Frontiers in Oncology最新文献

{"title":"The impact of management traps on surgical strategies in parathyroid benign and malignant tumors-related PHPT: a retrospective cohort study.","authors":"Guang-Wen Zhu, Xue Lv, Zhan Jiao","doi":"10.3389/fonc.2025.1535089","DOIUrl":"10.3389/fonc.2025.1535089","url":null,"abstract":"<p><strong>Background: </strong>Reducing the incidence rate of persistent/recurrent HPT after surgery is the key to the treatment of PHPT. The pitfalls of preoperative, intraoperative, and postoperative management in PHPT patients and their potential impact on surgical strategies need to be comprehensively investigated.</p><p><strong>Methods: </strong>The demographic, biochemical, radiological results and other clinical data of the enrolled 112 patients with primary hyperparathyroidism undergoing surgical treatment were obtained from our database in this retrospective cohort study. One-way analysis of variance was used for normally distributed variables, and Kruskal-Wallis H test was used for non-normally distributed variables. Pearson's chi-square test or Fisher's exact test was used for categorical variables, as appropriate.</p><p><strong>Results: </strong>The patients were divided into parathyroid adenoma group and atypical parathyroid tumor + parathyroid carcinoma group. The serum calcium levels, serum PTH levels in the APT+PC group were higher than those with benign lesions, but there was some overlap; and the clinical data showed no specificity in the differentiation of benign and malignant parathyroid tumors. A more significant finding in this cohort was that the tumor size was significantly larger in persistent/recurrent HPT group than in non-persistent/recurrent group (30.0 ± 12.6 mm vs.19.1± 8.3 mm, p < 0.01).</p><p><strong>Conclusion: </strong>In PHPT, there are pitfalls in preoperative, intraoperative, and postoperative management of parathyroid tumors, which affect the choice of surgical strategies. It is prudent to utilize the tumor-free margin En bloc resection in a variety of parathyroid neoplasms, in order to seek the chance of cure and avoid reoperation as much as possible.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1535089"},"PeriodicalIF":3.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intratumoral CD8+ tumor-infiltrating lymphocytes as prognostic predictors in radio-chemoradiotherapy-treated nasopharyngeal carcinoma.","authors":"Xinjing Li, Xiaoming Qiu, Cuihong Lin, Yuanying Liu, Yongbin Wang, Langlang Tang, Yuanhe Tong, Linbo Tang","doi":"10.3389/fonc.2025.1551980","DOIUrl":"10.3389/fonc.2025.1551980","url":null,"abstract":"<p><strong>Background: </strong>The prognostic value of tumor-infiltrating lymphocytes (TILs) in nasopharyngeal carcinoma (NPC) has been established. However, the prognostic significance of CD4+ and CD8+ TIL subtypes in NPC remains unclear.</p><p><strong>Methods: </strong>We collected 214 tissue samples diagnosed with NPC for immunohistochemical staining. The density of CD4+ and CD8+ TILs was evaluated in intratumoral (within tumor cell nests) and stromal (the surrounding stroma of tumor cell nests) areas. Correlations between TIL density and progression-free survival (PFS) and overall survival (OS) were analyzed.</p><p><strong>Results: </strong>High levels of intratumoral CD8+ TILs were significantly associated with reduced risk of disease progression (HR 0.382; 95% CI, 0.178-0.819, P = 0.013) and death (HR 0.265; 95% CI, 0.104-0.675, P = 0.005). Although high stromal CD8+ TIL levels were linked to higher PFS and OS, these differences did not reach statistical significance (P = 0.114 and P = 0.079, respectively). CD4+ TILs showed no significant correlation with PFS or OS. In multivariate analysis, intratumoral CD8+ TILs remained an independent prognostic factor for PFS and OS. Subgroup analysis revealed that in patients with locally advanced disease, high intratumoral CD8+ TILs were significantly associated with improved PFS (HR 0.329; 95% CI, 0.129-0.843, P = 0.021) and OS (HR 0.209; 95% CI, 0.064-0.681, P = 0.009). Conversely, in early-stage patients, neither CD8+ nor CD4+ TILs were significantly associated with PFS or OS.</p><p><strong>Conclusion: </strong>Our findings suggest that intratumoral CD8+ TILs serve as a reliable prognostic biomarker for NPC, with their prognostic value particularly pronounced in patients with locally advanced disease.