Frontiers in Neural Circuits最新文献_第6页

Acetylcholine facilitates localized synaptic potentiation and location specific feature binding 乙酰胆碱促进局部突触增强和位置特异性特征结合

3区医学

Frontiers in Neural Circuits Pub Date : 2023-11-10 DOI: 10.3389/fncir.2023.1239096

Yihao Yang, Victoria Booth, Michal Zochowski

{"title":"Acetylcholine facilitates localized synaptic potentiation and location specific feature binding","authors":"Yihao Yang, Victoria Booth, Michal Zochowski","doi":"10.3389/fncir.2023.1239096","DOIUrl":"https://doi.org/10.3389/fncir.2023.1239096","url":null,"abstract":"Forebrain acetylcholine (ACh) signaling has been shown to drive attention and learning. Recent experimental evidence of spatially and temporally constrained cholinergic signaling has sparked interest to investigate how it facilitates stimulus-induced learning. We use biophysical excitatory-inhibitory (E-I) multi-module neural network models to show that external stimuli and ACh signaling can mediate spatially constrained synaptic potentiation patterns. The effects of ACh on neural excitability are simulated by varying the conductance of a muscarinic receptor-regulated hyperpolarizing slow K+ current (m-current). Each network module consists of an E-I network with local excitatory connectivity and global inhibitory connectivity. The modules are interconnected with plastic excitatory synaptic connections, that change via a spike-timing-dependent plasticity (STDP) rule. Our results indicate that spatially constrained ACh release influences the information flow represented by network dynamics resulting in selective reorganization of inter-module interactions. Moreover the information flow depends on the level of synchrony in the network. For highly synchronous networks, the more excitable module leads firing in the less excitable one resulting in strengthening of the outgoing connections from the former and weakening of its incoming synapses. For networks with more noisy firing patterns, activity in high ACh regions is prone to induce feedback firing of synchronous volleys and thus strengthening of the incoming synapses to the more excitable region and weakening of outgoing synapses. Overall, these results suggest that spatially and directionally specific plasticity patterns, as are presumed necessary for feature binding, can be mediated by spatially constrained ACh release.","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135191494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: GABAergic circuits in health and disease. 编辑:gaba能回路在健康和疾病。

IF 3.5 3区医学

Frontiers in Neural Circuits Pub Date : 2023-10-31 eCollection Date: 2023-01-01 DOI: 10.3389/fncir.2023.1322193

Lisa Topolnik, Graziella Di Cristo, Elsa Rossignol

引用次数: 0

The flow of axonal information among hippocampal sub-regions 2: patterned stimulation sharpens routing of information transmission 海马亚区之间的轴突信息流 2：模式化刺激使信息传输路线更加清晰

IF 3.5 3区医学

Frontiers in Neural Circuits Pub Date : 2023-10-20 DOI: 10.3389/fncir.2023.1272925

Samuel Brandon Lassers, Yash S. Vakilna, William C. Tang, Gregory J. Brewer

{"title":"The flow of axonal information among hippocampal sub-regions 2: patterned stimulation sharpens routing of information transmission","authors":"Samuel Brandon Lassers, Yash S. Vakilna, William C. Tang, Gregory J. Brewer","doi":"10.3389/fncir.2023.1272925","DOIUrl":"https://doi.org/10.3389/fncir.2023.1272925","url":null,"abstract":"The sub-regions of the hippocampal formation are essential for episodic learning and memory formation, yet the spike dynamics of each region contributing to this function are poorly understood, in part because of a lack of access to the inter-regional communicating axons. Here, we reconstructed hippocampal networks confined to four subcompartments in 2D cultures on a multi-electrode array that monitors individual communicating axons. In our novel device, somal, and axonal activity was measured simultaneously with the ability to ascertain the direction and speed of information transmission. Each sub-region and inter-regional axons had unique power-law spiking dynamics, indicating differences in computational functions, with abundant axonal feedback. After stimulation, spiking, and burst rates decreased in all sub-regions, spikes per burst generally decreased, intraburst spike rates increased, and burst duration decreased, which were specific for each sub-region. These changes in spiking dynamics post-stimulation were found to occupy a narrow range, consistent with the maintenance of the network at a critical state. Functional connections between the sub-region neurons and communicating axons in our device revealed homeostatic network routing strategies post-stimulation in which spontaneous feedback activity was selectively decreased and balanced by decreased feed-forward activity. Post-stimulation, the number of functional connections per array decreased, but the reliability of those connections increased. The networks maintained a balance in spiking and bursting dynamics in response to stimulation and sharpened network routing. These plastic characteristics of the network revealed the dynamic architecture of hippocampal computations in response to stimulation by selective routing on a spatiotemporal scale in single axons.","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138553545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential. GABA能信号在酒精使用障碍和戒断中的作用：病理学意义和治疗潜力。

