General Psychiatry最新文献

{"title":"Triple digital divide and depressive symptoms among middle-aged and older Chinese adults: a disparity analysis.","authors":"Danxia Liu, Bo Zhang, Jing Guo","doi":"10.1136/gpsych-2024-101562","DOIUrl":"10.1136/gpsych-2024-101562","url":null,"abstract":"<p><strong>Background: </strong>The triple digital divide refers to the lack of internet access, use and knowledge among specific populations. In China, middle-aged and older adults and those living in rural areas or various regions of the country are more likely to have limited internet access and skills and, thus, have less accessibility to internet services. Few longitudinal studies have explored the association between the digital divide and the progression of depressive symptoms among middle-aged and older Chinese adults. Significantly, none of the existing studies have estimated this long-term relationship from a disparity perspective.</p><p><strong>Aims: </strong>This study investigates the association between the triple digital divide and depressive symptom trajectories among middle-aged and older adults in China during a 10-year follow-up period from 2011 to 2020.</p><p><strong>Methods: </strong>The sample for this secondary analysis comprises 3019 urban and 10 427 rural respondents selected from the China Health and Retirement Longitudinal Study baseline survey in 2011. Depressive symptoms were measured using the Center for Epidemiologic Studies Depression Scale. Employing longitudinal mixed-effects models, this study explored the association between the triple digital divide and depressive symptom trajectories among middle-aged and older Chinese adults by examining gender, rural-urban and regional disparities in this relationship.</p><p><strong>Results: </strong>Our findings revealed a significant association between the triple digital divide and increasing trajectories of depressive symptoms, showing significant disparities based on gender, rural-urban dwelling and regional location. Notably, for both male and female participants who resided in urban areas or the central region of the country, their ability to use the internet, coupled with enhanced internet skills and greater access to internet services, was found to have a mitigating effect on the increasing trajectories of depressive symptoms.</p><p><strong>Conclusions: </strong>To alleviate some of the confounding influences on the trajectory of depression in middle-aged and older adults, policymakers in China should continue to prioritise the development of internet technology, foster easy access to the internet to ensure it is 'elder-friendly', provide internet skill training platforms for this population and broaden access to various internet services appropriate for them. Additionally, the implementation of tailored interventions to address depression, especially targeting the more vulnerable cohorts, such as middle-aged and older women, those residing in rural areas and the western regions, is crucial. Such tailored approaches are essential for addressing the disparities and challenges associated with the triple digital divide.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"37 4","pages":"e101562"},"PeriodicalIF":5.3,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing prevalence of eating disorders in female adolescents compared with children and young adults: an analysis of real-time administrative data.","authors":"Binx Yezhe Lin, Dominic Moog, Hui Xie, Ching-Fang Sun, Wisteria Yushan Deng, Erin McDaid, Katherine V Liebesny, Anita S Kablinger, Kevin Young Xu","doi":"10.1136/gpsych-2024-101584","DOIUrl":"10.1136/gpsych-2024-101584","url":null,"abstract":"","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"37 4","pages":"e101584"},"PeriodicalIF":5.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11298723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consumption of sugary beverages, genetic predisposition and the risk of depression: a prospective cohort study.","authors":"Yanchun Chen, Hongxi Yang, Baihe Sheng, Lihui Zhou, Dun Li, Mengnan Zhang, Yaogang Wang","doi":"10.1136/gpsych-2023-101446","DOIUrl":"10.1136/gpsych-2023-101446","url":null,"abstract":"<p><strong>Background: </strong>The associations between sugary beverages and genetic predisposition to depression risk remain unclear.</p><p><strong>Aims: </strong>This study aimed to investigate the associations of sugar-sweetened beverages (SSBs), artificially sweetened beverages (ASBs) and natural juices (NJs) with depression and to assess whether these associations were modified by genetic predisposition.</p><p><strong>Methods: </strong>We used data from the UK Biobank of 180 599 individuals aged 39-72 years who were depression-free at baseline. Dietary intake of SSBs, ASBs and NJs was accessed by a 24-hour dietary recall between 2009 and 2012. The Polygenic Risk Score for depression was estimated and categorised as low (lowest tertile), intermediate (tertile 2) and high (highest tertile). Cox proportional hazard and substitution models were conducted to evaluate hazard ratios (HRs) and 95% CIs.