Tareq Alsaleh, Baha Fawwaz, Mohamad Khaled Almujarkesh, Hamza Akram, Calvin Jose, Nouman Shafique, Amna S Malik, Mustafa Arain, John George
{"title":"Antibiotic Prophylaxis for Peroral Cholangioscopy: A Systematic Review and Meta-analysis.","authors":"Tareq Alsaleh, Baha Fawwaz, Mohamad Khaled Almujarkesh, Hamza Akram, Calvin Jose, Nouman Shafique, Amna S Malik, Mustafa Arain, John George","doi":"10.1016/j.gie.2026.08.018","DOIUrl":"https://doi.org/10.1016/j.gie.2026.08.018","url":null,"abstract":"<p><strong>Background and aims: </strong>Antibiotic prophylaxis is commonly used before ERCP with peroral cholangioscopy, but supporting evidence is limited. We evaluated whether prophylaxis reduces post-procedural cholangitis after cholangioscopy.</p><p><strong>Methods: </strong>We searched Embase, PubMed, Web of Science, and Scopus through February 2026 for studies reporting cholangitis stratified by prophylaxis exposure. Random-effects meta-analysis was used to pool risk ratios.</p><p><strong>Results: </strong>Six studies including 2,531 patients and 2,575 procedures were included. The pooled cholangitis rate was 3.0% with prophylaxis and 7.8% without prophylaxis. Antibiotic prophylaxis was associated with lower cholangitis risk (risk ratio, 0.46; 95% confidence interval, 0.22-0.95; I<sup>2</sup> = 40.4%), although the estimate was of borderline significance and not robust to individual study removal. Certainty of evidence was very low.</p><p><strong>Conclusions: </strong>Antibiotic prophylaxis was associated with a reduction in post-cholangioscopy cholangitis that was of borderline significance and sensitive to individual studies. Prospective studies are needed to define optimal patient selection and regimens.</p>","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148791007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sung Yong Han, Dongwook Oh, Jung Wan Choe, Jong Hyun Lee, Moon Jae Chung, Sung Ill Jang, Se Woo Park, Jin Seok Park, Min Jae Yang, Eui Joo Kim, Jae Hee Cho
{"title":"Response.","authors":"Sung Yong Han, Dongwook Oh, Jung Wan Choe, Jong Hyun Lee, Moon Jae Chung, Sung Ill Jang, Se Woo Park, Jin Seok Park, Min Jae Yang, Eui Joo Kim, Jae Hee Cho","doi":"10.1016/j.gie.2026.07.002","DOIUrl":"https://doi.org/10.1016/j.gie.2026.07.002","url":null,"abstract":"","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148791100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corrigendum to \"Association between inflammatory bowel disease and hidradenitis suppurativa: an international multicenter retrospective study\" Gastrointest Endosc 2026;103(5, Suppl):S-1012–S-1013","authors":"","doi":"10.1016/j.gie.2026.06.030","DOIUrl":"https://doi.org/10.1016/j.gie.2026.06.030","url":null,"abstract":"","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":"13 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148717152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ishank Johri, Vikram Bhatia, Amar Mukund, Archana Rastogi, Chaggan Bihari, Srajit Singh, Rajan Vijayaraghavan, Phool Chand, Jaifrin Daniel
{"title":"EUS-guided biopsy using 19-gauge Franseen needle versus percutaneous ultrasound-guided biopsy using 18-gauge full-core cutting needle for parenchymal liver disease: A randomized controlled, non-inferiority trial.","authors":"Ishank Johri, Vikram Bhatia, Amar Mukund, Archana Rastogi, Chaggan Bihari, Srajit Singh, Rajan Vijayaraghavan, Phool Chand, Jaifrin Daniel","doi":"10.1016/j.gie.2026.07.046","DOIUrl":"https://doi.org/10.1016/j.gie.2026.07.046","url":null,"abstract":"<p><strong>Background and aims: </strong>There is limited data comparing endoscopic ultrasound-guided liver biopsy (EUS-LB) with percutaneous ultrasound-guided liver biopsy (PC-LB) regarding tissue adequacy, histologic yield, adverse events, and patient satisfaction.