Genomics最新文献

{"title":"The translation landscape revealed the novel micropeptides involved in myogenic differentiation of goat skeletal muscle satellite cells","authors":"Qianqian Pan ,&nbsp;Mengyu Lou ,&nbsp;Jing Jing ,&nbsp;Tianwei Liu ,&nbsp;Yan Huang ,&nbsp;Shuang Li ,&nbsp;Lu Zhu ,&nbsp;Yong Liu ,&nbsp;Sihuan Zhang ,&nbsp;Yinghui Ling","doi":"10.1016/j.ygeno.2026.111194","DOIUrl":"10.1016/j.ygeno.2026.111194","url":null,"abstract":"<div><div>Skeletal muscle development is crucial for goat meat production. While most research focuses on transcriptional regulation, translational control is often overlooked. This study integrated transcriptomic data to analyze the translational landscape during myogenic differentiation of goat skeletal muscle satellite cells (SMSCs). We found that differentiation pathways were activated at both levels, with enhancement at translation. Furthermore, we identified 25 novel lncORFs and 36 circORFs with coding potential. Among these, LncORF32653 and LncORF98488 encoded micropeptides promoting SMSCs proliferation and differentiation. We also identified circUSP25, encoding circUSP25-177aa, which inhibited proliferation but promoted differentiation. Thus, lncORF32653-53aa, lncORF98488-98aa, and circUSP25-177aa are key regulators of myogenesis, revealing the potential of RNAs annotated as non-coding to encode functional micropeptides.</div></div>","PeriodicalId":12521,"journal":{"name":"Genomics","volume":"118 2","pages":"Article 111194"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single cell transcriptomic atlas reveals distinct immune signatures following transfusion of COVID-19 convalescent plasma in severe COVID-19","authors":"Chengqi Gao ,&nbsp;Wei Xiao ,&nbsp;Chao Zhu ,&nbsp;Mengwei Liu ,&nbsp;Zhenguo Zeng ,&nbsp;Kun Xiao ,&nbsp;Kuai Yu","doi":"10.1016/j.ygeno.2025.111191","DOIUrl":"10.1016/j.ygeno.2025.111191","url":null,"abstract":"<div><div>The inflammatory responses of severe patients before and after Convalescent COVID-19 plasma (CCP) transfusion are poorly understood. To clarify the immune response and potential pro-inflammatory factors in severe patients after CCP transfusion, we performed single-cell RNA sequencing on peripheral blood mononuclear cells (PBMCs) from severe COVID-19 patients before and 24 h after CCP transfusion. At 24 h after CCP transfusion, T and B cell proportions increased modestly without significant changes in TCR/BCR diversity. Importantly, concurrent upregulation of S100A8 in both CD4 memory T cells and B cells suggests that CCP transfusion may promote an inflammatory response in these cell subsets. Cell communication analysis revealed that CCP transfusion induced selective disruption of NK cell communication with TCR-negative T cells and BCR-positive B cells. Our data suggest CCP transfusion promoted the inflammatory response and interrupt the communication between adaptive immune cells and innate immune cells in severe COVID-19.</div></div>","PeriodicalId":12521,"journal":{"name":"Genomics","volume":"118 2","pages":"Article 111191"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haplotype-resolved genome assembly of Musella lasiocarpa reveals the critical role of structural variations in chromosomal and genome evolution","authors":"Qing Liu ,&nbsp;Dongli Cui ,&nbsp;Yaqi Tian ,&nbsp;Yehan Wang ,&nbsp;Mathieu Rouard ,&nbsp;John Seymour Heslop-Harrison ,&nbsp;Trude Schwarzacher ,&nbsp;Ziwei Wang","doi":"10.1016/j.ygeno.2026.111210","DOIUrl":"10.1016/j.ygeno.2026.111210","url":null,"abstract":"<div><div><em>Musella lasiocarpa</em> (MLA, 2<em>n</em> = 18, Musaceae) is an endangered species native to south-western China. We assembled its haplotype-resolved, telomere-to-telomere genomes with a genome size of 503.6 Mb consisting of 52.8% repetitive DNA. A 134 bp tandem repeat, Mlcen, was identified at all centromeres, and telomere sequences were present at 30 of 36 assembled pseudo-chromosome ends. The