Geriatrics & Gerontology International最新文献

{"title":"Eye care practitioners and falls prevention for older adults: A scoping review","authors":"Jingyi Chen,&nbsp;Khyber Alam,&nbsp;Si Ye Lee,&nbsp;Anne-Marie Hill","doi":"10.1111/ggi.15098","DOIUrl":"10.1111/ggi.15098","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Eye care practitioners are well-placed in the community to provide falls prevention advice to older adults, but existing literature offers scant insight into whether this occurs in practice. This scoping review aimed to map and synthesize the evidence for community eye care practitioners' awareness and behaviors in falls prevention in older adults, as well as barriers and enablers to implementation of falls evidence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This review process was guided by the Arksey and O'Malley framework for scoping reviews and PRISMA-ScR guidelines. MEDLINE, CINAHL Complete, Embase, Web of Science and OpenMD were searched for published and gray literature between January 1990 to October 2024. Data were mapped against the World Falls Guidelines framework of: (i) risk stratification, (ii) assessment, and (iii) management, and a barriers and enablers framework.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 19 sources met the inclusion criteria. Few studies directly captured results from eye care practitioners. The results suggested a gap in implementation of falls guideline evidence. Community eye care practitioners had low levels of awareness about falls, and were not routinely implementing falls history taking, risk stratification and assessment of contrast, visual fields, and stereopsis. Eye care practitioners might not be referring patients for exercise and environmental interventions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The evidence suggests that eye care practitioners have some awareness of falls prevention, but might benefit from better understanding of evidence-based falls guidelines. There appeared to be gaps that exist between evidence and translation into practice. Future studies should explore practitioner experiences and implementation efforts to improve falls prevention in community eye care. <b>Geriatr Gerontol Int 2025; 25: 337–345</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 3","pages":"337-345"},"PeriodicalIF":2.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ggi.15098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between social frailty, use of digital device and depression among community-dwelling older adults: A population-based cross-sectional study","authors":"Mina Hwang,&nbsp;Yeji Hwang","doi":"10.1111/ggi.70005","DOIUrl":"10.1111/ggi.70005","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Social frailty is prevalent among community-dwelling older adults, and it is a leading factor associated with depression in this population. Digital devices can provide opportunities to engage in social or recreational activities, helping to reduce depression in older adults, regardless of their level of social frailty. However, little is known about which specific activities older adults engage in with such devices can lower depression. Therefore, this study aimed to examine which activities are associated with a lower likelihood of developing depression after adjusting for social frailty.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A secondary data analysis was carried out using the 2020 National Survey of Older Koreans, which includes a nationally representative sample of community-dwelling older adults in Korea (<i>n</i> = 9920). Depression was measured using the Geriatric Depression Scale, social frailty was measured with the Social Frailty Index and digital device use was measured using 11 items from the survey. The 11 items included sending and receiving text messages, searching for information, taking pictures or videos, watching videos, playing games, and more. The data were analyzed using weighted logistic regressions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In this study, 13% of participants showed depression. After adjusting for social frailty, the following activities were significantly related to lower odds of depression: playing games (OR 0.618, 95% CI 0.438–0.872, <i>P</i> = 0.006), and searching for and installing applications (OR 0.590, 95% CI 0.372–0.937, <i>P</i> = 0.025).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Older adults engaging in activities using digital devices are less likely to develop depression. Educational programs should be developed to teach older adults about various activities they can perform with digital devices. <b>Geriatr Gerontol Int 2025; 25: 434–441</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 3","pages":"434-441"},"PeriodicalIF":2.