</p><p><strong>Results: </strong>Over the 12-year follow-up, 4915 individuals developed depression. Higher consumption (>2 units/day) of SSBs (HR: 1.26, 95% CI 1.12 to 1.43) and ASBs (HR: 1.40, 95% CI 1.23 to 1.60) were both associated with an increased risk of depression. However, moderate consumption (>0-1 units/day) of NJs was associated with a lower risk of depression (HR: 0.89, 95% CI 0.83 to 0.95). Furthermore, genetic predisposition did not modify these associations (p interaction>0.05). In substitution models, the HRs for depression risk were 0.94 (95% CI 0.89 to 0.99) and 0.89 (95% CI 0.85 to 0.94), respectively, when 1 unit/day of SSBs or ASBs was replaced by an equivalent intake of NJs.</p><p><strong>Conclusions: </strong>Higher consumption of SSBs and ASBs was associated with an increased risk of depression; in contrast, moderate consumption of NJs was inversely associated with a lower risk of depression. In theory, substituting SSBs and ASBs with NJs would suppose a reduction of depression risk.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"37 4","pages":"e101446"},"PeriodicalIF":5.3,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11256058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141723400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing ruminative thinking behaviours in nurses: a cross-sectional study of 858 subjects in a tertiary care hospital","authors":"Huling Cao, Aiming Ding, Lihua Wang, Jianyu Cao, Haiyan Mao, Hui Tang, Guihong Yang, Junhua Gu","doi":"10.1136/gpsych-2023-101443","DOIUrl":"https://doi.org/10.1136/gpsych-2023-101443","url":null,"abstract":"To the editor: Nurses play a vital role in healthcare by providing direct medical care to patients, and their mental well-being significantly impacts the quality of service and patient satisfaction.1 Ruminative thinking involves repetitive thoughts about negative feelings, their causes and consequences. This common psychological behaviour in nurses can significantly impact their self-evaluation and result in feelings of worthlessness.2 However, there is a knowledge gap regarding the risk factors influencing ruminative thinking in practising nurses. Ruminative thinking has been linked to psychological processes such as empathy, social support and feedback-seeking behaviours. Empathy is crucial for the quality of care, a positive nurse–patient relationship and reducing medical disputes.3 Social support encompasses the psychological and material assistance that individuals receive from their social networks. Adequate social support contributes to bolstering an individual’s self-esteem and maintaining psychological well-being. Feedback-seeking behaviour is an active psychological approach through which individuals seek valuable information to modify their behaviours and achieve personal and professional objectives.4 We hypothesised that practising nurses have specific personal and professional risk factors that are integrally associated with these psychological processes and ruminative thinking. By examining the current state of ruminative thinking in practising nurses and its associated factors, we aimed to fill the knowledge gap and provide a foundation for potential interventions for this important psychological condition. This study was conducted in a busy tertiary hospital with over 2000 beds and a nurse-to-patient ratio of approximately 1:10, in a city with a population of over 8 million. The survey was distributed using the Questionnaire Star application. The survey method was communicated to the head nurses of each nursing unit. The head nurses then explained these details to eligible nurses during focused learning or training sessions before distributing the Questionnaire Star QR code. All participants were made aware of the …","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"141 1","pages":""},"PeriodicalIF":11.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141567374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissecting the association between gut microbiota, body mass index and specific depressive symptoms: a mediation Mendelian randomisation study","authors":"Tong Yu, Chengfeng Chen, Yuqing Yang, Mingqia Wang, Yantianyu Yang, Wanting Feng, Shiqi Yuan, Xiancang Ma, Jie Li, Bin Zhang","doi":"10.1136/gpsych-2023-101412","DOIUrl":"https://doi.org/10.1136/gpsych-2023-101412","url":null,"abstract":"Background Observational studies highlight the association between gut microbiota (GM) composition and depression; however, evidence for the causal relationship between GM and specific depressive symptoms remains lacking. Aims We aimed to evaluate the causal