distal gene-rich regions display high synteny, whereas retrotransposon polymorphisms between haplotypes occurred throughout chromosomes, contributing to diversity. Phylogenetic analysis shows MLA diverged from <em>Ensete</em> 42 million years ago, and together they share a common ancestor with <em>Musa</em>. Among 35,312 protein-coding genes, 14 up-regulated and 34 down-regulated transcription factors were identified under cold treatment. This high-quality genomic resource advances our understanding of MLA chromosomal evolution characterized by structural variations, repetitive DNA dynamics, and cold-responsive genes at both haplotype and species levels; and enables genome-assisted improvement of more resilient crops such as bananas and <em>Ensete</em>.</div></div>","PeriodicalId":12521,"journal":{"name":"Genomics","volume":"118 2","pages":"Article 111210"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146085369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of lead resistance in Wickerhamomyces anomalus: Insights from whole genome sequencing","authors":"Lijie Li,&nbsp;Ganqiqige Cha,&nbsp;Fengsheng Zhang","doi":"10.1016/j.ygeno.2025.111192","DOIUrl":"10.1016/j.ygeno.2025.111192","url":null,"abstract":"<div><div>Lead contamination in air, water, and soil has infiltrated foods and feeds, posing severe health risks to humans and animals and remaining a tough challenge. Yeast is a safe and efficient biosorbent for lead removal. This study explored <em>W. anomalus QF-11</em> lead resistance via whole-genome sequencing, finding it tolerates up to 7000 mg/L Pb²⁺. Under 4000 mg/L Pb²⁺ stress, it enhances resistance by scavenging ROS, increasing soluble protein, boosting SOD, POD and CAT activities, and elevating glutathione and trehalose levels. Its genome annotates 63 ABC transporters and antioxidant genes involved in lead adsorption, transportation and compartmentalization, with SODC, SODM, VAN1, TSL1 and others significantly upregulated. This study provides a theoretical basis for <em>W. anomalus QF-11</em> application as a Pb²⁺ biosorbent and data support for novel heavy metal adsorbent development.</div></div>","PeriodicalId":12521,"journal":{"name":"Genomics","volume":"118 2","pages":"Article 111192"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145905906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dbert2_LR: A deep learning-based model for predicting cis-regulatory elements in crops","authors":"Huan Liu ,&nbsp;Faxu Guo ,&nbsp;Longyu Huang ,&nbsp;Jian Wang ,&nbsp;Guomin Zhou ,&nbsp;Jianhua Zhang","doi":"10.1016/j.ygeno.2026.111201","DOIUrl":"10.1016/j.ygeno.2026.111201","url":null,"abstract":"<div><div>Cis-regulatory elements (CREs) are key determinants of gene expression underlying complex agronomic traits. However, accurately identifying CREs in crops with large and highly repetitive genomes (such as upland cotton) remains extremely challenging. To address this, we developed Dbert2_LR, a novel hybrid deep-learning framework that integrates the pretrained genomic foundation model DNABERT-2 with parallel bidirectional RNN and LSTM networks. This architecture efficiently captures both deep contextual dependencies and local sequence patterns in DNA, enabling high-accuracy classification of promoters, enhancers, and non-regulatory sequences. Systematic evaluations on Arabidopsis <em>thaliana</em> and upland cotton show that Dbert2_LR outperforms multiple benchmark models, achieving macro-averaged F1 scores of 0.890 and 0.637, respectively. More importantly, in-silico saturation mutagenesis (ISM) analysis confirmed that the model's decisions strongly depend on known transcription factor binding motifs such as TATA-box, DOF, and E-box, revealing its biological interpretability and helping overcome the “black-box” nature of deep learning. To facilitate broader use, we also developed user-friendly A_cre and C_cre prediction systems. This study provides a powerful new tool for functional annotation of complex crop genomes and lays the foundation for CRE-based molecular breeding design.