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ggi.70005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"For early diagnosis of young patients with Werner syndrome: Indication for genetic testing","authors":"Tetta Sato,&nbsp;Yoshiro Maezawa,&nbsp;Hisaya Kato,&nbsp;Mayumi Shoji,&nbsp;Yukari Maeda,&nbsp;Hiyori Kaneko,&nbsp;Kazuto Aono,&nbsp;Yoshitaka Kubota,&nbsp;Toshibumi Taniguchi,&nbsp;Toshiyuki Oshitari,&nbsp;Sei-Ichiro Motegi,&nbsp;Yoichi Takami,&nbsp;Hironori Nakagami,&nbsp;Akira Taniguchi,&nbsp;Kazuhisa Watanabe,&nbsp;Minoru Takemoto,&nbsp;Masaya Koshizaka,&nbsp;Rika Kosaki,&nbsp;Muneaki Matsuo,&nbsp;Hideo Kaneko,&nbsp;Kenji Ihara,&nbsp;Junko Oshima,&nbsp;Koutaro Yokote,&nbsp;Japan Ministry of Health, Labor and Welfare Research Project for Intractable Diseases, Genetic Progeroid Syndrome Research Group","doi":"10.1111/ggi.15094","DOIUrl":"10.1111/ggi.15094","url":null,"abstract":"&lt;p&gt;Werner syndrome (WS) is an autosomal recessive genetic disorder caused by mutations in the &lt;i&gt;WRN&lt;/i&gt; gene, which encodes a RecQ-type DNA helicase. Although this disease is known to show early aging phenotypes, such as gray hair, alopecia, cataracts, skin lesions, diabetes and dyslipidemia, starting shortly after puberty,&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; it is generally diagnosed in patients aged in their 40s, indicating a potential delay in timely assessment and intervention.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; In addition, because of the growing awareness of this disease, the patients suspected to have WS at a young age is increasing. Thus, there is an urgent need to diagnose WS at a young age; however, its strategy has not yet been established.&lt;/p&gt;&lt;p&gt;There have been no reports on the clinical symptoms among younger WS patients, despite the fact that the prevalence of each symptom in all age groups has been reported.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; To facilitate early detection and diagnosis, we examined the prevalence for each symptom in patients diagnosed with WS aged between their 10s and 20s. Using PubMed, with results by year as “1965–2024”, article type as “Case Reports”, and AGE as “Child: birth–18 years”, “Young Adult: 19–24 years” and “Adult: 19–44 years”, we searched for “Werner syndrome” and found 454 references.&lt;/p&gt;&lt;p&gt;Then, we applied the Japanese diagnostic criteria for WS 2012,&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; because they are the only criteria whose diagnostic accuracy was validated using genetic testing.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; Of these, 30 patients aged 10–30 years were diagnosed as WS. Of the 30 patients, 13 tested positive by genetic testing. The remaining 17 were not genetically diagnosed, but were diagnosed as “definite” or “probable” based on clinical symptoms according to the diagnostic criteria.&lt;/p&gt;&lt;p&gt;The mean age at diagnosis was 23.6 years for genetically confirmed cases, and 24.6 years for untested cases, respectively. The prevalence for each symptom in each group and all patients is shown in Table 1. Also the symptoms for each patient are shown in Tables S1 and S2.&lt;/p&gt;&lt;p&gt;In the group with positive genetic testing, cataracts, hair changes, short stature and low bodyweight were the most common symptoms, followed by abnormalities in glucose or lipid metabolism. In the group without genetic testing, cataracts, hair changes, abnormalities in glucose or lipid metabolism, short stature and low bodyweight showed a 100% prevalence. In all 30 patients, cataracts and hair changes were the most common, followed by short stature and low bodyweight, abnormalities in glucose or lipid metabolism, and skin changes. Although the prevalence for hypogonadism was high, the small number of cases made them difficult to compare.&lt;/p&gt;&lt;p&gt;We then compared the data with those of the Japanese WS Registry 2023, in which the average age was 51.0 years (Table 1).&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt; The prevalences of skin changes, soft tissue calcification, bird-like faces and abnormal voi","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 3","pages":"468-470"},"PeriodicalIF":2.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ggi.15094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between school bullying and late-life depression: Evidence from the China health and retirement longitudinal study","authors":"You Zuo,&nbsp;Lan Liu,&nbsp;Gong Chen,&nbsp;Guogui Huang","doi":"10.1111/ggi.70000","DOIUrl":"10.1111/ggi.70000","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Existing literature suggests that school bullying can have long-lasting effects on mental health, but its specific impact on late-life depression remain underexplored. This study aims to investigate the association between early-life school bullying experiences and depression symptoms in old age and the variations by sex, place of residence and educational level.