IF 3.5 3区医学

Frontiers in Neural Circuits Pub Date : 2023-10-20 eCollection Date: 2023-01-01 DOI: 10.3389/fncir.2023.1218737

Ravinder Naik Dharavath, Celeste Pina-Leblanc, Victor M Tang, Matthew E Sloan, Yuliya S Nikolova, Peter Pangarov, Anthony C Ruocco, Kevin Shield, Daphne Voineskos, Daniel M Blumberger, Isabelle Boileau, Nikki Bozinoff, Philip Gerretsen, Erica Vieira, Osnat C Melamed, Etienne Sibille, Lena C Quilty, Thomas D Prevot

{"title":"GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential.","authors":"Ravinder Naik Dharavath, Celeste Pina-Leblanc, Victor M Tang, Matthew E Sloan, Yuliya S Nikolova, Peter Pangarov, Anthony C Ruocco, Kevin Shield, Daphne Voineskos, Daniel M Blumberger, Isabelle Boileau, Nikki Bozinoff, Philip Gerretsen, Erica Vieira, Osnat C Melamed, Etienne Sibille, Lena C Quilty, Thomas D Prevot","doi":"10.3389/fncir.2023.1218737","DOIUrl":"10.3389/fncir.2023.1218737","url":null,"abstract":"Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the global disease burden, contributes substantially to societal and economic costs, and leads to approximately 3 million global deaths yearly. Alcohol use disorder (AUD) includes various drinking behavior patterns that lead to short-term or long-lasting effects on health. Ethanol, the main psychoactive molecule acting in alcoholic beverages, directly impacts the GABAergic system, contributing to GABAergic dysregulations that vary depending on the intensity and duration of alcohol consumption. A small number of interventions have been developed that target the GABAergic system, but there are promising future therapeutic avenues to explore. This review provides an overview of the impact of alcohol on the GABAergic system, the current interventions available for AUD that target the GABAergic system, and the novel interventions being explored that in the future could be included among first-line therapies for the treatment of AUD.","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71480314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autogenous cerebral processes: an invitation to look at the brain from inside out. 自主大脑过程：一种从内到外观察大脑的邀请。

IF 3.5 3区医学

Frontiers in Neural Circuits Pub Date : 2023-10-19 eCollection Date: 2023-01-01 DOI: 10.3389/fncir.2023.1253609

Pedro E Maldonado, Miguel Concha-Miranda, Miriam Schwalm

引用次数: 0

Potential for host-symbiont communication via neurotransmitters and neuromodulators in an aneural animal, the marine sponge Amphimedon queenslandica. 通过神经递质和神经调节剂与宿主共生体交流的潜力在非整倍体动物，海洋海绵昆士兰两栖动物中。

IF 3.5 3区医学

Frontiers in Neural Circuits Pub Date : 2023-09-29 eCollection Date: 2023-01-01 DOI: 10.3389/fncir.2023.1250694

Xueyan Xiang, Arturo A Vilar Gomez, Simone P Blomberg, Huifang Yuan, Bernard M Degnan, Sandie M Degnan

{"title":"Potential for host-symbiont communication via neurotransmitters and neuromodulators in an aneural animal, the marine sponge Amphimedon queenslandica.","authors":"Xueyan Xiang, Arturo A Vilar Gomez, Simone P Blomberg, Huifang Yuan, Bernard M Degnan, Sandie M Degnan","doi":"10.3389/fncir.2023.1250694","DOIUrl":"10.3389/fncir.2023.1250694","url":null,"abstract":"Interkingdom signalling within a holobiont allows host and symbionts to communicate and to regulate each other's physiological and developmental states. Here we show that a suite of signalling molecules that function as neurotransmitters and neuromodulators in most animals with nervous systems, specifically dopamine and trace amines, are produced exclusively by the bacterial symbionts of the demosponge Amphimedon queenslandica. Although sponges do not possess a nervous system, A. queenslandica expresses rhodopsin class G-protein-coupled receptors that are structurally similar to dopamine and trace amine receptors. When sponge larvae, which express these receptors, are exposed to agonists and antagonists of bilaterian dopamine and trace amine receptors, we observe marked changes in larval phototactic swimming behaviour, consistent with the sponge being competent to recognise and respond to symbiont-derived trace amine signals. These results indicate that monoamines synthesised by bacterial symbionts may be able to influence the physiology of the host sponge.","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41234112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Echinoderm radial glia in adult cell renewal, indeterminate growth, and regeneration. 棘皮放射状胶质细胞在成体细胞更新、不确定生长和再生中的作用。