</div></div>","PeriodicalId":12521,"journal":{"name":"Genomics","volume":"118 2","pages":"Article 111201"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145988944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of interindividual DNA methylation variability in rainbow trout (Oncorhynchus mykiss)","authors":"Gaëlle Lefort ,&nbsp;Aurélien Brionne ,&nbsp;Benoît Piégu ,&nbsp;Frédéric Terrier ,&nbsp;Antoine Pigeon ,&nbsp;Linda Beauclair ,&nbsp;Jérôme Roy ,&nbsp;Lucie Marandel ,&nbsp;Stéphane Panserat ,&nbsp;Delphine Lallias ,&nbsp;Vincent Coustham","doi":"10.1016/j.ygeno.2026.111211","DOIUrl":"10.1016/j.ygeno.2026.111211","url":null,"abstract":"<div><div>Interindividual epigenetic variability, particularly in DNA methylation, is now recognized as a significant contributor to phenotypic diversity in mammals including humans. These epivariable regions, which make up a small fraction of the genome, are strongly influenced by genetic factors and environmental factors, especially during early development. In this context, epigenetic variability of DNA methylation has been proposed as an adaptive force involved in various environmental responses. In fish and other vertebrates, environmental factors are known to influence the health, performance and welfare, likely through the alteration of the epigenetic landscape. However, whether interindividual epigenetic variability may contribute to the phenotypic plasticity of fishes is unknown. Here we provide a first description of the rainbow trout methylome interindividual variability using a whole-genome bisulfite sequencing approach in an isogenic line to minimize genetic variation. Variable methylation regions were identified in both liver and hypothalamus tissues of 12 replicate fishes and were found enriched at gene regulatory elements, such as promoters and first introns. Gene Ontology analysis revealed functional clusters related to cellular development, neural communication, metabolic balance, and immune response. Interestingly, some variably methylated regions are found at the same genomic loci in both tissues and showed a strong intraindividual correlation in methylation levels, suggesting establishment during early embryogenesis. Overall, our work demonstrates the existence of interindividual epigenetic variability in rainbow trout and provides valuable insights into the regulatory function of DNA methylation variation that is likely involved in developmental and physiological processes.</div></div>","PeriodicalId":12521,"journal":{"name":"Genomics","volume":"118 2","pages":"Article 111211"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146124515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GC–TOF–MS-based metabolomic and whole-transcriptomic analyses reveal the molecular mechanism of primary metabolite changes in pear fruit after methyl jasmonate treatment","authors":"Yubo Yuan ,&nbsp;Yangyang Chen ,&nbsp;Lisha Luo ,&nbsp;Yuanyuan Jia ,&nbsp;Kaijie Qi ,&nbsp;Zhihua Xie ,&nbsp;Hao Yin ,&nbsp;Shaoling Zhang ,&nbsp;Xiao Wu","doi":"10.1016/j.ygeno.2026.111195","DOIUrl":"10.1016/j.ygeno.2026.111195","url":null,"abstract":"<div><h3>Background</h3><div>Methyl jasmonate (MeJA) regulates plant development and reproductive processes and significantly influences metabolism. Pears are important economic fruits, but there is still limited research on the changes in primary metabolites in pears after MeJA treatment, and their molecular mechanisms are not yet clear.</div></div><div><h3>Results</h3><div>This study employed GC–TOF–MS to analyze primary metabolite changes in the peel and flesh of ‘Nanguo’ pears after MeJA treatment. The results showed that 174 and 156 metabolites were detected in the peel and flesh respectively, from which 7 and 2 differentially altered metabolites were subsequently screened out. We analysed the combined whole-transcriptome data and constructed relevant competitive endogenous RNA (ceRNA) and miRNA–target transcription factor regulatory networks for each differentially expressed compound.