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Data were derived from the Life History Survey of the China Health and Retirement Longitudinal Study in 2014, including 4333 older adults aged ≥60 years. School bullying was assessed on the basis of self-reported experiences during childhood. Depression symptoms were measured using the Center for Epidemiologic Studies Depression Scale-10. Poisson regression analyses were performed to examine the relationship between early-life school bullying experience and late-life depression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 4333 respondents, 607 (14%) reported being bullied during childhood, and 1274 (29.4%) exhibited symptoms of depression. Older adults who experienced school bullying were 1.17 times more likely to exhibit depression symptoms compared with those without such experiences (prevalence ratio [PR], 1.173; 95% confidence interval [CI], 1.027–1.3390). This association was more prominent among women (PR, 1.284; 95% CI, 1.093–1.475), rural residents (PR, 1.477; 95% CI, 1.210–1.803) and those with education at primary school level (PR, 1.172; 95% CI, 1.017–1.352). The results remained robust using an alternative school bullying cutoff and after imputing all missing data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Early-life school bullying is a significant risk factor for depression in later life, with its impact being particularly pronounced among women, rural residents and those with lower educational levels. These findings highlight the need for targeted mental health interventions for individuals with a history of early-life school bullying to mitigate long-term psychological effects. <b>Geriatr Gerontol Int 2025; 25: 454–462</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 3","pages":"454-462"},"PeriodicalIF":2.4,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ggi.70000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between early retirement and risk of frailty in later life: A population-based longitudinal study","authors":"Tsui-Hung Wang,&nbsp;Shao-Yun Chien,&nbsp;Wan-Ju Cheng,&nbsp;Ya-Wen Huang,&nbsp;Shi-Heng Wang,&nbsp;Wei-Lieh Huang,&nbsp;Ya-Ling Tzeng,&nbsp;Chih-Cheng Hsu,&nbsp;Wei J. Chen,&nbsp;Chi-Shin Wu","doi":"10.1111/ggi.15096","DOIUrl":"10.1111/ggi.15096","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Early retirement is prevalent and can alter daily habits, potentially impacting health. This study aims to explore the association between early retirement and frailty and to examine the modifying effect of sociodemographic characteristics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a population-based matched cohort study that included 1 779 628 early retirees aged 45–64 years and an equal number of employed individuals from Taiwan's National Health Insurance (2010–2021). Early retirement was defined as unemployment before age 65 years without reemployment. Frailty was assessed using the multimorbidity Frailty Index (mFI) based on the International Classification of Diseases, 10th Revision, Clinical Modification codes. Covariates such as demographics, socioeconomic status, and medical conditions were adjusted using propensity score weighting. Generalized estimating equations determined the association between early retirement and frailty. Subgroup analyses were conducted by age, sex, income and occupation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results showed that early retirees exhibited a significant increase in mFI score changes compared to their employed counterparts, with a coefficient rise of 0.372 (95% CI, 0.303–0.441). Early retirement was associated with higher mFI scores among younger individuals (aged 45–54 years); men; those with lower incomes; and individuals working as employers, private-sector employees, freelancers, farmers and fishers. Conversely, early retirement was linked to lower mFI scores among civil servants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings support the development of targeted retirement policies and occupational health programs. Further research on frailty mediators, such as physical activity, diet and social participation is crucial for improving clinical care and informing health policies to mitigate the negative impacts of early retirement on high-risk populations. <b>Geriatr Gerontol Int 2025; 25: 425–433</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 3","pages":"425-433"},"PeriodicalIF":2.4,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between decreased activities of daily living, decreased physical strength and future weight loss in community-dwelling older adults","authors":"Kazuhiro Hoshi MD,&nbsp;Koji Shibasaki MD, PhD,&nbsp;Mitsutaka Yakabe MD, PhD,&nbsp;Tatsuya Hosoi MD, PhD,&nbsp;Shoya Matsumoto MD, PhD,&nbsp;Shizuru Yamada MD,&nbsp;Seiji Hashimoto MD,&nbsp;Masahiro Akishita MD, PhD,&nbsp;Sumito Ogawa MD, PhD","doi":"10.1111/ggi.15097","DOIUrl":"10.1111/ggi.15097","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Weight loss is among the diagnostic criteria for frailty and is associated with increased mortality among older people. This study aimed to identify factors associated with future weight loss among community-dwelling older people.