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1551980"},"PeriodicalIF":3.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Divergent gene expression of <i>PTGS1</i> and <i>PTGS2</i> along the disease course of chronic myeloid leukaemia.","authors":"Denise K Wosniaki, Bianca N Kusma, Anelis M Marin, Eduardo C Munhoz, João S de H Farias, Eduarda B Mendes, Mateus N Aoki, Dalila L Zanette","doi":"10.3389/fonc.2025.1556956","DOIUrl":"10.3389/fonc.2025.1556956","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic myeloid leukaemia (CML) is a chronic myeloproliferative disorder caused by the reciprocal translocation of chromosomes 9 and 22. This genetic abnormality leads to the uncontrolled proliferation of myeloid lineage cells, ultimately causing leukaemia. Inflammation plays a significant role in the progression of various cancers, including lungs, colorectal, breast, head and neck, and haematological malignancies. Prostaglandins, which are key mediators in these processes, are synthesised by cyclooxygenases. Consequently, these genes are critical targets for studying CML due to their involvement in leukemogenesis.</p><p><strong>Methods: </strong>We investigated the expression levels of <i>PTGS1</i> and <i>PTGS2</i> genes in peripheral blood samples from CML patients. Quantitative PCR (qPCR) and in vitro cell culture experiments were used to assess gene expression. Statistical analysis included the Kruskal-Wallis test and simple linear regression models. Patients were stratified according to disease status, <i>BCR::ABL1</i> levels, treatment-free remission (TFR), and use of imatinib. The impact of NSAID use on gene expression was also evaluated.</p><p><strong>Results: </strong>Increased expression of <i>PTGS1</i> and <i>PTGS2</i> was observed in patients with favourable prognosis. Conversely, lower expression levels were found in patients with uncontrolled disease (high <i>BCR::ABL1</i> levels) compared to healthy controls, those in TFR, and patients undergoing imatinib treatment. NSAID use did not significantly alter <i>PTGS</i> gene expression. In vitro treatment of a CML cell line with imatinib also showed increased <i>PTGS1</i> expression.</p><p><strong>Discussion: </strong>These findings suggest a potential role of inflammatory pathways in CML progression and treatment response. The upregulation of <i>PTGS1</i> and <i>PTGS2</i> in patients with controlled disease and after imatinib treatment may indicate a link between COX enzyme activity and leukemogenesis. Further investigation is warranted to clarify the mechanistic role of these genes in CML pathophysiology and therapy outcomes.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1556956"},"PeriodicalIF":3.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of CD3 expression on outcome in pediatric anaplastic large cell lymphoma.","authors":"Ahmed Salah, Hanafy Hafez, Samah Semary, Eman Nageb, Sonia Soliman, Iman Zaky, Shahenda M Shahin, Leslie Lehmann, Alaa ElHaddad","doi":"10.3389/fonc.2025.1569370","DOIUrl":"https://doi.org/10.3389/fonc.2025.1569370","url":null,"abstract":"<p><strong>Background: </strong>Anaplastic large cell lymphoma (ALCL) constitutes 10-15% of childhood non-Hodgkin lymphoma. EFS is 70% and currently 80% with the additional of targeted agents such as CD30 directed conjugated monoclonal antibody brentuximab or ALK inhibitors such as crizotinib. Expression of CD3, a T-cell marker, can be lost or diminished in some ALCL cases. The literature is conflicting on whether CD3 expression affects prognosis, and it has been analyzed mostly in the relapse setting. The purpose of this study was to determine the effect of CD3 expression on survival and its relation to the other prognostic variables in newly diagnosed patients with pediatric ALCL treated at a single large pediatric oncology center.</p><p><strong>Methods: </strong>A retrospective study was done on 89 newly diagnosed pediatric ALCL patients (under 18 years old) treated at Children's Cancer Hospital Egypt (CCHE-57357) from July 2007 to December 2019. Immunohistochemistry was utilized to confirm the diagnosis and determine CD3 expression in tumor cells. The impact of CD3 expression on event-free survival (EFS), relapse-free survival (RFS) and overall survival (OS)) was analyzed.