IF 3.4 3区医学

Frontiers in Neural Circuits Pub Date : 2023-09-29 eCollection Date: 2023-01-01 DOI: 10.3389/fncir.2023.1258370

Vladimir Mashanov, Soji Ademiluyi, Denis Jacob Machado, Robert Reid, Daniel Janies

{"title":"Echinoderm radial glia in adult cell renewal, indeterminate growth, and regeneration.","authors":"Vladimir Mashanov, Soji Ademiluyi, Denis Jacob Machado, Robert Reid, Daniel Janies","doi":"10.3389/fncir.2023.1258370","DOIUrl":"10.3389/fncir.2023.1258370","url":null,"abstract":"Echinoderms are a phylum of marine deterostomes with a range of interesting biological features. One remarkable ability is their impressive capacity to regenerate most of their adult tissues, including the central nervous system (CNS). The research community has accumulated data that demonstrates that, in spite of the pentaradial adult body plan, echinoderms share deep similarities with their bilateral sister taxa such as hemichordates and chordates. Some of the new data reveal the complexity of the nervous system in echinoderms. In terms of the cellular architecture, one of the traits that is shared between the CNS of echinoderms and chordates is the presence of radial glia. In chordates, these cells act as the main progenitor population in CNS development. In mammals, radial glia are spent in embryogenesis and are no longer present in adults, being replaced with other neural cell types. In non-mammalian chordates, they are still detected in the mature CNS along with other types of glia. In echinoderms, radial glia also persist into the adulthood, but unlike in chordates, it is the only known glial cell type that is present in the fully developed CNS. The echinoderm radial glia is a multifunctional cell type. Radial glia forms the supporting scaffold of the neuroepithelium, exhibits secretory activity, clears up dying or damaged cells by phagocytosis, and, most importantly, acts as a major progenitor cell population. The latter function is critical for the outstanding developmental plasticity of the adult echinoderm CNS, including physiological cell turnover, indeterminate growth, and a remarkable capacity to regenerate major parts following autotomy or traumatic injury. In this review we summarize the current knowledge on the organization and function of the echinoderm radial glia, with a focus on the role of this cell type in adult neurogenesis.","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41234110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local and long-range GABAergic circuits in hippocampal area CA1 and their link to Alzheimer's disease. 海马CA1区的局部和长程GABA能回路及其与阿尔茨海默病的关系。

IF 3.5 3区医学

Frontiers in Neural Circuits Pub Date : 2023-09-29 eCollection Date: 2023-01-01 DOI: 10.3389/fncir.2023.1223891

Melissa Hernández-Frausto, Olesia M Bilash, Arjun V Masurkar, Jayeeta Basu

{"title":"Local and long-range GABAergic circuits in hippocampal area CA1 and their link to Alzheimer's disease.","authors":"Melissa Hernández-Frausto, Olesia M Bilash, Arjun V Masurkar, Jayeeta Basu","doi":"10.3389/fncir.2023.1223891","DOIUrl":"10.3389/fncir.2023.1223891","url":null,"abstract":"GABAergic inhibitory neurons are the principal source of inhibition in the brain. Traditionally, their role in maintaining the balance of excitation-inhibition has been emphasized. Beyond homeostatic functions, recent circuit mapping and functional manipulation studies have revealed a wide range of specific roles that GABAergic circuits play in dynamically tilting excitation-inhibition coupling across spatio-temporal scales. These span from gating of compartment- and input-specific signaling, gain modulation, shaping input-output functions and synaptic plasticity, to generating signal-to-noise contrast, defining temporal windows for integration and rate codes, as well as organizing neural assemblies, and coordinating inter-regional synchrony. GABAergic circuits are thus instrumental in controlling single-neuron computations and behaviorally-linked network activity. The activity dependent modulation of sensory and mnemonic information processing by GABAergic circuits is pivotal for the formation and maintenance of episodic memories in the hippocampus. Here, we present an overview of the local and long-range GABAergic circuits that modulate the dynamics of excitation-inhibition and disinhibition in the main output area of the hippocampus CA1, which is crucial for episodic memory. Specifically, we link recent findings pertaining to GABAergic neuron molecular markers, electrophysiological properties, and synaptic wiring with their function at the circuit level. Lastly, given that area CA1 is particularly impaired during early stages of Alzheimer's disease, we emphasize how these GABAergic circuits may contribute to and be involved in the pathophysiology.","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41234111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corticospinal excitability after 5-day Dry Immersion in women. 女性干浸泡5天后的皮质脊髓兴奋性。