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A multidimensional questionnaire-based prospective cohort study was carried out. The questionnaire included the Kihon Checklist, instrumental activities of daily living (IADL) scale, Activity Scale for the Elderly, Fall Risk Index-21 and Dietary Variety Score. The associations among the scores of the scales and the 3-year weight change from study entry were assessed. The participants were categorized into the non-weight loss group, &lt;4.5-kg weight loss group and &gt;4.5-kg weight loss group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 982 participants completed the follow up. Their mean age was 73.4 ± 5.1 years, and 545 (55.5%) participants were women. Among the IADL questionnaire subitems, depositing and withdrawing money from the bank, walking, interacting with people, taking medication, and cooking were associated with 3-year weight loss. Furthermore, cooking was strongly associated with weight loss. However, there was no association between eating frequency and weight loss. Finally, low IADL and physical function scores were associated with a doubled risk of future weight loss.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>An association was found between 3-year weight loss and physical fitness and IADL, such as walking, among community-dwelling older people. Future weight loss in older people can be caused by a decline in IADL and physical fitness before a decline in dietary intake. Furthermore, maintaining IADL and physical fitness can prevent future weight loss and frailty. <b>Geriatr Gerontol Int 2025; 25: 418–424</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 3","pages":"418-424"},"PeriodicalIF":2.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ggi.15097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Chronic low back pain and decreased physical activity are associated with social frailty incidence among community-dwelling older adults","authors":"Orhan Cicek,&nbsp;Ilkay Ogut,&nbsp;Merve Yilmaz Kars,&nbsp;Ilyas Akkar,&nbsp;Zeynep Iclal Turgut,&nbsp;Mustafa Hakan Dogan,&nbsp;Muhammet Cemal Kizilarslanoglu","doi":"10.1111/ggi.15095","DOIUrl":"10.1111/ggi.15095","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 3","pages":"475-476"},"PeriodicalIF":2.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of rate of force development in the quadriceps without increased maximal voluntary contraction through cardiac rehabilitation: A case series of three older patients","authors":"Takuji Adachi,&nbsp;Taisei Sano,&nbsp;Kenichi Shibata,&nbsp;Hideki Kitamura","doi":"10.1111/ggi.15091","DOIUrl":"10.1111/ggi.15091","url":null,"abstract":"&lt;p&gt;Cardiac rehabilitation is a comprehensive disease management program for patients with cardiovascular disease, offering established benefits in improving exercise tolerance, quality of life and prognosis.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; However, with the aging population, there is a growing need for rehabilitation strategies that enhance physical performance and activities of daily living in older patients. The rate of force development (RFD), defined as the velocity of force generation during muscle contraction, has emerged as a key indicator of muscle function, closely linked to daily functional tasks and the risk of falls.&lt;span&gt;&lt;sup&gt;2-4&lt;/sup&gt;&lt;/span&gt; Despite its potential relevance for designing tailored training regimens, clinical reports on the trajectory of RFD through conventional cardiac rehabilitation remain scarce.&lt;/p&gt;&lt;p&gt;We evaluated RFD in the quadriceps of three patients before and after a 3-month standard cardiac rehabilitation. The program followed guidelines,&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt; and included supervised exercise sessions at the hospital (one session per week: ergometer cycling, treadmill walking and resistance training), physical activity guidance including home exercises and educational classes. The measurement procedure of RFD and its reliability have been previously described.&lt;span&gt;&lt;sup&gt;6&lt;/sup&gt;&lt;/span&gt; RFD values were calculated as the mean change in torque per second (Δtorque / Δtime) during intervals of 0–50 ms (RFD&lt;sub&gt;50&lt;/sub&gt;), 0–100 ms (RFD&lt;sub&gt;100&lt;/sub&gt;) and 0–200 ms (RFD&lt;sub&gt;200&lt;/sub&gt;; unit: Nm/kg [bodyweight]/s). Minimal detectable change (MDC&lt;sub&gt;95&lt;/sub&gt;) for each indicator was calculated using the following formula: MDC&lt;sub&gt;95&lt;/sub&gt; = standard error of measurement (SEM) × 1.96 × √2. Based on our preliminary data,&lt;span&gt;&lt;sup&gt;6&lt;/sup&gt;&lt;/span&gt; the standard deviation (SD) of the two measurements and the interclass correlation coefficient (ICC) for calculating (SEM) were assumed as follows: RFD&lt;sub&gt;50&lt;/sub&gt;, SD 3.3, ICC 0.810; RFD&lt;sub&gt;100&lt;/sub&gt;, SD 1.0, ICC 0.918; RFD&lt;sub&gt;200&lt;/sub&gt;, SD 0.7, ICC 0.930; maximal voluntary contraction [MVC], SD 0.15, ICC 0.947.&lt;/p&gt;&lt;p&gt;Case 1 was a 76-year-old man who underwent coronary artery bypass grafting suffering from angina pectoris (hypertension, diabetes mellitus, left ventricular ejection fraction 50%, N-terminal pro brain natriuretic peptide 248 pg/mL, no history of heart failure, mean step counts 5197 steps/day at 3 months). Grip strength remained unchanged at 24 kg from baseline to follow up. The Short Physical Performance Battery (SPPB) score improved from 9 to 12 points, indicating a meaningful enhancement in physical performance.&lt;span&gt;&lt;sup&gt;7&lt;/sup&gt;&lt;/span&gt; RFD values increased after cardiac rehabilitation, with RFD&lt;sub&gt;100&lt;/sub&gt; and RFD&lt;sub&gt;200&lt;/sub&gt; exceeding MDC&lt;sub&gt;95&lt;/sub&gt;, whereas MVC did not change significantly (Figure 1).