General Psychiatry最新文献

{"title":"Depressive symptoms and immune depletion in Chinese patients with advanced hepatocellular carcinoma: a multicentre study on their correlation.","authors":"Yan Zhang, Wei Zhou, Zhiping Ma, Zutao Chen, Naiping Li, Xiaomin Zhu, Yunhai Yao","doi":"10.1136/gpsych-2024-101822","DOIUrl":"https://doi.org/10.1136/gpsych-2024-101822","url":null,"abstract":"","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 2","pages":"e101822"},"PeriodicalIF":5.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China.","authors":"Tao Wang, Haining He, Yanchen Shi, Ning Su, Minjie Zhu, Feng Yan, Yuanyuan Liu, Juan Li, Muni Tang, Wei Chen, Feng Bao, Huali Wang, Yuping Wang, Ying Liu, Yefeng Yuan, Xiaoyun Zuo, Xulai Zhang, Lijuan Cui, Wenyuan Wu, Chencheng Zhang, Yong Lu, Yiru Fang, Shifu Xiao","doi":"10.1136/gpsych-2024-101736","DOIUrl":"10.1136/gpsych-2024-101736","url":null,"abstract":"<p><strong>Background: </strong>As the population in China rapidly ages, the prevalence of mild cognitive impairment (MCI) is increasing considerably. However, the causes of MCI vary. The continued lack of understanding of the various subtypes of MCI impedes the implementation of effective measures to reduce the risk of advancing to more severe cognitive diseases.</p><p><strong>Aims: </strong>To estimate the prevalence and incidence rates of two MCI subtypes-amnestic MCI (aMCI) and vascular cognitive impairment without dementia (VCIND)-and to determine modifiable factors for them among older individuals in a multiregional Chinese cohort.</p><p><strong>Method: </strong>This 1-year longitudinal study surveyed a random sample of participants aged≥60 years from a large, community-dwelling cohort in China. Baseline lifestyle data were self-reported, while vascular and comorbid conditions were obtained from medical records and physical examinations. In total, 3514 and 2051 individuals completed the baseline and 1-year follow-up assessments, respectively. Logistic and linear regression analyses were used to identify the modifiable factors for MCI subtypes and predictors of cognitive decline, respectively.</p><p><strong>Results: </strong>Among our participants, aMCI and VCIND demonstrated prevalence of 14.83% and 2.71%, respectively, and annual incidence (per 1000 person-years) of 69.6 and 10.6, respectively. The risk factor for aMCI was age, whereas its protective factors were high education level, tea consumption and physical activity. Moreover, VCIND risk factors were age, hypertension and depression. The presence of endocrine disease, cerebral trauma or hypertension was associated with a faster decline in cognition over 1 year.</p><p><strong>Conclusions: </strong>MCI is a serious health problem in China that will only worsen as the population ages if no widespread interventions are implemented. Preventive strategies that promote brain activity and support healthy lifestyle choices are required. We identified modifiable factors for MCI in older individuals. The easy-to-adopt solutions such as tea consumption and physical activity can aid in preventing MCI.</p><p><strong>Trial registration number: </strong>NCT03672448.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 2","pages":"e101736"},"PeriodicalIF":5.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of dynamic interpersonal therapy in improving mentalising in patients with major depressive disorder and the mediating effect of mentalising on changes in depressive symptoms.","authors":"Wenhui Jiang, Jiayu Yao, Yuan Wang, Shanshan Su, Ziwei Zheng, Yang Yang, Jianyin Qiu","doi":"10.1136/gpsych-2024-101774","DOIUrl":"10.1136/gpsych-2024-101774","url":null,"abstract":"<p><strong>Background: </strong>Dynamic interpersonal therapy (DIT) is a short-term psychodynamic psychotherapy that has been shown to effectively reduce depressive symptoms in patients with major depressive disorder (MDD). In DIT, the depressive symptoms are formulated as responses to impaired mentalisation. DIT aims to alleviate depressive symptoms by improving mentalising.</p><p><strong>Aims: </strong>This study aimed to examine the effect of DIT on improving mentalising and the mediating effect of mentalising in changes in depressive symptoms.