Frontiers in Oncology最新文献

{"title":"Case report: Histiocytic sarcoma as transdifferentiation of a marginal zone lymphoma-a case presentation based on <i>post mortem</i> examination and review of the literature.","authors":"Annaïse J Jauch, Ilaria Alborelli, Ilaria Balestri, Fatime Krasniqi, Alexandar Tzankov, Benjamin Kasenda, Thomas Menter","doi":"10.3389/fonc.2025.1609694","DOIUrl":"https://doi.org/10.3389/fonc.2025.1609694","url":null,"abstract":"<p><strong>Background: </strong>Histiocytic sarcoma (HS) is a rare and aggressive hematopoietic malignancy characterized by the proliferation of cells resembling mature histiocytes. It typically presents in extranodal sites such as the skin, the gastrointestinal tract, and soft tissues and is often accompanied by systemic symptoms including fever and weight loss. HS occurs <i>de novo</i> or results from transformation/transdifferentiation from other hematological neoplasms, such as low-grade B-cell lymphomas. To date, only four cases of HS arising from marginal zone lymphomas (MZL) have been documented.</p><p><strong>Case presentation: </strong>We describe a 66-year-old female patient who presented primarily with abdominal pain and constitutional symptoms. The clinical evaluation showed significant hepatosplenomegaly and lymphadenopathy. A liver biopsy demonstrated a sinus-associated spread of HS. The patient died of suspected hemorrhagic shock before the diagnostic results were finalized and before rescue treatment could be initiated. The autopsy findings confirmed a widespread metastatic HS and concurrent MZL. The molecular analysis showed that both neoplasmas were clonally related, supporting the hypothesis of transformation/transdifferentiation of MZL into HS.</p><p><strong>Conclusion: </strong>We have reported the fifth unusual transformation of a MZL into a HS. Transformed/transdifferentiated HS is a rare and aggressive neoplasm. Evidence from the published case reports suggests that its clinical course may be more severe than <i>de novo</i> HS. This underscores the importance of investigating rare presentations and considering the possibility of an underlying pre-existing hematological malignancy.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1609694"},"PeriodicalIF":3.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early detection and management strategies for isolated splenic metastasis in cervical cancer: a case report.","authors":"Na Zhang","doi":"10.3389/fonc.2025.1639109","DOIUrl":"https://doi.org/10.3389/fonc.2025.1639109","url":null,"abstract":"<p><p>A 55-year-old woman experienced 2 months of vaginal bleeding after intercourse. After gynecological examination, cervical biopsy, and imaging examinations including magnetic resonance imaging (MRI) and positron emission tomography/computed tomography (PET/CT), she was diagnosed with stage IIB cervical squamous cell carcinoma, which was associated with <i>human papillomavirus</i> (HPV) infection. The patient subsequently underwent robotic-assisted para-aortic lymphadenectomy, and the pathology results showed no evidence of cancer spread. She completed a treatment plan that included chemoradiotherapy, delivering a total radiation dose of 93.2 Gy along with concurrent cisplatin chemotherapy. Although a post-treatment evaluation indicated a partial remission (PR), follow-up imaging revealed unusual findings in the spleen, which were later confirmed to be metastatic cancer. The patient underwent a laparoscopic splenectomy, and the postoperative pathology confirmed the presence of squamous cell carcinoma metastasis. Genetic testing identified multiple somatic mutations and a high mutational burden in the tumor. After surgery, she received chemotherapy and targeted therapy. At present, her condition is stable, and she has survived for 12 months. This case highlights the complex nature of cervical cancer metastasis and the important role of genetic testing in developing personalized treatment plans.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1639109"},"PeriodicalIF":3.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pleomorphic adenocarcinoma of the breast: a case report.","authors":"Yunkun Zhang, Pengchao Fan, Min Gao, Rui Cong, Qimin Wang, Dan Zhao, Jian Zhang, Yini Zhang, Lifen Wang","doi":"10.3389/fonc.2025.1644881","DOIUrl":"https://doi.org/10.3389/fonc.2025.1644881","url":null,"abstract":"<p><p>This article comprehensively reports a case of pleomorphic adenocarcinoma of the breast, a rare breast salivary gland-type tumor. A mass with a maximum diameter of 3.2 cm was detected through ultrasound within the upper outer quadrant in a 74-year-old woman undergoing left breast total mastectomy and sentinel lymph node exploration. Microscopically, the central part of the tumor was mostly arranged in the solid structures, some of which were cribriform and contained blue-stained secretions, while the periphery of the tumor had striated and glandular duct-like arranged structures. Some tumor cells had visible nucleoli and nuclear fission, with sparse cytoplasm. Immunohistochemistry revealed ER (-), PR (-), HER-2 (0), Bcl-2 (+), P63 (-), Calponin (-), S100 (+), E-cadherin (+), and Ki-67 (20%+). The next-generation sequencing (NGS) assay revealed a missense mutation within exon 7 in PIK3CA, which is related to the treatment of breast cancer. The patient received 1 course of oral Capecitabine treatment after surgery and was followed up for 2 years with no recurrence.