Geriatrics & Gerontology International最新文献

{"title":"Cognitive impairment and domain-specific life satisfaction among older adults: Findings from the Korean National Longitudinal Study on Aging","authors":"Inmyung Song,&nbsp;Dong-Sook Kim","doi":"10.1111/ggi.15053","DOIUrl":"10.1111/ggi.15053","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Overall life satisfaction among older adults is associated with cognitive impairment. However, little is known regarding its influence on satisfaction with specific domains of life, such as health, income status, and marital relationship. This study aims to analyze the relationship between cognitive impairment and satisfaction with specific domains of life in older Koreans.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study used data from the Korean National Longitudinal Study on Aging from 2014 to 2020. Cognitive function was measured with the Mini-Mental State Examination. Four different models are used to assess the effect of cognitive impairment on four different measures of life satisfaction. The dependent variable in each model was overall life satisfaction, satisfaction with health status, satisfaction with economic status, and satisfaction with marital relationship, respectively. A generalized estimating equation modeling approach was used to take advantage of panel data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the weighted sample, 54.1% of the participants were women. The mean (± standard error) age of all participants was 68.9 (±0.1) years old. A total of 1671 participants (24.8%) had cognitive impairment. After adjustment of other variables, individuals without cognitive impairment were more satisfied with overall life (B = 2.75, <i>P</i> &lt; 0.001), health status (B = 4.31, <i>P</i> &lt; 0.001), economic status (B = 2.83, <i>P</i> &lt; 0.001) and marital relationship (B = 3.36, <i>P</i> &lt; 0.001) than impaired individuals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Cognitive impairment in old age is significantly associated with overall life satisfaction as well as satisfaction with several domains of life, such as health, income status, and marital relationship. Cognitive impairment is more strongly associated with satisfaction with health status and marital relationship than on satisfaction with economic status. <b>Geriatr Gerontol Int 2025; 25: 182–189</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"182-189"},"PeriodicalIF":2.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of eribulin monotherapy for bone marrow carcinomatosis of breast cancer in a patient with Werner syndrome","authors":"Akihito Fujimi,&nbsp;Yasuhiro Nagamachi,&nbsp;Naofumi Yamauchi,&nbsp;Riku Hasebe,&nbsp;Naoki Onoyama,&nbsp;Naotaka Hayasaka,&nbsp;Teppei Matsuno,&nbsp;Kazuhiko Koike,&nbsp;Yoshiro Gotoh,&nbsp;Kohji Ihara,&nbsp;Junji Kato,&nbsp;Takuji Nishisato,&nbsp;Kazuyuki Murase,&nbsp;Goro Kutomi,&nbsp;Tokimasa Hida,&nbsp;Hisashi Uhara,&nbsp;Kohichi Takada","doi":"10.1111/ggi.15070","DOIUrl":"10.1111/ggi.15070","url":null,"abstract":"<p>Various complications and potential risks of serious adverse events lessens the intensity of chemotherapy in patients with Werner syndrome. Bone marrow carcinomatosis of breast cancer was developed in a patient with Werner syndrome. Eribulin proved well tolerated and effective in improving severe thrombocytopenia, leading to platelet transfusion-free status.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"316-318"},"PeriodicalIF":2.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the factors contributing to symptoms worsening in elderly care-facility residents with dementia: Difficulties encountered in dealing with COVID-19 clusters","authors":"Junpei Tanabe,&nbsp;Hungu Jung,&nbsp;Yuji Iwamoto,&nbsp;Shinya Ishii","doi":"10.1111/ggi.15057","DOIUrl":"10.1111/ggi.15057","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"323-325"},"PeriodicalIF":2.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for dysphagia in older people: A validation study of the psychometric properties of the Danish 4 Question Test (4QT-DK)","authors":"Sabina Mette Staal,&nbsp;Karl Bang Christensen,&nbsp;David Smithard,&nbsp;Albert Westergren,&nbsp;Dorte Melgaard","doi":"10.1111/ggi.15050","DOIUrl":"10.1111/ggi.15050","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The four-item questionnaire test (4QT) is a simple screening measure of dysphagia for older people. A positive answer to any item indicates the need for further assessment. The 4QT is fast, simple to apply and requires no training beforehand. However, it is not translated to Danish, and the psychometric properties in an older Danish population are unknown. The aim was to translate the 4QT to Danish, determine criterion validity according to the existing measures, the Minimal Eating Observation Form-II (MEOF-II) and Volume-Viscosity Swallow Test (V-VST), and determine construct and structural validity and reliability by exploring whether 4QT fits the assumptions of the Rasch model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The 4QT was translated and back-translated. A total of 73 participants aged ≥65 years were included and screened with the 4QT-DK, and assessed using the V-VST and MEOF-II. Criterion validity was assessed compared with the V-VST and MEOF-II according to sensitivity, specificity and predictive values. Construct and structural validity were examined using confirmatory factor analysis and Rasch model analysis investigating item and person fit, differential item functioning for sex, age, primary disease and local dependency. Reliability was assessed using Cronbach's coefficient alpha.