General Psychiatry最新文献

{"title":"Thorny but rosy: prosperities and difficulties in 'AI plus medicine' concerning data collection, model construction and clinical deployment.","authors":"Yujia Xia, Zhangsheng Yu","doi":"10.1136/gpsych-2023-101436","DOIUrl":"https://doi.org/10.1136/gpsych-2023-101436","url":null,"abstract":"","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"37 6","pages":"e101436"},"PeriodicalIF":5.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schizophrenia in children, adults and older people with intellectual disability compared with the general population: a Swedish register study (IDcare).","authors":"Trine Lise Bakken, Magnus Sandberg, Anna Axmon","doi":"10.1136/gpsych-2024-101673","DOIUrl":"https://doi.org/10.1136/gpsych-2024-101673","url":null,"abstract":"<p><strong>Abstract: </strong></p><p><strong>Background: </strong>The knowledge about the prevalence of schizophrenia among people with intellectual disabilities (ID) is sparse, particularly concerning the distribution in different age groups.</p><p><strong>Aims: </strong>To investigate the prevalence of diagnoses in the schizophrenia spectrum among people with ID compared with the general population (gPop).</p><p><strong>Methods: </strong>This was an 8-year longitudinal register study. The participants were all residents of Skåne on 1 January 2014. People with a diagnosis of ID (F7 in International Statistical Classification of Diseases and Related Health Problems 10th Revision) or Down syndrome (DS; Q90), or service and support for people with ID/autism spectrum disorder (ASD) comprised the ID cohort (n=14 716). After excluding family members of people in the ID cohort, the remaining population of Skåne comprised the gPop cohort (n=1 226 955).The primary outcome measure was having at least one diagnosis in the schizophrenia spectrum (F20-F29). Secondary outcomes were single diagnoses within the schizophrenia spectrum.</p><p><strong>Results: </strong>The prevalence of schizophrenia spectrum diagnoses was 7.2% in the ID cohort. This was more than an eightfold increase compared with the gPop (relative risk (RR) 8.45; 95% CI 7.94 to 9.00). The risk was also high among children (aged 0-18 years at the start of the study period; RR 9.42; 95% CI 7.36 to 12.05). In the subcohort comprising those with a diagnosis of DS, the risk of schizophrenia diagnosis was more than twice as high as in gPop. Concomitant ASD or genetic syndrome did not carry an excess risk among people with ID when compared with the gPop.</p><p><strong>Conclusions: </strong>The findings of the present study support earlier assumptions that people with vulnerable brains develop psychotic disorders more frequently and that the onset age is lower than among people in the gPop. Habilitation services for children and adolescents, as well as general mental health services, should keep in mind that schizophrenia may be present when children and adolescents show severely decreased functioning, anxiety or aggressive behaviour.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"37 6","pages":"e101673"},"PeriodicalIF":5.3,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scoping survey of dietetic resourcing for eating disorders: why is the dietitian's role marginalised in community eating disorders?","authors":"Elizabeth Roberts, Mala Watts, Safiya Riley, Kathryn Hart","doi":"10.1136/gpsych-2024-101604","DOIUrl":"https://doi.org/10.1136/gpsych-2024-101604","url":null,"abstract":"","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"37 6","pages":"e101604"},"PeriodicalIF":5.3,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the door to supportive housing: addressing the challenge of post-discharge transitions in safety-net psychiatric care.","authors":"Yaara Zisman-Ilani, Jessica G Kovach, Meera Chatterjee, Mary F Morrison","doi":"10.1136/gpsych-2024-101608","DOIUrl":"10.1136/gpsych-2024-101608","url":null,"abstract":"","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"37 6","pages":"e101608"},"PeriodicalIF":5.3,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SAS macro programme for Bang's Blinding Index to assess and visualise the success of blinding in randomised controlled trials.","authors":"Zongshi Qin, Yongpei Yu, Hongqiu Gu, Dongdong Shi, Zhen Wang, Jiani Wu, Toshiaki Furukawa, Yangfeng Wu","doi":"10.1136/gpsych-2024-101578","DOIUrl":"10.1136/gpsych-2024-101578","url":null,"abstract":"<p><p>This paper aims to present a Statistical Analysis Software (SAS) macro %BBIplus, offering estimation and visualisation methods for the Bang's Blinding Index (BBI) for