General Psychiatry最新文献

{"title":"Role of attachment style in the association between childhood adversities and non-suicidal self-injury among young adults: a multigroup structural equation study.","authors":"Rodolfo Rossi, Tommaso B Jannini, Valentina Socci, Francesca Pacitti, Alessandro Rossi, Giorgio Di Lorenzo","doi":"10.1136/gpsych-2023-101277","DOIUrl":"10.1136/gpsych-2023-101277","url":null,"abstract":"<p><strong>Background: </strong>Non-suicidal self-injury (NSSI) is a significant health concern among adolescents and young adults, often resulting from adverse childhood experiences (ACEs). Dissociation, post-traumatic symptoms and attachment style may have a role in shaping such associations.</p><p><strong>Aims: </strong>This study aims to provide a unified model of the impact of ACEs on NSSI, exploring complex post-traumatic stress disorder (cPTSD) symptoms and dissociation as potential mediators and the role of the predominant attachment style in affecting such associations.</p><p><strong>Methods: </strong>1010 young individuals attending the last year of high school participated in this cross-sectional study. ACEs, cPTSD, dissociation and NSSI were evaluated using self-report questionnaires. We fitted a path model of NSSI, with ACEs as exogenous variables and cPTSD and dissociation as sequential mediators. Secure, fearful and preoccupied attachment styles were modelled as grouping variables.</p><p><strong>Results: </strong>Our findings showed that dissociation mediated the impact of ACEs on NSSI in subjects with a fearful attachment style, as opposed to those with a preoccupied attachment for whom cPTSD symptoms mediated the ACEs-NSSI association.</p><p><strong>Conclusions: </strong>Attachment styles moderate the relationship between ACEs and NSSI, with either dissociation or post-traumatic symptomatology mediating the impact of ACEs on NSSI, depending on the predominant attachment style. Our results highlight the importance of attachment as a pathway modifier in the relationships between different psychopathology dimensions, providing a useful framework to better conceptualise the ACEs-NSSI association.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 2","pages":"e101277"},"PeriodicalIF":5.3,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative scale validation of the Dimensional Anhedonia Rating Scale in the treatment of Chinese patients with major depressive disorder.","authors":"Xiaojing Gu, Yun-Ai Su, Jingyu Lin, Xiaowei Chen, Donald M Bushnell, Dongjing Fu, Carol Jamieson, Heather Rozjabek, Tianmei Si","doi":"10.1136/gpsych-2024-101789","DOIUrl":"10.1136/gpsych-2024-101789","url":null,"abstract":"<p><strong>Background: </strong>The patient-reported Dimensional Anhedonia Rating Scale (DARS) has been adapted into Chinese, so there is a need to evaluate its measurement properties in a Chinese population.</p><p><strong>Aims: </strong>To evaluate the reliability and validity of the DARS among Chinese individuals with major depressive disorder (MDD) and its treatment sensitivity in a prospective clinical study.</p><p><strong>Methods: </strong>Data were from a multicentre, prospective clinical study (NCT03294525), which recruited both patients with MDD, who were followed for 8 weeks, and healthy controls (HCs), assessed at baseline only. The analysis included confirmatory factor analysis, validity and sensitivity to change.</p><p><strong>Results: </strong>Patients' mean (standard deviation (SD)) age was 34.8 (11.0) years, with 68.7% being female. 75.2% of patients with MDD had melancholic features, followed by 63.8% with anxious distress. Patients had experienced MDD for a mean (SD) of 9.2 (18) months. DARS scores covered the full range of severity with no major floor or ceiling effects. Confirmatory factor analysis showed adequate fit statistics (comparative fit index 0.976, goodness-of-fit index 0.935 and root mean square error of approximation 0.055). Convergent validity with anhedonia-related measures was confirmed. While the correlation between the DARS and the Hamilton Depression Rating Scale was not strong (r=0.31, baseline), the DARS was found to differentiate between levels of depression. Greater improvements in DARS scores were seen with the Hamilton Rating Scale for Depression responder group (effect size 1.16) compared with the non-responder group (effect size 0.46).