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>For criterion validity, the 4QT-DK showed high sensitivity (84% and 90% with the V-VST and MEOF-II, respectively). As expected, specificity was lower (36%, and 42%). Analyses confirmed the psychometric validity of the 4QT-DK. Reliability was low (Cronbach's alpha = 0.58) due to the number of items.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The 4QT-DK is a valid and sensitive measure for screening older people for dysphagia. Further studies are required to assess the psychometric properties and confirm findings in a larger Danish sample. <b>Geriatr Gerontol Int 2025; 25: 294–299</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"294-299"},"PeriodicalIF":2.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of brain volume changes associated with aging: Results from the fourth research on osteoarthritis/osteoporosis against disability survey","authors":"Koji Nakajima,&nbsp;Akitoshi Ogawa,&nbsp;Hiroyasu Kodama,&nbsp;Tomohiko Shirokoshi,&nbsp;Takahiro Osada,&nbsp;Seiki Konishi,&nbsp;Chiaki Horii,&nbsp;Yasushi Oshima,&nbsp;Toshiko Iidaka,&nbsp;Shigeyuki Muraki,&nbsp;Hiroyuki Oka,&nbsp;Hiroshi Kawaguchi,&nbsp;Toru Akune,&nbsp;Hiroshi Hashizume,&nbsp;Hiroshi Yamada,&nbsp;Munehito Yoshida,&nbsp;Kozo Nakamura,&nbsp;Masaaki Shojima,&nbsp;Sakae Tanaka,&nbsp;Noriko Yoshimura","doi":"10.1111/ggi.15033","DOIUrl":"10.1111/ggi.15033","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aims to investigate the impact of aging on brain volume among community residents in Japan, focusing on trends over time and specific brain structures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed data from the fourth survey (2015–2016) of the Research on Osteoarthritis/Osteoporosis Against Disability project, encompassing 2146 community residents from Japan's mountainous and coastal regions. A total of 1755 participants (81.8% of the baseline population) underwent extensive data collection including lifestyle and health questionnaires, anthropometric measurements and brain magnetic resonance imaging. The imaging data were processed to examine correlations between total brain volume, gray matter volume (GMV), white matter volume (WMV), cerebrospinal fluid volume and participant age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Analysis showed significant sex differences in total brain volume, with GMV demonstrating a strong negative correlation with age – more pronounced than the moderate negative correlation seen in WMV. Cerebrospinal fluid volume exhibited a strong positive correlation with age. Notably, specific brain regions such as the bilateral amygdala, hippocampus, thalamus and primary motor cortex showed significant age-related volume reductions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study confirms that GMV and WMV are smaller in older individuals in the Japanese population, with more pronounced differences in GMV. The amygdala, hippocampus, thalamus and primary motor cortex were particularly affected. <b>Geriatr Gerontol Int 2025; 25: 279–286</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"279-286"},"PeriodicalIF":2.4,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of exercise on cognitive function and glycated hemoglobin A1c among patients with type 2 diabetes mellitus and cognitive impairment: A systematic review and meta-analysis","authors":"Xiaoxue Li,&nbsp;Bin Chen,&nbsp;Xinyuan Liu,&nbsp;Jingya Ma","doi":"10.1111/ggi.15061","DOIUrl":"10.1111/ggi.15061","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the effects of exercise versus without-exercise group on global cognitive function, executive function, glycated hemoglobin A1c (HbA1c) and fasting plasma glucose in patients with type 2 diabetes mellitus and cognitive impairment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic search of Cqvip, SinoMed, Wanfang Data, CINAHL, Cochrane, Embase, Pubmed, Lippincott, Web of Science and Scopus was carried out. Randomized control trials were selected. The risk of bias was evaluated using the Cochrane Risk of Bias tool. The random-effects model was used to obtain the pooled estimates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eight trials with 884 participants were included. Exercise could significantly improve global cognitive function (standardized mean difference 0.82, 95% CI 0.53–1.12), executive function measured by the Trail-Marking Test part B (mean difference −20.43, 95% CI −36.20, −4.66), glycated hemoglobin A1c (%; mean difference −0.58, 95% CI −0.88, −0.29) and fasting plasma glucose (mg/dL; mean difference −17.61, 95% CI −32.67, −2.54).