</p><p><strong>Results: </strong>The median age was 10.7 years with male to female ratio 1.8:1. The majority of patients (85.4%) were ALK positive. CD3 was positive in 31 (34.8%) of patients. The median follow-up period was 60 months. The five-year OS, EFS, and RFS rates for the entire group were 84.3%, 73.1%, and 81.5%, respectively. CD3 positivity was associated with a higher incidence of CNS involvement (p=0.03) but did not significantly impact other patient outcomes (EFS, RFS and OS). However, stage, B symptoms, and skin involvement were linked to a shorter relapse-free survival.</p><p><strong>Conclusion: </strong>This study indicates that CD3 expression may not be a major factor predicting survival in newly diagnosed pediatric ALCL. Additional research is needed to understand its association with CNS positive disease.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1569370"},"PeriodicalIF":3.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating tumor DNA laboratory processes and clinical applications in nasopharyngeal carcinoma.","authors":"Ziman Wu, Haiyan Yang, Xinying Li, Xiang Ji, Chan Mo, Zhou Zheng, Yafei Xu, Dan Xiong","doi":"10.3389/fonc.2025.1520733","DOIUrl":"10.3389/fonc.2025.1520733","url":null,"abstract":"<p><p>Circulating tumor DNA (ctDNA), a subset of cell-free DNA (cfDNA), originates from primary tumors and metastatic lesions in cancer patients, often carrying genomic variations identical to those of the primary tumor. ctDNA analysis via liquid biopsy has proven to be a valuable biomarker for early cancer detection, minimal residual disease (MRD) assessment, monitoring tumor recurrence, and evaluating treatment efficacy. However, despite advancements in ctDNA analysis technologies, standardized protocols for its extraction and detection have yet to be established. Each step of the process-from pre-analytical variables to detection techniques-significantly impacts the accuracy and reliability of ctDNA analysis. This review examines recent developments in ctDNA detection methods, focusing on pre-analytical factors such as specimen types, collection tubes, centrifugation protocols, and storage conditions, alongside high-throughput and ultra-sensitive detection technologies. It also briefly discusses the clinical potential of liquid biopsy in nasopharyngeal carcinoma (NPC).</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1520733"},"PeriodicalIF":3.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological and imaging features of struma ovarii: a retrospective study.","authors":"Mei Chen, Shusheng Liao, Youfeng Xu, Xianwang Ye, Xiupeng Jia, Shengmin Zhang","doi":"10.3389/fonc.2025.1487812","DOIUrl":"10.3389/fonc.2025.1487812","url":null,"abstract":"<p><strong>Objectives: </strong>The struma ovarii (SO) is a rare disease, presenting significant challenges in achieving an accurate diagnosis. This study aims to delineate the clinicopathological and multimodal imaging characteristics of SO, enabling the precise diagnosis of this entity.</p><p><strong>Methods: </strong>A retrospective analysis was conducted of the clinicopathological manifestations, laboratory examination results, and imaging data (including ultrasound and MRI) of 40 SO patients who received treatment at the First Affiliated Hospital of Ningbo University over the period from January 2010 to February 2024.</p><p><strong>Results: </strong>The pathological results of 40 patients showed 21 pure SO, including 20 benign and one malignant; 19 patients had mixed SO, composed of 17 benign and two malignant. Three malignant cases were thyroid carcinoid. According to the ultrasound image, 40 SO patients were divided into three types: 22 cases were cystic, which had mainly single room or separations; 12 cases were mainly cystic-solid mixed, which had multiple septations and hyperechoic nodules; and six solid cases showed regular or irregular mass and rich blood supply. Five patients underwent contrast-enhanced ultrasound (CEUS) examination. The cystic wall and septation showed equal enhancement and slow regression. Two patients showed low enhancement in the protrusion and with slow regression. The MRI manifestations of SO are various. In this cohort, T1-weighted imaging (T1WI) showed hypo-intensity in six cases and heterogeneity in six cases; T2-weighted imaging (T2WI) showed hypo-intensity in two cases, heterogeneity in five cases, and hyper-intensity in four cases; diffusion-weighted imaging (DWI) showed hypo-intensity in two cases, heterogeneity in three cases, and hyper-intensity in four cases.