&lt;/p&gt;&lt;p&gt;Case 2 was an 81-year-old man hospitalized for heart failure with reduced ejection fraction (dyslipidemia, prior myocardial infarction, left ventricular","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 3","pages":"463-465"},"PeriodicalIF":2.4,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ggi.15091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Japanese version of the Clinical Frailty Scale","authors":"Hitoshi Komiya,&nbsp;Yusuke Suzuki,&nbsp;Kazuhisa Watanabe,&nbsp;Masaaki Nagae,&nbsp;Hirotaka Nakashima,&nbsp;Chisato Fujisawa,&nbsp;Shuzo Miyahara,&nbsp;Tomihiko Tajima,&nbsp;Tomomichi Sakai,&nbsp;Yasushi Takeya,&nbsp;Taro Kojima,&nbsp;Yumi Umeda-Kameyama,&nbsp;Shuji Kawashima,&nbsp;Hiroyuki Umegaki","doi":"10.1111/ggi.15092","DOIUrl":"10.1111/ggi.15092","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Among the many screening tools developed to detect frailty and disability in older adults, the Clinical Frailty Scale (CFS) is a valid, reliable, and easy-to-use tool and has been translated into several languages. The aim of this study was to demonstrate the validity of the Japanese version of the CFS (CFS-J).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The necessary permissions were obtained from Rockwood and colleagues. The Japanese version was prepared by translation (English to Japanese) and verified by back translation (Japanese to English). Concurrent criterion validity was assessed by evaluating the extent to which CFS relates to the Frailty Index (FI), the Frailty Index based on a Comprehensive Geriatric Assessment (FI-CGA), and Performance Status (PS), using Kendall's tau.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 223 patients admitted to the geriatric ward of an acute hospital between June 2021 and March 2023 were analyzed in the validation study. Mean age was 84.9 ± 5.9 years (range, 67–101 years), 128 (57.4%) were women, and the mean body mass index was 20.9 ± 4.0 kg/m². In a correlation analysis, significantly positive associations were found between the CFS-J and the FI (<i>r</i> = 0.713, <i>P</i> &lt; 0.001), the FI-CGA (<i>r</i> = 0.691, <i>P</i> &lt; 0.001), and PS (<i>r</i> = 0.669, P &lt; 0.001) for numerical variables. Significant positive associations were also found between the CFS-J and the FI (<i>r</i> = 0.567, <i>P</i> &lt; 0.001) and the FI-CGA (<i>r</i> = 0.591, <i>P</i> &lt; 0.001) for categorical valuables.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The CFS-J was found to be a valid instrument for identifying frailty in Japanese inpatients. <b>Geriatr Gerontol Int 2025; 25: 411–417</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 3","pages":"411-417"},"PeriodicalIF":2.4,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ggi.15092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between serum YKL-40 and VILIP 1 levels and brain volume in dementia patients","authors":"Didem Tezen,&nbsp;Esra Koçhan Kızılkılıç,&nbsp;Ayşegül Akkan Suzan,&nbsp;Ahmet Öz,&nbsp;Nazrin Gulmammadli,&nbsp;Serdar Arslan,&nbsp;Osman Kızılkılıç,&nbsp;Dildar Konukoğlu,&nbsp;Veysi Demirbilek,&nbsp;Melda Bozluolçay","doi":"10.1111/ggi.15075","DOIUrl":"10.1111/ggi.15075","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Alzheimer's disease (AD) is a chronic, progressive cognitive disorder characterized by prominent episodic memory impairment. The contribution of neuronal damage and neuroinflammation to this process has been investigated by measuring various substances. Two of the most promising substances in serum and plasma studies are visinin-like protein 1 (VILIP-1) and tyrosine (Y), lysine (K), leucine (L)-40 (YKL-40). These markers may lead to early diagnosis and new treatment options.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Serum VILIP-1 and YKL-40 levels were analyzed in 33 probable AD patients and 23 healthy controls. Cranial magnetic resonance imaging (MRI) was used for volumetric measurements. The results were compared with the control group and then the correlation analyze between markers and volumetric measurements of the patient group was achieved.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The right and left hippocampus and amygdala, left medial temporal, right rostral anterior cingulate, total brain, cortex, white matter, gray matter, subcortical gray matter, right and left total cortex volumes of the probable AD group were significantly lower than those of the control group. In the correlation analysis, the YKL-40 level and left posterior cingulate volume and the VILIP-1 level and left amygdala volume were negatively correlated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In AD, there is atrophy of the limbic structures, cortex, and white matter. While the relationship between these regions and neurodegenerative markers remains unclear, our findings highlight a notable correlation between YKL-40 and VILIP-1 levels and the left amygdala and left posterior cingulate cortex, respectively. <b>Geriatr Gerontol Int 2025; 25: 374–379</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 3","pages":"374-379"},"PeriodicalIF":2.4,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}