</p><p><strong>Methods: </strong>Outpatients received either DIT combined with antidepressant medication treatment (DIT group) or antidepressant medication treatment alone (ADM group) for 16 weeks. The Hamilton Depression Rating Scale (HAMD), Patient Health Questionnaire (PHQ) and Reflective Functioning Questionnaire (RFQ) were used. The intention-to-treat principle, mixed linear models, multiple imputation, Pearson's correlation analysis and mediation analysis were conducted. The per-protocol principle was used as sensitivity analysis.</p><p><strong>Results: </strong>The DIT group had significantly lower HAMD (least-squares (LS) mean difference=-3.756, p<0.001), PHQ (LS mean difference=-4.188, p<0.001), uncertainty about mental states in the RFQ (RFQ-U, LS mean difference=-2.116, p<0.001) and higher certainty about mental states in the RFQ (RFQ-C, LS mean difference=2.214, p=0.028) scores than the ADM group at post-treatment. The change in RFQ-C was marginally significantly correlated with the change in HAMD (r=-0.218, p_corrected=0.09). The change in RFQ-U was significantly correlated with the change in HAMD (r=0.269, p_corrected=0.024) and the change in PHQ (r=0.343, p_corrected<0.001). When using RFQ-U as the mediating variable and PHQ as the dependent variable, a significant mediating effect was found (p=0.043, 95% confidence interval 0.024 to 1.453).</p><p><strong>Conclusions: </strong>The DIT group yielded better outcomes compared with the ADM group in reducing depressive symptoms and improving mentalising. Improvements in mentalising were associated with reductions in depressive symptoms. These findings support that mentalising may contribute to the therapeutic effects of DIT in MDD.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 1","pages":"e101774"},"PeriodicalIF":5.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudo-psychiatric symptoms of superior semicircular canal dehiscence syndrome.","authors":"Quentin Legois, Yohan Gallois, Mathieu Marx, Olivier Deguine, Antoine Yrondi, Maximilien Redon, Christophe Arbus, Valentin Raymond","doi":"10.1136/gpsych-2024-101837","DOIUrl":"10.1136/gpsych-2024-101837","url":null,"abstract":"","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 1","pages":"e101837"},"PeriodicalIF":5.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanded access to psychedelic treatments: comparing American and Canadian policies.","authors":"Jérémie Richard, Albert Garcia-Romeu, Jack E Henningfield","doi":"10.1136/gpsych-2024-101894","DOIUrl":"10.1136/gpsych-2024-101894","url":null,"abstract":"","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 1","pages":"e101894"},"PeriodicalIF":5.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the subclinical level of problematic internet use and habenula volume: a look at mediation effect of neuroticism.","authors":"Halwa Zakia, Yusuke Kyuragi, Qi Dai, Naoya Oishi, Yuzuki Ishikawa, Lichang Yao, Morio Aki, Toshiya Murai, Hironobu Fujiwara","doi":"10.1136/gpsych-2024-101694","DOIUrl":"10.1136/gpsych-2024-101694","url":null,"abstract":"<p><strong>Background: </strong>Ongoing debates question the harm of internet use with the evolving technology, as many individuals transition from regular to problematic internet use (PIU). The habenula (Hb), located between the thalamus and the third ventricle, is implicated in various psychiatric disorders. In addition, personality features have been suggested to play a role in the pathophysiology of PIU.</p><p><strong>Aims: </strong>This study aimed to investigate Hb volumetry in individuals with subclinical PIU and the mediating effect of personality traits on this relationship.</p><p><strong>Methods: </strong>110 healthy adults in this cross-sectional study underwent structural magnetic resonance imaging. Hb segmentation was performed using a deep learning technique. The Internet Addiction Test (IAT) and the NEO Five-Factor Inventory were used to assess the PIU level and personality, respectively. Partial Spearman's correlation analyses were performed to explore the relationships between Hb volumetry, IAT and NEO. Multiple regression analysis was applied to identify personality traits that predict IAT scores. The significant trait was then treated as a mediator between Hb volume and IAT correlation in mediation analysis with a bootstrap value of 5000.