</p><p><strong>Conclusions: </strong>The incidence of SO is low, but there are some features in imaging. There were cystic, cystic-solid, or solid lesions in the appendage area; CEUS showed separations and solid components with rich blood flow and slow enhancement; MRI showed high signal on T2WI and multiple cysts and heterogeneous signal on T1WI, which were the imaging markers for SO. A comprehensive understanding of imaging manifestations can help radiologists identify this disease and provide a basis for an appropriate therapeutic regime.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1487812"},"PeriodicalIF":3.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early prediction of colorectal adenoma risk: leveraging large-language model for clinical electronic medical record data.","authors":"Xiaoyu Yang, Jinjian Xu, Hong Ji, Jun Li, Bingqing Yang, Liye Wang","doi":"10.3389/fonc.2025.1508455","DOIUrl":"10.3389/fonc.2025.1508455","url":null,"abstract":"<p><strong>Objective: </strong>To develop a non-invasive, radiation-free model for early colorectal adenoma prediction using clinical electronic medical record (EMR) data, addressing limitations in current diagnostic approaches for large-scale screening.</p><p><strong>Design: </strong>Retrospective analysis utilized 92,681 cases with EMR, spanning from 2012 to 2022, as the training cohort. Testing was performed on an independent test cohort of 19,265 cases from 2023. Several classical machine learning algorithms were applied in combination with the BGE-M3 large-language model (LLM) for enhanced semantic feature extraction. Area under the receiver operating characteristic curve (AUC) is the major metric for evaluating model performance. The Shapley additive explanations (SHAP) method was employed to identify the most influential risk factors.</p><p><strong>Results: </strong>XGBoost algorithm, integrated with BGE-M3, demonstrated superior performance (AUC = 0.9847) in the validation cohort. Notably, when applied to the independent test cohort, XGBoost maintained its strong predictive ability with an AUC of 0.9839 and an average advance prediction time of 6.88 hours, underscoring the effectiveness of the BGE-M3 model. The SHAP analysis further identified 16 high-impact risk factors, highlighting the interplay of genetic, lifestyle, and environmental influences on colorectal adenoma risk.</p><p><strong>Conclusion: </strong>This study developed a robust machine learning-based model for colorectal adenoma risk prediction, leveraging clinical EMR and LLM. The proposed model demonstrates high predictive accuracy and has the potential to enhance early detection, making it well-suited for large-scale screening programs. By facilitating early identification of individuals at risk, this approach may contribute to reducing the incidence and mortality associated with colorectal cancer.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1508455"},"PeriodicalIF":3.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosome, an important transmitter in the drug resistance of non-small cell lung cancer.","authors":"Hongzhi Ji, Li Zhang, Lingyun Ye","doi":"10.3389/fonc.2025.1539047","DOIUrl":"10.3389/fonc.2025.1539047","url":null,"abstract":"<p><p>Recent studies have promoted new insights into the biology of non-small cell lung cancer (NSCLC) and made considerable progress in the field of treatment, including targeted therapy for driver gene mutations. Immunotherapy (IO) is another breakthrough, which has achieved amazing clinical efficacy. However, the survival status of advanced NSCLC patients is still unsatisfactory. Drug resistance is an urgent problem to be solved in almost all anti-cancer treatment schemes. Nowadays, platinum based chemotherapy remains the standard treatment for patients with driver gene negative advanced NSCLC. Previous studies have shown that the reduction of intracellular accumulation of platinum drugs, DNA damage repair and the enhancement of detoxification effect all lead to platinum resistance. The mechanisms of tyrosine kinase inhibitors (TKIs) resistance include the emergence of secondary mutation, the activation of bypass signal