</p><p><strong>Conclusions: </strong>This study comprehensively evaluated the measurement properties of the DARS using a Chinese population with MDD. Overall, the Chinese version of DARS demonstrates good psychometric properties and has been found to be responsive to change during antidepressant treatment. The DARS is a suitable scale for assessing patient-reported anhedonia in future clinical trials.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 2","pages":"e101789"},"PeriodicalIF":5.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and effects of remotely supervised aerobic training and resistance training in older adults with mild cognitive impairment: a pilot three-arm randomised controlled trial.","authors":"Xiuxiu Huang, Shifang Zhang, Xiaoyan Zhao, Xinrui Li, Fulian Bao, Yue Lan, Yuyao Zhang, Ran An, Bei Li, Fang Yu, Yongan Sun, Qiaoqin Wan","doi":"10.1136/gpsych-2024-101858","DOIUrl":"10.1136/gpsych-2024-101858","url":null,"abstract":"<p><strong>Abstract: </strong></p><p><strong>Background: </strong>Evidence on the effects of different exercise interventions on cognitive function is insufficient.</p><p><strong>Aims: </strong>To evaluate the feasibility and effects of remotely supervised aerobic exercise (AE) and resistance exercise (RE) interventions in older adults with mild cognitive impairment (MCI).</p><p><strong>Methods: </strong>This study is a 6-month pilot three-arm randomised controlled trial. Eligible participants (n=108) were recruited and randomised to the AE group, RE group or control (CON) group with a 1:1:1 ratio. Interventions were delivered at home with remote supervision. We evaluated participants' global cognition, memory, executive function, attention, physical activity levels, physical performance and muscle strength of limbs at baseline, 3 months (T1) and 6 months (T2) after randomisation. A linear mixed-effects model was adopted for data analyses after controlling for covariates. Tukey's method was used for adjusting for multiple comparisons. Sensitivity analyses were performed after excluding individuals with low compliance rates.</p><p><strong>Results: </strong>15 (13.89%) participants dropped out. The median compliance rates in the AE group and RE group were 67.31% and 93.27%, respectively. After adjusting for covariates, the scores of the Alzheimer's Disease Assessment Scale-Cognitive subscale in the AE group decreased by 2.04 (95% confidence interval (CI) -3.41 to -0.67, t=-2.94, p=0.004) and 1.53 (95% CI -2.88 to -0.17, t=-2.22, p=0.028) points more than those in the CON group at T1 and T2, respectively. The effects of AE were still significant at T1 (estimate=-1.70, 95% CI -3.20 to -0.21, t=-2.69, p=0.021), but lost statistical significance at T2 after adjusting for multiple comparisons. As for executive function, the Stroop time interference in the RE group decreased by 11.76 s (95% CI -21.62 to -1.90, t=-2.81, p=0.015) more than that in the AE group at T2 after Tukey's adjustment. No other significant effects on cognitive functions were found.</p><p><strong>Conclusions: </strong>Both remotely supervised AE and RE programmes are feasible in older adults with MCI. AE has positive effects on global cognition, and RE improves executive function.</p><p><strong>Trial registration number: </strong>ChiCTR2100045582.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 2","pages":"e101858"},"PeriodicalIF":5.3,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive symptoms and immune depletion in Chinese patients with advanced hepatocellular carcinoma: a multicentre study on their correlation.","authors":"Yan Zhang, Wei Zhou, Zhiping Ma, Zutao Chen, Naiping Li, Xiaomin Zhu, Yunhai Yao","doi":"10.1136/gpsych-2024-101822","DOIUrl":"https://doi.org/10.1136/gpsych-2024-101822","url":null,"abstract":"","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 2","pages":"e101822"},"PeriodicalIF":5.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China.","authors":"Tao Wang, Haining He, Yanchen Shi, Ning Su, Minjie Zhu, Feng Yan, Yuanyuan Liu, Juan Li, Muni Tang, Wei Chen, Feng Bao, Huali Wang, Yuping Wang, Ying Liu, Yefeng Yuan, Xiaoyun Zuo, Xulai Zhang, Lijuan Cui, Wenyuan Wu, Chencheng Zhang, Yong Lu, Yiru Fang, Shifu Xiao","doi":"10.1136/gpsych-2024-101736","DOIUrl":"10.1136/gpsych-2024-101736","url":null,"abstract":"<p><strong>Background: </strong>As the population in China rapidly ages, the prevalence of mild cognitive impairment (MCI) is increasing considerably. However, the causes of MCI vary. The continued lack of understanding of the various subtypes of MCI impedes the implementation of effective measures to reduce the risk of advancing to more severe cognitive diseases.