relationship between GM and specific depressive symptoms as well as the mediating role of body mass index (BMI). Methods We performed a two-sample Mendelian randomisation (MR) analysis using genetic variants associated with GM and specific depressive symptoms from genome-wide association studies. The mediating role of BMI was subsequently explored using mediation analysis via two-step MR. Results MR evidence suggested the Bifidobacterium genus (β=–0.03; 95% CI –0.05 to –0.02; p<0.001 and β=–0.03; 95% CI –0.05 to –0.02; p<0.001) and Actinobacteria phylum (β=–0.04; 95% CI –0.06 to –0.02; p<0.001 and β=–0.03; 95% CI –0.05 to –0.03; p=0.001) had protective effects on both anhedonia and depressed mood. The Actinobacteria phylum also had protective effects on appetite changes (β=–0.04; 95% CI –0.06 to –0.01; p=0.005), while the Family XI had an antiprotective effect (β=0.03; 95% CI 0.01 to 0.04; p<0.001). The Bifidobacteriaceae family (β=–0.01; 95% CI –0.02 to –0.01; p=0.001) and Actinobacteria phylum (β=–0.02; 95% CI –0.03 to –0.01; p=0.001) showed protective effects against suicidality. The two-step MR analysis revealed that BMI also acted as a mediating moderator between the Actinobacteria phylum and appetite changes (mediated proportion, 34.42%) and that BMI partially mediated the effect of the Bifidobacterium genus (14.14% and 8.05%) and Actinobacteria phylum (13.10% and 8.31%) on both anhedonia and depressed mood. Conclusions These findings suggest a potential therapeutic effect of Actinobacteria and Bifidobacterium on both depression and obesity. Further studies are required to translate these findings into clinical practice. Data are available in a public, open access repository. All GWAS summary statistics are publicly available for download. The GWASs data for gut microbiota were provided by MiBioGen consortium (<https://mibiogen.gcc.rug.nl/>). The GWASs data for specific depressive symptoms were sourced from UK Biobank (<http://www.nealelab.is/uk-biobank>). The GWASs for BMI were provided by GIANT consortium ([https://portals.broadinstitute.org/collaboration/giant/index.php/GIANT_consortium_data_files][1]). [1]: https://portals.broadinstitute.org/collaboration/giant/index.php/GIANT_consortium_data_files","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"30 1","pages":""},"PeriodicalIF":11.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends and cohort variations of gender-specific major depressive disorders incidence in China: analysis based on the age-period-cohort-interaction model.","authors":"Xiyuan Hu, Chao Guo","doi":"10.1136/gpsych-2023-101479","DOIUrl":"10.1136/gpsych-2023-101479","url":null,"abstract":"<p><strong>Background: </strong>Major depressive disorders (MDDs) impose substantial burdens on individuals and society; however, further detailed analysis is still needed for its long-term trends.</p><p><strong>Aims: </strong>This study aimed to analyse the gender-specific temporal trends and cohort variations of MDD incidence among Chinese residents over the past three decades.</p><p><strong>Methods: </strong>Employing the age-period-cohort-interaction model and leveraging data from the Global Burden of Disease Study 2019, this research identified and analysed incidence trends of MDD among Chinese males and females aged 5-94 years from 1990 to 2019 across three dimensions, encompassing age, period and birth cohort.</p><p><strong>Results: </strong>The analysis reveals age-related effects, indicating heightened MDD risk among adolescents and older adults. Specifically, individuals entering the older adulthood at the age of 65-69 significantly increased the risk of MDD by 64.9%. People aged 90-94 years witnessed a 105.4% increase in MDD risk for the overall population, with females and males in this age group experiencing a 75.1% and 103.4% increase, respectively. In terms of period effects, the risk of MDD displayed a decline from 1990 to 1994, followed by a rebound in 2008. Cohort effects demonstrated diverse generational patterns, with generation I and generation III manifesting opposing 'age-as-level' trends. Generation II and generation IV exhibited 'cumulative disadvantage' and 'cumulative advantage' patterns, respectively. Age effects indicated an overall higher risk of MDD incidence in females, while cohort effects showed greater variations of MDD incidence among females.</p><p><strong>Conclusions: </strong>The study underscores the substantial effects of age, period and cohort on MDD across genders in China. Priority interventions targeting vulnerable populations, including children, adolescents, older adults, females and the post-millennium birth cohort, are crucial to mitigate the impact of MDD.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"37 4","pages":"e101479"},"PeriodicalIF":5.