Gastrointestinal endoscopy最新文献

{"title":"Top tips for traction during endoscopic submucosal dissection.","authors":"Molham Abdulsamad","doi":"10.1016/j.gie.2026.04.036","DOIUrl":"https://doi.org/10.1016/j.gie.2026.04.036","url":null,"abstract":"","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of recurrent esophageal strictures with a paclitaxel coated balloon dilator: Initial U.S. Experience.","authors":"Kenneth K Wang, Shahriar Sedghi, Gary T Reiss, Nicholas J Shaheen, Gerald W Dryden, Michael E Goldberg, Vivaik Tyagi","doi":"10.1016/j.gie.2026.04.038","DOIUrl":"https://doi.org/10.1016/j.gie.2026.04.038","url":null,"abstract":"<p><strong>Background and aims: </strong>Recurrent esophageal strictures reduce quality of life for patients and represent a significant burden for health care providers. A novel drug-coated balloon (DCB) dilator has been developed to decrease stricture recurrence. We report the first US-based prospective, study of the DCB evaluating pharmacokinetic (PK) parameters and clinical outcomes after treatment of recurrent esophageal strictures. This study was a sub-study conducted before initiating a randomized controlled trial but using the same entry criteria.</p><p><strong>Methods: </strong>25 patients with recurrent esophageal strictures were enrolled at 10 US centers. All patients' index treatment included endoscopy with stricture assessment with a functional lumen imaging probe (FLIP), symptom assessment using the Ogilvie score and Dysphagia Handicap Index (DHI), followed by dilation with the DCB. Follow-up was conducted at 1, 3, 6, and 12 months post-treatment with symptom assessments, endoscopy and FLIP performed at 6 months. Stricture recurrence was defined as a diameter <13mm on FLIP or any clinically-driven re-intervention.</p><p><strong>Results: </strong>Strictures were primarily peptic (88%) with a median of 6 lifetime dilations prior to entry. Freedom from stricture recurrence was 40% (10/25) in the 12 months post-DCB versus an expected 0% based on past history. Symptom were improved (by DHI and Ogilvie score) at 12 months. Systemic exposure to paclitaxel was limited, with only 7 subjects showing measurable levels of drug (0.1-0.2 ng/mL) in their blood after treatment. No adverse events were related to the DCB.</p><p><strong>Conclusions: </strong>Treatment of esophageal strictures with DCB demonstrated decreased recurrence of significant stricture compared to historical needs, improved dysphagia symptoms compared to baseline and limited systemic exposure to paclitaxel. Prospective randomized studies are needed to confirm these results.</p>","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic resection of low-grade dysplasia Barrett's esophagus: A multicenter retrospective study.","authors":"Sebastian Petruzzella, Thibaut Denat, Mariola Marx, Elodie Romailler, Meddy Dalex, Marie Philippart, Jean-Philippe Ratone, Solene Hoibian, Yanis Dahel, Marc Giovannini, Laurent Monino, Fabrice Caillol, Sébastien Godat","doi":"10.1016/j.gie.2026.04.037","DOIUrl":"https://doi.org/10.1016/j.gie.2026.04.037","url":null,"abstract":"<p><strong>Background and aims: </strong>Barrett's esophagus (BE) is a common precancerous condition requiring surveillance or treatment at various stages. Low-grade dysplasia (LGD) increases the risk of progression to high-grade dysplasia or esophageal adenocarcinoma, but histopathological assessment is challenging, and progression is unpredictable. Endoscopic resection, through mucosal or submucosal techniques, offers high efficacy, low complication rates, and shorter treatment duration. This study evaluated the effectiveness and safety of endoscopic eradication therapy in patients with LGD BE.</p><p><strong>Methods: </strong>This retrospective study included 119 patients with LGD BE treated at three tertiary centers. Patients underwent endoscopic mucosal resection (EMR) or, for nodular or retractile lesions, endoscopic submucosal dissection (ESD). The primary outcome was complete LGD eradication (CE-D), confirmed endoscopically and histologically. Secondary outcomes included adverse events, histopathology of resected specimens, treatment duration, and recurrence rates.