IF 3.5 3区医学

Frontiers in Neural Circuits Pub Date : 2023-09-22 eCollection Date: 2023-01-01 DOI: 10.3389/fncir.2023.1163346

Inna Nosikova, Alexandra Riabova, Vladimir Kitov, Elena Tomilovskaya

{"title":"Corticospinal excitability after 5-day Dry Immersion in women.","authors":"Inna Nosikova, Alexandra Riabova, Vladimir Kitov, Elena Tomilovskaya","doi":"10.3389/fncir.2023.1163346","DOIUrl":"10.3389/fncir.2023.1163346","url":null,"abstract":"In light of the development of manned astronautics and the increasing participation of women in space flights, the question of female body adaptation to microgravity conditions becomes relevant. Currently, one of the important directions in this issue is to study the effects of support withdrawal as a factor of weightlessness on the human sensorimotor system. Dry Immersion is one of the well-known ground-based models, which adequately reproduces the main physiological effects of space flight. The aim of this study was to evaluate the changes in motor evoked potentials of the lower leg gravity-dependent muscles in women after a 5-day Dry Immersion. We analyzed evoked responses to transcranial and trans-spinal magnetic stimulation. In this method, areas of interest (the motor cortex and lumbosacral thickening of the spinal cord) are stimulated with an electromagnetic stimulus. The experiment was conducted with the participation of 16 healthy female volunteers with a natural menstrual cycle. The thresholds, amplitudes, and latencies of motor potentials evoked by magnetic stimulation were assessed. We showed that 5-day exposure to support withdrawal leads to a decrease in motor-evoked potential thresholds and central motor conduction time, although changes in motor response amplitudes were ambiguous. The data obtained correspond to the results of previous research on Dry Immersion effects on the sensorimotor system in men.","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41094926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interneuron odyssey: molecular mechanisms of tangential migration. 中间神经元奥德赛：切向迁移的分子机制。

IF 3.5 3区医学

Frontiers in Neural Circuits Pub Date : 2023-09-14 eCollection Date: 2023-01-01 DOI: 10.3389/fncir.2023.1256455

Ikram Toudji, Asmaa Toumi, Émile Chamberland, Elsa Rossignol

{"title":"Interneuron odyssey: molecular mechanisms of tangential migration.","authors":"Ikram Toudji, Asmaa Toumi, Émile Chamberland, Elsa Rossignol","doi":"10.3389/fncir.2023.1256455","DOIUrl":"10.3389/fncir.2023.1256455","url":null,"abstract":"Cortical GABAergic interneurons are critical components of neural networks. They provide local and long-range inhibition and help coordinate network activities involved in various brain functions, including signal processing, learning, memory and adaptative responses. Disruption of cortical GABAergic interneuron migration thus induces profound deficits in neural network organization and function, and results in a variety of neurodevelopmental and neuropsychiatric disorders including epilepsy, intellectual disability, autism spectrum disorders and schizophrenia. It is thus of paramount importance to elucidate the specific mechanisms that govern the migration of interneurons to clarify some of the underlying disease mechanisms. GABAergic interneurons destined to populate the cortex arise from multipotent ventral progenitor cells located in the ganglionic eminences and pre-optic area. Post-mitotic interneurons exit their place of origin in the ventral forebrain and migrate dorsally using defined migratory streams to reach the cortical plate, which they enter through radial migration before dispersing to settle in their final laminar allocation. While migrating, cortical interneurons constantly change their morphology through the dynamic remodeling of actomyosin and microtubule cytoskeleton as they detect and integrate extracellular guidance cues generated by neuronal and non-neuronal sources distributed along their migratory routes. These processes ensure proper distribution of GABAergic interneurons across cortical areas and lamina, supporting the development of adequate network connectivity and brain function. This short review summarizes current knowledge on the cellular and molecular mechanisms controlling cortical GABAergic interneuron migration, with a focus on tangential migration, and addresses potential avenues for cell-based interneuron progenitor transplants in the treatment of neurodevelopmental disorders and epilepsy.","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41104511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0