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the effectiveness of internet-based interventions for mental health outcomes: an umbrella review","authors":"Mi Zhang, Chuan Fan, Lijun Ma, Huixue Wang, Zhenyue Zu, Linxi Yang, Fenglan Chen, Wenzhuo Wei, Xiaoming Li","doi":"10.1136/gpsych-2023-101355","DOIUrl":"https://doi.org/10.1136/gpsych-2023-101355","url":null,"abstract":"Internet-based interventions (IBIs) for behavioural health have been prevalent for over two decades, and a growing proportion of individuals with mental health concerns prefer these emerging digital alternatives. However, the effectiveness and acceptability of IBIs for various mental health disorders continue to be subject to scholarly debate. We performed an umbrella review of meta-analyses (MAs), conducting literature searches in PubMed, Web of Science, Embase, Cochrane and Ovid Medline from their inception to 17 January 2023. A total of 87 MAs, reporting on 1683 randomised controlled trials and 295 589 patients, were included. The results indicated that IBIs had a moderate effect on anxiety disorder (standardised mean difference (SMD)=0.53, 95% CI 0.44 to 0.62) and post-traumatic stress disorder (PTSD) (SMD=0.63, 95% CI 0.38 to 0.89). In contrast, the efficacy on depression (SMD=0.45, 95% CI 0.39 to 0.52), addiction (SMD=0.23, 95% CI 0.16 to 0.31), suicidal ideation (SMD=0.23, 95% CI 0.16 to 0.30), stress (SMD=0.41, 95% CI 0.33 to 0.48) and obsessive–compulsive disorder (SMD=0.47, 95% CI 0.22 to 0.73) was relatively small. However, no significant effects were observed for personality disorders (SMD=0.07, 95% CI −0.13 to 0.26). Our findings suggest a significant association between IBIs and improved mental health outcomes, with particular effectiveness noted in treating anxiety disorders and PTSD. However, it is noteworthy that the effectiveness of IBIs was impacted by high dropout rates during treatment. Furthermore, our results indicated that guided IBIs proved to be more effective than unguided ones, playing a positive role in reducing dropout rates and enhancing patient adherence rates. PROSPERO registration number: CRD42023417366.","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"45 1","pages":""},"PeriodicalIF":11.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141742427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presurgical structural imaging and clinical outcome in combined bed nucleus of the stria terminalis-nucleus accumbens deep brain stimulation for treatment-resistant depression.","authors":"Fengting Wang, Lulin Dai, Tao Wang, Yingying Zhang, Yuhan Wang, Yijie Zhao, Yixin Pan, Liuguan Bian, Dianyou Li, Shikun Zhan, Yijie Lai, Valerie Voon, Bomin Sun","doi":"10.1136/gpsych-2023-101210","DOIUrl":"10.1136/gpsych-2023-101210","url":null,"abstract":"<p><strong>Background: </strong>Structural imaging holds great potential for precise targeting and stimulation for deep brain stimulation (DBS). The anatomical information it provides may serve as potential biomarkers for predicting the efficacy of DBS in treatment-resistant depression (TRD).</p><p><strong>Aims: </strong>The primary aim is to identify preoperative imaging biomarkers that correlate with the efficacy of DBS in patients with TRD.</p><p><strong>Methods: </strong>Preoperative imaging parameters were estimated and correlated with the 6-month clinical outcome of patients with TRD receiving combined bed nucleus of the stria terminalis (BNST)-nucleus accumbens (NAc) DBS. White matter (WM) properties were extracted and compared between the response/non-response and remission/non-remission groups. Structural connectome was constructed and analysed using graph theory. Distances of the volume of activated tissue (VAT) to the main modulating tracts were also estimated to evaluate the correlations.</p><p><strong>Results: </strong>Differences in fibre bundle properties of tracts, including superior thalamic radiation and reticulospinal tract, were observed between the remission and non-remission groups. Distance of the centre of the VAT to tracts connecting the ventral tegmental area and the anterior limb of internal capsule on the left side varied between the remission and non-remission groups (p=0.010, t=3.07). The normalised clustering coefficient (γ) and the small-world property (σ) in graph analysis correlated with the symptom improvement after the correction of age.</p><p><strong>Conclusions: </strong>Presurgical structural alterations in WM tracts connecting the frontal area with subcortical regions, as well as the distance of the VAT to the modulating tracts, may influence the clinical outcome of BNST-NAc DBS. These findings provide potential imaging biomarkers for the DBS treatment for patients with TRD.