</p><p><strong>Results: </strong>Of the 119 patients (75% men; mean age 62 years), EMR was performed in 97% and ESD in 3 cases. LGD was confirmed by two different pathologists in 87% and by repeat biopsy in 70% before treatment. CE-D was achieved in 95% of patients. Histopathology revealed LGD in 50%, high-grade dysplasia in 9%, adenocarcinoma in 3%, and non-dysplastic findings in others. Early complications occurred in 2.5%, and late adverse events in 12%, all managed conservatively or endoscopically. LGD recurred in 10% of patients over a median follow-up of 905 days.</p><p><strong>Conclusions: </strong>Endoscopic therapy with EMR or ESD appears effective and safe for selected patients with LGD in BE, with low recurrence rates. In addition to lesion eradication, it provides histological assessment, allowing detection of more advanced pathology in some cases. These findings suggest that resection may represent a valuable adjunct or alternative within current treatment strategies.</p>","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Bleeding Following Endoscopic Retrograde Cholangiopancreatography: A Systematic Review and Meta-analysis.","authors":"Aamir Saeed, Hina Akbar, Yasi Xiao, Anand Kumar, Rishi Pawa, Alexander Schlachterman, Thomas Kowalski, Mark Radlinski, Anthony Gamboa, Janak Shah, Claudio R Tombazzi, Mansour A Parsi, Mustafa Arain, Faisal Kamal","doi":"10.1016/j.gie.2026.04.035","DOIUrl":"https://doi.org/10.1016/j.gie.2026.04.035","url":null,"abstract":"<p><strong>Background and aims: </strong>Endoscopic retrograde cholangiopancreatography (ERCP) is associated with complications, including bleeding, which occurs in up to 1.3% cases. This meta-analysis aims to identify and quantify risk factors associated with post-ERCP bleeding.</p><p><strong>Methods: </strong>A comprehensive literature search of electronic databases was conducted from inception to January 10, 2025. Studies were eligible if they used multivariate analysis to identify predictors of post-ERCP bleeding. Risk factors reported in at least two studies were pooled using a random-effects model to calculate odds ratios (OR) with 95% confidence intervals (CI). A further subgroup analysis was performed, including risk factors for post-sphincterotomy and post-endoscopic papillectomy bleeding.</p><p><strong>Results: </strong>Twenty-seven studies (4 prospective and 23 retrospective studies) comprising 149870 patients were included, of whom 1865 experienced post-ERCP bleeding. Twenty potential risk factors were analyzed. The meta-analysis identified several factors significantly associated with an increased odds of post-ERCP bleeding in pooled adjusted analysis, including: male gender (OR 1.24, 95% CI: 1.05, 1.46), anticoagulation therapy (OR 2.75, 95% CI: 1.66, 4.56), cirrhosis (OR 2.54, 95% CI 1.76, 3.65), hemodialysis (OR 5.82, 95% CI: 3.32, 10.18), coagulopathy (OR 11.01, 95% CI: 2.50, 48.40), endoscopic sphincterotomy (OR 3.19, 95% CI: 1.69, 6.01), precut sphincterotomy (OR 2.24, 95% CI: 1.52, 3.30), and intraoperative bleeding (OR 2.57, 95% CI: 1.80, 3.66). Several factors in pooled adjusted analysis were not found to be significantly associated with higher odds of post-ERCP bleeding, including high body mass index, NSAID use, antiplatelet therapy, thrombocytopenia, common bile duct stones, cholangitis, endoscopic papillary balloon dilatation and covered self-expandable metal stents insertion.