molecular diagnosis can be challenging due to the absence of variant hotspots and the high number of variants described. This review aimed to perform an overview of TSC1/2 variants submitted in the ClinVar database. Variants of uncertain significance (VUS), missense and single nucleotide variants were the most frequent in clinical significance (37-40%), molecular consequence (37%-39%) and variation type (82%-83%) categories in ClinVar in TSC1 and TSC2 variants, respectively. Frameshift and nonsense VUS have potential for pathogenic reclassification if further functional and segregation studies were performed. Indeed, there were few functional assays deposited in the database and literature. In addition, we did not observe hotspots for variation and many variants presented conflicting submissions regarding clinical significance. This study underscored the importance of disseminating molecular diagnostic results in a public database to render the information largely accessible and promote accurate diagnosis. We encourage the performance of functional studies evaluating the pathogenicity of TSC1/2 variants.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10876083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139905501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shades of white: The Petunia long corolla tube clade evolutionary history. 白色的阴影矮牵牛长花冠筒支系的进化史。

IF 2.1 4区生物学

Genetics and Molecular Biology Pub Date : 2024-02-12 eCollection Date: 2024-01-01 DOI: 10.1590/1415-4757-GMB-2023-0279

Alice Backes, Caroline Turchetto, Geraldo Mäder, Ana Lúcia A Segatto, Sandro L Bonatto, Loreta B Freitas

{"title":"Shades of white: The Petunia long corolla tube clade evolutionary history.","authors":"Alice Backes, Caroline Turchetto, Geraldo Mäder, Ana Lúcia A Segatto, Sandro L Bonatto, Loreta B Freitas","doi":"10.1590/1415-4757-GMB-2023-0279","DOIUrl":"10.1590/1415-4757-GMB-2023-0279","url":null,"abstract":"Delimiting species is challenging in recently diverged species, and adaptive radiation is fundamental to understanding the evolutionary processes because it requires multiple ecological opportunities associated with adaptation to biotic and abiotic environments. The young Petunia genus (Solanaceae) is an excellent opportunity to study speciation because of its association with pollinators and unique microenvironments. This study evaluated the phylogenetic relationships among a Petunia clade species with different floral syndromes that inhabit several environments. We based our work on multiple individuals per lineage and employed nuclear and plastid phylogenetic markers and nuclear microsatellites. The phylogenetic tree revealed two main groups regarding the elevation of the distribution range, whereas microsatellites showed high polymorphism-sharing splitting lineages into three clusters. Isolation by distance, migration followed by new environment colonization, and shifts in floral syndrome were the motors for lineage differentiation, including infraspecific structuring, which suggests the need for taxonomic revision in the genus.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10882218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139930794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0