</p><p><strong>Results: </strong>Relative Hb volume was negatively correlated with IAT scores (partial rho=-0.142, p=0.009). The IAT score was positively correlated with neuroticism (partial rho=0.430, p<0.001) and negatively correlated with extraversion, agreeableness and conscientiousness (partial rho=-0.213, p<0.001; partial rho=-0.279, p<0.001; and partial rho=-0.327, p<0.001). There was a significant indirect effect of Hb volume on this model (β=-0.061, p=0.048, boot 95% confidence interval: -0.149 to -0.001).</p><p><strong>Conclusions: </strong>This study uncovered a crucial link between reduced Hb volume and heightened PIU. Our findings highlight neuroticism as a key risk factor for developing PIU. Moreover, neuroticism was shown to mediate the relationship between Hb volume and PIU tendency, offering valuable insight into the complexities of this interaction.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 1","pages":"e101694"},"PeriodicalIF":5.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for the diagnosis and treatment of depressive disorders by integrating Chinese and Western medicine (English edition).","authors":"Lanying Liu, Jianjun Wang, Wei Li, Jing Gao, Wangtao Li, Yan Li, Liyuan Luo, Liyuan Guo, Yiying Hu, Yongjun Chen, Hongyan Chen, Lin Yu, Bin Fen, Hongxiao Jia, Zhangjin Zhang, Zhaojun Yan, Wei Chen, Zhangsheng Yu, Zhen Wang","doi":"10.1136/gpsych-2024-101747","DOIUrl":"10.1136/gpsych-2024-101747","url":null,"abstract":"","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 1","pages":"e101747"},"PeriodicalIF":5.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peer support for discharge from hospital to community mental healthcare: a cost analysis.","authors":"Andrew Healey, Akshaykumar Patel, Jacqueline Marks, Stephen Bremner, Rhiannon Foster, Sarah L Gibson, Lucy Pollyanna Goldsmith, Mike Lucock, Julie Repper, Miles Rinaldi, Alan Simpson, Sarah White, Michael Ussher, Steve Gillard","doi":"10.1136/gpsych-2024-101671","DOIUrl":"10.1136/gpsych-2024-101671","url":null,"abstract":"","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 1","pages":"e101671"},"PeriodicalIF":5.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of home environment on neuropsychiatric development in preterm infants discharged from NICU at 18 months corrected age.","authors":"Yuan Tian, Chuncao Zhang, Feng Liu, Xia Hong, Li Shen, Jinjin Chen, Haifeng Jiang","doi":"10.1136/gpsych-2024-101634","DOIUrl":"10.1136/gpsych-2024-101634","url":null,"abstract":"<p><strong>Abstract: </strong></p><p><strong>Background: </strong>There have been numerous intervention studies focusing on the development of preterm infants, but there has been limited investigation into the home environment as a determinant of developmental outcomes in preterm infants. The aspects and extent to which the home environment affects the early (18 months corrected age) neuropsychological development of preterm infants are still unclear.</p><p><strong>Aims: </strong>This study aimed to analyse the effect of the home environment on the neuropsychiatric development of preterm infants at 18 months corrected age after discharge from the neonatal intensive care unit (NICU). It also sought to provide a basis for promoting neuropsychiatric development among preterm infants by improving the home environment.</p><p><strong>Methods: </strong>In this retrospective cross-sectional study, 275 preterm infants born between January 2019 and January 2022 were followed up for systematic management after discharge from the NICU at Shanghai Children's Hospital. The Home Nurture Environment Questionnaire was used to assess the home environment of the infants and analyse its impact on the developmental quotient (evaluated by the Gesell Developmental Scale) and the rate of developmental delays at 18 months corrected age.</p><p><strong>Results: </strong>A total of 41.454% of the infants were extremely preterm. The developmental quotient scores at 18 months corrected age were in the middle of the scale. The language domain had the highest rate of developmental delay (46.182%), followed by the adaptive domain (37.091%). Multiple logistic regression analyses showed that compared with infants in supportive home environments, infants with moderate/unsupportive home environments had significantly elevated risks of development delay: 2.162-fold for global (odds ratio (OR) 2.162, 95% confidence interval (CI) 1.274 to 3.665, p=0.004), 2.193-fold for fine motor (OR 2.193, 95% CI 1.161 to 4.140, p=0.016), 2.249-fold for language (OR 2.249, 95% CI 1.336 to 3.786, p=0.002) and 2.042-fold for personal-social (OR 2.042, 95% CI 1.149 to 3.628, p=0.015).