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Exercise can improve cognitive function, glycated hemoglobin A1c and fasting plasma glucose among type 2 diabetes mellitus patients with cognitive impairment. Additional studies with higher methodological quality are expected to draw more definite conclusions. This finding could provide a reference for clinical decision-making and guide future research initiatives. <b>Geriatr Gerontol Int 2025; 25: 148–159</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"148-159"},"PeriodicalIF":2.4,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural correlates of age-related hearing loss: An MRI and FDG-PET study","authors":"Ryota Sakurai,&nbsp;Yuri Kim,&nbsp;Maki Nishinakagawa,&nbsp;Keigo Hinakura,&nbsp;Yoshinori Fujiwara,&nbsp;Kenji Ishii","doi":"10.1111/ggi.15052","DOIUrl":"10.1111/ggi.15052","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Age-related hearing loss (ARHL) is a common problem among older adults and contributes to adverse health outcomes such as cognitive impairment. However, the neural mechanisms underlying ARHL remain unclear. We aimed to reveal the structural and metabolic (i.e., neural activity) correlates of ARHL using magnetic resonance imaging (MRI) and positron emission tomography with 18F-fluorodeoxyglucose (FDG-PET).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 162 community-dwelling older adults without cerebral disorders or cognitive impairment (Mini-Mental State Examination score &lt; 24) were included in this study. Auditory acuity was measured using a pure-tone average (PTA) of hearing thresholds for the better-hearing ear for 0.5–4-kHz tones. ARHL was defined as a PTA of &gt;40 dB (i.e., greater than moderate hearing loss). The participants then underwent MRI and FDG-PET at rest to assess changes in brain structure and activity associated with ARHL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 162 participants, 27 (16.6%) had ARHL. A region-of-interest analysis focusing on the bilateral superior temporal gyrus showed significantly lower glucose metabolism in this region, including in the auditory cortex (BA 41 and 42), in participants with ARHL than in those without ARHL. In contrast, no significant structural differences were observed between the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings suggest that, prior to structural changes, the effects of ARHL may manifest in neural activity, which is strongly reflected in the regions involved in auditory processing. It is possible that ARHL first alters neural activity in auditory-related regions owing to reduced auditory stimulation. <b>Geriatr Gerontol Int 2025; 25: 300–306</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"300-306"},"PeriodicalIF":2.4,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional disparities in home health care utilization for older adults and their associated factors at the secondary medical area level: A nationwide study in Japan” [Letter]","authors":"Sari Luthfiyah,&nbsp;Wannarat Lawang,&nbsp;Fathimath Shifaza","doi":"10.1111/ggi.15069","DOIUrl":"10.1111/ggi.15069","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"329-330"},"PeriodicalIF":2.4,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in biomarkers for senescence: Bridging basic research to clinic","authors":"Takeshi Fukumoto,&nbsp;Tatsuo Shimosawa,&nbsp;Mitsutaka Yakabe,&nbsp;Shota Yoshida,&nbsp;Yohko Yoshida","doi":"10.1111/ggi.15054","DOIUrl":"10.1111/ggi.15054","url":null,"abstract":"<p>In this review, we review the current status of biomarkers for aging and possible perspectives on anti-aging or rejuvenation from the standpoint of biomarkers. Aging is observed in all cells and organs, and we focused on research into senescence in the skin, musculoskeletal system, immune system, and cardiovascular system. Commonly used biomarkers include SA-βgal, cell-cycle markers, senescence-associated secretory phenotype (SASP) factors, damage-associated molecular patterns (DAMPs), and DNA-damage-related markers. In addition, each organ or cell has its specific markers. Generally speaking, a combination of biomarkers is required to define age-related changes. When considering the translation of basic research, biomarkers that are highly sensitive, highly specific, with validation and reliability as well as being non-invasive are optimal; however, currently reported markers do not fulfill the prerequisite for biomarkers. In addition, rodent models of aging do not necessarily represent human aging, and markers in rodent or cell models are not applicable in clinical settings. The prerequisite of clinically applicable biomarkers is that they provide useful information for clinical decision-making, such as predicting disease risk, diagnosing disease, monitoring disease progression, or guiding treatment decisions. Therefore, the development of non-invasive robust, reliable, and useful biomarkers in humans is necessary to develop anti-aging therapy for humans. <b>Geriatr Gerontol Int 2025; 25: 139–147</b>.</p>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"139-147"},"PeriodicalIF":2.4,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ggi.15054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on “Frailty as a predictor of mortality in the oldest old: A systematic review and meta-analysis”","authors":"Shubham Kumar,&nbsp;Ahmad Neyazi,&nbsp;Rachana Mehta,&nbsp;Ranjana Sah","doi":"10.1111/ggi.15065","DOIUrl":"10.1111/ggi.15065","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"328-329"},"PeriodicalIF":2.4,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}