</p><p><strong>Conclusion: </strong>In conclusion, this meta-analysis identified that the anticoagulation therapy, cirrhosis, hemodialysis, coagulation disorder, endoscopic sphincterotomy, precut sphincterotomy, and male gender are associated with an increased odds of post-ERCP bleeding in the pooled adjusted analysis. Conversely, age, high BMI, cholangitis, choledocholithiasis, pancreatic duct stones, needle-knife sphincterotomy, NSAIDs use, and antiplatelet therapy were not significantly associated with higher odds of post-ERCP bleeding in pooled adjusted analysis. Incorporating our results into a prediction model may assist in identifying patients at increased risk, optimizing informed consent, and guiding prevention and management strategies for post-ERCP bleeding.</p>","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"6 ARE DISPOSABLE DUODENOSCOPES THE FUTURE OF ERCP? INSIGHTS FROM A MULTICENTER U.S. UTILIZATION STUDY","authors":"Charudatta Wankhade,&nbsp;Haroon M. Shahid,&nbsp;Amy Tyberg,&nbsp;Avik Sarkar,&nbsp;Iman Andalib,&nbsp;Monica Gaidhane,&nbsp;Michel Kahaleh","doi":"10.1016/S0016-5107(26)00300-7","DOIUrl":"10.1016/S0016-5107(26)00300-7","url":null,"abstract":"","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":"103 5","pages":"Page S-3"},"PeriodicalIF":7.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"603 UNDERSTANDING WHY RACIAL DISPARITIES PERSIST IN ERCP ACCESS: A COMPREHENSIVE NATIONAL ANAYLYSIS","authors":"Kunjal H. Shah,&nbsp;Sachin Prasad,&nbsp;Matthew Lee,&nbsp;Nneka Mezu,&nbsp;Michael Owolabi,&nbsp;Varun Chahal,&nbsp;Danielle Thor,&nbsp;Anudeep Jala,&nbsp;Tania Siu Xiao","doi":"10.1016/S0016-5107(26)00328-7","DOIUrl":"10.1016/S0016-5107(26)00328-7","url":null,"abstract":"","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":"103 5","pages":"Page S-15"},"PeriodicalIF":7.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2 COMPARISON OF SAFETY BETWEEN POWER-CONTROLLED AND TEMPERATURE-CONTROLLED INTRADUCTAL RADIOFREQUENCY ABLATION IN MALIGNANT DISTAL BILIARY OBSTRUCION: PRELIMINARY RESULTS FROM A MULTICENTER RANDOMIZED CONTROLLED TRIAL","authors":"Min Je Sung,&nbsp;Jae Hee Cho,&nbsp;Huapyong Kang,&nbsp;Jung Wan Choe,&nbsp;Sang Hoon Lee,&nbsp;Dong Woo Shin,&nbsp;Dong Wook Lee,&nbsp;SEUNG-JUN KIM","doi":"10.1016/S0016-5107(26)00296-8","DOIUrl":"10.1016/S0016-5107(26)00296-8","url":null,"abstract":"","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":"103 5","pages":"Page S-1"},"PeriodicalIF":7.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"383 EFFICACY AND SAFETY OF ENDOSCOPIC ULTRASOUND-GUIDED CHOLEDOCHODUODENOSTOMY (EUS-CDS) COMPARED WITH ENDOSCOPIC ULTRASOUND-GUIDED GALLBLADDER DRAINAGE (EUS-GBD) FOR PALLIATION OF MALIGNANT DISTAL BILIARY OBSTRUCTION: A SYSTEMATIC REVIEW AND META-ANALYSIS","authors":"Saurabh Chandan,&nbsp;Tareq Alsaleh,&nbsp;Babu P. Mohan,&nbsp;Sneh Sonaiya,&nbsp;Abdullah Abbasi,&nbsp;Sahib Singh,&nbsp;Sagar J. Pathak,&nbsp;Mohammad Bilal,&nbsp;Kambiz S. Kadkhodayan,&nbsp;Mustafa A. Arain,&nbsp;Gursimran S. Kochhar,&nbsp;Muhammad K. Hasan,&nbsp;Douglas G. Adler","doi":"10.1016/S0016-5107(26)00322-6","DOIUrl":"10.1016/S0016-5107(26)00322-6","url":null,"abstract":"","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":"103 5","pages":"Page S-13"},"PeriodicalIF":7.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"601 COMPLETION CHOLECYSTECTOMY: SURGICAL INDICATIONS AND OUTCOMES AFTER SUBTOTAL CHOLECYSTECTOMY","authors":"Yael E. Weisz,&nbsp;Brynne A. Ichiuji,&nbsp;Jessica Raya,&nbsp;Patrick McGillen,&nbsp;Hector Ramos,&nbsp;Kazuhide Matsushima","doi":"10.1016/S0016-5107(26)00326-3","DOIUrl":"10.1016/S0016-5107(26)00326-3","url":null,"abstract":"","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":"103 5","pages":"Page S-15"},"PeriodicalIF":7.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sa1904 CAROLI DISEASE PRESENTING WITH RETROPERITONEAL ABSCESS AND FECAL FISTULA: EXPANDING THE SPECTRUM OF EXTRAHEPATIC COMPLICATIONS","authors":"Muhammad Imtanan Fazal,&nbsp;Iqra Nawaz,&nbsp;Ira Abid,&nbsp;Fatima Zafar,&nbsp;Muhammad Romail Manan,&nbsp;Nabeeha Noor","doi":"10.1016/S0016-5107(26)00354-8","DOIUrl":"10.1016/S0016-5107(26)00354-8","url":null,"abstract":"","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":"103 5","pages":"Page S-28"},"PeriodicalIF":7.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}