</p><p><strong>Aims: </strong>To estimate the prevalence and incidence rates of two MCI subtypes-amnestic MCI (aMCI) and vascular cognitive impairment without dementia (VCIND)-and to determine modifiable factors for them among older individuals in a multiregional Chinese cohort.</p><p><strong>Method: </strong>This 1-year longitudinal study surveyed a random sample of participants aged≥60 years from a large, community-dwelling cohort in China. Baseline lifestyle data were self-reported, while vascular and comorbid conditions were obtained from medical records and physical examinations. In total, 3514 and 2051 individuals completed the baseline and 1-year follow-up assessments, respectively. Logistic and linear regression analyses were used to identify the modifiable factors for MCI subtypes and predictors of cognitive decline, respectively.</p><p><strong>Results: </strong>Among our participants, aMCI and VCIND demonstrated prevalence of 14.83% and 2.71%, respectively, and annual incidence (per 1000 person-years) of 69.6 and 10.6, respectively. The risk factor for aMCI was age, whereas its protective factors were high education level, tea consumption and physical activity. Moreover, VCIND risk factors were age, hypertension and depression. The presence of endocrine disease, cerebral trauma or hypertension was associated with a faster decline in cognition over 1 year.</p><p><strong>Conclusions: </strong>MCI is a serious health problem in China that will only worsen as the population ages if no widespread interventions are implemented. Preventive strategies that promote brain activity and support healthy lifestyle choices are required. We identified modifiable factors for MCI in older individuals. The easy-to-adopt solutions such as tea consumption and physical activity can aid in preventing MCI.</p><p><strong>Trial registration number: </strong>NCT03672448.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 2","pages":"e101736"},"PeriodicalIF":5.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of dynamic interpersonal therapy in improving mentalising in patients with major depressive disorder and the mediating effect of mentalising on changes in depressive symptoms.","authors":"Wenhui Jiang, Jiayu Yao, Yuan Wang, Shanshan Su, Ziwei Zheng, Yang Yang, Jianyin Qiu","doi":"10.1136/gpsych-2024-101774","DOIUrl":"10.1136/gpsych-2024-101774","url":null,"abstract":"<p><strong>Background: </strong>Dynamic interpersonal therapy (DIT) is a short-term psychodynamic psychotherapy that has been shown to effectively reduce depressive symptoms in patients with major depressive disorder (MDD). In DIT, the depressive symptoms are formulated as responses to impaired mentalisation. DIT aims to alleviate depressive symptoms by improving mentalising.</p><p><strong>Aims: </strong>This study aimed to examine the effect of DIT on improving mentalising and the mediating effect of mentalising in changes in depressive symptoms.</p><p><strong>Methods: </strong>Outpatients received either DIT combined with antidepressant medication treatment (DIT group) or antidepressant medication treatment alone (ADM group) for 16 weeks. The Hamilton Depression Rating Scale (HAMD), Patient Health Questionnaire (PHQ) and Reflective Functioning Questionnaire (RFQ) were used. The intention-to-treat principle, mixed linear models, multiple imputation, Pearson's correlation analysis and mediation analysis were conducted. The per-protocol principle was used as sensitivity analysis.</p><p><strong>Results: </strong>The DIT group had significantly lower HAMD (least-squares (LS) mean difference=-3.756, p<0.001), PHQ (LS mean difference=-4.188, p<0.001), uncertainty about mental states in the RFQ (RFQ-U, LS mean difference=-2.116, p<0.001) and higher certainty about mental states in the RFQ (RFQ-C, LS mean difference=2.214, p=0.028) scores than the ADM group at post-treatment. The change in RFQ-C was marginally significantly correlated with the change in HAMD (r=-0.218, p_corrected=0.09). The change in RFQ-U was significantly correlated with the change in HAMD (r=0.269, p_corrected=0.024) and the change in PHQ (r=0.343, p_corrected<0.001). When using RFQ-U as the mediating variable and PHQ as the dependent variable, a significant mediating effect was found (p=0.043, 95% confidence interval 0.024 to 1.453).