</div></div><div><h3>Conclusions</h3><div>Our results provide an informative insight to the molecular regulatory network by which MeJA treatment changes the primary metabolism in pears, providing a theoretical basis for improving fruit quality during storage.</div></div>","PeriodicalId":12521,"journal":{"name":"Genomics","volume":"118 2","pages":"Article 111195"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145943237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-regulatory crosstalk between m5C, m7G, and o8G RNA modifications via QKI/YBX1 axis in myocardial ischemia-reperfusion injury","authors":"Ziqiang Yang ,&nbsp;Suyun Chen ,&nbsp;Siman Shen ,&nbsp;Wanglong Liu ,&nbsp;Kun Ding ,&nbsp;Fangni Cao ,&nbsp;Simeng Li ,&nbsp;Minjuan Zeng ,&nbsp;Jianning Chen ,&nbsp;Li Xu ,&nbsp;Liangqing Zhang","doi":"10.1016/j.ygeno.2026.111193","DOIUrl":"10.1016/j.ygeno.2026.111193","url":null,"abstract":"<div><h3>Background</h3><div>Ischemia–reperfusion (I/R) injury in the heart triggers oxidative stress and alters post-transcriptional gene regulation. Reactive oxygen species (ROS) generated during oxidative stress induce RNA modifications such as 8-oxo-guanosine (o8G). Other modifications including 5-methylcytosine (m5C) and 7-methylguanosine (m7G) may also contribute to cardiac dysfunction. While the roles of individual RNA modifications in I/R injury are increasingly recognized, the global dynamics and crosstalk among these modifications under oxidative stress remain largely unexplored.</div></div><div><h3>Methods</h3><div>We performed high-throughput sequencing specific to each modification, integrated with mRNA transcriptome profiling of an IR injury mouse model. Differentially modified transcripts were subjected to GO and KEGG enrichment analyses to elucidate their functional relevance. Mechanistically, we demonstrated that RNA modification regulators with distinct functional roles can physically interact with each other, as shown by co-immunoprecipitation and immunofluorescence assays. Global changes in RNA modification levels under the model conditions were assessed using dot blot analysis. Furthermore, the regulatory effects of these enzymes on target mRNA stability were evaluated via Actinomycin D transcriptional inhibition assays.</div></div><div><h3>Results</h3><div>We found that the levels of all three modifications, m5C, m7G, and o8G were increased in IR by dot blot and observed a significant upregulation of three modification peaks under I/R by MeRIP-seq. Both m5C and o8G were predominantly enriched in CDS, while m7G displayed a dynamic redistribution. Our study focuses on the co-regulation crosstalk among three modifications. Functionally, singly or combinatorially modified transcripts were enriched in actin cytoskeleton regulation. Mechanistically, the transcripts of the regulators can be modified by each other and QKI can modulate the global modification level of o8G. QKI and YBX1 interact with each other to cooperatively stabilize ACTN4 mRNA, thereby maintaining cytoskeletal integrity.</div></div><div><h3>Conclusion</h3><div>Our results establish that QKI and YBX1 modulate the actin cytoskeleton via a coordinated network of m5C, m7G, and o8G in I/R injury.