randomised controlled trials (RCTs) with various designs. We developed the SAS macro programme %BBIplus to facilitate the implementation of BBI. This user-friendly programme allows for easy and rapid estimation and visualisation of BBI across different scenarios, including pairwise comparison RCTs with two arms, double-dummy design RCTs with three arms and factorial design RCTs with four arms. The programme requires no pre-existing data set, and users only need to input the number of individuals of correct, uncertain or wrong guesses in each intervention or control group. We illustrate the functionality of %BBIplus using blinding assessment data from three previously published RCTs: BBR (adjunctive berberine reduces antipsychotic-associated weight gain and metabolic syndrome in patients with schizophrenia: a randomised controlled trial), SELECT-TDCS (the sertraline versus electrical current therapy for treating depression clinical study: results from a factorial, randomised controlled trial) and ELECT-TDCS (trial of electrical direct-current therapy versus escitalopram for depression) studies. The programme estimates the BBI for each arm, providing point estimates, 95% CI and associated p values. Additionally, %BBIplus can visualise the estimations through forest plots and make the judgement for the success of blinding easily and rapidly. This tool caters to the needs of clinical trial investigators, offering a comprehensive solution for estimating and visualising the blinding index under various RCT designs.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"37 6","pages":"e101578"},"PeriodicalIF":5.3,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic insights into male autism spectrum disorder in a small cohort of Indian simplex families: findings from whole exome sequencing.","authors":"Srividhya Durbagula, Snijesh Valiya Parambath, Ashitha Siddappa Niranjana Murthy, Meghana Rameshraju K, Chetan Ghati Kasturirangan, Gautham Arunachal Udupi, Nallur B Ramachandra, Aparna Huligerepura Sosalegowda, Vijaya Raman, Aruna Korlimarla, Naveen Kumar Chandappa Gowda","doi":"10.1136/gpsych-2024-101606","DOIUrl":"https://doi.org/10.1136/gpsych-2024-101606","url":null,"abstract":"","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"37 6","pages":"e101606"},"PeriodicalIF":5.3,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What do we mean when we talk about socioeconomic status? Implications for measurement, mechanisms and interventions from a critical review on adolescent mental health.","authors":"Mirela Zaneva, Tsvetomira Dumbalska, Aaron Reeves, Lucy Bowes","doi":"10.1136/gpsych-2023-101455","DOIUrl":"10.1136/gpsych-2023-101455","url":null,"abstract":"<p><p>Low socioeconomic status (SES) is a well-established risk factor for general and mental health problems. However, there is no widely accepted definition or operationalisation for SES, leading to varied interpretations in research. In a critical review of the child and adolescent mental health literature, we map how SES is defined and measured. We examined 334 relevant papers from 2013 to 2024 and found significant variability in the operationalisation of SES. Our analysis revealed fundamental problems such as the lack of clear definitions, insufficient detail on variables used and limited measures directly reported by adolescents. We discuss issues related to measurement techniques and their impact on reproducibility, policy development and intervention design. Based on our findings, we recommend using SES measures that directly assess the socioeconomic position of children and adolescents. Additionally, we recommend researchers improve transparency and specificity in reporting the measures used and the rationale behind their selection. The wide range of distinct measures used to represent SES, coupled with insufficient reporting, likely hampers our understanding of which underlying factors truly drive observed effects and impedes the establishment of causal relationships. This, in turn, makes the path to effective health interventions more challenging.