</p><p><strong>Methods: </strong>In this single-center, parallel-group, non-inferiority trial, we randomized participants 1:1 to EUS-LB (19-G Franseen-tip biopsy needle; modified wet-heparin suction; left and/or right lobe) or PC-LB (18-G BioPince™ full-core needle; right lobe). The primary endpoint was specimen adequacy, defined as total specimen length (TSL) ≥15 mm and complete portal tracts (CPT) ≥8. Non-inferiority was assessed using absolute risk difference with a prespecified margin of -10%.</p><p><strong>Results: </strong>Ninety participants were randomized. In intention-to-treat analysis, the primary endpoint was achieved in 44/45(97.8%) of EUS-LB and 29/45(64.4%) of PC-LB group (risk difference +33.3%; 95%CI: +17.9% to +48.1%), meeting non-inferiority and demonstrating superiority (p<0.001). With EUS-LB and PC-LB, the median TSL was 6.9cm versus 2.0cm and the median CPT number was 42 versus 9, respectively (both p<0.001). Even a single pass of EUS-LB outperformed PC-LB, with respect to sample adequacy, TSL, total CPT, and biopsy area (all p<0.001). PC-LB specimens were less fragmented (median 1 vs 13; p<0.001) and had greater median width (747.8μm vs. 667.2μm; p<0.001). Adverse events occurred more frequently with EUS-LB (26.7% vs. 4.4%; p=0.007); all but one were minor. Post-procedural pain was minimal, and satisfaction ratings were high in both groups.</p><p><strong>Conclusions: </strong>EUS-LB was non-inferior and superior to PC-LB for the prespecified adequacy endpoint, yielding substantially greater specimen length and CPT counts, with more frequent but predominantly minor adverse events.</p><p><strong>Trial registration: </strong>CTRI/2023/10/058529; NCT06047327.</p>","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Best of Colonoscopy for 2026","authors":"David L. Diehl","doi":"10.1016/j.gie.2026.07.045","DOIUrl":"https://doi.org/10.1016/j.gie.2026.07.045","url":null,"abstract":"","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":"4 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148715512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jintao Guo, Yuan Sun, Guoxin Wang, Sheng Wang, Nan Ge, Jinlong Hu, Shupeng Wang, Rongmin Xu, Siyu Sun
{"title":"Retrievable Anchor-Assisted Endoscopic Ultrasound guided Gastroenterostomy for Diverse Clinical Scenarios of Upper Gastrointestinal Obstruction: A Pilot Feasibility Study.","authors":"Jintao Guo, Yuan Sun, Guoxin Wang, Sheng Wang, Nan Ge, Jinlong Hu, Shupeng Wang, Rongmin Xu, Siyu Sun","doi":"10.1016/j.gie.2026.08.007","DOIUrl":"https://doi.org/10.1016/j.gie.2026.08.007","url":null,"abstract":"<p><strong>Background and aims: </strong>Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) is a promising treatment for gastric outlet obstruction (GOO), but is technically challenging. This study aimed to evaluate the safety and effectiveness of a novel technique, retrievable anchor-assisted EUS-GE (AA-EUS-GE).</p><p><strong>Methods: </strong>In this pilot feasibility study, patients with benign or malignant GOO underwent AA-EUS-GE using a retrievable anchor system and an electrocautery-enhanced lumen-apposing metal stent. The primary outcomes were technical and clinical (tolerance of solid diet within one week post-procedure) success rates.</p><p><strong>Results: </strong>Twelve patients were enrolled (August 2023 to February 2025). Both technical and clinical success rates were 100%. The median procedure time was 30 minutes. All patients resumed liquid intake by day 2, soft diets by day 3, and regular diets within 7 days. No procedure-related serious adverse events occurred.</p><p><strong>Conclusions: </strong>In this cohort, AA-EUS-GE demonstrated excellent feasibility and safety, achieving a very high success rate without serious complications.</p>","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}