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1644881"},"PeriodicalIF":3.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and meta-analysis on computed tomography angiography mapping for deep inferior epigastric perforator flap breast reconstruction.","authors":"Roshan S Rupra, Francesca Ruccia, Kian Daneshi, Fatema Aftab, Yousif F Yousif, Gul R Khan, Sina Dehnadi, Yaqoob H AlSaidi, Nicola Maggialetti, Giovanni Lorusso, Maria Yan, Ankur Khajuria","doi":"10.3389/fonc.2025.1600476","DOIUrl":"https://doi.org/10.3389/fonc.2025.1600476","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer remains the most prevalent cancer among women globally, necessitating effective reconstructive options post-mastectomy. The deep inferior epigastric perforator (DIEP) flap is the gold standard for autologous breast reconstruction, though anatomical variability of perforators presents surgical challenges. Computed tomography angiography (CTA) has been proposed to enhance preoperative planning and reduce operative time. The aim of this study is to identify how CTA affects surgical outcomes in autologous breast reconstruction.</p><p><strong>Methods: </strong>A systematic review and meta-analysis (PROSPERO: CRD42024596646) were conducted per PRISMA guidelines. A comprehensive search of six databases identified studies comparing CTA with non-CTA imaging for DIEP flap reconstruction. Primary outcomes included operative time and flap loss rates. Risk of bias was assessed using ROBINS-I and RoB2, with quality appraised via AMSTAR-2 and GRADE.</p><p><strong>Results: </strong>Eighteen studies (3870 patients, 4283 flaps) were included. CTA guidance reduced unilateral flap operative time (mean 304.98 min vs. 390.18 min, CI -12.9 to 5.7; P = 0.2367), as well as partial and total flap loss rates (OR: 0.26, 95% CI: 0.14-0.47; OR: 0.30, 95% CI: 0.13-0.68). High heterogeneity (I² = 98.7%) limited generalizability. Prior reviews showed limitations in study design integrity, whereas this study achieved a high-confidence rating.</p><p><strong>Conclusions: </strong>Preoperative CTA improves surgical outcomes in DIEP flap reconstruction, though evidence quality is variable. Future research should compare CTA with MRA, assess cost-effectiveness, integrate AI-assisted imaging, and explore MRI-based protocols for optimized preoperative planning in microsurgical breast cancer reconstruction and enhanced oncologic care delivery.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD42024596646, idenitifier CRD42024596646.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1600476"},"PeriodicalIF":3.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-printed biopolymer-based microneedle for enhanced photodynamic therapy in melanoma treatment.","authors":"Aishat Adejoke Obalola, Heidi Abrahamse, Sathish Sundar Dhilip Kumar","doi":"10.3389/fonc.2025.1642448","DOIUrl":"https://doi.org/10.3389/fonc.2025.1642448","url":null,"abstract":"<p><p>Melanoma is a highly aggressive cancer with poor prognosis and resistance to many treatments, especially after metastasis. Developing new preventive and adjuvant therapies is critical for improving melanoma outcomes. Photodynamic therapy (PDT) has shown potential in selectively targeting malignant cells while minimizing damage to healthy tissue. However, improving the delivery of photosensitizers (PS) to melanoma cells while reducing systemic toxicity remains a challenge. Microneedles, a transcutaneous drug delivery method, offer advantages such as better patient compliance and easier management compared to traditional methods like intramuscular or intravenous injection. Despite these benefits, manufacturing precise microneedles remains a hurdle. Recent research has focused on 3D printing techniques for creating transdermal drug delivery devices, including microneedles. This review summarizes recent advantages in 3D printed biopolymer-based drug delivery systems using microneedles, evaluates their potential, and discusses the challenges and future prospects of 3D printing in transdermal therapy.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1642448"},"PeriodicalIF":3.