</div></div>","PeriodicalId":12521,"journal":{"name":"Genomics","volume":"118 2","pages":"Article 111193"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of an FSH induced liver organoid model for investigating lipid metabolism abnormalities and study of the regulatory role of key lncRNAs","authors":"Xue Yu,&nbsp;Congcong Shen,&nbsp;Pingping Huang,&nbsp;Bingwen Li,&nbsp;Bailing Zhou,&nbsp;Lijing Wang,&nbsp;Shuoxuan Wang,&nbsp;Yurui Xu,&nbsp;Meng Li,&nbsp;Jie Qu,&nbsp;Guodong Hu,&nbsp;Jihua Wang","doi":"10.1016/j.ygeno.2026.111209","DOIUrl":"10.1016/j.ygeno.2026.111209","url":null,"abstract":"<div><h3>Background</h3><div>The health problems of the elderly, especially the elderly women, are increasingly concerned. The prevalence of abnormal liver lipid metabolism in women after menopause is increasing, which is highly related to estrogen and follicle stimulating hormone. However, hormone replacement therapy is highly controversial, and will bring risks such as breast cancer and coronary heart disease. Therefore, this study aims to build an effective and convenient in vitro disease model and perform functional verification to analyze the molecular mechanism of candidate lncRNAs participating in FSH-induced liver lipid metabolism.</div></div><div><h3>Result</h3><div>The results indicated the successful preliminary establishment of an in vitro model for FSH-induced lipid metabolism abnormalities. High-throughput sequencing and bioinformatics analysis revealed a total of 174 differentially expressed lncRNAs. Utilizing a comprehensive database, we screened five candidate lncRNAs and conducted interference tests specifically on the upregulated lncRNA ENSMUST00000244884. The findings demonstrated that knocking down this lncRNA led to an increase in the expression of the LXR and ACOX1 genes, which are crucial for lipid metabolism. Consequently, the lipid metabolism abnormality phenotype was alleviated.</div></div><div><h3>Conclusion</h3><div>Based on the experimental results, we have determined that bile-derived liver organoids are well-suited for constructing an in vitro disease model of hormone-induced lipid metabolism abnormalities, enabling effective observation of lipid phenotypes. Furthermore, we have screened and identified lncRNAs involved in hormone-regulated lipid metabolism abnormalities at the non-coding regulatory level. These findings offer potential diagnostic markers and therapeutic targets for disorders related to lipid metabolism.</div></div>","PeriodicalId":12521,"journal":{"name":"Genomics","volume":"118 2","pages":"Article 111209"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated multi-omics analysis reveals gamma-aminobutyric acid as a key regulator of social genetic effects on residual feed intake in pigs","authors":"Patrick Kofi Makafui Tecku ,&nbsp;Zhenjian Zhao ,&nbsp;Dong Chen ,&nbsp;Shengdi Cui ,&nbsp;Junge Wang ,&nbsp;Shixin Yu ,&nbsp;Ziyang Chen ,&nbsp;Yaoxi Zhou ,&nbsp;Runjie Huang ,&nbsp;Wenxuan Zhou ,&nbsp;Jia Xue ,&nbsp;Guoqing Tang","doi":"10.1016/j.ygeno.2026.111207","DOIUrl":"10.1016/j.ygeno.2026.111207","url":null,"abstract":"<div><div>Residual feed intake (RFI) is an important indicator of feed efficiency influenced by social interactions. However, the molecular mechanisms underlying social genetic effects on RFI (RFI-SGE) remain unclear. This study employed multi-omics analysis to investigate RFI-SGE in pigs, analyzing liver, ileum, and cecum tissues from high and low RFI-SGE groups. Transcriptomic and proteomic analyses revealed significant differences in gene and protein expressions, with liver pathways enriched in oxidative phosphorylation and ileum pathways linked to amino acid metabolism. Metabolomic analysis identified gamma-aminobutyric acid (GABA) as consistently upregulated in high RFI-SGE pigs. Integrated analysis revealed strong associations between GABA and its biosynthetic genes and upstream precursors (<em>MAOB</em>, <em>DAO</em>, <em>ASS1</em>, and <em>OAT</em>). Enhanced GABA signaling may improve social adaptability, metabolic regulation, and feed efficiency in pigs. The identification of GABA as a potential key regulator of RFI-SGE provides valuable insights for improving feed efficiency and animal welfare through targeted breeding strategies.</div></div>","PeriodicalId":12521,"journal":{"name":"Genomics","volume":"118 2","pages":"Article 111207"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}