</p><p><strong>Conclusions: </strong>The DIT group yielded better outcomes compared with the ADM group in reducing depressive symptoms and improving mentalising. Improvements in mentalising were associated with reductions in depressive symptoms. These findings support that mentalising may contribute to the therapeutic effects of DIT in MDD.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 1","pages":"e101774"},"PeriodicalIF":5.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudo-psychiatric symptoms of superior semicircular canal dehiscence syndrome.","authors":"Quentin Legois, Yohan Gallois, Mathieu Marx, Olivier Deguine, Antoine Yrondi, Maximilien Redon, Christophe Arbus, Valentin Raymond","doi":"10.1136/gpsych-2024-101837","DOIUrl":"10.1136/gpsych-2024-101837","url":null,"abstract":"","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 1","pages":"e101837"},"PeriodicalIF":5.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanded access to psychedelic treatments: comparing American and Canadian policies.","authors":"Jérémie Richard, Albert Garcia-Romeu, Jack E Henningfield","doi":"10.1136/gpsych-2024-101894","DOIUrl":"10.1136/gpsych-2024-101894","url":null,"abstract":"","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 1","pages":"e101894"},"PeriodicalIF":5.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the subclinical level of problematic internet use and habenula volume: a look at mediation effect of neuroticism.","authors":"Halwa Zakia, Yusuke Kyuragi, Qi Dai, Naoya Oishi, Yuzuki Ishikawa, Lichang Yao, Morio Aki, Toshiya Murai, Hironobu Fujiwara","doi":"10.1136/gpsych-2024-101694","DOIUrl":"10.1136/gpsych-2024-101694","url":null,"abstract":"<p><strong>Background: </strong>Ongoing debates question the harm of internet use with the evolving technology, as many individuals transition from regular to problematic internet use (PIU). The habenula (Hb), located between the thalamus and the third ventricle, is implicated in various psychiatric disorders. In addition, personality features have been suggested to play a role in the pathophysiology of PIU.</p><p><strong>Aims: </strong>This study aimed to investigate Hb volumetry in individuals with subclinical PIU and the mediating effect of personality traits on this relationship.</p><p><strong>Methods: </strong>110 healthy adults in this cross-sectional study underwent structural magnetic resonance imaging. Hb segmentation was performed using a deep learning technique. The Internet Addiction Test (IAT) and the NEO Five-Factor Inventory were used to assess the PIU level and personality, respectively. Partial Spearman's correlation analyses were performed to explore the relationships between Hb volumetry, IAT and NEO. Multiple regression analysis was applied to identify personality traits that predict IAT scores. The significant trait was then treated as a mediator between Hb volume and IAT correlation in mediation analysis with a bootstrap value of 5000.</p><p><strong>Results: </strong>Relative Hb volume was negatively correlated with IAT scores (partial rho=-0.142, p=0.009). The IAT score was positively correlated with neuroticism (partial rho=0.430, p<0.001) and negatively correlated with extraversion, agreeableness and conscientiousness (partial rho=-0.213, p<0.001; partial rho=-0.279, p<0.001; and partial rho=-0.327, p<0.001). There was a significant indirect effect of Hb volume on this model (β=-0.061, p=0.048, boot 95% confidence interval: -0.149 to -0.001).</p><p><strong>Conclusions: </strong>This study uncovered a crucial link between reduced Hb volume and heightened PIU. Our findings highlight neuroticism as a key risk factor for developing PIU. Moreover, neuroticism was shown to mediate the relationship between Hb volume and PIU tendency, offering valuable insight into the complexities of this interaction.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 1","pages":"e101694"},"PeriodicalIF":5.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for the diagnosis and treatment of depressive disorders by integrating Chinese and Western medicine (English edition).","authors":"Lanying Liu, Jianjun Wang, Wei Li, Jing Gao, Wangtao Li, Yan Li, Liyuan Luo, Liyuan Guo, Yiying Hu, Yongjun Chen, Hongyan Chen, Lin Yu, Bin Fen, Hongxiao Jia, Zhangjin Zhang, Zhaojun Yan, Wei Chen, Zhangsheng Yu, Zhen Wang","doi":"10.1136/gpsych-2024-101747","DOIUrl":"10.1136/gpsych-2024-101747","url":null,"abstract":"","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 1","pages":"e101747"},"PeriodicalIF":5.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}