pathways, the abnormality of downstream signal pathways and the transformation of phenotype. The mechanisms of immune checkpoint inhibitors (ICIs) resistance are more complex. A variety of cells, cytokines and metabolites participate in it to form an immunosuppressive microenvironment, resulting in the impairment of effector T cell function. Exosomes are small molecules secreted by a variety of cells. They can carry information such as miRNA, lncRNA, and protein, and play a pivotal role in signal transduction between cells. More and more studies show that exosomes are important transmitters in lung cancer cells, which can transfer drug resistance information from drug-resistant cells to sensitive cells. However, the underling specific mechanisms need to be further explored to find a new breakthrough for overcoming drug resistance of NSCLC.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1539047"},"PeriodicalIF":3.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Laser speckle flowgraphy in a patient with uveitis due to immune-related adverse events by immune checkpoint inhibitors.","authors":"Satoru Kase, Yui Yamashita, Satoshi Takeuchi, Susumu Ishida","doi":"10.3389/fonc.2025.1492011","DOIUrl":"10.3389/fonc.2025.1492011","url":null,"abstract":"<p><strong>Purpose: </strong>It remains unknown whether choroidal circulation could be altered at the onset of immune checkpoint inhibitor (ICI) uveitis compared with that before ICI treatment. Herein we report a patient with Vogt-Koyanagi-Harada (VKH) disease-like uveitis in the unaffected eye as an immune-related adverse effect (irAE) due to ICIs for metastatic choroidal melanoma who had received enucleation. Moreover, choroidal circulation and choroidal thickness were measured before and after treatment.</p><p><strong>Methods: </strong>A 58-year-old man had a medical history of enucleation in his left eye due to choroidal melanoma 6 years ago. Metastatic lesions in the gastrointestinal tracts and lung were found, and then he received ICIs three times. About 1 month later, he suffered from blurred vision and metamorphopsia in his right eye. Choroidal circulation was evaluated by mean blur rate (MBR), a relative value showing choroidal blood velocity on laser speckle flowgraphy. Central choroidal thickness (CCT) was measured on optical coherence tomography.</p><p><strong>Results: </strong>Since ophthalmic findings revealed VKH-like uveitis, oral prednisolone of 30 mg was given for 2 weeks, which were then tapered. MBR was reduced and CCT increased at the onset of ICI uveitis compared with its baseline and resolution after corticosteroid treatment.</p><p><strong>Conclusions: </strong>Choroidal circulation was disrupted, possibly due to ICI-induced autoinflammatory reaction to the choroid, which was managed by corticosteroid treatment. The combination of MBR and CCT could be a useful biomarker for managing the patients with VKH-like uveitis by ICIs.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1492011"},"PeriodicalIF":3.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bringing value to cancer research.","authors":"Casey J Allen, Horn M Danea, Fabrice Smieliauskas, Stephen Edge, Rachel A Greenup","doi":"10.3389/fonc.2025.1580575","DOIUrl":"10.3389/fonc.2025.1580575","url":null,"abstract":"<p><p>This article argues for incorporating a broader definition of \"value\" into cancer clinical trials. Current trials primarily focus on efficacy and safety, neglecting patient-reported outcomes (PROs) such as quality of life, financial toxicity, and time burden, as well as cost-effectiveness. We propose a novel framework integrating oncologic outcomes, PROs, and cost analyses. We also propose a multidimensional visual tool, such as a radar chart, to facilitate better-informed, value-based shared decision-making. This requires a collaborative approach, involving stakeholders in defining value metrics. While acknowledging challenges such as increased administrative burden and data interpretation complexities, a comprehensive framework can substantially improve patient-centered cancer care. The ultimate goal is to standardize value assessment in cancer research, leading to more equitable and effective care.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1580575"},"PeriodicalIF":3.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}