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring 2D and 3D radiomic models for predicting microvascular invasion in hepatocellular carcinoma: a novel perspective on tumor heterogeneity.","authors":"Zexin Yin, Meilong Wu, Youyao Li, Zhike Li, Shiyun Bao, Liping Liu","doi":"10.3389/fonc.2025.1590655","DOIUrl":"https://doi.org/10.3389/fonc.2025.1590655","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to develop models for predicting microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients prior to surgery using two-dimensional (2D) and three-dimensional (3D) radiomics features from contrast-enhanced computed tomography (CT). The study compares the predictive performance of various models and explores the potential of radiomics to capture tumor spatial heterogeneity.</p><p><strong>Materials and methods: </strong>A total of 150 hepatocellular carcinoma (HCC) patients who underwent contrast-enhanced CT examination and curative resection were included in this study. 2D features from the largest cross-sectional slice, as well as 3D radiomic features, were extracted from the non-contrast (NC), arterial phase (AP), portal venous phase (PVP), and balanced phase (BP) images. Feature selection was performed using the least absolute shrinkage and selection operator (LASSO) algorithm, and predictive models were constructed using logistic regression and XGBoost machine learning algorithms. The predictive performance of the models was evaluated using the area under the receiver operating characteristic curve (AUC).</p><p><strong>Results: </strong>The 2D BP model (AUC = 0.801) and 3D PVP model (AUC = 0.876) showed superior performance among single-sequence models. The 2D multi-sequence model (AUC = 0.851) outperformed the 3D combined model (AUC = 0.811). Radiomics-based models outperformed clinical feature-based models, and combining radiomics scores with clinical features improved prediction accuracy. However, 3D models did not significantly outperform 2D models.</p><p><strong>Conclusion: </strong>Both 2D and 3D radiomics models are effective for predicting MVI in HCC patients preoperatively. While the 3D model captures spatial heterogeneity, the 2D model excels at capturing local texture features. This study provides new insights into radiomics in HCC, contributing to its clinical application and standardization.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1590655"},"PeriodicalIF":3.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A deep learning approach for brain tumour classification and detection in MRI images using YOLOv7.","authors":"Ramya Nimmagadda, P Kalpana Devi","doi":"10.3389/fonc.2025.1508326","DOIUrl":"https://doi.org/10.3389/fonc.2025.1508326","url":null,"abstract":"<p><p>The medical imaging field has grown tremendously due to the latest digital imaging and artificial intelligence (AI) advancements. These advancements have improved tumour classification accuracy, time, cost efficiency, etc. Radiologists utilize an MRI scan due to its exceptional capacity to identify even the most minor alterations in brain activity. This research uses YOLOv7, a Deep Learning (DL) model, to classify and detect brain tumours and to conduct a detailed analysis of the frequently used structures for tumour identification. The study uses a brain MRI dataset from Roboflow with 2870 labelled pictures divided into four types of tumours. Our brain tumour dataset has four distinct classes: pituitary, gliomas, meningiomas, and no tumours. This preprocessed sample was used to assess the performance of deep learning models on identifying and classifying brain tumours. Throughout the preprocessing stage, aspect ratio normalization and resizing algorithms are applied to improve tumour localization for bounding box-based detection. YOLOv7 performs admirably, with a recall score of 0.813 and a box detection accuracy of 0.837. Remarkably, the mAP value for the 0.5 IoU threshold is 0.879. During box identification within the extended IoU spectrum of 0.5 for a to 0.95, the mAP value was 0.442.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1508326"},"PeriodicalIF":3.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12485631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TFF2, a novel serum diagnostic biomarker for early pancreatic cancer.","authors":"Xiangyu Wu, Xiuhong Huang","doi":"10.3389/fonc.2025.1633069","DOIUrl":"https://doi.org/10.3389/fonc.2025.1633069","url":null,"abstract":"<p><strong>Background: </strong>Early detection and intervention are critical for improving the prognosis of pancreatic cancer (PC), but effective screening tests remain unavailable.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 92 PC cases, 50 benign pancreatic disease cases, 92 periampullary adenocarcinoma cases, and 92 healthy controls from September 2020 to September 2024 at Handan Central Hospital. Serum levels of CA199 and CEA were measured, and their diagnostic performance was evaluated by the area under the receiver operating characteristic (ROC) curve (AUC). Additionally, publicly available cancer genome datasets were analyzed to identify specific serum biomarkers for early PC, and clinical serum samples were collected to validate their expression and diagnostic utility.