</p><p><strong>Conclusions: </strong>A supportive home environment is a crucial protective factor for the neuropsychological development of preterm infants. It is associated with higher developmental quotient scores and protects against neuropsychiatric delays. Incorporating evaluation and continuous improvement of the home environment into the management framework for preterm infants to promote optimal neurodevelopment is essential.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 1","pages":"e101634"},"PeriodicalIF":5.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicidal ideation and suicide attempt among pregnant adolescent girls in Ghana: a cross-sectional study.","authors":"Emmanuel Nii-Boye Quarshie, Erica Danfrekua Dickson, Sandra Naa-Shasha Quarshie, Sophia Ewuenye Adwoa Kpebu, Kwaku Oppong Asante","doi":"10.1136/gpsych-2024-101643","DOIUrl":"10.1136/gpsych-2024-101643","url":null,"abstract":"<p><strong>Background: </strong>Globally, suicide is the third leading cause of death among girls aged 15-19 years. However, there is a growing concern that suicide research has paid little attention to pregnant adolescent girls, particularly in low-income and middle-income countries, including Ghana, where nearly one in seven adolescents experiences (unwanted) pregnancy.</p><p><strong>Aims: </strong>To assess the prevalence and correlates of suicidal ideation and suicide attempt and the self-reported reasons for attempted suicide among pregnant adolescent girls in Ghana.</p><p><strong>Methods: </strong>We collected cross-sectional data (between August 2022 and December 2023) using structured anonymous questionnaires from a sample of 449 pregnant adolescent girls (aged 14-19 years) drawn from the three geographical zones of Ghana. We applied bivariable and multivariable analysis techniques to the data.</p><p><strong>Results: </strong>Overall, 28.51% (95% confidence interval (CI) 24.37% to 32.93%) reported suicidal ideation, and 18.04% (95% CI 14.59% to 21.91%) reported suicide attempt during the current pregnancy. Participants who reported attempted suicide endorsed more interpersonal reasons (eg, to communicate distress, to seek help or to influence others) than intrapersonal reasons for their attempted suicide. In the final adjusted logistic regression models, food insecurity (adjusted odds ratio (aOR)=2.69; 95% CI 1.34 to 5.41; p=0.005) was uniquely associated with increased odds of suicidal ideation. Adverse childhood experiences (aOR=3.04; 95% CI 1.33 to 6.97; p=0.008), history of attempted suicide before current pregnancy (aOR=3.47; 95% CI 1.27 to 9.47; p=0.0.015) and depression (measured by the 5-item World Health Organization Well-Being Index; aOR=0.31; 95% CI 0.12 to 0.77; p=0.012) were uniquely associated with increased odds of suicide attempt. Five variables were commonly associated with increased odds of both suicidal ideation and suicide attempt: conflict with parents, alcohol use, pregnancy-related anxiety, history of attempted suicide and intimate partner violence. While being in junior high school was uniquely associated with reduced odds of suicidal ideation, intimate partner's acceptance of paternity was commonly associated with reduced odds of both suicidal ideation and suicide attempt.</p><p><strong>Conclusions: </strong>Although the prevalence estimates of suicidal ideation and suicide attempt in this study are comparable with known rates among non-pregnant adolescent girls in Ghana, additional research is needed to nuance our understanding of the correlates identified in this study. The evidence also highlights a need for both routine antepartum primary care mental health screening for suicidality and related risks and targeted prevention and intervention programmes.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 1","pages":"e101643"},"PeriodicalIF":5.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}