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"37 6","pages":"e101455"},"PeriodicalIF":5.3,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental illness segregation and truncated autonomy within medical assistance in dying legislative frameworks in Colombia and Canada.","authors":"Hamer Bastidas-Bilbao, Ximena Palacios-Espinosa, Donna E Stewart, Vicky Stergiopoulos","doi":"10.1136/gpsych-2024-101675","DOIUrl":"https://doi.org/10.1136/gpsych-2024-101675","url":null,"abstract":"","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"37 6","pages":"e101675"},"PeriodicalIF":5.3,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Desipramine reverses remote memory deficits by activating calmodulin-CaMKII pathway in a UTX knockout mouse model of Kabuki syndrome.","authors":"Lei Chen, Yuting Li, Minggang Liu, Zhaohui Lan, Xu Zhang, Xiujuan Yang, Qian Zhao, Shuai Wang, Longyong Xu, Ying Zhou, Yifang Kuang, Tatsuo Suzuki, Katsuhiko Tabuchi, Eiki Takahashi, Miou Zhou, Charlie Degui Chen, Tianle Xu, Weidong Li","doi":"10.1136/gpsych-2023-101430","DOIUrl":"10.1136/gpsych-2023-101430","url":null,"abstract":"<p><strong>Background: </strong>Kabuki syndrome (KS) is a rare developmental disorder characterised by multiple congenital anomalies and intellectual disability. <i>UTX</i> (ubiquitously transcribed tetratricopeptide repeat, X chromosome), which encodes a histone demethylase, is one of the two major pathogenic risk genes for KS. Although intellectual disability is a key phenotype of KS, the role of <i>UTX</i> in cognitive function remains unclear. Currently, no targeted therapies are available for KS.</p><p><strong>Aims: </strong>This study aimed to investigate how <i>UTX</i> regulates cognition, to explore the mechanisms underlying <i>UTX</i> dysfunction and to identify potential molecular targets for treatment.</p><p><strong>Methods: </strong>We generated <i>UTX</i> conditional knockout mice and found that <i>UTX</i> deletion downregulated calmodulin transcription by disrupting H3K27me3 (trimethylated histone H3 at lysine 27) demethylation.</p><p><strong>Results: </strong><i>UTX</i>-knockout mice showed decreased phosphorylation of calcium / calmodulin-dependent protein kinase II, impaired long-term potentiation and deficit in remote contextual fear memory. These effects were reversed by an Food and Drug Administration-approved drug desipramine.</p><p><strong>Conclusions: </strong>Our results reveal an epigenetic mechanism underlying the important role of <i>UTX</i> in synaptic plasticity and cognitive function, and suggest that desipramine could be a potential treatment for KS.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"37 5","pages":"e101430"},"PeriodicalIF":5.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive symptomatology, NT-proBNP levels and health status in patients with heart failure: a prospective observational study.","authors":"Mahmoud Balata, Marc Ulrich Becher, Rupert Conrad","doi":"10.1136/gpsych-2024-101596","DOIUrl":"https://doi.org/10.1136/gpsych-2024-101596","url":null,"abstract":"<p><strong>Background: </strong>Depressive symptoms frequently occur in patients with heart failure (HF). However, research on the relationship between these symptoms and N-terminal pro-brain natriuretic peptide (NT-proBNP), a key biomarker for HF severity and treatment, is scarce and yields inconsistent results.</p><p><strong>Aims: </strong>This study investigates the relationship among depressive symptomatology, NT-proBNP and health status in a cohort of patients with HF. Additionally, it assesses the impact of depressive symptoms on their clinical outcomes.</p><p><strong>Methods: </strong>A cohort of 151 patients with HF was followed for 1 year. The Hospital Anxiety and Depression Scale-Depression (HADS-D) Score was used to assess anxiety and depressive symptoms, and NT-proBNP levels were measured. Health status was evaluated using the Kansas City Cardiomyopathy Questionnaire (KCCQ).</p><p><strong>Results: </strong>Patients with HADS-D scores>5 points showed significantly higher NT-proBNP levels and lower KCCQ scores at baseline. Over the year, changes in HADS-D scores correlated positively with changes in NT-proBNP levels and negatively with changes in KCCQ scores. A baseline HADS-D score>5 points was significantly associated with an increased risk of the composite outcome of all-cause mortality and HF hospitalisation, even after adjusting for baseline characteristics (adjusted hazard ratio (HR): 2.17; 95% CI 1.05 to 4.48; p=0.036).</p><p><strong>Conclusions: </strong>HADS-D scores are significantly correlated with NT-proBNP levels and health status in patients with HF. A baseline HADS-D score>5 points is significantly associated with an elevated risk for the composite outcome of all-cause mortality and hospitalisation due to HF.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"37 5","pages":"e101596"},"PeriodicalIF":5.3,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11474672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142462764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}