</p><p><strong>Results: </strong>CA199 and CEA effectively differentiated PC from benign pancreatic diseases and normal controls. However, they demonstrated limited value for distinguishing PC and periampullary carcinoma, with AUC values of 0.571 and 0.604, respectively. Trefoil factor 2 (TFF2), a gene encoding exocrine protein, was found to be specifically upregulated in pancreatic intraepithelial neoplasia and PC, with no significant expression observed in benign pancreatic diseases, cholangiocarcinoma, or hepatocellular carcinoma. Importantly, serum TFF2 levels were significantly elevated in the PC group, with AUC values of 0.947 for distinguishing PC from normal controls and 0.856 for differentiating it from periampullary adenocarcinoma, outperforming CA199 and CEA. The combination of TFF2 enhanced accuracy of CA199 and CEA to discriminate PC from periampullary adenocarcinoma.</p><p><strong>Conclusions: </strong>Serum TFF2 is a promising test for early screening of PC and may enhance diagnostic performance when combined with CA199 and CEA.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1633069"},"PeriodicalIF":3.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular profiling of circulating tumor cells guides effective EGFR inhibitor treatment in advanced hepatocellular carcinoma: a case report.","authors":"Wei Chiu, San-Chi Chen, Yee Chao, Jan-Mou Lee","doi":"10.3389/fonc.2025.1608604","DOIUrl":"https://doi.org/10.3389/fonc.2025.1608604","url":null,"abstract":"<p><p>Circulating tumor cells (CTCs) hold promise for use in personalized medicine for hepatocellular carcinoma (HCC). Their abundance and molecular characteristics may predict disease prognosis and could be used to monitor responses to treatment in specific types of cancers. The present case report described a 52-year-old woman with metastatic HCC with an extensive treatment history. The patient's CTCs demonstrated EGFR surface mutations, specifically, an EGFR exon 19 deletion and an L858R mutation. Based on this finding, the patient's metastatic lung lesions were treated with an EGFR tyrosine kinase inhibitor-based regimen, which achieved a partial response that was confirmed using the Response Evaluation Criteria in Solid Tumors (version 1.1). Notably, the patient benefited from this therapy regimen for a period of 14 months. The progression of precision medicine in HCC has been hampered by difficulties in identifying cancer driver genes and the limited utilization of histological diagnosis. The findings of the present study suggest that molecular analysis of CTCs may have the potential to guide personalized HCC treatment strategies in the future.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1608604"},"PeriodicalIF":3.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-lipolysis-stimulated lipoprotein receptor antibody-drug conjugate to treat triple-negative breast cancer.","authors":"Zhuoxin Zora Zhou, Davis Ballard, Tanvi Varadkar, Jiashuai Zhang, Zhantao Du, Ashley George, Aaron Krabacher, Rachel Yengo, Lufang Zhou, Xiaoguang Margaret Liu","doi":"10.3389/fonc.2025.1663743","DOIUrl":"https://doi.org/10.3389/fonc.2025.1663743","url":null,"abstract":"<p><p>Triple-negative breast cancer (TNBC), the most aggressive breast cancer subtype (ER^-/PR^-/HER2^-), is characterized by rapid proliferation, high metastatic rate and frequent recurrence. The development of targeted therapies for TNBC, such as antibody-drug conjugates (ADCs), has been limited by the lack of promising cell surface receptors. Our recent findings revealed that lipolysis-stimulated lipoprotein receptor (LSR) is overexpressed in breast cancer patients. The objective of this study was to develop an anti-LSR monoclonal antibody (mAb) and ADC for TNBC treatment. We observed high transcript and surface expression of LSR across various breast cancer subtypes, with over 63% of TNBC patient tissue samples exhibiting elevated expression. A new mAb targeting the extracellular domain of LSR was developed, engineered, and evaluated <i>in vitro</i> and <i>in vivo</i>. The ADC, constructed by conjugating LSR mAb with a cytotoxic agent mertansine (DM1), demonstrated potent anti-TNBC cytotoxicity in three cell lines. <i>In vivo</i> anti-cancer efficacy was evaluated in two TNBC xenografted mouse models, where a 24 mg/kg-body weight dose of LSR mAb-DM1 reduced tumor burden by 85% in one model and prevented tumor regrowth in the second model. Notably, no off-target effects or systemic toxicity were observed in animal models during or after treatment. This study highlights LSR as a promising therapeutic target and the anti-LSR mAb and ADC as potential targeted therapies for TNBC.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1663743"},"PeriodicalIF":3.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}