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"37 3","pages":"e101210"},"PeriodicalIF":5.3,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11191758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower synaptic density and its association with cognitive dysfunction in patients with obsessive-compulsive disorder.","authors":"Qian Xiao, Jiale Hou, Ling Xiao, Ming Zhou, Zhiyou He, Huixi Dong, Shuo Hu","doi":"10.1136/gpsych-2023-101208","DOIUrl":"10.1136/gpsych-2023-101208","url":null,"abstract":"<p><strong>Background: </strong>Understanding synaptic alteration in obsessive-compulsive disorder (OCD) is crucial for elucidating its pathological mechanisms, but <i>in vivo</i> research on this topic remains limited.</p><p><strong>Aims: </strong>This study aimed to identify the synaptic density indicators in OCD and explore the relationship between cognitive dysfunction and synaptic density changes in OCD.</p><p><strong>Methods: </strong>This study enrolled 28 drug-naive adults with OCD aged 18-40 years and 16 healthy controls (HCs). Three-dimensional T1-weighted structural magnetic resonance imaging and ¹⁸F-SynVesT-1 positron emission tomography were conducted. Cognitive function was assessed using the Wisconsin Cart Sorting Test (WCST) in patients with OCD and HCs. Correlative analysis was performed to examine the association between synaptic density reduction and cognitive dysfunction.</p><p><strong>Results: </strong>Compared with HCs, patients with OCD showed reduced synaptic density in regions of the cortico-striato-thalamo-cortical circuit such as the bilateral putamen, left caudate, left parahippocampal gyrus, left insula, left parahippocampal gyrus and left middle occipital lobe (voxel p<0.001, uncorrected, with cluster level above 50 contiguous voxels). The per cent conceptual-level responses of WCST were positively associated with the synaptic density reduction in the left middle occipital gyrus (R²=0.1690, p=0.030), left parahippocampal gyrus (R²=0.1464, p=0.045) and left putamen (R²=0.1967, p=0.018) in patients with OCD.</p><p><strong>Conclusions: </strong>Adults with OCD demonstrated lower ¹⁸F-labelled difluoro analogue of ¹⁸F-SynVesT-1 compared with HCs, indicating potentially lower synaptic density. This is the first study to explore the synaptic density in patients with OCD and provides insights into potential biological targets for cognitive dysfunctions in OCD.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"37 3","pages":"e101208"},"PeriodicalIF":11.9,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11184172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of post-traumatic stress disorder and depressive symptoms among civilians residing in armed conflict-affected regions: a systematic review and meta-analysis.","authors":"Syed Hassan Ahmed, Aabia Zakai, Maha Zahid, Muhammad Youshay Jawad, Rui Fu, Michael Chaiton","doi":"10.1136/gpsych-2023-101438","DOIUrl":"10.1136/gpsych-2023-101438","url":null,"abstract":"<p><strong>Background: </strong>Globally, populations afflicted by armed conflict are known to have high rates of mental health disorders.</p><p><strong>Aims: </strong>This meta-analysis aims to estimate the prevalence of post-traumatic stress disorder (PTSD) and depressive symptoms among civilians residing in armed conflict-affected regions.</p><p><strong>Methods: </strong>This meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. A literature search employing MEDLINE(R), Embase Classic+Embase, APA PsycINFO, Ovid Healthstar, Journal@Ovid Full Text, Cochrane, PTSDpubs and CINAHL was conducted from inception until 19 March 2024 to identify relevant studies. Quality assessment was performed using the Joanna Briggs Institute Critical Appraisal Checklist for Prevalence Studies, and a Comprehensive Meta-Analysis was used to conduct the statistical analysis.</p><p><strong>Results: </strong>The search yielded 38 595 articles, of which 57 were considered eligible for inclusion. The included studies comprised data from 64 596 participants. We estimated a prevalence of 23.70% (95% CI 19.50% to 28.40%) for PTSD symptoms and 25.60% (95% CI 20.70% to 31.10%) for depressive features among war-afflicted civilians. The subgroup analysis based on time since the war and the country's economic status revealed the highest prevalence for both PTSD and depressive symptoms was present during the years of war and in low/middle-income countries.</p><p><strong>Conclusions: </strong>The results of this study provide conclusive evidence of the detrimental impacts of armed conflict on mental health outcomes. Hence, it is crucial to emphasise the significance of both physical and mental health in the aftermath of war and take appropriate humanistic measures to overcome challenges in the management of psychiatric illnesses.</p><p><strong>Prospero registration number: </strong>CRD42023416096.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"37 3","pages":"e101438"},"PeriodicalIF":11.9,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11177673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}